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Year Number of Results
1963 4
1964 3
1965 1
1966 3
1967 1
1968 1
1969 2
1970 4
1971 6
1972 9
1973 12
1974 22
1975 38
1976 51
1977 51
1978 54
1979 62
1980 106
1981 162
1982 205
1983 265
1984 426
1985 510
1986 633
1987 652
1988 672
1989 669
1990 682
1991 756
1992 702
1993 687
1994 695
1995 791
1996 632
1997 635
1998 594
1999 538
2000 527
2001 514
2002 488
2003 497
2004 525
2005 505
2006 435
2007 495
2008 529
2009 488
2010 507
2011 541
2012 551
2013 542
2014 498
2015 504
2016 446
2017 422
2018 401
2019 443
2020 429
2021 359
2022 324
2023 295
2024 303
2025 95

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21,681 results

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Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview.
Meneses A, Perez-Garcia G, Ponce-Lopez T, Tellez R, Gallegos-Cari A, Castillo C. Meneses A, et al. Rev Neurosci. 2011;22(3):365-71. doi: 10.1515/RNS.2011.024. Epub 2011 May 13. Rev Neurosci. 2011. PMID: 21591908 Review.
Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs and animal models are eliciting a growing interest, hence the aim of this work is to present a brief overview with a focus on the SHR …
Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs a …
Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat.
Doris PA. Doris PA. Physiol Genomics. 2017 Nov 1;49(11):601-617. doi: 10.1152/physiolgenomics.00065.2017. Epub 2017 Sep 15. Physiol Genomics. 2017. PMID: 28916635 Free PMC article. Review.
The application of gene mapping methods to uncover the genetic basis of hypertension in the inbred spontaneously hypertensive rat (SHR) began over 25 yr ago. This animal provides a useful model of genetic high blood pressure, and some of its fea …
The application of gene mapping methods to uncover the genetic basis of hypertension in the inbred spontaneously hypertensi …
An Evaluation of Cardiac Health in the Spontaneously Hypertensive Rat Colony: Implications of Evolutionary Driven Increases in Concentric Hypertrophy.
Holjak EJB, Savinova I, Nelson VL, Ogilvie LM, Ng AM, Edgett BA, Platt MJ, Brunt KR, Ask K, Simpson JA. Holjak EJB, et al. Am J Hypertens. 2022 Mar 8;35(3):264-271. doi: 10.1093/ajh/hpab155. Am J Hypertens. 2022. PMID: 34605538 Free PMC article.
BACKGROUND: The Spontaneously Hypertensive Rat (SHR) Colony was established in 1963 and is the most commonly used rodent model for studying heart failure (HF). ...Thus, the object of this review was to investigate whether the hypertension-induced seque …
BACKGROUND: The Spontaneously Hypertensive Rat (SHR) Colony was established in 1963 and is the most commonly use …
The Assembled Genome of the Stroke-Prone Spontaneously Hypertensive Rat.
Kalbfleisch TS, Hussien AbouEl Ela NA, Li K, Brashear WA, Kochan KJ, Hillhouse AE, Zhu Y, Dhande IS, Kline EJ, Hudson EA, Murphy TD, Thibaud-Nissen F, Smith ML, Doris PA. Kalbfleisch TS, et al. Hypertension. 2023 Jan;80(1):138-146. doi: 10.1161/HYPERTENSIONAHA.122.20140. Epub 2022 Nov 4. Hypertension. 2023. PMID: 36330812 Free PMC article.
BACKGROUND: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, the most widely used model of human cardiovascular disease. ...RESULTS: The assembly analysis indicates that this assembly is comparab …
BACKGROUND: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat …
The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?
Nabika T, Ohara H, Kato N, Isomura M. Nabika T, et al. Hypertens Res. 2012 May;35(5):477-84. doi: 10.1038/hr.2012.30. Epub 2012 Mar 8. Hypertens Res. 2012. PMID: 22399095 Review.
The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke. SHRSP, as well as the spontaneously hypertensive rat, the parental strain of SHRSP, has made a tremendous contri …
The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral s …
Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat.
Pravenec M, Šilhavý J, Mlejnek P, Šimáková M, Mráček T, Pecinová A, Tauchmannová K, Hütl M, Malínská H, Kazdová L, Neckář J, Kolář F, Žurmanová J, Novotný J, Houštěk J. Pravenec M, et al. Physiol Res. 2021 Dec 30;70(Suppl4):S471-S484. doi: 10.33549/physiolres.934740. Physiol Res. 2021. PMID: 35199537 Free PMC article. Review.
To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR-mtBN, SHR-mtF344 and SHR-mtLEW), harboring all major mtDNA haplotypes present in common inbred strains on the nuclear …
To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR …
Recent advances in genetics of the spontaneously hypertensive rat.
Pravenec M, Kurtz TW. Pravenec M, et al. Curr Hypertens Rep. 2010 Feb;12(1):5-9. doi: 10.1007/s11906-009-0083-9. Curr Hypertens Rep. 2010. PMID: 20425152 Free PMC article. Review.
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. ...Recombinant inbred strains derived from SHR and Brown Norway progenitors, together with S …
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and asso …
The spontaneously hypertensive rat: insight into the pathogenesis of irritative symptoms in benign prostatic hyperplasia and young anxious males.
Steers WD, Clemow DB, Persson K, Sherer TB, Andersson KE, Tuttle JB. Steers WD, et al. Exp Physiol. 1999 Jan;84(1):137-47. doi: 10.1111/j.1469-445x.1999.tb00079.x. Exp Physiol. 1999. PMID: 10081714 Review.
Taken together these observations implicate both peripheral and central sympathetic pathways in the motor control of the urinary bladder especially with disease states. We have used the hypertensive and behaviourally hyperactive spontaneously hypertensive …
Taken together these observations implicate both peripheral and central sympathetic pathways in the motor control of the urinary bladder esp …
Drug reinforcement in a rat model of attention deficit/hyperactivity disorder--the Spontaneously Hypertensive Rat (SHR).
Vendruscolo LF, Izídio GS, Takahashi RN. Vendruscolo LF, et al. Curr Drug Abuse Rev. 2009 May;2(2):177-83. doi: 10.2174/1874473710902020177. Curr Drug Abuse Rev. 2009. PMID: 19630747 Review.
Therefore, animal models to study this kind of psychiatric comorbidity are needed. The Spontaneously Hypertensive Rat (SHR) strain shows neurochemical and behavioral characteristics which make it a suitable model of ADHD. Compared with their normotensi …
Therefore, animal models to study this kind of psychiatric comorbidity are needed. The Spontaneously Hypertensive Rat ( …
Heightened respiratory-parasympathetic coupling to airways in the spontaneously hypertensive rat.
Moraes DJA, da Silva MP, de Souza DP, Felintro V, Paton JFR. Moraes DJA, et al. J Physiol. 2021 Jun;599(12):3237-3252. doi: 10.1113/JP280981. Epub 2021 May 12. J Physiol. 2021. PMID: 33873234 Free article.
We show that the respiratory-modulated bronchiolar tone, pulmonary parasympathetic efferent activity, and the firing frequency and synaptic excitation of bronchoconstrictor motoneurones in the nucleus ambiguus were all enhanced in spontaneous hypertensive (SH) rats. …
We show that the respiratory-modulated bronchiolar tone, pulmonary parasympathetic efferent activity, and the firing frequency and synaptic …
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