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Year Number of Results
2004 1
2006 4
2007 2
2008 4
2009 2
2010 3
2011 6
2012 3
2013 7
2014 9
2015 11
2016 7
2017 14
2018 12
2019 10
2020 9
2021 6
2022 5
2023 10
2024 10
2025 9
2026 5

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138 results

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Page 1
MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities.
Gatesman TA, Varadharajan S, Johnson BJ, Duchatel RJ, Pathak R, Cruz AF, Wolfe HG, Halligan K, Garton LG, Johnson MA, Li F, Chilukuri A, Tjoa K, Halbert ME, Plute TJ, Jane EP, David Premkumar DR, Perez JL, Michel JJ, Gersey ZC, Shiva S, Kohanbash G, Vicha A, Zapotocky M, Felker J, Carlson S, Pearce TM, Gittes GK, Hu B, Prochownik EV, Wang X, Wu YL, Abel TJ, Mantica M, Pollack IF, Rich JN, Dun MD, Mack SC, Agnihotri S. Gatesman TA, et al. Among authors: mack sc. Cell Rep. 2026 Jun 23;45(6):117522. doi: 10.1016/j.celrep.2026.117522. Epub 2026 Jun 12. Cell Rep. 2026. PMID: 42287636 Free article.
Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma.
Ippagunta SM, Arabzade A, Varadharajan S, Emanus E, Bland A, Kardian A, Laboe N, Sun H, Zheng T, Hancock A, Zhai M, Caesar E, Park M, Orisme W, Johnson M, Rodgers B, Turner GH, Steinberg J, Freeman B, Roussel MF, Shelat A, Kriwacki R, Merchant TE, Deneen B, Taylor MD, Agnihotri S, Pruett-Miller S, Steele JA, Kavirayani AM, Ellison DW, Onar-Thomas A, Robinson G, Mack SC, Bertrand KC. Ippagunta SM, et al. Among authors: mack sc. Neuro Oncol. 2026 May 3:noag100. doi: 10.1093/neuonc/noag100. Online ahead of print. Neuro Oncol. 2026. PMID: 42080900 Free article.
Dominant clones leverage developmental epigenomic states to drive ependymoma.
Kardian AS, Sun H, Ippagunta S, Laboe N, Varadharajan S, Yu K, Chen HC, Emanus E, Zheng T, Deneen RM, Connelly JP, Wang YD, Zhan J, Liu H, Lowe K, Bugbee T, Pathak R, Bland A, Mehta S, Cochiolo S, Arabzade A, Holcomb B, Budd KM, Kembuan G, Wright T, Caesar E, Park M, Hancock A, Gee D, Murdoch J, Xiao Y, McBrayer SK, Merchant TE, Qi J, Durbin AD, Schwarz LA, Wang L, Donson AM, Foreman NK, Agnihotri S, Lavado A, Baker SJ, Ellison DW, Lee HK, Pruett-Miller SM, Bertrand KC, Deneen B, Mack SC. Kardian AS, et al. Among authors: mack sc. Nature. 2026 Apr;652(8111):1027-1037. doi: 10.1038/s41586-026-10270-8. Epub 2026 Mar 25. Nature. 2026. PMID: 41882368 Free PMC article.
Discovery of genetic susceptibility variants in pediatric and adult ependymoma.
Strauss JD, Shetty PB, Tsavachidis S, Byun J, Mack SC, Xiangjun X, Armstrong TS, Gilbert MR; (on behalf of NCI-CONNECT); Mirabello L, Bhatia S, Leisenring WM, Morton LM, Armstrong GT, Foss-Skiftesvik J, Hagen CM, Bybjerg-Grauholm J; iPSYCH Consortium; Ghozal M, Bonaventure A, Clavel J, Bondy ML; (on behalf of GICC); Amos CI, Hoang TT, Scheurer ME. Strauss JD, et al. Among authors: mack sc. Neurooncol Adv. 2026 Jan 16;8(1):vdag004. doi: 10.1093/noajnl/vdag004. eCollection 2026 Jan-Dec. Neurooncol Adv. 2026. PMID: 41869074 Free PMC article.
Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis.
Xiao Y, Shi DD, Guo L, Neumann E, Levitt MM, Kaphle P, Shipman T, Li H, Cai F, Ramirez DMO, Zacharias LG, Chen Z, Lin M, Puliyappadamba VT, Chen T, Savani MR, Peña S, Wansapura J, Mathews TP, Mishra P, Kim YJ, Raj P, Richardson TE, Xu J, Mack SC, Rahme GJ, Bernstein BE, DeBerardinis RJ, Tirosh I, Suvà ML, Xu L, Abdullah KG, McBrayer SK. Xiao Y, et al. Among authors: mack sc. bioRxiv [Preprint]. 2025 Aug 13:2025.08.12.667486. doi: 10.1101/2025.08.12.667486. bioRxiv. 2025. PMID: 40832272 Free PMC article. Preprint.
B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response.
Mehta S, Ippagunta S, Varadharajan S, Kardian A, Laboe N, Dinh D, Jones AB, Meehl MM, Ibañez J, Emanus E, Dao T, Ward MB, Orisme W, Lange S, Langfitt D, Steinberg J, Chiang J, Vogel P, Sheppard H, Ellison DW, Mack SC, Krenciute G. Mehta S, et al. Among authors: mack sc. Clin Cancer Res. 2025 Sep 2;31(17):3754-3770. doi: 10.1158/1078-0432.CCR-24-3083. Clin Cancer Res. 2025. PMID: 40586675 Free PMC article.
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma.
Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. Mack SC, et al. J Exp Med. 2025 Jun 2;222(6):e2019019605052025C. doi: 10.1084/jem.2019019605052025C. Epub 2025 May 20. J Exp Med. 2025. PMID: 40392229 Free PMC article. No abstract available.
Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression.
Lu C, Kang T, Zhang J, Yang K, Liu Y, Song K, Lin Q, Dixit D, Gimple RC, Zhang Q, Shi Z, Fan X, Wu Q, Li D, Shan D, Gao J, Gu D, You H, Li Y, Yang J, Zhao L, Qiu Z, Yang H, Zhao N, Gao W, Tao W, Lu Y, Chen Y, Ji J, Zhu Z, Kang C, Man J, Agnihotri S, Wang Q, Lin F, Qian X, Mack SC, Hu Z, Li C, Taylor MD, Liu N, Zhang N, Lu M, You Y, Rich JN, Zhang W, Wang X. Lu C, et al. Among authors: mack sc. Nat Commun. 2025 Mar 26;16(1):2974. doi: 10.1038/s41467-025-58366-5. Nat Commun. 2025. PMID: 40140646 Free PMC article.
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.
Fan JJ, Erickson AW, Carrillo-Garcia J, Wang X, Skowron P, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Suárez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadiñanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD, Huang X. Fan JJ, et al. Among authors: mack sc. Dev Cell. 2025 Jun 9;60(11):1532-1549.e7. doi: 10.1016/j.devcel.2025.01.001. Epub 2025 Jan 24. Dev Cell. 2025. PMID: 39862856 Free PMC article.
138 results