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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 2
1978 1
1981 4
1982 1
1983 3
1984 8
1985 4
1986 6
1987 5
1988 5
1989 11
1990 22
1991 19
1992 26
1993 26
1994 35
1995 36
1996 41
1997 27
1998 32
1999 39
2000 56
2001 62
2002 67
2003 98
2004 91
2005 126
2006 141
2007 175
2008 225
2009 191
2010 251
2011 283
2012 268
2013 322
2014 347
2015 357
2016 369
2017 399
2018 450
2019 441
2020 460
2021 473
2022 471
2023 459
2024 429
2025 460
2026 193

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7,102 results

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Page 1
Statins: a repurposed drug to fight cancer.
Jiang W, Hu JW, He XR, Jin WL, He XY. Jiang W, et al. J Exp Clin Cancer Res. 2021 Jul 24;40(1):241. doi: 10.1186/s13046-021-02041-2. J Exp Clin Cancer Res. 2021. PMID: 34303383 Free PMC article. Review.
As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties …
As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular ris …
Statins and cancer.
Vallianou NG, Kostantinou A, Kougias M, Kazazis C. Vallianou NG, et al. Anticancer Agents Med Chem. 2014 Jun;14(5):706-12. doi: 10.2174/1871520613666131129105035. Anticancer Agents Med Chem. 2014. PMID: 24295174 Review.
Statins have pleiotropic properties and might exert an effect even in the field of cancer. ...As compared to statin non-users, patients using statins prior to cancer diagnosis were 15% less likely to die from any cause or cancer specifica …
Statins have pleiotropic properties and might exert an effect even in the field of cancer. ...As compared to statin non …
Statins and prostate cancer-hype or hope? The epidemiological perspective.
Craig EL, Stopsack KH, Evergren E, Penn LZ, Freedland SJ, Hamilton RJ, Allott EH. Craig EL, et al. Prostate Cancer Prostatic Dis. 2022 Apr;25(4):641-649. doi: 10.1038/s41391-022-00554-1. Epub 2022 Jun 22. Prostate Cancer Prostatic Dis. 2022. PMID: 35732821 Free PMC article. Review.
Mechanisms responsible for purported anti-cancer effects of statins are not well understood but may offer insight into prostate cancer biology. ...RESULTS: Data from prospective observational studies generally reported a lower risk of fatal prostate cancer …
Mechanisms responsible for purported anti-cancer effects of statins are not well understood but may offer insight into prostat …
Statins and Colorectal Cancer - A Systematic Review.
Dobrzycka M, Spychalski P, Łachiński AJ, Kobiela P, Jędrusik P, Kobiela J. Dobrzycka M, et al. Exp Clin Endocrinol Diabetes. 2020 Apr;128(4):255-262. doi: 10.1055/a-0668-5692. Epub 2018 Aug 27. Exp Clin Endocrinol Diabetes. 2020. PMID: 30149418
Some studies reported better overall and cancer specific survival rates in patients using statins before and during colorectal cancer treatment. ...CONCLUSIONS: Accumulating evidence suggests that statins may have a role in colorectal cancer pre …
Some studies reported better overall and cancer specific survival rates in patients using statins before and during colorectal …
Statins and prostate cancer-hype or hope? The biological perspective.
Longo J, Freedland SJ, Penn LZ, Hamilton RJ. Longo J, et al. Prostate Cancer Prostatic Dis. 2022 Apr;25(4):650-656. doi: 10.1038/s41391-022-00557-y. Epub 2022 Jun 29. Prostate Cancer Prostatic Dis. 2022. PMID: 35768578 Review.
Growing evidence suggests that men prescribed a statin for cholesterol control have a lower risk of advanced prostate cancer (PCa) and improved treatment outcomes; however, the mechanism by which statins elicit their anti-neoplastic effects is not well unders …
Growing evidence suggests that men prescribed a statin for cholesterol control have a lower risk of advanced prostate cancer ( …
Statins and Cancer Prevention-Association Does Not Mean Causation.
Das S, Freedland SJ. Das S, et al. Cancer Prev Res (Phila). 2023 Jan 4;16(1):1-3. doi: 10.1158/1940-6207.CAPR-22-0420. Cancer Prev Res (Phila). 2023. PMID: 36597731 Free PMC article.
Given the key role of cholesterol in cancer, statins may therefore have anticancer activities. However, clinical studies investigating the association between statin usage and cancer development have been few and inconsistent. ...This editorial analyze …
Given the key role of cholesterol in cancer, statins may therefore have anticancer activities. However, clinical studies inves …
Statins and cancer prevention.
Demierre MF, Higgins PD, Gruber SB, Hawk E, Lippman SM. Demierre MF, et al. Nat Rev Cancer. 2005 Dec;5(12):930-42. doi: 10.1038/nrc1751. Nat Rev Cancer. 2005. PMID: 16341084 Review.
Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer preventio …
Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for …
Pleiotropic effects of statins: A focus on cancer.
Ahmadi M, Amiri S, Pecic S, Machaj F, Rosik J, Łos MJ, Alizadeh J, Mahdian R, da Silva Rosa SC, Schaafsma D, Shojaei S, Madrakian T, Zeki AA, Ghavami S. Ahmadi M, et al. Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165968. doi: 10.1016/j.bbadis.2020.165968. Epub 2020 Sep 12. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32927022 Free article. Review.
The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by competitively blocking the active site of the enzyme. ...However, whether statins have clinically meaningful anti-cancer effects remains an are …
The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by competitively blo …
Attempts to use statins in cancer therapy: An update.
Matusewicz L, Czogalla A, Sikorski AF. Matusewicz L, et al. Tumour Biol. 2020 Jul;42(7):1010428320941760. doi: 10.1177/1010428320941760. Tumour Biol. 2020. PMID: 32662332 Free article. Review.
Although it could be speculated that almost everything has been said concerning the use of statins in cancer therapy, statins as anticancer drugs have both committed supporters and opponents, for whom the dispute about the legitimacy of statin use in …
Although it could be speculated that almost everything has been said concerning the use of statins in cancer therapy, stati …
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer.
Han JX, Tao ZH, Wang JL, Zhang L, Yu CY, Kang ZR, Xie Y, Li J, Lu S, Cui Y, Xu J, Zhao E, Wang M, Chen J, Wang Z, Liu Q, Chen HM, Su W, Zou TH, Zhou CB, Hong J, Chen H, Xiong H, Chen YX, Fang JY. Han JX, et al. Nat Microbiol. 2023 May;8(5):919-933. doi: 10.1038/s41564-023-01363-5. Epub 2023 Apr 17. Nat Microbiol. 2023. PMID: 37069401
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a potential chemopreventive effect. ...Together, our study provides insights into an anti-ca …
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and …
7,102 results