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Page 1
Did you mean spliceosomal hnrnp assembly (74 results)?
Spliceosome structure and function.
Will CL, Lührmann R. Will CL, et al. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a003707. doi: 10.1101/cshperspect.a003707. Cold Spring Harb Perspect Biol. 2011. PMID: 21441581 Free PMC article. Review.
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. ...However, elucidation of the precise nature of the spliceosome's active site, awaits the generation o …
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs …
Mechanisms and Regulation of Alternative Pre-mRNA Splicing.
Lee Y, Rio DC. Lee Y, et al. Annu Rev Biochem. 2015;84:291-323. doi: 10.1146/annurev-biochem-060614-034316. Epub 2015 Mar 12. Annu Rev Biochem. 2015. PMID: 25784052 Free PMC article. Review.
Split eukaryotic genes contain intervening sequences or introns disrupting protein-coding exons, and intron removal occurs by repeated assembly of a large and highly dynamic ribonucleoprotein complex termed the spliceosome, which is composed of five small …
Split eukaryotic genes contain intervening sequences or introns disrupting protein-coding exons, and intron removal occurs by repeated as …
A unique mechanism of snRNP core assembly.
Wang Y, Chen X, Kong X, Chen Y, Xiang Z, Xiang Y, Hu Y, Hou Y, Zhou S, Shen C, Mu L, Su D, Zhang R. Wang Y, et al. Nat Commun. 2025 Apr 2;16(1):3166. doi: 10.1038/s41467-025-58461-7. Nat Commun. 2025. PMID: 40175367 Free PMC article.
The assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). ...The direc …
The assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA …
Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly.
Shenasa H, Movassat M, Forouzmand E, Hertel KJ. Shenasa H, et al. RNA. 2020 Oct;26(10):1389-1399. doi: 10.1261/rna.075135.120. Epub 2020 Jun 10. RNA. 2020. PMID: 32522889 Free PMC article.
Position-dependent splicing repression occurs at spliceosomal E-complex, suggesting that U1 snRNP binds but cannot facilitate higher order spliceosomal assembly. To test the hypothesis that the structure of U1 snRNA changes during activation or repress …
Position-dependent splicing repression occurs at spliceosomal E-complex, suggesting that U1 snRNP binds but cannot facilitate …
Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
Yang F, Bian T, Zhan X, Chen Z, Xing Z, Larsen NA, Zhang X, Shi Y. Yang F, et al. Nat Commun. 2023 Feb 17;14(1):897. doi: 10.1038/s41467-023-36489-x. Nat Commun. 2023. PMID: 36797247 Free PMC article.
Three RNA helicases - DDX42, DDX46 and DHX15 - are found to be associated with human U2 snRNP, but their roles and mechanisms in U2 snRNP and spliceosome assembly are insufficiently understood. ...These findings reveal the distinct roles of DDX42 and D …
Three RNA helicases - DDX42, DDX46 and DHX15 - are found to be associated with human U2 snRNP, but their roles and mechanisms in U2 …
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Hluchý M, Gajdušková P, Ruiz de Los Mozos I, Rájecký M, Kluge M, Berger BT, Slabá Z, Potěšil D, Weiß E, Ule J, Zdráhal Z, Knapp S, Paruch K, Friedel CC, Blazek D. Hluchý M, et al. Nature. 2022 Sep;609(7928):829-834. doi: 10.1038/s41586-022-05204-z. Epub 2022 Sep 14. Nature. 2022. PMID: 36104565
Splicing factor 3B subunit 1 (SF3B1) protein-a subunit of the U2 small nuclear ribonucleoprotein(6)-is phosphorylated during spliceosome activation(7-10), but the kinase that is responsible has not been identified. ...We demonstrate a central role of CDK11 in …
Splicing factor 3B subunit 1 (SF3B1) protein-a subunit of the U2 small nuclear ribonucleoprotein(6)-is phosphorylated during …
Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex.
Zhang L, Batters C, Aibara S, Gordiyenko Y, Žumer K, Schmitzová J, Maier K, Cramer P, Zhang S. Zhang L, et al. Nat Commun. 2025 Jul 1;16(1):5823. doi: 10.1038/s41467-025-60979-9. Nat Commun. 2025. PMID: 40595577 Free PMC article.
RNA polymerase II (Pol II) facilitates co-transcriptional splicing by recruiting the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to the nascent transcripts. Here, we report the cryo-electron microscopy structure of a transcribing Pol II-U1 snRNP …
RNA polymerase II (Pol II) facilitates co-transcriptional splicing by recruiting the U1 small nuclear ribonucleoprotein partic …
The Cajal body.
Morris GE. Morris GE. Biochim Biophys Acta. 2008 Nov;1783(11):2108-15. doi: 10.1016/j.bbamcr.2008.07.016. Epub 2008 Aug 3. Biochim Biophys Acta. 2008. PMID: 18755223 Free article. Review.
The interaction of coilin with other proteins appears to increase the efficiency of several nuclear processes by concentrating their components in the Cajal body. The best-known of these processes is the modification and assembly of U snRNPs, some of which ev …
The interaction of coilin with other proteins appears to increase the efficiency of several nuclear processes by concentrating their …
The SMN complex.
Gubitz AK, Feng W, Dreyfuss G. Gubitz AK, et al. Exp Cell Res. 2004 May 15;296(1):51-6. doi: 10.1016/j.yexcr.2004.03.022. Exp Cell Res. 2004. PMID: 15120993 Review.
SMN is part of a stable multiprotein complex that is found in all metazoan cells in the cytoplasm and in nuclear Gems. The SMN complex contains, in addition to SMN, at least six other proteins, named Gemins2-7, and plays an essential role in the assembly of the s …
SMN is part of a stable multiprotein complex that is found in all metazoan cells in the cytoplasm and in nuclear Gems. The SMN comple …
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly.
Zhou Y, Tong C, Shi Z, Zhang Y, Xiong X, Shen X, Li X, Yin Y. Zhou Y, et al. Nat Struct Mol Biol. 2025 Jun;32(6):1038-1049. doi: 10.1038/s41594-025-01501-z. Epub 2025 Mar 6. Nat Struct Mol Biol. 2025. PMID: 40050462
The U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, yet the mechanism underlying its synergy with other splicing regulators for efficient spliceosome assembly remains elusive. .. …
The U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, …
852 results