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2011 1
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Page 1
Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction.
Muir KC, Harris DD, Kanuparthy M, Hu J, Nho JW, Stone C, Banerjee D, Sellke FW, Feng J. Muir KC, et al. Cells. 2026 Jan 26;15(3):234. doi: 10.3390/cells15030234. Cells. 2026. PMID: 41677601 Free PMC article. Review.
Emerging evidence demonstrates that spike protein-mediated effects, independent of productive viral infection, disrupt endothelial homeostasis through angiotensin-converting enzyme 2 (ACE2) dysregulation, integrin engagement, altered calcium signaling, juncti …
Emerging evidence demonstrates that spike protein-mediated effects, independent of productive viral infection, disrupt endo …
SARS-CoV-2 spike protein induces endothelial dysfunction in 3D engineered vascular networks.
Stern B, Monteleone P, Zoldan J. Stern B, et al. J Biomed Mater Res A. 2024 Apr;112(4):524-533. doi: 10.1002/jbm.a.37543. Epub 2023 Apr 8. J Biomed Mater Res A. 2024. PMID: 37029655 Free PMC article.
We show that this vascular dysfunction is caused by an increase in inflammatory cytokines, associated with the COVID-19 cytokine storm, released from SARS-CoV-2 spike protein treated endothelial cells. Following treatment with the corticosteroid dexame …
We show that this vascular dysfunction is caused by an increase in inflammatory cytokines, associated with the COVID-19 cytokine stor …
Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells.
Raghavan S, Leo MD. Raghavan S, et al. Front Pharmacol. 2022 Apr 25;13:872736. doi: 10.3389/fphar.2022.872736. eCollection 2022. Front Pharmacol. 2022. PMID: 35548336 Free PMC article.
Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalizatio …
Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cul …
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin alpha5beta1 and NF-kappaB signaling.
Robles JP, Zamora M, Adan-Castro E, Siqueiros-Marquez L, Martinez de la Escalera G, Clapp C. Robles JP, et al. J Biol Chem. 2022 Mar;298(3):101695. doi: 10.1016/j.jbc.2022.101695. Epub 2022 Feb 7. J Biol Chem. 2022. PMID: 35143839 Free PMC article.
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. ...However, the mechanisms by which ECs are dysregulated in COVID-19 are unclear. Here, we show that the spike protein of SARS-CoV-2 al …
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. ...Howeve …
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation.
Perico L, Morigi M, Galbusera M, Pezzotta A, Gastoldi S, Imberti B, Perna A, Ruggenenti P, Donadelli R, Benigni A, Remuzzi G. Perico L, et al. Front Immunol. 2022 Mar 7;13:827146. doi: 10.3389/fimmu.2022.827146. eCollection 2022. Front Immunol. 2022. PMID: 35320941 Free PMC article.
Detection of circulating spike protein in the sera of severe COVID-19 patients was evaluated by ELISA. In vitro experiments were performed on human microvascular endothelial cells from the derma and lung exposed to SARS-CoV-2-derived spike protein …
Detection of circulating spike protein in the sera of severe COVID-19 patients was evaluated by ELISA. In vitro experiments we …
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1.
Han M, Pandey D. Han M, et al. Am J Respir Cell Mol Biol. 2021 Sep;65(3):300-308. doi: 10.1165/rcmb.2020-0544OC. Am J Respir Cell Mol Biol. 2021. PMID: 34003736 Free PMC article.
Endothelial dysfunction is implicated in the thrombotic events reported in patients with coronavirus disease (COVID-19), but the underlying molecular mechanisms are unknown. ...Indeed, the elevation of PAI-1 is recognized as an early marker of endothelial …
Endothelial dysfunction is implicated in the thrombotic events reported in patients with coronavirus disease (COVID-19), but t …
CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID.
Thomas D, Noishiki C, Gaddam S, Wu D, Manhas A, Liu Y, Tripathi D, Kathale N, Adkar SS, Garhyan J, Liu C, Xu B, Ross EG, Dalman RL, Wang KC, Oro AE, Sallam K, Lee JT, Wu JC, Sayed N. Thomas D, et al. Nat Cardiovasc Res. 2024 Oct;3(10):1249-1265. doi: 10.1038/s44161-024-00543-8. Epub 2024 Oct 14. Nat Cardiovasc Res. 2024. PMID: 39402206 Free PMC article.
Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dy …
Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechani …
SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells.
Meyer K, Patra T, Vijayamahantesh, Ray R. Meyer K, et al. J Virol. 2021 Aug 10;95(17):e0079421. doi: 10.1128/JVI.00794-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34160250 Free PMC article.
Taken together, we identified that human endothelial cells exposed to cell culture supernatant derived from SARS-CoV-2 spike protein expression displayed cellular senescence markers, leading to enhanced leukocyte adhesion. IMPORTANCE The present study was aim …
Taken together, we identified that human endothelial cells exposed to cell culture supernatant derived from SARS-CoV-2 spike …
SARS-CoV-2 and the spike protein in endotheliopathy.
Perico L, Benigni A, Remuzzi G. Perico L, et al. Trends Microbiol. 2024 Jan;32(1):53-67. doi: 10.1016/j.tim.2023.06.004. Epub 2023 Jun 12. Trends Microbiol. 2024. PMID: 37393180 Free PMC article. Review.
More recently, a rapidly growing number of reports have indicated that SARS-CoV-2 can interact directly with endothelial cells through the spike protein, leading to multiple instances of endothelial dysfunction. Here, we describe all the availab …
More recently, a rapidly growing number of reports have indicated that SARS-CoV-2 can interact directly with endothelial cells throug …
SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling.
Perico L, Morigi M, Pezzotta A, Locatelli M, Imberti B, Corna D, Cerullo D, Benigni A, Remuzzi G. Perico L, et al. Sci Rep. 2023 Jul 14;13(1):11392. doi: 10.1038/s41598-023-38382-5. Sci Rep. 2023. PMID: 37452090 Free PMC article.
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in inducing lung vascular damage and th …
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. …
110 results