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Page 1
Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging.
Zhang Y, Bai J, Cui Z, Li Y, Gao Q, Miao Y, Xiong B. Zhang Y, et al. Nat Aging. 2023 Nov;3(11):1372-1386. doi: 10.1038/s43587-023-00498-8. Epub 2023 Oct 16. Nat Aging. 2023. PMID: 37845508
Here, we applied untargeted metabolomics to identify spermidine as a critical metabolite in ovaries to protect oocytes against aging. In particular, we found that the spermidine level was reduced in ovaries of aged mice and that supplementation with spermidine …
Here, we applied untargeted metabolomics to identify spermidine as a critical metabolite in ovaries to protect oocytes against aging. …
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
In a Drosophila aging model, spermidine boosts mitochondrial respiratory capacity, an effect that requires the autophagy regulator Atg7 and the mitophagy mediators Parkin and Pink1. Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of o …
In a Drosophila aging model, spermidine boosts mitochondrial respiratory capacity, an effect that requires the autophagy regulator At …
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Sperm …
Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elast …
Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy.
Zhou Y, Wang D, Xiao Q, Ma L, Gou H, Ru Y, Tang J, Xu X, Chen X, Sun W, Li L, Xu Y. Zhou Y, et al. Free Radic Biol Med. 2025 Feb 1;227:379-394. doi: 10.1016/j.freeradbiomed.2024.12.016. Epub 2024 Dec 8. Free Radic Biol Med. 2025. PMID: 39657843
Mechanistically, SPD reduced STING-TBK1 phosphorylation by scavenging mitochondrial-derived dsDNA in a mitophagy-dependent manner, its therapeutic effect was abolished by incorporation of cGAMP, a STING activator. In summary, our study reveals the mechanism of PDLSCs deple …
Mechanistically, SPD reduced STING-TBK1 phosphorylation by scavenging mitochondrial-derived dsDNA in a mitophagy-dependent manner, it …
Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation.
Borsky P, Holmannova D, Soukup O, Fiala Z, Maresova T, Hanzlova M, Philipp T, Borska L. Borsky P, et al. Nutr Res Rev. 2025 Dec 17;39:e8. doi: 10.1017/S0954422425100292. Nutr Res Rev. 2025. PMID: 41404767 Review.
This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, which is mediated by the induction and maintenance of autophagy and mitophagy, but also on their potential clinical relevance. The an …
This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, …
PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment.
Jang JS, Hong SJ, Mo S, Kim MK, Kim YG, Lee Y, Kim HH. Jang JS, et al. Redox Biol. 2024 Feb;69:103023. doi: 10.1016/j.redox.2023.103023. Epub 2023 Dec 30. Redox Biol. 2024. PMID: 38181706 Free PMC article.
PTEN-induced kinase 1 (PINK1), a mitochondrial serine/threonine kinase, is an essential protein for mitochondrial quality control as it protects cells from oxidative stress by promoting degradation of damaged mitochondria through mitophagy. However, the pathophysiological …
PTEN-induced kinase 1 (PINK1), a mitochondrial serine/threonine kinase, is an essential protein for mitochondrial quality control as it prot …
Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein.
Fairley LH, Lejri I, Grimm A, Eckert A. Fairley LH, et al. Int J Mol Sci. 2023 Mar 10;24(6):5297. doi: 10.3390/ijms24065297. Int J Mol Sci. 2023. PMID: 36982371 Free PMC article.
Abnormal tau impairs almost every aspect of mitochondrial function, from mitochondrial respiration to mitophagy. The aim of our study was to investigate the effects of spermidine, a polyamine which exerts neuroprotective effects, on mitochondrial function in a cellu …
Abnormal tau impairs almost every aspect of mitochondrial function, from mitochondrial respiration to mitophagy. The aim of our study …
Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae.
Kaur J, Goldsmith J, Tankka A, Bustamante Eguiguren S, Gimenez AA, Vick L, Debnath J, Vlahakis A. Kaur J, et al. J Cell Sci. 2021 Jun 1;134(11):jcs253781. doi: 10.1242/jcs.253781. Epub 2021 Jun 7. J Cell Sci. 2021. PMID: 34096604 Free PMC article.
Here, we demonstrate a requirement for Atg32 in promoting spermidine production during respiratory growth and heat-induced mitochondrial stress. During respiratory growth, mitophagy-deficient yeast exhibit profound heat-stress induced defects in growth and viability …
Here, we demonstrate a requirement for Atg32 in promoting spermidine production during respiratory growth and heat-induced mitochondr …
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Hofer SJ, et al. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. Autophagy. 2021. PMID: 34105442 Free PMC article.
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Apart from nutrition, spermidine is available to mammalian organisms from intracellular biosynthesis and microbial production in the gut. ...
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Apart from …
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans.
Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X. Yang X, et al. Aging (Albany NY). 2020 Sep 9;12(17):16852-16866. doi: 10.18632/aging.103578. Epub 2020 Sep 9. Aging (Albany NY). 2020. PMID: 32902411 Free PMC article.
Here, we show that spermidine inhibits memory loss in AD worms and improves behavioral performance, e.g., locomotor capacity, in a PD worm model, both via the PINK1-PDR1-dependent mitophagy pathway. ...While possible intertwined interactions between mitophagy …
Here, we show that spermidine inhibits memory loss in AD worms and improves behavioral performance, e.g., locomotor capacity, in a PD …
53 results