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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1971 1
1972 1
1973 1
1974 2
1975 1
1976 6
1977 6
1978 6
1979 11
1980 8
1981 3
1982 9
1983 11
1984 17
1985 13
1986 9
1987 18
1988 20
1989 21
1990 31
1991 45
1992 48
1993 45
1994 41
1995 58
1996 54
1997 55
1998 51
1999 50
2000 62
2001 74
2002 66
2003 71
2004 74
2005 75
2006 89
2007 78
2008 106
2009 110
2010 96
2011 120
2012 146
2013 108
2014 94
2015 93
2016 108
2017 100
2018 80
2019 68
2020 92
2021 89
2022 89
2023 94
2024 76
2025 76
2026 40

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2,755 results

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Page 1
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs.
Kang JY, Wen Z, Pan D, Zhang Y, Li Q, Zhong A, Yu X, Wu YC, Chen Y, Zhang X, Kou PC, Geng J, Wang YY, Hua MM, Zong R, Li B, Shi HJ, Li D, Fu XD, Li J, Nelson DL, Guo X, Zhou Y, Gou LT, Huang Y, Liu MF. Kang JY, et al. Science. 2022 Aug 12;377(6607):eabj6647. doi: 10.1126/science.abj6647. Epub 2022 Aug 12. Science. 2022. PMID: 35951695
Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoprotei …
Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and tra …
Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment.
Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M. Cheng S, et al. Science. 2022 Oct 21;378(6617):eabq4835. doi: 10.1126/science.abq4835. Epub 2022 Oct 21. Science. 2022. PMID: 36264786
Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development. ...MARDO assembly around mitochondria was promoted by the RNA-binding protein ZAR1 and directed …
Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for oocyte meiotic maturat …
LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.
Li H, Zhao H, Yang C, Su R, Long M, Liu J, Shi L, Xue Y, Su YQ. Li H, et al. Adv Sci (Weinh). 2023 Jun;10(18):e2300043. doi: 10.1002/advs.202300043. Epub 2023 Apr 21. Adv Sci (Weinh). 2023. PMID: 37083226 Free PMC article.
Nevertheless, how the fate of maternal mRNAs is determined remains largely elusive. RNA-binding proteins (RBPs) are crucial regulators of oogenesis, yet the identity of the full complement of RBPs expressed in oocytes is unknown. ...Therefore, RNP complexes tethered by LSM …
Nevertheless, how the fate of maternal mRNAs is determined remains largely elusive. RNA-binding proteins (RBPs) are crucial regulator …
The maternal-to-zygotic transition.
Brantley S, Di Talia S. Brantley S, et al. Curr Biol. 2024 Jun 3;34(11):R519-R523. doi: 10.1016/j.cub.2024.04.044. Curr Biol. 2024. PMID: 38834020 Free article. Review.
IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts.
Li C, Tan YP, Gao D, Su R, Xu K, Liu SC, Li XF, Lu YH, Yi LT, Wang G, Ou XH, Meng TG, Sun QY. Li C, et al. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf520. doi: 10.1093/nar/gkaf520. Nucleic Acids Res. 2025. PMID: 40530690 Free PMC article.
During maternal-to-zygotic transition, oocytes and embryos undergo massive maternal mRNA degradation. Three key events are related to RNA degradation: oocyte meiotic resumption, fertilization, and zygotic genome activation (ZGA). In this study, we unexpectedly disco …
During maternal-to-zygotic transition, oocytes and embryos undergo massive maternal mRNA degradation. Three key events are related to …
The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells.
Asada N, Ginsberg P, Paust HJ, Song N, Riedel JH, Turner JE, Peters A, Kaffke A, Engesser J, Wang H, Zhao Y, Khatri R, Gild P, Dahlem R, Diercks BP, Das S, Ignatova Z, Huber TB, Prinz I, Gagliani N, Mittrücker HW, Krebs CF, Panzer U. Asada N, et al. Nat Immunol. 2025 Apr;26(4):557-566. doi: 10.1038/s41590-025-02105-x. Epub 2025 Mar 6. Nat Immunol. 2025. PMID: 40050432 Free PMC article.
Here, we showed that human and mouse CD4(+) T(RM) cells existed in a poised state and stored messenger RNAs encoding proinflammatory cytokines without protein production. At steady state, cytokine mRNA translation in T(RM) cells was suppressed by the integrat …
Here, we showed that human and mouse CD4(+) T(RM) cells existed in a poised state and stored messenger RNAs encoding proinflam …
Heterogeneity in mRNA Translation.
Sonneveld S, Verhagen BMP, Tanenbaum ME. Sonneveld S, et al. Trends Cell Biol. 2020 Aug;30(8):606-618. doi: 10.1016/j.tcb.2020.04.008. Epub 2020 May 25. Trends Cell Biol. 2020. PMID: 32461030 Free article. Review.
During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. ...Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molec …
During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. ...Surprisingly, …
ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development.
Wu YK, Su R, Jiang ZY, Wu YW, Rong Y, Ji SY, Liu J, Niu Z, Li Z, Xue Y, Lu F, Fan HY. Wu YK, et al. Genome Biol. 2025 May 8;26(1):120. doi: 10.1186/s13059-025-03593-8. Genome Biol. 2025. PMID: 40340906 Free PMC article.
Zygotic arrest 1 (ZAR1) and its homolog, ZAR2, are RNA-binding proteins that are important for the regulation of maternal mRNA stability. ...Similarly, differential expression of maternal transcripts in oocytes with or without Zar1/2 differs when analyzed using tota …
Zygotic arrest 1 (ZAR1) and its homolog, ZAR2, are RNA-binding proteins that are important for the regulation of maternal mRNA …
2,755 results