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2022 16
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1,833 results
Use COVID-19 filters from PubMed Clinical Queries to refine your search See more SARS-CoV-2 literature, sequence, and clinical content from NCBI
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Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding.
Robins LI, Keim EK, Robins DB, Edgar JS, Meschke JS, Gafken PR, Williams JF. Robins LI, et al. ACS Omega. 2021 Dec 14;6(51):35593-35599. doi: 10.1021/acsomega.1c05297. eCollection 2021 Dec 28. ACS Omega. 2021. PMID: 34984290 Free PMC article.
Interleukin-6 (IL-6) has been implicated in the pathogenesis of inflammatory events including those seen with COVID-19 patients. Positive clinical responses to monoclonal antibodies directed against IL-6 receptors (IL-6Rs) suggest that interference with IL-6-depende …
Interleukin-6 (IL-6) has been implicated in the pathogenesis of inflammatory events including those seen with COVID-19 patient …
Mental Health Implications of the COVID-19 Pandemic Among Children and Adolescents: What Do We Know so Far?
Listernick ZI, Badawy SM. Listernick ZI, et al. Pediatric Health Med Ther. 2021 Dec 20;12:543-549. doi: 10.2147/PHMT.S315887. eCollection 2021. Pediatric Health Med Ther. 2021. PMID: 34984040 Free PMC article. Review.
The COVID-19 pandemic is an unprecedented time in global history and has many emerging challenges and consequences. ...
The COVID-19 pandemic is an unprecedented time in global history and has many emerging challenges and consequences. ...
COVID-19 in the context of autologous hematopoietic stem cell transplantation for a patient with autoimmune disease.
Alsuliman T, Stocker N, de Wyngaert ZV, Ikhlef S, Ellouz C, Corre E, Banet A, Ricard L, Dulery R, Meynard JL, Malard F, Stankoff B, Farge-Bancel D, Brissot E, Mohty M, Marjanovic Z. Alsuliman T, et al. Curr Res Transl Med. 2021 Dec 24;70(2):103332. doi: 10.1016/j.retram.2021.103332. Online ahead of print. Curr Res Transl Med. 2021. PMID: 34979485 No abstract available.
A Patient-Specific Re-Engineered Cardiomyocyte Model Confirms the Circumstance-Dependent Arrhythmia Risk Associated with the African-Specific Common SCN5A Polymorphism (p.S1103Y): Implications for the Increased Sudden Deaths Observed in Black Individuals During the COVID-19 Pandemic.
Hamrick SK, Kim CJ, Tester DJ, Giudicessi JR, Ackerman MJ. Hamrick SK, et al. Heart Rhythm. 2021 Dec 31:S1547-5271(21)02521-2. doi: 10.1016/j.hrthm.2021.12.029. Online ahead of print. Heart Rhythm. 2021. PMID: 34979239
BACKGROUND: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, a marked increase in sudden cardiac death (SCD) was observed. ...OBJECTIVE: To ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (A …
BACKGROUND: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, a marked increase in sudden cardiac d …
Correlation between ABO Blood Group Phenotype and the Risk of COVID-19 Infection and Severity of Disease in a Saudi Arabian Cohort.
Jawdat D, Hajeer A, Massadeh S, Aljawini N, Abedalthagafi MS, Alaamery M. Jawdat D, et al. J Epidemiol Glob Health. 2022 Jan 3. doi: 10.1007/s44197-021-00023-3. Online ahead of print. J Epidemiol Glob Health. 2022. PMID: 34978705
Herein, we explored the association between ABO blood group phenotypes and COVID-19 susceptibility and severity in a Saudi Arabian cohort. METHODS: In this retrospective cohort study, we performed ABO typing on a total of 373 Saudi patients infected with SARS-CoV-2 …
Herein, we explored the association between ABO blood group phenotypes and COVID-19 susceptibility and severity in a Saudi Ara …
Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection.
Cui Q, Garcia G Jr, Zhang M, Wang C, Li H, Zhou T, Sun G, Arumugaswami V, Shi Y. Cui Q, et al. iScience. 2021 Dec 24:103684. doi: 10.1016/j.isci.2021.103684. Online ahead of print. iScience. 2021. PMID: 34977495 Free PMC article.
The COVID-19 outbreak poses a serious threat to global public health. ...Importantly, the safety profile of the compound is favorable. There is no obvious toxicity observed in uninfected cells treated with the compound. Thus, this compound holds great potenti …
The COVID-19 outbreak poses a serious threat to global public health. ...Importantly, the safety profile of the compound is fa …
Investigation of the Molecular Mechanism of Coagulopathy in Severe and Critical Patients With COVID-19.
Elieh Ali Komi D, Rahimi Y, Asghari R, Jafari R, Rasouli J, Mohebalizadeh M, Abbasi A, Nejadrahim R, Rezazadeh F, Shafiei-Irannejad V. Elieh Ali Komi D, et al. Front Immunol. 2021 Dec 16;12:762782. doi: 10.3389/fimmu.2021.762782. eCollection 2021. Front Immunol. 2021. PMID: 34975853 Free PMC article.
Coagulopathy is a frequently reported finding in the pathology of coronavirus disease 2019 (COVID-19); however, the molecular mechanism, the involved coagulation factors, and the role of regulatory proteins in homeostasis are not fully investigated. ...Disruptions i …
Coagulopathy is a frequently reported finding in the pathology of coronavirus disease 2019 (COVID-19); however, the molecular …
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.
Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Li W, et al. Cell Rep. 2021 Dec 15:110210. doi: 10.1016/j.celrep.2021.110210. Online ahead of print. Cell Rep. 2021. PMID: 34971573 Free PMC article.
In contrast, CV3-25 inhibits membrane fusion by binding to an epitope in the stem helix region of the S2 subunit that is highly conserved among beta-coronaviruses. Thus, vaccine immunogen designs that incorporate the conserved regions in the RBD and stem helix regio …
In contrast, CV3-25 inhibits membrane fusion by binding to an epitope in the stem helix region of the S2 subunit that is highly conse …
Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection.
Ma J, Liu J, Gao D, Li X, Zhang Q, Lv L, Wang Y, Li J, Zhu Y, Wu Z, Hu H, Li Y, Ma L, Liu Q, Hu Z, Zhang S, Zhou Y, Wang M, Leng L. Ma J, et al. Adv Sci (Weinh). 2021 Dec 31:e2104192. doi: 10.1002/advs.202104192. Online ahead of print. Adv Sci (Weinh). 2021. PMID: 34971128
Coronavirus disease 2019 (COVID-19) patients with impact on skin and hair loss are reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detected in the skin of some patients; however, the detailed pathological features of skin tissues from patie …
Coronavirus disease 2019 (COVID-19) patients with impact on skin and hair loss are reported. Severe acute respiratory syndrome …
Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.
Masterson CH, Ceccato A, Artigas A, Dos Santos C, Rocco PR, Rolandsson Enes S, Weiss DJ, McAuley D, Matthay MA, English K, Curley GF, Laffey JG. Masterson CH, et al. Intensive Care Med Exp. 2021 Dec 31;9(1):61. doi: 10.1186/s40635-021-00424-5. Intensive Care Med Exp. 2021. PMID: 34970706 Free PMC article. Review.
More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells. These investigations have taken on an added importance and urgency during the COVID-19 pandemic, with multiple trials in progress across the globe. In pa …
More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells. These investigations have t …
Prolonged viral positivity induced recurrent coronavirus disease 2019 (COVID-19) pneumonia in patients receiving anti-CD20 monoclonal antibody treatment: Case reports.
Deveci B, Saba R. Deveci B, et al. Medicine (Baltimore). 2021 Dec 30;100(52):e28470. doi: 10.1097/MD.0000000000028470. Medicine (Baltimore). 2021. PMID: 34967391 Free PMC article.
Pneumonia is the most life-threatening complication of the disease. Prolonged viral shedding in hematological patients with COVID-19 has been demonstrated; however, data on COVID-19 patients receiving anti-CD20 monoclonal antibody therapy are limited. …
Pneumonia is the most life-threatening complication of the disease. Prolonged viral shedding in hematological patients with COVID- …
Human mesenchymal stem cells treatment for severe COVID-19: 1-year follow-up results of a randomized, double-blind, placebo-controlled trial.
Shi L, Yuan X, Yao W, Wang S, Zhang C, Zhang B, Song J, Huang L, Xu Z, Fu JL, Li Y, Xu R, Li TT, Dong J, Cai J, Li G, Xie Y, Shi M, Li Y, Zhang Y, Xie WF, Wang FS. Shi L, et al. EBioMedicine. 2021 Dec 24;75:103789. doi: 10.1016/j.ebiom.2021.103789. Online ahead of print. EBioMedicine. 2021. PMID: 34963099 Free PMC article.
BACKGROUND: The long-term consequences of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment for COVID-19 patients are yet to be reported. This study assessed the 1-year outcomes in patients with severe COVID-19, who we …
BACKGROUND: The long-term consequences of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment for COVID …
Advanced In Vitro Lung Models for Drug and Toxicity Screening: The Promising Role of Induced Pluripotent Stem Cells.
Moreira A, Müller M, Costa PF, Kohl Y. Moreira A, et al. Adv Biol (Weinh). 2021 Dec 27:e2101139. doi: 10.1002/adbi.202101139. Online ahead of print. Adv Biol (Weinh). 2021. PMID: 34962104 Review.
The substantial socioeconomic burden of lung diseases, recently highlighted by the disastrous impact of the coronavirus disease 2019 (COVID-19) pandemic, accentuates the need for interventive treatments capable of decelerating disease progression, limiting organ dam …
The substantial socioeconomic burden of lung diseases, recently highlighted by the disastrous impact of the coronavirus disease 2019 (COV …
Detection of persistent SARS-CoV-2 IgG antibodies in oral mucosal fluid and upper respiratory tract specimens following COVID-19 mRNA vaccination.
Mades A, Chellamathu P, Kojima N, Lopez L, MacMullan MA, Denny N, Angel AN, Santacruz M, Casian JG, Brobeck M, Nirema N, Klausner JD, Turner F, Slepnev VI, Ibrayeva A. Mades A, et al. Sci Rep. 2021 Dec 27;11(1):24448. doi: 10.1038/s41598-021-03931-3. Sci Rep. 2021. PMID: 34961780 Free PMC article.
COVID-19 mRNA vaccines are highly effective at preventing COVID-19. Prior studies have found detectable SARS-CoV-2 IgG antibodies in oral mucosal specimens of participants with history of COVID-19. To assess the development of oral SARS-C …
COVID-19 mRNA vaccines are highly effective at preventing COVID-19. Prior studies have found detectable SARS-CoV …
Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy.
Watanabe M, Nishikawaji Y, Kawakami H, Kosai KI. Watanabe M, et al. Viruses. 2021 Dec 14;13(12):2502. doi: 10.3390/v13122502. Viruses. 2021. PMID: 34960772 Free PMC article. Review.
Several gene therapy products, including oncolytic virus (OV), which predominantly replicates in and kills cancer cells, and COVID-19 vaccines have recently been commercialized. Recombinant adenoviruses, including replication-defective adenoviral vector and c …
Several gene therapy products, including oncolytic virus (OV), which predominantly replicates in and kills cancer cells, and COVID …
Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World Population.
Gustiananda M, Sulistyo BP, Agustriawan D, Andarini S. Gustiananda M, et al. Vaccines (Basel). 2021 Dec 9;9(12):1459. doi: 10.3390/vaccines9121459. Vaccines (Basel). 2021. PMID: 34960205 Free PMC article.
SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of SARS-CoV-2 and stimulate protective T-cell responses are important for reducing symptoms and limiting the infection. ...The data presented here will contribute …
SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of SARS-CoV-2 and stimulate p …
COVID-19 mRNA Based Vaccine Immune-Response Assessment in Nursing Home Residents for Public Health Decision.
San Segundo D, Comins-Boo A, Lamadrid-Perojo P, Irure-Ventura J, Castillo-Otí JM, Wallman R, Calvo-Montes J, Méndez-Legaza JM, Baamonde-Calzada C, Sánchez-Molina I, Lecue-Martínez M, Ventisca-Pérez S, Batlle-López A, Hoyos ML. San Segundo D, et al. Vaccines (Basel). 2021 Dec 2;9(12):1429. doi: 10.3390/vaccines9121429. Vaccines (Basel). 2021. PMID: 34960173 Free PMC article.
Nursing home residents (NHR) have been targeted as a vaccination priority due to their higher risk of worse outcome after COVID-19 infection. The mRNA-based vaccine BTN2b2 was first approved in Europe for NHRs. ...A representative sample of 624 NHR subjects in North …
Nursing home residents (NHR) have been targeted as a vaccination priority due to their higher risk of worse outcome after COVID-19 …
Abol-Enein pouch modification after radical cystectomy in bladder rhabdomyosarcoma in 5 years old child during COVID-19 pandemic: A case report.
Ginting JT, Sigumonrong Y. Ginting JT, et al. Int J Surg Case Rep. 2022 Jan;90:106701. doi: 10.1016/j.ijscr.2021.106701. Epub 2021 Dec 20. Int J Surg Case Rep. 2022. PMID: 34956826 Free PMC article.
However, during the COVID-19 pandemic, radical cystectomy becomes a concern due to the risk of virus transmission. ...CONCLUSION: In our center, radical cystectomy could be performed in child with bladder rhabdomyosarcoma during COVID-19 pandemic. The …
However, during the COVID-19 pandemic, radical cystectomy becomes a concern due to the risk of virus transmission. ...CONCLUSI …
Clinical update on the use of mesenchymal stem cells in COVID-19.
Saleh FA, Ghazzawi J. Saleh FA, et al. Am J Transl Res. 2021 Nov 15;13(11):12195-12205. eCollection 2021. Am J Transl Res. 2021. PMID: 34956446 Free PMC article. Review.
With the limited therapeutic effects of pharmacological therapies, attention has been drawn to alternative ones such as stem-cell based therapy particularly with mesenchymal stem cells (MSCs). ...Herein, we shed light on the therapeutic agents that hav …
With the limited therapeutic effects of pharmacological therapies, attention has been drawn to alternative ones such as stem-cell …
1,833 results