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Did you mean stem cell and gene osteoarthritis (128 results)?
The Effect of Intra-articular versus Intravenous Injection of Mesenchymal Stem Cells on Experimentally-Induced Knee Joint Osteoarthritis.
Mostafa A, Korayem HE, Fekry E, Hosny S. Mostafa A, et al. J Microsc Ultrastruct. 2020 May 20;9(1):31-38. doi: 10.4103/JMAU.JMAU_2_20. eCollection 2021 Jan-Mar. J Microsc Ultrastruct. 2020. PMID: 33850710 Free PMC article.
AIM AND OBJECTIVES: This study investigates the possible therapeutic effects of intra-articular versus intravenous injection of umbilical cord blood mesenchymal stem cells (UCB-MSCs) against mono-iodoacetate-induced OA of the knee joints in male albino rats, …
AIM AND OBJECTIVES: This study investigates the possible therapeutic effects of intra-articular versus intravenous injection of umbilical co …
Surgical treatment of complex meniscus tear and disease: state of the art.
Ozeki N, Seil R, Krych AJ, Koga H. Ozeki N, et al. J ISAKOS. 2021 Jan;6(1):35-45. doi: 10.1136/jisakos-2019-000380. Epub 2020 Sep 17. J ISAKOS. 2021. PMID: 33833044 Free article. Review.
The meniscus is important for load distribution, shock absorption and stability of the knee joint. Meniscus injury or meniscectomy results in decreased function of the meniscus and increased risk of knee osteoarthritis. ...Advancements in biological augmentat …
The meniscus is important for load distribution, shock absorption and stability of the knee joint. Meniscus injury or meniscectomy re …
Adipose-derived stromal vascular fraction processed with different systems for the treatment of knee osteoarthritis: a pilot study on cell proliferation and clinical results.
Papalia R, Zampogna B, Russo F, Vasta S, Campi S, Saccone L, Di Giacomo G, Vadalà G, Denaro V. Papalia R, et al. J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5 Suppl. 1):113-119. IORS Special Issue on Orthopedics. J Biol Regul Homeost Agents. 2020. PMID: 33739015 Review.
In recent years, the interest in stromal vascular fraction (SVF) therapy for conservative treatment of osteoarthritis has grown significantly. This study aims to assess three different processing systems (micro-fragmentation, filtration, or slow centrifugation) in terms of …
In recent years, the interest in stromal vascular fraction (SVF) therapy for conservative treatment of osteoarthritis has grown signi …
A Novel Strategy to Enhance Microfracture Treatment With Stromal Cell-Derived Factor-1 in a Rat Model.
Mustapich T, Schwartz J, Palacios P, Liang H, Sgaglione N, Grande DA. Mustapich T, et al. Front Cell Dev Biol. 2021 Feb 4;8:595932. doi: 10.3389/fcell.2020.595932. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33634095 Free PMC article.
However, microfracture often results in filling of the chondral defect with fibrocartilage, which exhibits poor durability and sub-optimal mechanical properties. Stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for mesenchymal stem cells (MSC …
However, microfracture often results in filling of the chondral defect with fibrocartilage, which exhibits poor durability and sub-optimal m …
From the Basis of Epimorphic Regeneration to Enhanced Regenerative Therapies.
Laplace-Builhé B, Bahraoui S, Jorgensen C, Djouad F. Laplace-Builhé B, et al. Front Cell Dev Biol. 2021 Jan 21;8:605120. doi: 10.3389/fcell.2020.605120. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33585444 Free PMC article. Review.
Current cell-based therapies to treat degenerative diseases such as osteoarthritis (OA) fail to offer long-term beneficial effects. The therapeutic effects provided by mesenchymal stem cell (MSC) injection, characterized by reduced pain and an improved …
Current cell-based therapies to treat degenerative diseases such as osteoarthritis (OA) fail to offer long-term beneficial eff …
Open-Wedge High Tibial Osteotomy Associated With Lipogems Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis - Retrospective Study.
Magnanelli S, Screpis D, Di Benedetto P, Natali S, Causero A, Zorzi C. Magnanelli S, et al. Acta Biomed. 2020 Dec 30;91(14-S):e2020022. doi: 10.23750/abm.v91i14-S.10992. Acta Biomed. 2020. PMID: 33559633 Free PMC article.
Autologous adipose derived stem cells (aASCs) are used in cartilage regeneration and in the treatment of early osteoarthritis. ...METHODS: In this study we analyze 85 patients treated with HTO for varus knee osteoarthritis with or without Lipoge …
Autologous adipose derived stem cells (aASCs) are used in cartilage regeneration and in the treatment of early osteoarthrit …
Mesenchymal Stem Cells for Treatment of Tendon and Ligament Injuries-clinical Evidence.
Trebinjac S, Gharairi M. Trebinjac S, et al. Med Arch. 2020 Oct;74(5):387-390. doi: 10.5455/medarh.2020.74.387-390. Med Arch. 2020. PMID: 33424096 Free PMC article.
In double blind randomized control trial (RCT) Wang and coauthors combined allogenic precursor mesenchymal stem cells (MPC) with hyaluronic acid (HA) and compared with hyaluronic acid alone in 17 patients underwent ACL reconstruction. Intensity of pain and quality o …
In double blind randomized control trial (RCT) Wang and coauthors combined allogenic precursor mesenchymal stem cells (MPC) wi …
Mesenchymal Stem Cell Implantation in Knee Osteoarthritis: Midterm Outcomes and Survival Analysis in 467 Patients.
Kim YS, Suh DS, Tak DH, Chung PK, Koh YG. Kim YS, et al. Orthop J Sports Med. 2020 Dec 17;8(12):2325967120969189. doi: 10.1177/2325967120969189. eCollection 2020 Dec. Orthop J Sports Med. 2020. PMID: 33415176 Free PMC article.
BACKGROUND: A cell-based tissue engineering approach that uses mesenchymal stem cells (MSCs) has addressed the issue of articular cartilage repair in knees with osteoarthritis (OA). PURPOSE: To evaluate the midterm outcomes, analyze the survival rates, …
BACKGROUND: A cell-based tissue engineering approach that uses mesenchymal stem cells (MSCs) has addressed the issue of …
Mesenchymal stem cells - a promising strategy for treating knee osteoarthritis.
Wang J, Zhou L, Zhang Y, Huang L, Shi Q. Wang J, et al. Bone Joint Res. 2020 Oct;9(10):719-728. doi: 10.1302/2046-3758.910.BJR-2020-0031.R3. Bone Joint Res. 2020. PMID: 33399474 Free PMC article.
AIMS: The purpose of our study was to determine whether mesenchymal stem cells (MSCs) are an effective and safe therapeutic agent for the treatment of knee osteoarthritis (OA), owing to their cartilage regeneration potential. METHODS: We searched PubMe …
AIMS: The purpose of our study was to determine whether mesenchymal stem cells (MSCs) are an effective and safe therapeutic ag …
Safety and Efficacy of Cultured/Noncultured Mesenchymal Stromal Cells without Concurrent Surgery for Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials.
Hall M, McCafferty J, Agarwalla A, Nwachuku I, Liu JN, Amin NH. Hall M, et al. J Long Term Eff Med Implants. 2020;30(1):31-47. doi: 10.1615/JLongTermEffMedImplants.2020035281. J Long Term Eff Med Implants. 2020. PMID: 33389914
The quantity of studies investigating mesenchymal stromal cells (MSCs) for knee osteoarthritis (OA) treatment is not restricted, unlike the amount of randomized controlled trials (RCTs) that can be found in the literature. ...In addition to PROMs and AEs, we …
The quantity of studies investigating mesenchymal stromal cells (MSCs) for knee osteoarthritis (OA) treatment is not re …
Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
An JS, Tsuji K, Onuma H, Araya N, Isono M, Hoshino T, Inomata K, Hino J, Miyazato M, Hosoda H, Kangawa K, Nakagawa Y, Katagiri H, Miyatake K, Sekiya I, Muneta T, Koga H. An JS, et al. Osteoarthritis Cartilage. 2021 Mar;29(3):380-388. doi: 10.1016/j.joca.2020.12.014. Epub 2020 Dec 31. Osteoarthritis Cartilage. 2021. PMID: 33388431 Free article.
Monoiodoacetic acid (MIA) was injected intra-articularly to induce IFP fibrosis and persistent pain. CNP was injected after acute inflammatory phase in the same knee joint. Time-course pain-avoidance behavior tests and histological analyses were performed to examine the ef …
Monoiodoacetic acid (MIA) was injected intra-articularly to induce IFP fibrosis and persistent pain. CNP was injected after acute inflammato …
Intra-articular injection of human synovium-derived mesenchymal stem cells in beagles with surgery-induced osteoarthritis.
Kim YS, Kim YI, Koh YG. Kim YS, et al. Knee. 2021 Jan;28:159-168. doi: 10.1016/j.knee.2020.11.021. Epub 2020 Dec 29. Knee. 2021. PMID: 33385696 Free article.
BACKGROUND: Recently, cell-based tissue engineering approaches using mesenchymal stem cells (MSCs) have been used to treat osteoarthritis (OA). ...The dogs were divided into five groups (n = 12) according to the injection material: G1, sham group; G2, …
BACKGROUND: Recently, cell-based tissue engineering approaches using mesenchymal stem cells (MSCs) have been used to tr …
Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis.
Buzaboon N, Alshammary S. Buzaboon N, et al. Stem Cells Cloning. 2020 Dec 17;13:117-136. doi: 10.2147/SCCAA.S268940. eCollection 2020. Stem Cells Cloning. 2020. PMID: 33364786 Free PMC article. Review.
INTRODUCTION: Osteoarthritis causes a progressive deterioration to the protective cartilage between the joints leading to chronic pain and disability. This review focuses on the intrinsic potential of MSCs to stabilize and repair the cartilage tissue of the knee joi …
INTRODUCTION: Osteoarthritis causes a progressive deterioration to the protective cartilage between the joints leading to chronic pai …
Metabolic Syndrome Predisposes to Osteoarthritis: Lessons from Model System.
Pragasam SSJ, Venkatesan V. Pragasam SSJ, et al. Cartilage. 2021 Dec;13(1_suppl):1598S-1609S. doi: 10.1177/1947603520980161. Epub 2020 Dec 17. Cartilage. 2021. PMID: 33327733 Free PMC article.
Gaining insights, primary cultures of articular chondrocytes complemented with altered cellular expressions of COL2A1 and MMP-13 from WNIN/Gr-Ob rats, indicating osteoarthritis (OA) progression. CONCLUSION: Multiple metabolic perturbations featured in WNIN/Gr-Ob rats were …
Gaining insights, primary cultures of articular chondrocytes complemented with altered cellular expressions of COL2A1 and MMP-13 from WNIN/G …
Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques.
Lyons LP, Weinberg JB, Wittstein JR, McNulty AL. Lyons LP, et al. Osteoarthritis Cartilage. 2021 Apr;29(4):471-479. doi: 10.1016/j.joca.2020.11.008. Epub 2020 Dec 8. Osteoarthritis Cartilage. 2021. PMID: 33307179 Free PMC article. Review.
Injury to the meniscus is common and frequently leads to the development of post-traumatic osteoarthritis (PTOA). Many times meniscus injuries occur coincident with anterior cruciate ligament (ACL) injuries and lead to a bloody joint effusion. ...In this review, we illustr …
Injury to the meniscus is common and frequently leads to the development of post-traumatic osteoarthritis (PTOA). Many times meniscus …
Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas.
Yuan C, Pan Z, Zhao K, Li J, Sheng Z, Yao X, Liu H, Zhang X, Yang Y, Yu D, Zhang Y, Xu Y, Zhang ZY, Huang T, Liu W, Ouyang H. Yuan C, et al. Bone Res. 2020 Nov 12;8(1):38. doi: 10.1038/s41413-020-00109-x. Bone Res. 2020. PMID: 33298863 Free PMC article.
The limited molecular classifications and disease signatures of osteoarthritis (OA) impede the development of prediagnosis and targeted therapeutics for OA patients. ...The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct …
The limited molecular classifications and disease signatures of osteoarthritis (OA) impede the development of prediagnosis and target …
Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis.
Wang K, Li F, Yuan Y, Shan L, Cui Y, Qu J, Lian F. Wang K, et al. Mol Ther Nucleic Acids. 2020 Sep 16;22:1078-1091. doi: 10.1016/j.omtn.2020.09.014. eCollection 2020 Dec 4. Mol Ther Nucleic Acids. 2020. PMID: 33294294 Free PMC article.
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as important mediators of intercellular communication in response to cartilage damage. In this study, we sought to characterize the inhibitory role of microRNA (miR)-31 encapsulated …
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as important mediators of intercellular c …
Efficacy and safety of intra-articular injection of mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis.
Ma W, Liu C, Wang S, Xu H, Sun H, Fan X. Ma W, et al. Medicine (Baltimore). 2020 Dec 4;99(49):e23343. doi: 10.1097/MD.0000000000023343. Medicine (Baltimore). 2020. PMID: 33285713 Free PMC article.
OBJECTIVE: To evaluate the effects and safety of intra-articular injection of mesenchymal stem cells on patients with knee osteoarthritis by a systematic review and meta-analysis. ...The proportion of patients with adverse events in the MSCs treatment …
OBJECTIVE: To evaluate the effects and safety of intra-articular injection of mesenchymal stem cells on patients with knee …
Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis.
Vinet-Jones H, F Darr K. Vinet-Jones H, et al. Regen Med. 2020 Oct;15(10):2153-2161. doi: 10.2217/rme-2020-0069. Epub 2020 Dec 4. Regen Med. 2020. PMID: 33275470 Free article.
Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat, Lipogems()) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA). Materials & methods: A total of 25 subjects w …
Aim: We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat, Lipogems()) is a viable alternative for treatment of …
Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration.
Xu X, Liang Y, Li X, Ouyang K, Wang M, Cao T, Li W, Liu J, Xiong J, Li B, Xia J, Wang D, Duan L. Xu X, et al. Biomaterials. 2021 Feb;269:120539. doi: 10.1016/j.biomaterials.2020.120539. Epub 2020 Nov 18. Biomaterials. 2021. PMID: 33243424
Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable therapy for cartilage degeneration of osteoarthritis (OA). ...Altogether, transplantation of SF-MSCs with in situ chondrogenesis enabled by E7-Exo delivered KGN holds promi …
Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable therapy for cartilage degeneration of …
172 results