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Reversible Histone Modifications Contribute to the Frozen and Thawed Recovery States of Wood Frog Brains.
Bloskie T, Taiwo OO, Storey KB. Bloskie T, et al. Among authors: storey kb. Biomolecules. 2024 Jul 12;14(7):839. doi: 10.3390/biom14070839. Biomolecules. 2024. PMID: 39062553 Free PMC article.
Two other permissive modifications (H3R8me2a, H3K9ac) also trended downwards following freezing stress. Together, these data are strongly supportive of the proposed global transcriptional states of hypometabolic freeze tolerance and rebounded thawed recovery. Our findings …
Two other permissive modifications (H3R8me2a, H3K9ac) also trended downwards following freezing stress. Together, these data are stro …
Small RNA and Freeze Survival: The Cryoprotective Functions of MicroRNA in the Frozen Muscle Tissue of the Grey Tree Frog.
Rehman S, Storey KB. Rehman S, et al. Among authors: storey kb. Metabolites. 2024 Jul 17;14(7):387. doi: 10.3390/metabo14070387. Metabolites. 2024. PMID: 39057710 Free PMC article.
The grey tree frog, Dryophytes versicolor, survives whole-body freezing for weeks during cold winter months. Survival in a state devoid of available food, water, or oxygen forces a reliance on metabolic rate depression (MRD) and the reprioritization of bodily functions. Th …
The grey tree frog, Dryophytes versicolor, survives whole-body freezing for weeks during cold winter months. Survival in a state devo …
DNA hypomethylation in wood frog liver under anoxia and dehydration stresses.
Kupakuwana P, Singh G, Storey KB. Kupakuwana P, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2024 Oct-Dec;274:111005. doi: 10.1016/j.cbpb.2024.111005. Epub 2024 Jul 3. Comp Biochem Physiol B Biochem Mol Biol. 2024. PMID: 38969165 Free article.
Wood frogs are freeze-tolerant vertebrates that can endure weeks to months frozen during the winter without breathing and with as much as 65% of total body water frozen as extracellular ice. Underlying tolerances of anoxia and of cellular dehydration support whole b …
Wood frogs are freeze-tolerant vertebrates that can endure weeks to months frozen during the winter without breathing and with as muc …
Proteomic analysis of Rana sylvatica reveals differentially expressed proteins in liver in response to anoxia, dehydration or freezing stress.
Li Y, Minic Z, Hüttmann N, Khraibah A, Storey KB, Berezovski MV. Li Y, et al. Among authors: storey kb. Sci Rep. 2024 Jul 4;14(1):15388. doi: 10.1038/s41598-024-65417-2. Sci Rep. 2024. PMID: 38965296 Free PMC article.
They can slow their metabolic activity to a near halt and endure freezing of 65-70% of their total body water as extracellular ice during hibernation, returning to normal when the temperatures rise again. To investigate the molecular adaptations of freeze-tolerant wood fro …
They can slow their metabolic activity to a near halt and endure freezing of 65-70% of their total body water as extracellular ice du …
Dynamics of epigenetic regulation in Dryophytes versicolor skeletal muscle: Lysine methylation and acetylation involvement in metabolic rate depression.
Rehman S, Storey KB. Rehman S, et al. Among authors: storey kb. J Therm Biol. 2024 May;122:103865. doi: 10.1016/j.jtherbio.2024.103865. Epub 2024 May 9. J Therm Biol. 2024. PMID: 38761482
For the breadth of the winter, Dryophytes versicolor can survive full body freezing utilizing a phenomenon known as metabolic rate depression (MRD). Epigenetic transcriptional control on gene expression, such as histone methylation and acetylation, can aid in implementing …
For the breadth of the winter, Dryophytes versicolor can survive full body freezing utilizing a phenomenon known as metabolic rate de …
Hepatic transcriptome and gut microbiome provide insights into freeze tolerance in the high-altitude frog, Nanorana parkeri.
Niu Y, Li X, Zhang H, Xu T, Wei D, An Z, Storey KB. Niu Y, et al. Among authors: storey kb. Comp Biochem Physiol Part D Genomics Proteomics. 2023 Dec;48:101147. doi: 10.1016/j.cbd.2023.101147. Epub 2023 Oct 1. Comp Biochem Physiol Part D Genomics Proteomics. 2023. PMID: 37797475
In the present study, we addressed two goals: (1) analysis of the effects of whole body freezing on the liver transcriptome, and (2) assess modifications of the gut microbiome as a consequence of freezing. ...Moreover, freezing had a significant effect on int …
In the present study, we addressed two goals: (1) analysis of the effects of whole body freezing on the liver transcriptome, and (2) …
Hepatic citrate synthase suppression in the freeze-tolerant wood frog (Rana sylvatica).
Varma A, Storey KB. Varma A, et al. Among authors: storey kb. Int J Biol Macromol. 2023 Jul 1;242(Pt 1):124718. doi: 10.1016/j.ijbiomac.2023.124718. Epub 2023 May 5. Int J Biol Macromol. 2023. PMID: 37148930
Present study investigated the regulation of CS from wood frog liver during freezing. CS was purified to homogeneity by a two-step chromatographic process. Kinetic and regulatory parameters of the enzyme were investigated and, notably, demonstrated a significant decrease i …
Present study investigated the regulation of CS from wood frog liver during freezing. CS was purified to homogeneity by a two-step ch …
Role of NADP+-dependent isocitrate dehydrogenase from muscle tissue of Rana sylvatica in ROS defense during freeze-tolerance.
Mattice AMS, Varma A, Storey KB. Mattice AMS, et al. Among authors: storey kb. Biochimie. 2023 Jul;210:14-21. doi: 10.1016/j.biochi.2023.03.008. Epub 2023 Mar 21. Biochimie. 2023. PMID: 36958591
Immunoblotting showed reduced serine and threonine phosphorylation of muscle IDH from frozen frogs and decreased serine phosphorylation on IDH from dehydrated frogs relative to control and anoxic states, demonstrating a reversible phosphorylation regulatory mechanism for I …
Immunoblotting showed reduced serine and threonine phosphorylation of muscle IDH from frozen frogs and decreased serine phosphorylati …
MicroRNA transcriptomics in liver of the freeze-tolerant gray tree frog (Dryophytes versicolor) indicates suppression of energy-expensive pathways.
Ingelson-Filpula WA, Hadj-Moussa H, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. Cell Biochem Funct. 2023 Apr;41(3):309-320. doi: 10.1002/cbf.3783. Epub 2023 Feb 23. Cell Biochem Funct. 2023. PMID: 36823992
We identified 11 miRNAs differentially regulated during freezing (miR-140-3p, miR-181a-5p, miR-206-3p, miR-451a, miR-19a-3p, miR-101-3p, miR-30e-5p, miR-142-3p and -5p, miR-21-5p, and miR-34a-5p). ...
We identified 11 miRNAs differentially regulated during freezing (miR-140-3p, miR-181a-5p, miR-206-3p, miR-451a, miR-19a-3p, miR-101- …
mRNA m(6) A methylation in wood frog brain is maintained during freezing and anoxia.
Wade S, Hadj-Moussa H, Storey KB. Wade S, et al. Among authors: storey kb. J Exp Zool A Ecol Integr Physiol. 2023 Apr;339(3):325-334. doi: 10.1002/jez.2681. Epub 2023 Jan 26. J Exp Zool A Ecol Integr Physiol. 2023. PMID: 36703486
As such, we investigated the most abundant RNA modification, adenosine methylation (N(6) -methyladenosine; m(6) A) in wood frog brains during 24 h periods of freezing and anoxia. This was followed by an examination of levels of RNA methyltransferases, demethyltransferases, …
As such, we investigated the most abundant RNA modification, adenosine methylation (N(6) -methyladenosine; m(6) A) in wood frog brains durin …
TXNIP shuttling - a key molecular link in regulating inflammation and mitochondrial dysfunction in freeze tolerant wood frogs.
Singh G, Storey KB. Singh G, et al. Among authors: storey kb. Gene. 2023 Mar 20;857:147184. doi: 10.1016/j.gene.2023.147184. Epub 2023 Jan 7. Gene. 2023. PMID: 36627089
Interestingly, the high glucose levels induced in response to freezing can amplify oxidative stress's effects (reactive oxygen species, ROS) and induce inflammation and mitochondrial dysfunction. Since both freezing and dehydration stress (independent of freezing …
Interestingly, the high glucose levels induced in response to freezing can amplify oxidative stress's effects (reactive oxygen specie …
Freeze-induced suppression of pyruvate kinase in liver of the wood frog (Rana sylvatica).
Varma A, Storey KB. Varma A, et al. Among authors: storey kb. Adv Biol Regul. 2023 May;88:100944. doi: 10.1016/j.jbior.2022.100944. Epub 2022 Dec 17. Adv Biol Regul. 2023. PMID: 36542984
Furthermore, a test of thermal stability showed that PK from liver of frozen wood frogs showed greater stability as compared with PK from control animals. Taken together, these results suggest that PK is negatively regulated, and glycolysis is suppressed, during freezin …
Furthermore, a test of thermal stability showed that PK from liver of frozen wood frogs showed greater stability as compared with PK …
Role of FOXO transcription factors in the tolerance of whole-body freezing in the wood frog, Rana sylvatica.
Rehman S, Hadj-Moussa H, Hawkins L, Storey KB. Rehman S, et al. Among authors: storey kb. Cryobiology. 2023 Mar;110:44-48. doi: 10.1016/j.cryobiol.2022.12.018. Epub 2022 Dec 17. Cryobiology. 2023. PMID: 36539050
The wood frog (Rana Sylvatica) can endure the sub-zero temperatures of winter by freezing up to 65% of total body water as extracellular ice and retreating into a prolonged hypometabolic state. ...Immunoblotting was used to assess total and phosphorylated amounts of FOXO p …
The wood frog (Rana Sylvatica) can endure the sub-zero temperatures of winter by freezing up to 65% of total body water as extracellu …
The regulation of m(6)A-related proteins during whole-body freezing of the freeze-tolerant wood frog.
Rehman S, Varma A, Gupta A, Storey KB. Rehman S, et al. Among authors: storey kb. Biochem Cell Biol. 2023 Feb 1;101(1):77-86. doi: 10.1139/bcb-2022-0164. Epub 2022 Dec 3. Biochem Cell Biol. 2023. PMID: 36462217
In the study, regulation of m(6)A-related proteins in the liver of R. sylvatica was analyzed during 24 h frozen and 8 h thaw conditions. Decreases in the activity of demethylases of 28.44 0.4% and 24.1 0.9% of control values in frozen and thaw tissues, respectively, …
In the study, regulation of m(6)A-related proteins in the liver of R. sylvatica was analyzed during 24 h frozen and 8 h thaw conditio …
Hypoxia inducible factor-1alpha responds to freezing, anoxia and dehydration stresses in a freeze-tolerant frog.
Storey JM, Li Z, Storey KB. Storey JM, et al. Among authors: storey kb. Cryobiology. 2023 Mar;110:79-85. doi: 10.1016/j.cryobiol.2022.11.242. Epub 2022 Nov 26. Cryobiology. 2023. PMID: 36442660
Independent exposures of wood frogs to anoxia or dehydration stresses (two components of freezing) also triggered upregulation of hif-1alpha transcripts and/or HIF-1alpha protein in liver and kidney with variable responses in other tissues. The results show active modulati …
Independent exposures of wood frogs to anoxia or dehydration stresses (two components of freezing) also triggered upregulation of hif …
Commentary: On the merit of an early contributor of the "Preparation for Oxidative Stress" (POS) theory.
Moreira DC, Campos ÉG, Giraud-Billoud M, Storey KB, Hermes-Lima M. Moreira DC, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2023 Feb;276:111341. doi: 10.1016/j.cbpa.2022.111341. Epub 2022 Nov 8. Comp Biochem Physiol A Mol Integr Physiol. 2023. PMID: 36368609
Over next 25 years, the phenomenon was described in detail in more than one hundred studies of animals under conditions of aestivation, hypoxia/anoxia, freezing, severe dehydration, ultraviolet exposure, air exposure of water-breathing animals, salinity stress, and others. …
Over next 25 years, the phenomenon was described in detail in more than one hundred studies of animals under conditions of aestivation, hypo …
Role of unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs.
Niles J, Singh G, Storey KB. Niles J, et al. Among authors: storey kb. Cell Stress Chaperones. 2023 Jan;28(1):61-77. doi: 10.1007/s12192-022-01307-8. Epub 2022 Nov 8. Cell Stress Chaperones. 2023. PMID: 36346580 Free PMC article.
Only frozen muscle showed preference for proteasomal degradation of misfolded proteins via upregulation of EDEM (ERAD). ...Overall, we conclude that wood frog organs activate the UPR as a means of stabilizing and repairing cellular proteins to best survive freezing …
Only frozen muscle showed preference for proteasomal degradation of misfolded proteins via upregulation of EDEM (ERAD). ...Overall, w …
Sub-zero microRNA expression in the liver of the frozen hatchling painted turtle, Chrysemys picta marginata.
Varma A, Breedon SA, Storey KB. Varma A, et al. Among authors: storey kb. Sci Total Environ. 2023 Jan 20;857(Pt 1):159304. doi: 10.1016/j.scitotenv.2022.159304. Epub 2022 Oct 8. Sci Total Environ. 2023. PMID: 36220468
The Midland painted turtle (Chrysemys picta marginata) are the highest known vertebrate species to experience and survive freezing and sub-zero temperatures. Painted turtles typically hatch from their eggs in the fall and remain underground in their nests until the followi …
The Midland painted turtle (Chrysemys picta marginata) are the highest known vertebrate species to experience and survive freezing an …
Status of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in liver and skin of the freeze tolerant wood frog.
Douglas K, Logan SM, Storey KB. Douglas K, et al. Among authors: storey kb. Cryobiology. 2022 Oct;108:27-33. doi: 10.1016/j.cryobiol.2022.08.003. Epub 2022 Sep 10. Cryobiology. 2022. PMID: 36100073
The wood frog (Rana sylvatica) has adapted full-body freezing and thawing as a means of sub-zero winter survival and early-breeding in ephemeral pools. ...This study employed the use of immunoblotting to examine response of a potent cell cycle and apoptosis regulator, know …
The wood frog (Rana sylvatica) has adapted full-body freezing and thawing as a means of sub-zero winter survival and early-breeding i …
DNA Hypomethylation May Contribute to Metabolic Recovery of Frozen Wood Frog Brains.
Bloskie T, Storey KB. Bloskie T, et al. Among authors: storey kb. Epigenomes. 2022 Jul 12;6(3):17. doi: 10.3390/epigenomes6030017. Epigenomes. 2022. PMID: 35893013 Free PMC article.
The present study examines the role of DNA methylation, a core epigenetic mechanism, in the response of wood frog brains to freezing. We use immunoblot analysis to track the relative expression of DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins and …
The present study examines the role of DNA methylation, a core epigenetic mechanism, in the response of wood frog brains to freezing. …
RAGE management: ETS1- EGR1 mediated transcriptional networks regulate angiogenic factors in wood frogs.
Al-Attar R, Storey KB. Al-Attar R, et al. Among authors: storey kb. Cell Signal. 2022 Oct;98:110408. doi: 10.1016/j.cellsig.2022.110408. Epub 2022 Jul 14. Cell Signal. 2022. PMID: 35842171
Freeze-tolerant species, such as wood frogs (Rana sylvatica), are susceptible to multiple co-occurring stresses that they must overcome to survive. Freezing is accompanied by mechanical stress and dehydration due to ice crystal formation in the extracellular space, ischemi …
Freeze-tolerant species, such as wood frogs (Rana sylvatica), are susceptible to multiple co-occurring stresses that they must overcome to s …
MicroRNA biogenesis proteins follow tissue-dependent expression during freezing in Dryophytes versicolor.
Ingelson-Filpula WA, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. J Comp Physiol B. 2022 Sep;192(5):611-622. doi: 10.1007/s00360-022-01444-7. Epub 2022 Jun 24. J Comp Physiol B. 2022. PMID: 35748902
Four of these proteins (Dicer, Drosha, Trbp, Xpo5) were upregulated in liver of frozen frogs, suggesting enhanced capacity for miRNA biogenesis, whereas expression of four proteins in frozen muscle (Ago1, Ago2, Dgcr8, Xpo5) and six proteins in kidney (Ago1, Ago2, Ag …
Four of these proteins (Dicer, Drosha, Trbp, Xpo5) were upregulated in liver of frozen frogs, suggesting enhanced capacity for miRNA …
DNA damage and repair responses to freezing and anoxia stresses in wood frogs, Rana sylvatica.
Lung ZD, Storey KB. Lung ZD, et al. Among authors: storey kb. J Therm Biol. 2022 Jul;107:103274. doi: 10.1016/j.jtherbio.2022.103274. Epub 2022 May 31. J Therm Biol. 2022. PMID: 35701025
Wood frogs, Rana sylvatica, endure the freezing of 65% of total body water while overwintering in cold climates, enduring not only internal ice formation but also long-term anoxia due to cessation of heartbeat and breathing. ...Large increases in Mre11 and Ku70 expression …
Wood frogs, Rana sylvatica, endure the freezing of 65% of total body water while overwintering in cold climates, enduring not only in …
One-step purification and regulation of fructose 1,6-bisphosphatase from the liver of the freeze-tolerant wood frog, Rana sylvatica.
Varma A, Storey KB. Varma A, et al. Among authors: storey kb. Cell Biochem Funct. 2022 Jul;40(5):491-500. doi: 10.1002/cbf.3710. Epub 2022 May 23. Cell Biochem Funct. 2022. PMID: 35604283
The present study characterized the regulation of fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11) from wood frog liver during freezing, FBPase being a crucial enzyme regulating gluconeogenesis. Liver FBPase was purified to homogeneity from control and frozen wood …
The present study characterized the regulation of fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11) from wood frog liver during freezing …
Lessons from nature: Leveraging the freeze-tolerant wood frog as a model to improve organ cryopreservation and biobanking.
Al-Attar R, Storey KB. Al-Attar R, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2022 Aug-Sep;261:110747. doi: 10.1016/j.cbpb.2022.110747. Epub 2022 Apr 20. Comp Biochem Physiol B Biochem Mol Biol. 2022. PMID: 35460874 Review.
The freeze-tolerant wood frog, Rana sylvatica, is one of the very few vertebrate species known to endure full body freezing in winter and thaw in early spring without any significant sign of damage. Once frozen, wood frogs show no cardiac or lung activity, brain fun …
The freeze-tolerant wood frog, Rana sylvatica, is one of the very few vertebrate species known to endure full body freezing in winter …
A "notch" in the cellular communication network in response to anoxia by wood frog (Rana sylvatica).
Gupta A, Storey KB. Gupta A, et al. Among authors: storey kb. Cell Signal. 2022 May;93:110305. doi: 10.1016/j.cellsig.2022.110305. Epub 2022 Mar 10. Cell Signal. 2022. PMID: 35283291
Wood frogs (Rana sylvatica) experience months of whole-body freezing during winter. Anoxia is one of the side stresses along with cell dehydration and hyperglycemia. ...
Wood frogs (Rana sylvatica) experience months of whole-body freezing during winter. Anoxia is one of the side stresses along with cel …
Mitochondrial DNA methyltransferases and their regulation under freezing and dehydration stresses in the freeze-tolerant wood frog, Rana sylvatica.
Singh G, Storey KB. Singh G, et al. Among authors: storey kb. Biochem Cell Biol. 2022 Apr;100(2):171-178. doi: 10.1139/bcb-2021-0519. Epub 2022 Feb 1. Biochem Cell Biol. 2022. PMID: 35104156
We examined the mitochondrial protein levels of DNMT-1, DNMT-3A, DNMT-3B, and DNMT-3L as well as mitochondrial DNMT activity in the liver and heart to assess the involvement of DNMT in the survival of freezing and dehydration stresses (cellular dehydration being a componen …
We examined the mitochondrial protein levels of DNMT-1, DNMT-3A, DNMT-3B, and DNMT-3L as well as mitochondrial DNMT activity in the liver an …
Muscles in Winter: The Epigenetics of Metabolic Arrest.
Ingelson-Filpula WA, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. Epigenomes. 2021 Dec 16;5(4):28. doi: 10.3390/epigenomes5040028. Epigenomes. 2021. PMID: 34968252 Free PMC article. Review.
Mammalian hibernation is the best recognized example of winter MRD, but some turtle species spend the winter unable to breathe air and use MRD to survive with little or no oxygen (hypoxia/anoxia), and various frogs endure the freezing of about two-thirds of their total bod …
Mammalian hibernation is the best recognized example of winter MRD, but some turtle species spend the winter unable to breathe air and use M …
Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia.
Gupta A, Storey KB. Gupta A, et al. Among authors: storey kb. Life (Basel). 2021 Dec 17;11(12):1422. doi: 10.3390/life11121422. Life (Basel). 2021. PMID: 34947952 Free PMC article.
Wood frogs (Rana sylvatica) display well-developed anoxia tolerance as one component of their capacity to endure prolonged whole-body freezing during the winter months. Under anoxic conditions, multiple cellular responses are triggered to efficiently cope with stress by su …
Wood frogs (Rana sylvatica) display well-developed anoxia tolerance as one component of their capacity to endure prolonged whole-body fre …
MicroRNA Cues from Nature: A Roadmap to Decipher and Combat Challenges in Human Health and Disease?
Singh G, Storey KB. Singh G, et al. Among authors: storey kb. Cells. 2021 Nov 30;10(12):3374. doi: 10.3390/cells10123374. Cells. 2021. PMID: 34943882 Free PMC article. Review.
Many animals must endure harsh environmental conditions in nature, including cold/freezing temperatures, oxygen limitation (anoxia/hypoxia), and food or water scarcity, often requiring them to revamp their metabolic organization, frequently on a seasonal or life stage basi …
Many animals must endure harsh environmental conditions in nature, including cold/freezing temperatures, oxygen limitation (anoxia/hy …
Antioxidant and non-specific immune defenses in partially freeze-tolerant Xizang plateau frogs, Nanorana parkeri.
Niu Y, Zhang X, Zhang H, Xu T, Men S, Storey KB, Chen Q. Niu Y, et al. Among authors: storey kb. J Therm Biol. 2021 Dec;102:103132. doi: 10.1016/j.jtherbio.2021.103132. Epub 2021 Nov 19. J Therm Biol. 2021. PMID: 34863473
The Xizang plateau frog Nanorana parkeri can tolerate brief and partial freezing of their body. To determine the significant role of antioxidant defense and non-specific immune defense in freezing survival of this species, we assayed parameters of oxidative damage, …
The Xizang plateau frog Nanorana parkeri can tolerate brief and partial freezing of their body. To determine the significant role of …
Role of MicroRNAs in Extreme Animal Survival Strategies.
Hadj-Moussa H, Hawkins LJ, Storey KB. Hadj-Moussa H, et al. Among authors: storey kb. Methods Mol Biol. 2022;2257:311-347. doi: 10.1007/978-1-0716-1170-8_16. Methods Mol Biol. 2022. PMID: 34432286
Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana.
Williamson SM, Ingelson-Filpula WA, Hadj-Moussa H, Storey KB. Williamson SM, et al. Among authors: storey kb. J Insect Physiol. 2021 Oct;134:104298. doi: 10.1016/j.jinsphys.2021.104298. Epub 2021 Aug 17. J Insect Physiol. 2021. PMID: 34411584
The goldenrod gall moth (Epiblema scudderiana) is a cold hardy insect that survives subzero temperatures during the winter by supercooling bodily fluids to approximately -40 C, allowing the insect to remain unfrozen despite the freezing temperatures. This is characterized …
The goldenrod gall moth (Epiblema scudderiana) is a cold hardy insect that survives subzero temperatures during the winter by supercooling b …
Mitochondria and the Frozen Frog.
Storey JM, Wu S, Storey KB. Storey JM, et al. Among authors: storey kb. Antioxidants (Basel). 2021 Apr 1;10(4):543. doi: 10.3390/antiox10040543. Antioxidants (Basel). 2021. PMID: 33915853 Free PMC article. Review.
The wood frog, Rana sylvatica, is the best-studied of a small group of amphibian species that survive whole body freezing during the winter months. These frogs endure the freezing of 65-70% of their total body water in extracellular ice masses. ...This article explo …
The wood frog, Rana sylvatica, is the best-studied of a small group of amphibian species that survive whole body freezing during the …
Coordinated expression of Jumonji and AHCY under OCT transcription factor control to regulate gene methylation in wood frogs during anoxia.
Gupta A, Storey KB. Gupta A, et al. Among authors: storey kb. Gene. 2021 Jul 1;788:145671. doi: 10.1016/j.gene.2021.145671. Epub 2021 Apr 19. Gene. 2021. PMID: 33887369
Wood frogs (Rana sylvatica) can survive extended periods of whole body freezing. Freezing imparts multiple stresses on cells that include anoxia and dehydration, but these can also be experienced as independent stresses. ...
Wood frogs (Rana sylvatica) can survive extended periods of whole body freezing. Freezing imparts multiple stresses on cells t …
Freezing stress adaptations: Critical elements to activate Nrf2 related antioxidant defense in liver and skeletal muscle of the freeze tolerant wood frogs.
Zhang J, Gupta A, Storey KB. Zhang J, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2021 Jun-Jul;254:110573. doi: 10.1016/j.cbpb.2021.110573. Epub 2021 Feb 3. Comp Biochem Physiol B Biochem Mol Biol. 2021. PMID: 33548505
Elevated DNA binding activity was observed in frozen frogs as compared to unfrozen controls for both liver and skeletal muscle. Interestingly, high glucose also enhanced binding to the ARE (antioxidant response element) in vitro in unfrozen frogs for both tissues. ...Our s …
Elevated DNA binding activity was observed in frozen frogs as compared to unfrozen controls for both liver and skeletal muscle. Inter …
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review.
Roufayel R, Mezher R, Storey KB. Roufayel R, et al. Among authors: storey kb. Curr Mol Med. 2021;21(8):620-629. doi: 10.2174/1566524020666210104113003. Curr Mol Med. 2021. PMID: 33397238 Review.
The retinoblastoma (Rb) protein coupled with the E2F transcription factor family was demonstrated to have roles in controlling the cell cycle during freezing and associated environmental stresses (anoxia, dehydration). Rb phosphorylation or acetylation at different sites p …
The retinoblastoma (Rb) protein coupled with the E2F transcription factor family was demonstrated to have roles in controlling the cell cycl …
Regulation of an important glycolytic enzyme, pyruvate kinase, through phosphorylation in the larvae of a species of freeze-tolerant insect, Eurosta solidaginis.
Abboud J, Green SR, Smolinski MB, Storey KB. Abboud J, et al. Among authors: storey kb. Insect Mol Biol. 2021 Apr;30(2):176-187. doi: 10.1111/imb.12687. Epub 2020 Dec 23. Insect Mol Biol. 2021. PMID: 33280175
PK was purified from control (5 C-acclimated) and frozen (-15 C-acclimated) larvae and enzyme kinetic properties, structural stability, and post-translational modifications were examined in both enzyme forms. The K(m) phosphoenolpyruvate (PEP) of frozen PK was 20% h …
PK was purified from control (5 C-acclimated) and frozen (-15 C-acclimated) larvae and enzyme kinetic properties, structural stabilit …
Purification and Regulation of Pyruvate Kinase from the Foot Muscle of the Anoxia and Freeze Tolerant Marine Snail, Littorina littorea.
Smolinski MB, Varma A, Green SR, Storey KB. Smolinski MB, et al. Among authors: storey kb. Protein J. 2020 Oct;39(5):531-541. doi: 10.1007/s10930-020-09934-9. Epub 2020 Oct 23. Protein J. 2020. PMID: 33095404
The intertidal marine snail, Littorina littorea, has evolved to survive bouts of anoxia and extracellular freezing brought about by changing tides and subsequent exposure to harsh environmental conditions. ...This study investigated the kinetic, physical, and regulatory pr …
The intertidal marine snail, Littorina littorea, has evolved to survive bouts of anoxia and extracellular freezing brought about by c …
Regulation of NF-κB, FHC and SOD2 in response to oxidative stress in the freeze tolerant wood frog, Rana sylvatica.
Gupta A, Brooks C, Storey KB. Gupta A, et al. Among authors: storey kb. Cryobiology. 2020 Dec;97:28-36. doi: 10.1016/j.cryobiol.2020.10.012. Epub 2020 Oct 17. Cryobiology. 2020. PMID: 33080279
The present study of the NF-kappaB pathway focussed on freezing time points, 4 h frozen and 24 h frozen for liver and skeletal muscle in wood frog. ...Results obtained from nuclear distribution analysis were consistent with the total protein levels showing in …
The present study of the NF-kappaB pathway focussed on freezing time points, 4 h frozen and 24 h frozen for liver and s …
Freeze tolerance and the underlying metabolite responses in the Xizang plateau frog, Nanorana parkeri.
Niu Y, Cao W, Wang J, He J, Storey KB, Ding L, Tang X, Chen Q. Niu Y, et al. Among authors: storey kb. J Comp Physiol B. 2021 Jan;191(1):173-184. doi: 10.1007/s00360-020-01314-0. Epub 2020 Oct 6. J Comp Physiol B. 2021. PMID: 33025179
Herein, we investigate the freeze tolerance of this species and profile changes in liver and skeletal muscle metabolite levels using an untargeted LC-MS-based metabolomic approach to investigate molecular mechanisms that may contribute to freezing survival. We found that t …
Herein, we investigate the freeze tolerance of this species and profile changes in liver and skeletal muscle metabolite levels using an unta …
Correction: Proteomics of intracellular freezing survival.
Thorne MAS, Britovšek NK, Hawkins L, Lilley KS, Storey KB. Thorne MAS, et al. Among authors: storey kb. PLoS One. 2020 Sep 17;15(9):e0239641. doi: 10.1371/journal.pone.0239641. eCollection 2020. PLoS One. 2020. PMID: 32941543 Free PMC article.
RAGE against the stress: Mitochondrial suppression in hypometabolic hearts.
Al-Attar R, Storey KB. Al-Attar R, et al. Among authors: storey kb. Gene. 2020 Nov 30;761:145039. doi: 10.1016/j.gene.2020.145039. Epub 2020 Aug 8. Gene. 2020. PMID: 32777527
The wood frog (Rana sylvatica) can tolerate full body freezing in winter. As a protective response, wood frogs dehydrate their cells and accumulate large quantities of glucose as an intracellular cryoprotectant. Freezing causes ischemia since blood delivery to organ …
The wood frog (Rana sylvatica) can tolerate full body freezing in winter. As a protective response, wood frogs dehydrate their cells …
Marine periwinkle stress-responsive microRNAs: A potential factor to reflect anoxia and freezing survival adaptations.
Zhang J, Hadj-Moussa H, Storey KB. Zhang J, et al. Among authors: storey kb. Genomics. 2020 Nov;112(6):4385-4398. doi: 10.1016/j.ygeno.2020.07.036. Epub 2020 Jul 27. Genomics. 2020. PMID: 32730984 Free article.
Anoxia led to substantial differential miRNA expression patterns, whereas freezing stress showed a relatively high degree of individual variance in miRNA expression. ...Our study demonstrated that conserved miRNAs reflect survival adaptations by marine periwinkles under an …
Anoxia led to substantial differential miRNA expression patterns, whereas freezing stress showed a relatively high degree of individu …
MondoA:MLX complex regulates glucose-dependent gene expression and links to circadian rhythm in liver and brain of the freeze-tolerant wood frog, Rana sylvatica.
Singh G, Storey KB. Singh G, et al. Among authors: storey kb. Mol Cell Biochem. 2020 Oct;473(1-2):203-216. doi: 10.1007/s11010-020-03820-9. Epub 2020 Jul 7. Mol Cell Biochem. 2020. PMID: 32638259
The wood frog, Rana sylvatica, is one of only a few vertebrate species that display natural freeze tolerance. Frogs survive the freezing of about two-thirds of their body water as extracellular ice over the winter months. ...Wood frog liver and brain tissues were analyzed, …
The wood frog, Rana sylvatica, is one of only a few vertebrate species that display natural freeze tolerance. Frogs survive the freezing …
Proteomics of intracellular freezing survival.
Thorne MAS, Britovšek NK, Hawkins L, Lilley KS, Storey KB. Thorne MAS, et al. Among authors: storey kb. PLoS One. 2020 May 26;15(5):e0233048. doi: 10.1371/journal.pone.0233048. eCollection 2020. PLoS One. 2020. PMID: 32453791 Free PMC article.
DAW1, a nematode cultured from the Antarctic, has the extraordinary physiological ability to survive total intracellular freezing throughout all of its compartments. While a few other organisms, all nematodes, have subsequently also been found to survive freezing in …
DAW1, a nematode cultured from the Antarctic, has the extraordinary physiological ability to survive total intracellular freezing thr …
Regulation of antioxidant systems in response to anoxia and reoxygenation in Rana sylvatica.
Gupta A, Storey KB. Gupta A, et al. Among authors: storey kb. Comp Biochem Physiol B Biochem Mol Biol. 2020 Jun;243-244:110436. doi: 10.1016/j.cbpb.2020.110436. Epub 2020 Apr 1. Comp Biochem Physiol B Biochem Mol Biol. 2020. PMID: 32247058
These frogs can endure prolonged oxygen deprivation as well as dehydration to ~60% of total body water lost and, combining these two abilities, they survive whole body freezing for weeks at a time during the winter. Episodes of anoxia/reoxygenation or freeze/thaw can trigg …
These frogs can endure prolonged oxygen deprivation as well as dehydration to ~60% of total body water lost and, combining these two abiliti …
Advances and applications of environmental stress adaptation research.
Hawkins LJ, Storey KB. Hawkins LJ, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2020 Feb;240:110623. doi: 10.1016/j.cbpa.2019.110623. Epub 2019 Nov 25. Comp Biochem Physiol A Mol Integr Physiol. 2020. PMID: 31778815 Review.
Evolution has produced animals that survive extreme fluctuations in environmental conditions including freezing temperatures, anoxia, desiccating conditions, and prolonged periods without food. For example, the wood frog survives whole-body freezing every winter, ar …
Evolution has produced animals that survive extreme fluctuations in environmental conditions including freezing temperatures, anoxia, …
194 results