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548 results

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Page 1
5'-Phosphorylation Strengthens Sticky-End Cohesions.
Li Z, Zheng M, Liu L, Seeman NC, Mao C. Li Z, et al. J Am Chem Soc. 2021 Sep 22;143(37):14987-14991. doi: 10.1021/jacs.1c07279. Epub 2021 Sep 13. J Am Chem Soc. 2021. PMID: 34516099
Sticky-end cohesion plays a critical role in molecular biology and nucleic acid nanotechnology. ...Herein, we have used rationally designed 3D DNA crystals as a tool to experimentally investigate the modulation of 5'-phosphorylation on sticky-end cohes …
Sticky-end cohesion plays a critical role in molecular biology and nucleic acid nanotechnology. ...Herein, we have used ration …
A sticky-end probe biosensor for homogeneous detection of transcription factor binding activity.
Mendes JPP, Zhu N, Wong PK. Mendes JPP, et al. SLAS Technol. 2023 Oct;28(5):345-350. doi: 10.1016/j.slast.2023.05.001. Epub 2023 May 21. SLAS Technol. 2023. PMID: 37220830 Free article.
We design a sticky-end biosensor for the SOX9 transcription factor based on the consensus sequence and characterize its sensing performance. ...Taken together, our study provides a conceptual framework for the design and optimization of sticky-end prob …
We design a sticky-end biosensor for the SOX9 transcription factor based on the consensus sequence and characterize its sensin …
Design of Orthogonal DNA Sticky-End Cohesion Based on Configuration-Specific Molecular Recognition.
Zhang T, Wei B. Zhang T, et al. J Am Chem Soc. 2022 Oct 12;144(40):18479-18484. doi: 10.1021/jacs.2c07181. Epub 2022 Sep 29. J Am Chem Soc. 2022. PMID: 36173287
In sticky-end cohesion, sequence complementarity is the key to design specific recognition among many DNA nanostructure units. The binding orthogonality usually arises from sticky-end pairs of different sequences. Instead of creating orthogonal species …
In sticky-end cohesion, sequence complementarity is the key to design specific recognition among many DNA nanostructure units. …
Non-homologous end-joining, a sticky affair.
van Gent DC, van der Burg M. van Gent DC, et al. Oncogene. 2007 Dec 10;26(56):7731-40. doi: 10.1038/sj.onc.1210871. Oncogene. 2007. PMID: 18066085 Review.
Most mammalian cells rely primarily on the non-homologous end-joining pathway of DNA double-strand break (DSB) repair to accomplish this task. This review focuses both on the core non-homologous end-joining machinery, which consists of DNA-dependent protein kinase a …
Most mammalian cells rely primarily on the non-homologous end-joining pathway of DNA double-strand break (DSB) repair to accomplish t …
Has immunoglobulin come to a sticky end?
Langman RE, Cohn M. Langman RE, et al. Scand J Immunol. 1991 Feb;33(2):99-109. doi: 10.1111/j.1365-3083.1991.tb03739.x. Scand J Immunol. 1991. PMID: 2017661 No abstract available.
PAM-independent ultra-specific activation of CRISPR-Cas12a via sticky-end dsDNA.
Zhang W, Mu Y, Dong K, Zhang L, Yan B, Hu H, Liao Y, Zhao R, Shu W, Ye Z, Lu Y, Wan C, Sun Q, Li L, Wang H, Xiao X. Zhang W, et al. Nucleic Acids Res. 2022 Dec 9;50(22):12674-12688. doi: 10.1093/nar/gkac1144. Nucleic Acids Res. 2022. PMID: 36484104 Free PMC article.
Here, we discovered a new targeting substrate for LbaCas12a (Lachnospiraceae bacterium Cas12a), namely double-stranded DNA (dsDNA) with a sticky-end region (PAM-SE+ dsDNA). We discovered that CRISPR-Cas12a had special enzymatic properties for this substrate DNA, inc …
Here, we discovered a new targeting substrate for LbaCas12a (Lachnospiraceae bacterium Cas12a), namely double-stranded DNA (dsDNA) with a …
STICKY SILICONE OIL.
Ghoraba HH, Zaky AG, Abd Al Fatah HM, El Gemai EEDM, Heikal MA. Ghoraba HH, et al. Retina. 2017 Aug;37(8):1599-1606. doi: 10.1097/IAE.0000000000001377. Retina. 2017. PMID: 28590320
OBJECTIVE: To report and analyze the phenomenon of sticky silicone oil on the retina at the time of its removal. BACKGROUND: Silicone oil has been used for more than 25 years as a long-term retinal tamponade in the surgical management of patients with complex retinal detac …
OBJECTIVE: To report and analyze the phenomenon of sticky silicone oil on the retina at the time of its removal. BACKGROUND: Silicone …
Coarse-Grained Simulations of DNA Reveal Angular Dependence of Sticky-End Binding.
Gravina NM, Gumbart JC, Kim HD. Gravina NM, et al. J Phys Chem B. 2021 Apr 29;125(16):4016-4024. doi: 10.1021/acs.jpcb.1c00432. Epub 2021 Apr 19. J Phys Chem B. 2021. PMID: 33870695 Free PMC article.
This reaction is generally understood as a bimolecular reaction dictated by the local concentration of the sticky ends. Its dependence on the relative orientation between the sticky ends, however, is less understood. Here we report on the interactions between DNA …
This reaction is generally understood as a bimolecular reaction dictated by the local concentration of the sticky ends. Its dependenc …
548 results