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STAT Signaling and Its Anti-Apoptotic Effects in Dehydrated Xenopus laevis.

Biggar Y, Kamath AA, Breedon SA, Storey KB. Biggar Y, et al. Among authors: storey kb. Biol Cell. 2026 May;118(5):e70069. doi: 10.1111/boc.70069. Biol Cell. 2026. PMID: 42068036 Free PMC article.

Xenopus laevis survives seasonal droughts by entering a hypometabolic state known as aestivation. One of the mechanisms employed by X. laevis to mitigate aestivation-induced tissue atrophy is gene regulation of pro-survival proteins. ...Overall, our results indicate …

Xenopus laevis survives seasonal droughts by entering a hypometabolic state known as aestivation. One of the mechanisms employed by X …

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NF-κB signaling and its anti-apoptotic effects in liver & skeletal muscle of dehydrated Xenopus laevis.

Biggar Y, Kamath AA, Breedon SA, Storey KB. Biggar Y, et al. Among authors: storey kb. Exp Cell Res. 2025 Jun 1;449(1):114579. doi: 10.1016/j.yexcr.2025.114579. Epub 2025 Apr 28. Exp Cell Res. 2025. PMID: 40306608 Free article.

During these conditions, X. laevis enters aestivation whereby its metabolic rate is suppressed, urea and ammonia levels increase, and its physiological functions slow. ...Overall, our results serve to expand our knowledge of the anti-apoptotic mechanisms underlying the nat …

During these conditions, X. laevis enters aestivation whereby its metabolic rate is suppressed, urea and ammonia levels increase, and …

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The mRNA N⁶-Methyladenosine Response to Dehydration in Xenopus laevis.

Rehman S, Parent M, Storey KB. Rehman S, et al. Among authors: storey kb. Animals (Basel). 2024 Nov 15;14(22):3288. doi: 10.3390/ani14223288. Animals (Basel). 2024. PMID: 39595341 Free PMC article.

During extreme dehydration, X. laevis undergoes estivation, a state characterized by increased urea and ammonia levels, depression of the metabolic rate, and tissue hypoxia. ...

During extreme dehydration, X. laevis undergoes estivation, a state characterized by increased urea and ammonia levels, depression of …

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Histone Arginine Methylation as a Regulator of Gene Expression in the Dehydrating African Clawed Frog (Xenopus laevis).

Rehman S, Parent M, Storey KB. Rehman S, et al. Among authors: storey kb. Genes (Basel). 2024 Sep 1;15(9):1156. doi: 10.3390/genes15091156. Genes (Basel). 2024. PMID: 39336747 Free PMC article.

The African clawed frog (Xenopus laevis) endures prolonged periods of dehydration while estivating underground during the dry season. Epigenetic modifications play crucial roles in regulating gene expression in response to environmental changes. ...

The African clawed frog (Xenopus laevis) endures prolonged periods of dehydration while estivating underground during the dry season. …

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REVIEW: Evidence supporting the 'preparation for oxidative stress' (POS) strategy in animals in their natural environment.

Giraud-Billoud M, Moreira DC, Minari M, Andreyeva A, Campos ÉG, Carvajalino-Fernández JM, Istomina A, Michaelidis B, Niu C, Niu Y, Ondei L, Prokić M, Rivera-Ingraham GA, Sahoo D, Staikou A, Storey JM, Storey KB, Vega IA, Hermes-Lima M. Giraud-Billoud M, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2024 Jul;293:111626. doi: 10.1016/j.cbpa.2024.111626. Epub 2024 Mar 21. Comp Biochem Physiol A Mol Integr Physiol. 2024. PMID: 38521444 Review.

Under conditions such as hypoxia/anoxia, temperature and salinity stress, or seasonal changes (e.g. hibernation, estivation), stress-tolerant species down-regulate pathways to decrease energy expenditures until the return of less challenging conditions. ...

Under conditions such as hypoxia/anoxia, temperature and salinity stress, or seasonal changes (e.g. hibernation, estivation), stress- …

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Aestivation in Nature: Physiological Strategies and Evolutionary Adaptations in Hypometabolic States.

Jiang C, Storey KB, Yang H, Sun L. Jiang C, et al. Among authors: storey kb. Int J Mol Sci. 2023 Sep 14;24(18):14093. doi: 10.3390/ijms241814093. Int J Mol Sci. 2023. PMID: 37762394 Free PMC article. Review.

Aestivation is considered to be one of the "purest" hypometabolic states in nature, as it involves aerobic dormancy that can be induced and sustained without complex factors. Animals that undergo aestivation to protect themselves from environmental stressors such as …

Aestivation is considered to be one of the "purest" hypometabolic states in nature, as it involves aerobic dormancy that can be induc …

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Cardiac microRNA expression profile in response to estivation.

Naranjo M, Breedon SA, Storey KB. Naranjo M, et al. Among authors: storey kb. Biochimie. 2023 Jul;210:22-34. doi: 10.1016/j.biochi.2023.01.001. Epub 2023 Jan 7. Biochimie. 2023. PMID: 36627041

MicroRNA (miRNA) are known to regulate translation by targeting messenger RNA (mRNA) for degradation or temporary storage, with several studies having reported that miRNA is differentially expressed during MRD, including estivation. Thus, we hypothesized that miRNA would b …

MicroRNA (miRNA) are known to regulate translation by targeting messenger RNA (mRNA) for degradation or temporary storage, with several stud …

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Chaperone proteins: universal roles in surviving environmental stress.

Storey JM, Storey KB. Storey JM, et al. Among authors: storey kb. Cell Stress Chaperones. 2023 Sep;28(5):455-466. doi: 10.1007/s12192-022-01312-x. Epub 2022 Nov 28. Cell Stress Chaperones. 2023. PMID: 36441380 Free PMC article. Review.

The current review provides an update on recent advances in understanding the roles and responses of chaperones in aiding animals to deal with environmental stress, offering new information on chaperone action in supporting survival strategies including torpor, hibernation, anaer …

The current review provides an update on recent advances in understanding the roles and responses of chaperones in aiding animals to deal wi …

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Commentary: On the merit of an early contributor of the "Preparation for Oxidative Stress" (POS) theory.

Moreira DC, Campos ÉG, Giraud-Billoud M, Storey KB, Hermes-Lima M. Moreira DC, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2023 Feb;276:111341. doi: 10.1016/j.cbpa.2022.111341. Epub 2022 Nov 8. Comp Biochem Physiol A Mol Integr Physiol. 2023. PMID: 36368609

Over next 25 years, the phenomenon was described in detail in more than one hundred studies of animals under conditions of aestivation, hypoxia/anoxia, freezing, severe dehydration, ultraviolet exposure, air exposure of water-breathing animals, salinity stress, and others. …

Over next 25 years, the phenomenon was described in detail in more than one hundred studies of animals under conditions of aestivation …

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Molecular and functional characterization of the luqin-type neuropeptide signaling system in the sea cucumber Apostichopus japonicus.

Li C, Zheng Y, Cong X, Liu H, Storey KB, Chen M. Li C, et al. Among authors: storey kb. Peptides. 2022 Sep;155:170839. doi: 10.1016/j.peptides.2022.170839. Epub 2022 Jul 12. Peptides. 2022. PMID: 35839946

Furthermore, we observed significantly increased expression of AjLQP (about 17.63 fold, p < 0.01) in intestine of deeply aestivating sea cucumbers, which suggests that AjLQ might be involved in feeding inhibition during aestivation. The present study provides a first in

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Furthermore, we observed significantly increased expression of AjLQP (about 17.63 fold, p < 0.01) in intestine of deeply aestivating sea

…

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Regulation of the unfolded protein response during dehydration stress in African clawed frogs, Xenopus laevis.

Malik AI, Storey JM, Storey KB. Malik AI, et al. Among authors: storey kb. Cell Stress Chaperones. 2023 Sep;28(5):529-540. doi: 10.1007/s12192-022-01275-z. Epub 2022 Apr 29. Cell Stress Chaperones. 2023. PMID: 35484355 Free PMC article.

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Pro- and anti-apoptotic microRNAs are differentially regulated during estivation in Xenopus laevis.

Biggar Y, Ingelson-Filpula WA, Storey KB. Biggar Y, et al. Among authors: storey kb. Gene. 2022 Apr 20;819:146236. doi: 10.1016/j.gene.2022.146236. Epub 2022 Jan 31. Gene. 2022. PMID: 35114277

Xenopus laevis, the African clawed frog, undergoes seasonal estivation to survive periods of drought when its lake-bed habitats dry up. The frog can lose 30% of its total body water, leading to conditions of impaired blood flow and ischemia which risk cellular survival un …

Xenopus laevis, the African clawed frog, undergoes seasonal estivation to survive periods of drought when its lake-bed habitats dry u …

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Seasonal cellular stress phenomena and phenotypic plasticity in land snail Helix lucorum populations from different altitudes.

Staikou A, Feidantsis K, Gkanatsiou O, Bibos MN, Hatziioannou M, Storey KB, Michaelidis B. Staikou A, et al. Among authors: storey kb. J Exp Biol. 2021 Dec 15;224(24):jeb243298. doi: 10.1242/jeb.243298. Epub 2021 Dec 14. J Exp Biol. 2021. PMID: 34796901

Additionally, the intense reactivation of snail metabolic rate upon arousal from hibernation or estivation may provoke stress. Land snails, Helix lucorum, display a wide altitudinal distribution resulting in populations being exposed to different seasonal temperature varia …

Additionally, the intense reactivation of snail metabolic rate upon arousal from hibernation or estivation may provoke stress. Land s …

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Role of MicroRNAs in Extreme Animal Survival Strategies.

Hadj-Moussa H, Hawkins LJ, Storey KB. Hadj-Moussa H, et al. Among authors: storey kb. Methods Mol Biol. 2022;2257:311-347. doi: 10.1007/978-1-0716-1170-8_16. Methods Mol Biol. 2022. PMID: 34432286

We examine the role of miRNA in strategies of biochemical adaptation including mammalian hibernation, freeze tolerance, freeze avoidance, anoxia and hypoxia survival, estivation, and dehydration tolerance. By comparing these seemingly different adaptive programs in traditi …

We examine the role of miRNA in strategies of biochemical adaptation including mammalian hibernation, freeze tolerance, freeze avoidance, an …

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mTOR Signaling in Metabolic Stress Adaptation.

Wu CW, Storey KB. Wu CW, et al. Among authors: storey kb. Biomolecules. 2021 May 1;11(5):681. doi: 10.3390/biom11050681. Biomolecules. 2021. PMID: 34062764 Free PMC article. Review.

Here, we review current knowledge of the role that mTOR plays in contributing to natural hypometabolic states such as hibernation, estivation, hypoxia/anoxia tolerance, and dauer diapause. Studies across a diverse range of animal species reveal that mTOR exhibits unique re …

Here, we review current knowledge of the role that mTOR plays in contributing to natural hypometabolic states such as hibernation, estiva …

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Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis.

Wu CW, Tessier SN, Storey KB. Wu CW, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2020 Aug-Sep;246-247:110461. doi: 10.1016/j.cbpb.2020.110461. Epub 2020 Jun 1. Comp Biochem Physiol B Biochem Mol Biol. 2020. PMID: 32497588

In arid conditions, the African Clawed frog Xenopus laevis enters a state of estivation dormancy as an adaptive survival strategy. Under estivation, X. laevis experience severe dehydration stress as 25-35% of total body water is lost. ...

In arid conditions, the African Clawed frog Xenopus laevis enters a state of estivation dormancy as an adaptive survival strategy. Un …

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MiR-200-3p Is Potentially Involved in Cell Cycle Arrest by Regulating Cyclin A during Aestivation in Apostichopus japonicus.

Wang S, Chen M, Yin Y, Storey KB. Wang S, et al. Among authors: storey kb. Cells. 2019 Aug 6;8(8):843. doi: 10.3390/cells8080843. Cells. 2019. PMID: 31390757 Free PMC article.

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally induced aestivation in marine invertebrates. We hypothesized that mechanisms that arrest energy-expensive cell cycle activity would contribute significantly to establish …

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally induced aestivation in marine …

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Neuropeptide precursors and neuropeptides in the sea cucumber Apostichopus japonicus: a genomic, transcriptomic and proteomic analysis.

Chen M, Talarovicova A, Zheng Y, Storey KB, Elphick MR. Chen M, et al. Among authors: storey kb. Sci Rep. 2019 Jun 20;9(1):8829. doi: 10.1038/s41598-019-45271-3. Sci Rep. 2019. PMID: 31222106 Free PMC article.

Therefore, we need to learn more about the biology of A. japonicus, including processes such as aestivation, evisceration, regeneration and albinism. One of the major classes of molecules that regulate physiology and behaviour in animals are neuropeptides, and a few bioact …

Therefore, we need to learn more about the biology of A. japonicus, including processes such as aestivation, evisceration, regenerati …

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Twenty years of the 'Preparation for Oxidative Stress' (POS) theory: Ecophysiological advantages and molecular strategies.

Giraud-Billoud M, Rivera-Ingraham GA, Moreira DC, Burmester T, Castro-Vazquez A, Carvajalino-Fernández JM, Dafre A, Niu C, Tremblay N, Paital B, Rosa R, Storey JM, Vega IA, Zhang W, Yepiz-Plascencia G, Zenteno-Savin T, Storey KB, Hermes-Lima M. Giraud-Billoud M, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2019 Aug;234:36-49. doi: 10.1016/j.cbpa.2019.04.004. Epub 2019 Apr 10. Comp Biochem Physiol A Mol Integr Physiol. 2019. PMID: 30978470 Review.

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Estivation-responsive microRNAs in a hypometabolic terrestrial snail.

Hoyeck MP, Hadj-Moussa H, Storey KB. Hoyeck MP, et al. Among authors: storey kb. PeerJ. 2019 Feb 20;7:e6515. doi: 10.7717/peerj.6515. eCollection 2019. PeerJ. 2019. PMID: 30809463 Free PMC article.

Herein, we investigated the regulation of microRNA in the induction of estivation. Changes in the expression levels of 75 highly conserved microRNAs were analysed in snail foot muscle, of which 26 were significantly upregulated during estivation compared with contro …

Herein, we investigated the regulation of microRNA in the induction of estivation. Changes in the expression levels of 75 highly cons …

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The potential contribution of miRNA-200-3p to the fatty acid metabolism by regulating AjEHHADH during aestivation in sea cucumber.

Chen M, Wang S, Li X, Storey KB, Zhang X. Chen M, et al. Among authors: storey kb. PeerJ. 2018 Oct 2;6:e5703. doi: 10.7717/peerj.5703. eCollection 2018. PeerJ. 2018. PMID: 30310746 Free PMC article.

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally-induced aestivation by a marine invertebrate more recently. In the present study, we hypothesized that miRNA-200-3p may contribute to establish rapid biological control …

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally-induced aestivation by a mari …

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A potential antiapoptotic regulation: The interaction of heat shock protein 70 and apoptosis-inducing factor mitochondrial 1 during heat stress and aestivation in sea cucumber.

Wang S, Li X, Chen M, Storey KB, Wang T. Wang S, et al. Among authors: storey kb. J Exp Zool A Ecol Integr Physiol. 2018 May 28. doi: 10.1002/jez.2180. Online ahead of print. J Exp Zool A Ecol Integr Physiol. 2018. PMID: 29808567

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally induced aestivation in marine invertebrates. A characteristic feature of aestivation in this species is the degeneration of the intestine. ...The gene and protein …

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally induced aestivation in marine …

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Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis.

Dawson NJ, Biggar Y, Malik AI, Storey KB. Dawson NJ, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2018 Oct;224:245-252. doi: 10.1016/j.cbpb.2018.01.003. Epub 2018 Jan 10. Comp Biochem Physiol B Biochem Mol Biol. 2018. PMID: 29331521

The African clawed frog, Xenopus laevis, can withstand extremely arid conditions through aestivation, resulting in dehydration and urea accumulation. Aestivating X. laevis reduce their metabolic rate, and rely on anaerobic glycolysis to meet reduced ATP demands. ...

The African clawed frog, Xenopus laevis, can withstand extremely arid conditions through aestivation, resulting in dehydration and ur …

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Regulation of the insulin-Akt signaling pathway and glycolysis during dehydration stress in the African clawed frog Xenopus laevis.

Wu CW, Tessier SN, Storey KB. Wu CW, et al. Among authors: storey kb. Biochem Cell Biol. 2017 Dec;95(6):663-671. doi: 10.1139/bcb-2017-0117. Epub 2017 Jul 14. Biochem Cell Biol. 2017. PMID: 28708941

Estivation is an adaptive stress response utilized by some amphibians during periods of drought in the summer season. ...Overall, we provide evidence that shows that the insulin signaling pathway in X. laevis is regulated in a tissue-specific manner during dehydration stre …

Estivation is an adaptive stress response utilized by some amphibians during periods of drought in the summer season. ...Overall, we …

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Purification and Characterization of Lactate Dehydrogenase in the Foot Muscle and Hepatopancreas of Otala lactea.

MacLean IA, Mattice AM, Adam NJ, Storey KB. MacLean IA, et al. Among authors: storey kb. Protein J. 2016 Dec;35(6):467-480. doi: 10.1007/s10930-016-9689-3. Protein J. 2016. PMID: 27858264

Overall, foot muscle LDH enters a low phosphorylation state during estivation allowing more efficiency in consuming pyruvate with higher thermal stability but less structural stability. Hepatopancreas LDH becomes dephosphorylated in the estivating snail that decreas …

Overall, foot muscle LDH enters a low phosphorylation state during estivation allowing more efficiency in consuming pyruvate with hig …

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Gene structure, expression, and DNA methylation characteristics of sea cucumber cyclin B gene during aestivation.

Zhu A, Chen M, Zhang X, Storey KB. Zhu A, et al. Among authors: storey kb. Gene. 2016 Dec 5;594(1):82-88. doi: 10.1016/j.gene.2016.09.006. Epub 2016 Sep 4. Gene. 2016. PMID: 27601256

The present study identified the gene structure of the cell cycle regulator, cyclin B, and detected the expression levels of this gene over three stages of the annual aestivation-arousal cycle. Furthermore, the DNA methylation characteristics of cyclin B were analyzed in n …

The present study identified the gene structure of the cell cycle regulator, cyclin B, and detected the expression levels of this gene over …

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Understanding mechanism of sea cucumber Apostichopus japonicus aestivation: Insights from TMT-based proteomic study.

Chen M, Li X, Zhu A, Storey KB, Sun L, Gao T, Wang T. Chen M, et al. Among authors: storey kb. Comp Biochem Physiol Part D Genomics Proteomics. 2016 Sep;19:78-89. doi: 10.1016/j.cbd.2016.06.005. Epub 2016 Jun 17. Comp Biochem Physiol Part D Genomics Proteomics. 2016. PMID: 27376927

Among them, 630 proteins showed significant differential expression when comparing three conditions of sea cucumbers: non-aestivating (active), deep-aestivation (at least 15days of continuous aestivation), and arousal after aestivation (renewed moving and fee …

Among them, 630 proteins showed significant differential expression when comparing three conditions of sea cucumbers: non-aestivating (activ …

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Global metabolite analysis of the land snail Theba pisana hemolymph during active and aestivated states.

Bose U, Centurion E, Hodson MP, Shaw PN, Storey KB, Cummins SF. Bose U, et al. Among authors: storey kb. Comp Biochem Physiol Part D Genomics Proteomics. 2016 Sep;19:25-33. doi: 10.1016/j.cbd.2016.05.004. Epub 2016 Jun 6. Comp Biochem Physiol Part D Genomics Proteomics. 2016. PMID: 27318654

Many animals lower their metabolism in response to high temperatures and/or arid conditions, a phenomenon called aestivation. The biological significance for this is clear; by strongly suppressing metabolic rate to low levels, animals minimize their exposure to stressful c …

Many animals lower their metabolism in response to high temperatures and/or arid conditions, a phenomenon called aestivation. The bio …

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Genes and associated peptides involved with aestivation in a land snail.

Adamson KJ, Wang T, Rotgans BA, Kruangkum T, Kuballa AV, Storey KB, Cummins SF. Adamson KJ, et al. Among authors: storey kb. Gen Comp Endocrinol. 2017 May 15;246:88-98. doi: 10.1016/j.ygcen.2015.10.013. Epub 2015 Oct 20. Gen Comp Endocrinol. 2017. PMID: 26497253

Some animals can undergo a remarkable transition from active normal life to a dormant state called aestivation; entry into this hypometabolic state ensures that life continues even during long periods of environmental hardship. ...In conclusion, we provide the first detail …

Some animals can undergo a remarkable transition from active normal life to a dormant state called aestivation; entry into this hypom …

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Comparative phosphoproteomic analysis of intestinal phosphorylated proteins in active versus aestivating sea cucumbers.

Chen M, Zhu A, Storey KB. Chen M, et al. Among authors: storey kb. J Proteomics. 2016 Mar 1;135:141-150. doi: 10.1016/j.jprot.2015.09.016. Epub 2015 Sep 16. J Proteomics. 2016. PMID: 26385000

The sea cucumber Apostichopus japonicus is becoming an excellent model marine invertebrate for studies of environmentally-induced aestivation. Reversible protein phosphorylation as a regulatory mechanism in aestivation is known for some terrestrial aestivators but h …

The sea cucumber Apostichopus japonicus is becoming an excellent model marine invertebrate for studies of environmentally-induced aestiva …

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Differential peptide expression in the central nervous system of the land snail Theba pisana, between active and aestivated.

Adamson KJ, Wang T, Rotgans BA, Kuballa AV, Storey KB, Cummins SF. Adamson KJ, et al. Among authors: storey kb. Peptides. 2016 Jun;80:61-71. doi: 10.1016/j.peptides.2015.08.012. Epub 2015 Aug 21. Peptides. 2016. PMID: 26303007

In this study, we use the land snail Theba pisana to identify peptides that may be involved in the hypometabolic state known as aestivation. We found a total of 22 neuropeptides in the central nervous system (CNS) that were differentially produced during activity and ae …

In this study, we use the land snail Theba pisana to identify peptides that may be involved in the hypometabolic state known as aestivati …

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Regulation of hypometabolism: insights into epigenetic controls.

Storey KB. Storey KB. J Exp Biol. 2015 Jan 1;218(Pt 1):150-9. doi: 10.1242/jeb.106369. J Exp Biol. 2015. PMID: 25568462 Review.

Strong depression of metabolic rate, often to only 1-20% of normal resting rate, is a core survival strategy of multiple forms of hypometabolism across the animal kingdom, including hibernation, anaerobiosis, aestivation and freeze tolerance. Global biochemical controls ar …

Strong depression of metabolic rate, often to only 1-20% of normal resting rate, is a core survival strategy of multiple forms of hypometabo …

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DNA methylation levels analysis in four tissues of sea cucumber Apostichopus japonicus based on fluorescence-labeled methylation-sensitive amplified polymorphism (F-MSAP) during aestivation.

Zhao Y, Chen M, Storey KB, Sun L, Yang H. Zhao Y, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2015 Mar;181:26-32. doi: 10.1016/j.cbpb.2014.11.001. Epub 2014 Nov 16. Comp Biochem Physiol B Biochem Mol Biol. 2015. PMID: 25461675

The incidence of DNA methylation was different across tissue types in the non-aestivation stage: intestine (30.16%), respiratory tree (27.61%), muscle (27.94%) and body wall (56.25%). Our results show that hypermethylation accompanied deep-aestivation in A. japonicu …

The incidence of DNA methylation was different across tissue types in the non-aestivation stage: intestine (30.16%), respiratory tree …

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Differential gene expression in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation.

Zhao Y, Yang H, Storey KB, Chen M. Zhao Y, et al. Among authors: storey kb. Mar Genomics. 2014 Dec;18 Pt B:173-83. doi: 10.1016/j.margen.2014.07.001. Epub 2014 Jul 16. Mar Genomics. 2014. PMID: 25038515

Sea cucumbers, Apostichopus japonicus, experience seasonally high water temperatures during the summer months and enter aestivation to survive. Aestivation is characterized by strong metabolic rate depression which is supported by a series of strategies including re …

Sea cucumbers, Apostichopus japonicus, experience seasonally high water temperatures during the summer months and enter aestivation t …

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RNA-seq dependent transcriptional analysis unveils gene expression profile in the intestine of sea cucumber Apostichopus japonicus during aestivation.

Zhao Y, Yang H, Storey KB, Chen M. Zhao Y, et al. Among authors: storey kb. Comp Biochem Physiol Part D Genomics Proteomics. 2014 Jun;10:30-43. doi: 10.1016/j.cbd.2014.02.002. Epub 2014 Mar 27. Comp Biochem Physiol Part D Genomics Proteomics. 2014. PMID: 24713300

In the present study, we constructed a global gene expression profile of the intestine tissue of A. japonicus using RNA-seq to identify transcriptional responses associated with transitions between different states: non-aestivation (NA), deep-aestivation (DA), and a …

In the present study, we constructed a global gene expression profile of the intestine tissue of A. japonicus using RNA-seq to identify tran …

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Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis.

Katzenback BA, Dawson NJ, Storey KB. Katzenback BA, et al. Among authors: storey kb. J Comp Physiol B. 2014 Jul;184(5):601-11. doi: 10.1007/s00360-014-0824-1. Epub 2014 Mar 21. J Comp Physiol B. 2014. PMID: 24651940

The African clawed frog, Xenopus laevis, is able to withstand extremely arid conditions by estivating, in conjunction with dehydration tolerance and urea accumulation. Estivating X. laevis reduce their metabolic rate and recruit anaerobic glycolysis, driven by lacta …

The African clawed frog, Xenopus laevis, is able to withstand extremely arid conditions by estivating, in conjunction with dehydratio …

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Large-scale identification and comparative analysis of miRNA expression profile in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation.

Chen M, Storey KB. Chen M, et al. Among authors: storey kb. Mar Genomics. 2014 Feb;13:39-44. doi: 10.1016/j.margen.2014.01.002. Epub 2014 Jan 17. Mar Genomics. 2014. PMID: 24444870

We identified 279 sea cucumber miRNAs, including 15 novel miRNAs specific to sea cucumber. Animals sampled during deep aestivation (DA; after at least 15 days of continuous torpor) were compared with animals from a non-aestivation (NA) state (animals that had passed …

We identified 279 sea cucumber miRNAs, including 15 novel miRNAs specific to sea cucumber. Animals sampled during deep aestivation (D …

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High-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation.

Chen M, Zhang X, Liu J, Storey KB. Chen M, et al. Among authors: storey kb. PLoS One. 2013 Oct 15;8(10):e76120. doi: 10.1371/journal.pone.0076120. eCollection 2013. PLoS One. 2013. PMID: 24143179 Free PMC article.

We identified 308 sea cucumber miRNAs, including 18 novel miRNAs specific to sea cucumber. Animals sampled during deep aestivation (DA) after at least 15 days of continuous torpor, were compared with animals from a non-aestivation (NA) state (animals that had passed …

We identified 308 sea cucumber miRNAs, including 18 novel miRNAs specific to sea cucumber. Animals sampled during deep aestivation (D …

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Dehydration mediated microRNA response in the African clawed frog Xenopus laevis.

Wu CW, Biggar KK, Storey KB. Wu CW, et al. Among authors: storey kb. Gene. 2013 Oct 25;529(2):269-75. doi: 10.1016/j.gene.2013.07.064. Epub 2013 Aug 17. Gene. 2013. PMID: 23958654

The African clawed frog, Xenopus laevis, is periodically subjected to arid summers in South Africa, and utilizes entry into the hypometabolic state of estivation as a mechanism of long term survival. During estivation, frogs must typically deal with substantial dehy …

The African clawed frog, Xenopus laevis, is periodically subjected to arid summers in South Africa, and utilizes entry into the hypometaboli …

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Insights into the in vivo regulation of glutamate dehydrogenase from the foot muscle of an estivating land snail.

Bell RA, Dawson NJ, Storey KB. Bell RA, et al. Among authors: storey kb. Enzyme Res. 2012;2012:317314. doi: 10.1155/2012/317314. Epub 2012 Mar 26. Enzyme Res. 2012. PMID: 22536484 Free PMC article.

Analysis of purified foot muscle GDH from control and estivating conditions revealed that estivated GDH was approximately 3-fold more active in catalyzing glutamate deamination as compared to control. ...The increased activity of the high-phosphate form of GDH seen …

Analysis of purified foot muscle GDH from control and estivating conditions revealed that estivated GDH was approximately 3-fo …

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Aestivation: signaling and hypometabolism.

Storey KB, Storey JM. Storey KB, et al. J Exp Biol. 2012 May 1;215(Pt 9):1425-33. doi: 10.1242/jeb.054403. J Exp Biol. 2012. PMID: 22496277 Free article.

Aestivation is a survival strategy used by many vertebrates and invertebrates to endure arid environmental conditions. ...Cell signaling is crucial to achieving both a hypometabolic state and reorganizing multiple metabolic pathways to optimize long-term viability during …

Aestivation is a survival strategy used by many vertebrates and invertebrates to endure arid environmental conditions. ...Cell signal …

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The emerging roles of microRNAs in the molecular responses of metabolic rate depression.

Biggar KK, Storey KB. Biggar KK, et al. Among authors: storey kb. J Mol Cell Biol. 2011 Jun;3(3):167-75. doi: 10.1093/jmcb/mjq045. Epub 2010 Dec 21. J Mol Cell Biol. 2011. PMID: 21177365 Free article. Review.

Metabolic rate depression is an important survival strategy for many animal species and a common element of hibernation, torpor, estivation, anoxia and diapause. Studies of the molecular mechanisms that regulate reversible transitions to and from hypometabolic states have …

Metabolic rate depression is an important survival strategy for many animal species and a common element of hibernation, torpor, estivati …

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Metabolic regulation and gene expression during aestivation.

Storey KB, Storey JM. Storey KB, et al. Prog Mol Subcell Biol. 2010;49:25-45. doi: 10.1007/978-3-642-02421-4_2. Prog Mol Subcell Biol. 2010. PMID: 20069403 Review.

The biochemical regulation of aestivation, a state of aerobic hypometabolism, achieves actions including strong overall suppression of metabolic rate, reprioritization of energy use by diverse cell functions, and enhancement of defenses such as protein chaperones and antio …

The biochemical regulation of aestivation, a state of aerobic hypometabolism, achieves actions including strong overall suppression o …

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Regulation of type-1 protein phosphatase in a model of metabolic arrest.

Ramnanan CJ, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. BMB Rep. 2009 Dec 31;42(12):817-22. doi: 10.5483/bmbrep.2009.42.12.817. BMB Rep. 2009. PMID: 20044954 Free article.

Type-1 phosphatase (PP-1) was assessed in foot muscle (FM) and hepatopancreas (HP) of estivating (EST) Otala lactea. Snail PP-1 displayed several conserved traits, including sensitivity to inhibitors, substrate affinity, and reduction in size to a 39 kDa catalytic subunit …

Type-1 phosphatase (PP-1) was assessed in foot muscle (FM) and hepatopancreas (HP) of estivating (EST) Otala lactea. Snail PP-1 displ …

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The regulation of AMPK signaling in a natural state of profound metabolic rate depression.

Ramnanan CJ, McMullen DC, Groom AG, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. Mol Cell Biochem. 2010 Feb;335(1-2):91-105. doi: 10.1007/s11010-009-0246-7. Epub 2009 Sep 15. Mol Cell Biochem. 2010. PMID: 19756961

We determined that AMPK is activated in a model system (desert snail Otala lactea) during a physiological state of profound metabolic rate depression (estivation) in the absence of a rise in AMP. Kinetic characterization indicated a strong increase in AMPK activity and pho …

We determined that AMPK is activated in a model system (desert snail Otala lactea) during a physiological state of profound metabolic rate d …

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Regulation of global protein translation and protein degradation in aerobic dormancy.

Ramnanan CJ, Allan ME, Groom AG, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. Mol Cell Biochem. 2009 Mar;323(1-2):9-20. doi: 10.1007/s11010-008-9959-2. Epub 2008 Nov 16. Mol Cell Biochem. 2009. PMID: 19011953

Reductions in levels of markers of ribosomal biogenesis and a tissue-specific reduction in the phosphorylation state of eIF4E and eIF4GI were also evident after 14 days of estivation. Activity of the 20S proteasome decreased by 60-80% after 2 days of estivation and …

Reductions in levels of markers of ribosomal biogenesis and a tissue-specific reduction in the phosphorylation state of eIF4E and eIF4GI wer …

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The regulation of thapsigargin-sensitive sarcoendoplasmic reticulum Ca(2+)-ATPase activity in estivation.

Ramnanan CJ, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. J Comp Physiol B. 2008 Jan;178(1):33-45. doi: 10.1007/s00360-007-0197-9. Epub 2007 Aug 10. J Comp Physiol B. 2008. PMID: 17690892

Estivation (aerobic dormancy) is characterized by sustained metabolic rate depression, which is crucial to survival in the face of unfavorable environmental conditions and enables the preservation of endogenous fuel reserves. ...Western blotting confirmed that SERCA protei …

Estivation (aerobic dormancy) is characterized by sustained metabolic rate depression, which is crucial to survival in the face of un …

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Akt and its downstream targets play key roles in mediating dormancy in land snails.

Ramnanan CJ, Groom AG, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2007 Nov;148(3):245-55. doi: 10.1016/j.cbpb.2007.06.002. Epub 2007 Jun 12. Comp Biochem Physiol B Biochem Mol Biol. 2007. PMID: 17611133

The Akt (protein kinase B) signaling pathway regulates diverse responses in cells and the present study analyzes its role in the estivating desert snail Otala lactea. Kinetic analysis (maximal velocity, substrate affinities) determined that Akt was activated in tissues of …

The Akt (protein kinase B) signaling pathway regulates diverse responses in cells and the present study analyzes its role in the estivati …

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Suppression of Na+/K+-ATPase activity during estivation in the land snail Otala lactea.

Ramnanan CJ, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. J Exp Biol. 2006 Feb;209(Pt 4):677-88. doi: 10.1242/jeb.02052. J Exp Biol. 2006. PMID: 16449562

As one of the largest consumers of cellular ATP, the plasma membrane Na+/K+-ATPase is a potentially key target for regulation during estivation. Na+/K+-ATPase was investigated in foot muscle and hepatopancreas of the land snail Otala lactea, comparing active and estivat …

As one of the largest consumers of cellular ATP, the plasma membrane Na+/K+-ATPase is a potentially key target for regulation during esti …

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Glucose-6-phosphate dehydrogenase regulation during hypometabolism.

Ramnanan CJ, Storey KB. Ramnanan CJ, et al. Among authors: storey kb. Biochem Biophys Res Commun. 2006 Jan 6;339(1):7-16. doi: 10.1016/j.bbrc.2005.10.036. Epub 2005 Oct 18. Biochem Biophys Res Commun. 2006. PMID: 16256936

Compared with active snails, G6PDH Vmax increased by 50%, Km for glucose-6-phosphate decreased by 50%, Ka Mg x citrate decreased by 35%, and activation energy (from Arrhenius plots) decreased by 35% during estivation. DEAE-Sephadex chromatography separated two peaks of act …

Compared with active snails, G6PDH Vmax increased by 50%, Km for glucose-6-phosphate decreased by 50%, Ka Mg x citrate decreased by 35%, and …

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Adventures in oxygen metabolism.

Storey KB. Storey KB. Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov;139(3):359-69. doi: 10.1016/j.cbpc.2004.02.018. Comp Biochem Physiol B Biochem Mol Biol. 2004. PMID: 15544961 Review.

Lessons drawn from my training in Peter's laboratory have led me on continuing explorations of adaptations in enzyme function, signal transduction, gene expression, and antioxidant defenses ranging over systems of anoxia tolerance, freezing survival, estivation, and mammal …

Lessons drawn from my training in Peter's laboratory have led me on continuing explorations of adaptations in enzyme function, signal transd …

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Metabolic rate depression in animals: transcriptional and translational controls.

Storey KB, Storey JM. Storey KB, et al. Biol Rev Camb Philos Soc. 2004 Feb;79(1):207-33. doi: 10.1017/s1464793103006195. Biol Rev Camb Philos Soc. 2004. PMID: 15005178 Review.

Metabolic rate depression is an important survival strategy for many animal species and a common element of hibernation, torpor, aestivation, anaerobiosis, diapause, and anhydrobiosis. Studies of the biochemical mechanisms that regulate reversible transitions to and from h …

Metabolic rate depression is an important survival strategy for many animal species and a common element of hibernation, torpor, aestivat …

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Urea and KCl have differential effects on enzyme activities in liver and muscle of estivating versus nonestivating species.

Cowan KJ, Storey KB. Cowan KJ, et al. Among authors: storey kb. Biochem Cell Biol. 2002;80(6):745-55. doi: 10.1139/o02-144. Biochem Cell Biol. 2002. PMID: 12555807

The effects of 300 mM urea or 300 mM KCl on the maximal activities of 25 enzymes of intermediary metabolism were assessed in extracts of liver and muscle from spadefoot toads (Scaphiopus couchii), leopard frogs (Rana pipiens), and rats to assess their sensitivity to these osmolyt …

The effects of 300 mM urea or 300 mM KCl on the maximal activities of 25 enzymes of intermediary metabolism were assessed in extracts of liv …

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Life in the slow lane: molecular mechanisms of estivation.

Storey KB. Storey KB. Comp Biochem Physiol A Mol Integr Physiol. 2002 Nov;133(3):733-54. doi: 10.1016/s1095-6433(02)00206-4. Comp Biochem Physiol A Mol Integr Physiol. 2002. PMID: 12443930 Review.

Estivation is a state of aerobic hypometabolism used by organisms to endure seasonally arid conditions, often in desert environments. Estivating species are often active for only a few weeks each year to feed and breed and then retreat to estivate in sheltere …

Estivation is a state of aerobic hypometabolism used by organisms to endure seasonally arid conditions, often in desert environments. …

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Tyrosine kinases and phosphatases in the estivating spadefoot toad.

Cowan KJ, Storey KB. Cowan KJ, et al. Among authors: storey kb. Cell Physiol Biochem. 2001;11(3):161-72. doi: 10.1159/000047803. Cell Physiol Biochem. 2001. PMID: 11410711

To endure seasonally arid conditions, spadefoot toads (Scaphiopus couchii) spend 9-10 months underground each year in a hypometabolic state, termed estivation. Protein tyrosine kinases (PTKs) and phosphatases (PTPs) were evaluated in organs of control and estivating …

To endure seasonally arid conditions, spadefoot toads (Scaphiopus couchii) spend 9-10 months underground each year in a hypometabolic state, …

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The muscle fatty acid binding protein of spadefoot toad (Scaphiopus couchii).

Stewart JM, Claude JF, MacDonald JA, Storey KB. Stewart JM, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2000 Mar;125(3):347-57. doi: 10.1016/s0305-0491(99)00188-1. Comp Biochem Physiol B Biochem Mol Biol. 2000. PMID: 10818268

Fatty acid binding protein was purified from skeletal muscle of the spadefoot toad (Scaphiopus couchii), an estivating species. While estivating, this animal relies on the fatty acid oxidation for energy. Hence we were interested in the behaviour of fatty acid bindi …

Fatty acid binding protein was purified from skeletal muscle of the spadefoot toad (Scaphiopus couchii), an estivating species. While …

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Gene expression during estivation in spadefoot toads, Scaphiopus couchii: upregulation of riboflavin binding protein in liver.

Storey KB, Dent ME, Storey JM. Storey KB, et al. J Exp Zool. 1999 Aug 1;284(3):325-33. J Exp Zool. 1999. PMID: 10404124

A cDNA library constructed from liver of 2-month estivating female spadefoot toads, Scaphiopus couchii, was differentially screened to reveal genes that were induced or upregulated during estivation. ...Northern hybridization showed that toad RfBP was largely liver- …

A cDNA library constructed from liver of 2-month estivating female spadefoot toads, Scaphiopus couchii, was differentially screened t …

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Reversible phosphorylation control of skeletal muscle pyruvate kinase and phosphofructokinase during estivation in the spadefoot toad, Scaphiopus couchii.

Cowan KJ, Storey KB. Cowan KJ, et al. Among authors: storey kb. Mol Cell Biochem. 1999 May;195(1-2):173-81. doi: 10.1023/a:1006932221288. Mol Cell Biochem. 1999. PMID: 10395081

These kinetic properties suggest that Peak II PK is the less active form, and coupled with the shift to predominantly the Peak II form during estivation (87% Peak II vs. 13% Peak I), are consistent with a suppression of PK activity in estivating muscle, as part of t …

These kinetic properties suggest that Peak II PK is the less active form, and coupled with the shift to predominantly the Peak II form durin …

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Antioxidant defenses and metabolic depression. The hypothesis of preparation for oxidative stress in land snails.

Hermes-Lima M, Storey JM, Storey KB. Hermes-Lima M, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 1998 Jul;120(3):437-48. doi: 10.1016/s0305-0491(98)10053-6. Comp Biochem Physiol B Biochem Mol Biol. 1998. PMID: 9787804 Review.

The roles of enzymatic antioxidant defenses in the natural tolerance of environmental stresses that impose changes in oxygen availability and oxygen consumption on animals is discussed with a particular focus on the biochemistry of estivation and metabolic depression in pu …

The roles of enzymatic antioxidant defenses in the natural tolerance of environmental stresses that impose changes in oxygen availability an …

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Antioxidant defenses and lipid peroxidation damage in estivating toads, Scaphiopus couchii.

Grundy JE, Storey KB. Grundy JE, et al. Among authors: storey kb. J Comp Physiol B. 1998 Mar;168(2):132-42. doi: 10.1007/s003600050129. J Comp Physiol B. 1998. PMID: 9542148

Tissue-specific changes in antioxidant defenses and lipid peroxidation damage were analyzed in spadefoot toads, Scaphiopus couchii, to determine how these responded during estivation, a state of suppressed oxygen consumption. Maximal activities of glutathione-S-transferase …

Tissue-specific changes in antioxidant defenses and lipid peroxidation damage were analyzed in spadefoot toads, Scaphiopus couchii, to deter …

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Glycolytic controls in estivation and anoxia: a comparison of metabolic arrest in land and marine molluscs.

Brooks SP, Storey KB. Brooks SP, et al. Among authors: storey kb. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1103-14. doi: 10.1016/s0300-9629(97)00237-5. Comp Biochem Physiol A Physiol. 1997. PMID: 9505420 Review.

The large reductions in metabolic rate during estivation and anoxia can translate into considerable energy savings when dormant animals are compared to active animals. ...

The large reductions in metabolic rate during estivation and anoxia can translate into considerable energy savings when dormant anima …

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Oxidative stress: animal adaptations in nature.

Storey KB. Storey KB. Braz J Med Biol Res. 1996 Dec;29(12):1715-33. Braz J Med Biol Res. 1996. PMID: 9222437 Review.

In recent studies using various animal models (anoxia-tolerant turtles, freeze-tolerant snakes and frogs, estivating snails) our laboratory has explored the adaptations of antioxidant defenses that allow such organisms to deal with rapid changes in tissue oxygenation with …

In recent studies using various animal models (anoxia-tolerant turtles, freeze-tolerant snakes and frogs, estivating snails) our labo …

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Protein kinase involvement in land snail aestivation and anoxia: protein kinase A kinetic properties and changes in second messenger compounds during depressed metabolism.

Brooks SP, Storey KB. Brooks SP, et al. Among authors: storey kb. Mol Cell Biochem. 1996 Mar 23;156(2):153-61. doi: 10.1007/BF00426338. Mol Cell Biochem. 1996. PMID: 9095472

Changes in the concentration of protein kinase second messenger compounds were followed over the first 24 h of aestivation and anoxia exposure in the terrestrial snail Otala lactea (Muller) (Pulmonata, Helicidae). ...A transient increase in foot muscle cyclic GMP concentra …

Changes in the concentration of protein kinase second messenger compounds were followed over the first 24 h of aestivation and anoxia …

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Metabolic adaptations supporting anoxia tolerance in reptiles: recent advances.

Storey KB. Storey KB. Comp Biochem Physiol B Biochem Mol Biol. 1996 Jan;113(1):23-35. doi: 10.1016/0305-0491(95)02043-8. Comp Biochem Physiol B Biochem Mol Biol. 1996. PMID: 8936040 Review.

The biochemical regulation of metabolic arrest is proving to have common molecular principles that extend across phylogenetic lines and that are conserved in different types of arrested states (not only anaerobiosis but also estivation, hibernation, etc.). Our new studies …

The biochemical regulation of metabolic arrest is proving to have common molecular principles that extend across phylogenetic lines and that …

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Xanthine oxidase and xanthine dehydrogenase from an estivating land snail.

Hermes-Lima M, Storey KB. Hermes-Lima M, et al. Among authors: storey kb. Z Naturforsch C J Biosci. 1995 Sep-Oct;50(9-10):685-94. doi: 10.1515/znc-1995-9-1015. Z Naturforsch C J Biosci. 1995. PMID: 8579686

During arousal from estivation in land snails, Otala lactea, active metabolic functions are restored within minutes and oxygen consumption increases dramatically. ...Both XO and XO+XDH activites were significantly higher in snails after 35 days of estivation compare …

During arousal from estivation in land snails, Otala lactea, active metabolic functions are restored within minutes and oxygen consum …

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Antioxidant defenses and metabolic depression in a pulmonate land snail.

Hermes-Lima M, Storey KB. Hermes-Lima M, et al. Among authors: storey kb. Am J Physiol. 1995 Jun;268(6 Pt 2):R1386-93. doi: 10.1152/ajpregu.1995.268.6.R1386. Am J Physiol. 1995. PMID: 7611513

During arousal from estivation oxygen consumption by land snails (Otala lactea) increases severalfold. To determine whether snails prepared for an accompanying rise in the rates of oxyradical generation by altering their antioxidant defense mechanisms, changes in the activ …

During arousal from estivation oxygen consumption by land snails (Otala lactea) increases severalfold. To determine whether snails pr …

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Protein phosphorylation patterns during aestivation in the land snail Otala lactea.

Brooks SP, Storey KB. Brooks SP, et al. Among authors: storey kb. Mol Cell Biochem. 1995 Feb 9;143(1):7-13. doi: 10.1007/BF00925921. Mol Cell Biochem. 1995. PMID: 7776961

SDS-PAGE analysis of cytosolic proteins showed an aestivation-related decrease in relative protein phosphorylation between 30-35 kDa and 40-45 kDa. A relative increase in phosphorylation during aestivation was observed for proteins between 16-22 kDa.(ABSTRACT TRUNCA …

SDS-PAGE analysis of cytosolic proteins showed an aestivation-related decrease in relative protein phosphorylation between 30-35 kDa …

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Evidence for aestivation specific proteins in Otala lactea.

Brooks SP, Storey KB. Brooks SP, et al. Among authors: storey kb. Mol Cell Biochem. 1995 Feb 9;143(1):15-20. doi: 10.1007/BF00925922. Mol Cell Biochem. 1995. PMID: 7776954

Snails in four different physiological states were compared: active controls, short term aestivating snails (injected and allowed to enter aestivation), long term aestivating snails (aestivated for 14 days, injected, and maintained in the aestivating state), and snails aro …

Snails in four different physiological states were compared: active controls, short term aestivating snails (injected and allowed to enter …

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Metabolic depression in land snails: in vitro analysis of protein kinase involvement in pyruvate kinase control in isolated Otala lactea tissues.

Brooks SP, Storey KB. Brooks SP, et al. Among authors: storey kb. J Exp Zool. 1994 Sep 1;269(6):507-14. doi: 10.1002/jez.1402690603. J Exp Zool. 1994. PMID: 7931123

Hepatopancreas and foot muscle were removed from active and estivating land snails and incubated in vitro under aerobic and anoxic conditions. Pyruvate kinase (PK), cAMP-dependent protein kinase (PKA), and protein kinase second messenger compounds (cyclic AMP and inositol …

Hepatopancreas and foot muscle were removed from active and estivating land snails and incubated in vitro under aerobic and anoxic co …

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Urea and salt effects on enzymes from estivating and non-estivating amphibians.

Grundy JE, Storey KB. Grundy JE, et al. Among authors: storey kb. Mol Cell Biochem. 1994 Feb 9;131(1):9-17. doi: 10.1007/BF01075719. Mol Cell Biochem. 1994. PMID: 8047069

The effects of urea, cations (K+,NH4,Na+,Cs+,Li+), and trimethylamines on the maximal activities and kinetic properties of pyruvate kinase (PK) and phosphofructokinase (PFK) from skeletal muscle were analyzed in two anuran amphibians, an estivating species, the spadefoot t …

The effects of urea, cations (K+,NH4,Na+,Cs+,Li+), and trimethylamines on the maximal activities and kinetic properties of pyruvate kinase ( …

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Metabolic rate depression and biochemical adaptation in anaerobiosis, hibernation and estivation.

Storey KB, Storey JM. Storey KB, et al. Q Rev Biol. 1990 Jun;65(2):145-74. doi: 10.1086/416717. Q Rev Biol. 1990. PMID: 2201054 Review.

Facultative metabolic rate depression is the common adaptive strategy of anaerobiosis, hibernation, and estivation, as well as a number of other arrested states. By reducing metabolic rate by a factor ranging from 5 to 100 fold or more, animals gain a comparable extension …

Facultative metabolic rate depression is the common adaptive strategy of anaerobiosis, hibernation, and estivation, as well as a numb …

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