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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1919 1
1933 2
1935 1
1947 1
1948 3
1949 1
1950 3
1951 2
1952 1
1954 5
1955 5
1956 1
1957 2
1958 4
1959 6
1960 4
1961 1
1962 1
1963 1
1965 4
1966 3
1967 2
1968 10
1969 13
1970 5
1971 19
1972 17
1973 9
1974 13
1975 15
1976 15
1977 21
1978 19
1979 23
1980 22
1981 29
1982 27
1983 31
1984 48
1985 56
1986 40
1987 45
1988 66
1989 70
1990 60
1991 97
1992 78
1993 106
1994 98
1995 103
1996 102
1997 114
1998 119
1999 151
2000 146
2001 207
2002 210
2003 260
2004 331
2005 337
2006 387
2007 417
2008 451
2009 465
2010 481
2011 527
2012 576
2013 635
2014 678
2015 632
2016 698
2017 674
2018 702
2019 814
2020 894
2021 949
2022 869
2023 887
2024 945
2025 879
2026 2

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15,370 results

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Page 1
Replication stalling and DNA microsatellite instability.
Gadgil R, Barthelemy J, Lewis T, Leffak M. Gadgil R, et al. Biophys Chem. 2017 Jun;225:38-48. doi: 10.1016/j.bpc.2016.11.007. Epub 2016 Nov 22. Biophys Chem. 2017. PMID: 27914716 Free PMC article. Review.
Collectively, these repeats comprise approximately 3% of the human genome Subramanian et al. (2003), Lander and Lander (2001) [1,2], and represent a large reservoir of loci highly prone to mutations Sun et al. (2012), Ellegren (2004) [3,4] that contribute to human evolution and d …
Collectively, these repeats comprise approximately 3% of the human genome Subramanian et al. (2003), Lander and Lander (2001) [1,2], and rep …
Polymerase stalling during replication, transcription and translation.
Edenberg ER, Downey M, Toczyski D. Edenberg ER, et al. Curr Biol. 2014 May 19;24(10):R445-52. doi: 10.1016/j.cub.2014.03.060. Curr Biol. 2014. PMID: 24845677 Free article. Review.
In response to replication stress such as DNA damage, the cell activates a checkpoint and promotes repair or bypass at the lesion. Transcriptional stress leading to stalling of RNA polymerase can also be caused by DNA damage, and recognizing stalled RNA polymerase c …
In response to replication stress such as DNA damage, the cell activates a checkpoint and promotes repair or bypass at the lesion. Transcrip …
RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences.
Agapov A, Olina A, Kulbachinskiy A. Agapov A, et al. Nucleic Acids Res. 2022 Apr 8;50(6):3018-3041. doi: 10.1093/nar/gkac174. Nucleic Acids Res. 2022. PMID: 35323981 Free PMC article. Review.
Depending on the type of DNA lesion, it may be correctly bypassed by RNAP, or lead to transcriptional mutagenesis, or result in transcription stalling. Various lesions can affect the loading of the templating base into the active site of RNAP, or interfere with nucleotide …
Depending on the type of DNA lesion, it may be correctly bypassed by RNAP, or lead to transcriptional mutagenesis, or result in transcriptio …
m6A alters ribosome dynamics to initiate mRNA degradation.
Murakami S, Olarerin-George AO, Liu JF, Zaccara S, Hawley B, Jaffrey SR. Murakami S, et al. Cell. 2025 Jul 10;188(14):3728-3743.e20. doi: 10.1016/j.cell.2025.04.020. Epub 2025 May 6. Cell. 2025. PMID: 40328256
We find that m(6)A is a potent inducer of ribosome stalling, and these stalls lead to ribosome collisions that form a unique conformation unlike those seen in other contexts. ...Ribosome stalling and collision at m(6)A is followed by recruitment of YTHDF m(6) …
We find that m(6)A is a potent inducer of ribosome stalling, and these stalls lead to ribosome collisions that form a unique c …
Divergent stalling sequences sense and control cellular physiology.
Ito K, Chiba S, Pogliano K. Ito K, et al. Biochem Biophys Res Commun. 2010 Feb 26;393(1):1-5. doi: 10.1016/j.bbrc.2010.01.073. Epub 2010 Feb 1. Biochem Biophys Res Commun. 2010. PMID: 20117091 Free PMC article. Review.
The stalled ribosome alters messenger RNA secondary structure and thereby contributes to regulation of the cis-located target gene expression at different levels. The stalling sequences are divergent but likely to utilize non-uniform nature of the peptide bond forma …
The stalled ribosome alters messenger RNA secondary structure and thereby contributes to regulation of the cis-located target gene ex …
Replication stalling activates SSB for recruitment of DNA damage tolerance factors.
Thrall ES, Piatt SC, Chang S, Loparo JJ. Thrall ES, et al. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208875119. doi: 10.1073/pnas.2208875119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191223 Free PMC article.
It is well known that most bacterial TLS polymerases must interact with the sliding-clamp processivity factor to carry out TLS, but recent work in Escherichia coli has revealed that single-stranded DNA-binding protein (SSB) plays a key role in enriching the TLS polymerase Pol IV …
It is well known that most bacterial TLS polymerases must interact with the sliding-clamp processivity factor to carry out TLS, but recent w …
Characterization of ribosome stalling and no-go mRNA decay stimulated by the fragile X protein, FMRP.
Scarpitti MR, Pastore B, Tang W, Kearse MG. Scarpitti MR, et al. J Biol Chem. 2024 Aug;300(8):107540. doi: 10.1016/j.jbc.2024.107540. Epub 2024 Jul 4. J Biol Chem. 2024. PMID: 38971316 Free PMC article.
FMRP is most notably a translational repressor and is thought to inhibit translation elongation by stalling ribosomes as FMRP-bound polyribosomes from brain tissue are resistant to puromycin and nuclease treatment. ...Taken together, these data support that FMRP stalls …
FMRP is most notably a translational repressor and is thought to inhibit translation elongation by stalling ribosomes as FMRP-bound p …
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P. Kokic G, et al. Nat Commun. 2021 Jan 12;12(1):279. doi: 10.1038/s41467-020-20542-0. Nat Commun. 2021. PMID: 33436624 Free PMC article.
Remdesivir is incorporated by the RdRp into the growing RNA product and allows for addition of three more nucleotides before RNA synthesis stalls. Here we use synthetic RNA chemistry, biochemistry and cryo-electron microscopy to establish the molecular mechanism of remdesi …
Remdesivir is incorporated by the RdRp into the growing RNA product and allows for addition of three more nucleotides before RNA synthesis …
Translational buffering by ribosome stalling in upstream open reading frames.
Bottorff TA, Park H, Geballe AP, Subramaniam AR. Bottorff TA, et al. PLoS Genet. 2022 Oct 31;18(10):e1010460. doi: 10.1371/journal.pgen.1010460. eCollection 2022 Oct. PLoS Genet. 2022. PMID: 36315596 Free PMC article.
We find that a terminal diproline-dependent elongating ribosome stall in the UL4 uORF prevents decreases in main ORF protein expression when ribosome loading onto the mRNA is reduced. This uORF-mediated buffering is insensitive to the location of the ribosome stall …
We find that a terminal diproline-dependent elongating ribosome stall in the UL4 uORF prevents decreases in main ORF protein expressi …
Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?
Rowlands H, Dhavarasa P, Cheng A, Yankulov K. Rowlands H, et al. Front Genet. 2017 Jun 22;8:86. doi: 10.3389/fgene.2017.00086. eCollection 2017. Front Genet. 2017. PMID: 28690636 Free PMC article. Review.
At such positions the forks slow down or even stall. Dedicated factors stabilize the fork and prevent its rotation or collapse, while other factors resolve the replication block and facilitate the resumption of elongation. The fate of histones during replication stallin …
At such positions the forks slow down or even stall. Dedicated factors stabilize the fork and prevent its rotation or collapse, while …
15,370 results
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