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MicroRNA-mediated regulation of hypoxic kidney adaptation in naked mole-rats (Heterocephalus glaber).
Attaie Y, Breedon SA, Rehman S, Ojaghi M, Kadamani KL, Pamenter ME, Storey KB. Attaie Y, et al. Among authors: storey kb. Biochimie. 2026 Feb 4;244:54-63. doi: 10.1016/j.biochi.2026.02.007. Online ahead of print. Biochimie. 2026. PMID: 41651162 Free article.
Here, we characterized the miRNA expression profile in kidneys of the naked mole-rat (Heterocephalus glaber), a subterranean rodent renowned for its exceptional hypoxia tolerance. Small RNA from naked-mole rat kidneys was sequenced under …
Here, we characterized the miRNA expression profile in kidneys of the naked mole-rat (Heterocephalus glaber), a subterr …
Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-Rat Heterocephalus glaber.
Ingelson-Filpula WA, Kadamani KL, Ojaghi M, Pamenter ME, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. Muscles. 2026 Jan 14;5(1):6. doi: 10.3390/muscles5010006. Muscles. 2026. PMID: 41562858 Free PMC article.
(1) Background: The naked mole-rat (Heterocephalus glaber) survives hypoxia-reoxygenation stresses by utilizing metabolic rate depression, achieved in part by downregulating nonessential genes and processes to conserve endogenous cellular resources and preven …
(1) Background: The naked mole-rat (Heterocephalus glaber) survives hypoxia-reoxygenation stresses by utilizing metabol …
Hypoxia-induced downregulation of RNA m(6)A protein machinery in the naked mole-rat heart.
Ingelson-Filpula WA, Kadamani KL, Ojaghi M, Pamenter ME, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. Biochimie. 2024 Oct;225:125-132. doi: 10.1016/j.biochi.2024.05.017. Epub 2024 May 22. Biochimie. 2024. PMID: 38788827 Free article.
Naked mole-rats, Heterocephalus glaber, are champion hypoxia-tolerant rodents that live under low oxygen conditions in their subterranean burrows. ...
Naked mole-rats, Heterocephalus glaber, are champion hypoxia-tolerant rodents that live under low oxygen conditions in …
The relationship between hypoxia exposure and circulating cortisol levels in social and solitary African mole-rats: An initial report.
Hart DW, Bennett NC, Best C, van Jaarsveld B, Cheng H, Ivy CM, Kirby AM, Munro D, Sprenger RJ, Storey KB, Milsom WK, Pamenter ME. Hart DW, et al. Among authors: storey kb. Gen Comp Endocrinol. 2023 Aug 1;339:114294. doi: 10.1016/j.ygcen.2023.114294. Epub 2023 Apr 28. Gen Comp Endocrinol. 2023. PMID: 37120097 Free article.
Consequently, this study exposed three social African mole-rat species and two solitary mole-rat species to normoxia, or acute hypoxia and then measured their respective plasma glucocorticoid (cortisol) concentrations. Social mole-rats ha …
Consequently, this study exposed three social African mole-rat species and two solitary mole-rat species to norm …
Small RNA sequencing in hypoxic naked mole-rat hearts suggests microRNA regulation of RNA- and translation-related processes.
Ingelson-Filpula WA, Cheng H, Eaton L, Pamenter ME, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. FEBS Lett. 2022 Nov;596(21):2821-2833. doi: 10.1002/1873-3468.14499. Epub 2022 Sep 27. FEBS Lett. 2022. PMID: 36120811 Free article.
The naked mole-rat (Heterocephalus glaber) regularly endures intermittent periods of hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)-a strategy of conserving cellular resources by downregulating nonessential gene expression an …
The naked mole-rat (Heterocephalus glaber) regularly endures intermittent periods of hypoxia in its burrows, surviving …
Naked mole-rats resist the accumulation of hypoxia-induced oxidative damage.
Hadj-Moussa H, Eaton L, Cheng H, Pamenter ME, Storey KB. Hadj-Moussa H, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2022 Nov;273:111282. doi: 10.1016/j.cbpa.2022.111282. Epub 2022 Jul 28. Comp Biochem Physiol A Mol Integr Physiol. 2022. PMID: 35907588
Naked mole-rats are among the few mammals with the ability to endure severe hypoxia. These unique rodents use metabolic rate depression along with various molecular mechanisms to successfully overcome the challenges of oxygen-limitation, which they experience …
Naked mole-rats are among the few mammals with the ability to endure severe hypoxia. These unique rodents use metabolic …
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ. Buffenstein R, et al. Among authors: storey kb. Biol Rev Camb Philos Soc. 2022 Feb;97(1):115-140. doi: 10.1111/brv.12791. Epub 2021 Sep 3. Biol Rev Camb Philos Soc. 2022. PMID: 34476892 Free PMC article. Review.
The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. ...Here, we provide a comprehensive critical review of naked mole-rat biology and attempt to clarify some of these misconceptions....
The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. ...Here, we provide a …
MicroRNA-mediated inhibition of AMPK coordinates tissue-specific downregulation of skeletal muscle metabolism in hypoxic naked mole-rats.
Hadj-Moussa H, Chiasson S, Cheng H, Eaton L, Storey KB, Pamenter ME. Hadj-Moussa H, et al. Among authors: storey kb. J Exp Biol. 2021 Aug 1;224(15):jeb242968. doi: 10.1242/jeb.242968. Epub 2021 Aug 10. J Exp Biol. 2021. PMID: 34374781
Naked mole-rats reduce their metabolic requirements to tolerate severe hypoxia. However, the regulatory mechanisms that underpin this metabolic suppression have yet to be elucidated. 5'-AMP-activated protein kinase (AMPK) is the cellular 'master' energy effec …
Naked mole-rats reduce their metabolic requirements to tolerate severe hypoxia. However, the regulatory mechanisms that …
Hypoxic naked mole-rat brains use microRNA to coordinate hypometabolic fuels and neuroprotective defenses.
Hadj-Moussa H, Pamenter ME, Storey KB. Hadj-Moussa H, et al. Among authors: storey kb. J Cell Physiol. 2021 Jul;236(7):5080-5097. doi: 10.1002/jcp.30216. Epub 2020 Dec 11. J Cell Physiol. 2021. PMID: 33305831
Naked mole-rats are among the mammalian champions of hypoxia tolerance. They evolved adaptations centered around reducing metabolic rate to overcome the challenges experienced in their underground burrows. ...Together, this demonstrated the induction of anaer …
Naked mole-rats are among the mammalian champions of hypoxia tolerance. They evolved adaptations centered around reduci …
Differential protein phosphorylation is responsible for hypoxia-induced regulation of the Akt/mTOR pathway in naked mole rats.
Al-Attar R, Childers CL, Nguyen VC, Pamenter ME, Storey KB. Al-Attar R, et al. Among authors: storey kb. Comp Biochem Physiol A Mol Integr Physiol. 2020 Apr;242:110653. doi: 10.1016/j.cbpa.2020.110653. Epub 2020 Jan 8. Comp Biochem Physiol A Mol Integr Physiol. 2020. PMID: 31926299
Naked mole rats (NMRs, Heterocephalus glaber) are among the most hypoxia-tolerant mammals known. ...
Naked mole rats (NMRs, Heterocephalus glaber) are among the most hypoxia-tolerant mammals known. ...
12 results