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Narcolepsy during Childhood: An Update.
Rocca FL, Pizza F, Ricci E, Plazzi G. Rocca FL, et al. Neuropediatrics. 2015 Jun;46(3):181-98. doi: 10.1055/s-0035-1550152. Epub 2015 May 11. Neuropediatrics. 2015. PMID: 25961600 Review.
Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations, and fragmented nocturnal sleep usually arising in adolescence or young adulthood. ...As in adults, the occurrenc …
Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep …
Infancy narcolepsy: Streptococcus infection as a causal factor.
Lopes DA, Coelho FM, Pradella-Hallinan M, de Araújo Melo MH, Tufik S. Lopes DA, et al. Sleep Sci. 2015 Jan-Mar;8(1):49-52. doi: 10.1016/j.slsci.2015.02.002. Epub 2015 Feb 18. Sleep Sci. 2015. PMID: 26483943 Free PMC article.
Streptococcal infections are suggested as a risk factor for narcolepsy. This hypothesis is supported by the presence of anti-streptolysin antibodies in 65% of patients with narcolepsy. ...We report here the case of a child diagnosed with narcolepsy with catap …
Streptococcal infections are suggested as a risk factor for narcolepsy. This hypothesis is supported by the presence of anti-streptol …
Genetic association, seasonal infections and autoimmune basis of narcolepsy.
Singh AK, Mahlios J, Mignot E. Singh AK, et al. J Autoimmun. 2013 Jun;43:26-31. doi: 10.1016/j.jaut.2013.02.003. Epub 2013 Mar 13. J Autoimmun. 2013. PMID: 23497937 Free PMC article. Review.
In recent years, a growing number of potential autoimmune disorders affecting neurons in the central nervous system have been identified, including narcolepsy. ...More recently, narcolepsy was identified in association with seasonal streptococcus, H1N1 infect …
In recent years, a growing number of potential autoimmune disorders affecting neurons in the central nervous system have been identified, in …
Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.
Kornum BR, Faraco J, Mignot E. Kornum BR, et al. Curr Opin Neurobiol. 2011 Dec;21(6):897-903. doi: 10.1016/j.conb.2011.09.003. Epub 2011 Sep 30. Curr Opin Neurobiol. 2011. PMID: 21963829 Review.
Recent data have shown a robust seasonality of disease onset in children and associations with Streptococcus Pyogenes, and influenza A H1N1-infection and H1N1-vaccination, pointing towards processes such as molecular mimicry or bystander activation as crucial for disease d …
Recent data have shown a robust seasonality of disease onset in children and associations with Streptococcus Pyogenes, and influenza …
A coordinated cross-disciplinary research initiative to address an increased incidence of narcolepsy following the 2009-2010 Pandemrix vaccination programme in Sweden.
Feltelius N, Persson I, Ahlqvist-Rastad J, Andersson M, Arnheim-Dahlström L, Bergman P, Granath F, Adori C, Hökfelt T, Kühlmann-Berenzon S, Liljeström P, Maeurer M, Olsson T, Örtqvist Å, Partinen M, Salmonson T, Zethelius B. Feltelius N, et al. J Intern Med. 2015 Oct;278(4):335-53. doi: 10.1111/joim.12391. Epub 2015 Jun 30. J Intern Med. 2015. PMID: 26123389 Free article. Review.
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy. ...Patients with narcolepsy were also found to have increased levels of interferon-gamma production in response to streptococcus-ass …
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy. ...Pat …
Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset.
Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Aran A, et al. Sleep. 2009 Aug;32(8):979-83. doi: 10.1093/sleep/32.8.979. Sleep. 2009. PMID: 19725248 Free PMC article.
This study evaluated whether Streptococcus pyogenes and Helicobacter pylori infections are triggers for narcolepsy. DESIGN: Retrospective, case-control. ...CONCLUSIONS: Streptococcal infections are probably a significant environmental trigger for narcolepsy.. …
This study evaluated whether Streptococcus pyogenes and Helicobacter pylori infections are triggers for narcolepsy. DESIGN: Re …
Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases.
Ambati A, Poiret T, Svahn BM, Valentini D, Khademi M, Kockum I, Lima I, Arnheim-Dahlström L, Lamb F, Fink K, Meng Q, Kumar A, Rane L, Olsson T, Maeurer M. Ambati A, et al. J Intern Med. 2015 Sep;278(3):264-76. doi: 10.1111/joim.12355. Epub 2015 Mar 22. J Intern Med. 2015. PMID: 25683265 Free article.
RESULTS: IFN-γ production was significantly increased in whole blood from narcolepsy cases in response to streptococcus serotype M6 (P = 0.0065) and streptodornase B protein (P = 0.0050). ...CONCLUSION: β-haemolytic GAS may be involved in triggering autoimmune respo …
RESULTS: IFN-γ production was significantly increased in whole blood from narcolepsy cases in response to streptococcus seroty …
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children.
Aran A, Einen M, Lin L, Plazzi G, Nishino S, Mignot E. Aran A, et al. Sleep. 2010 Nov;33(11):1457-64. doi: 10.1093/sleep/33.11.1457. Sleep. 2010. PMID: 21102987 Free PMC article.
MEASUREMENTS AND RESULTS: patients were separated into children with onset of narcolepsy prior to (53%), around (29%), and after (18%) puberty. ...Streptococcus-positive throat infections were reported in 20% of cases within 6 months of onset of narcolepsy. P …
MEASUREMENTS AND RESULTS: patients were separated into children with onset of narcolepsy prior to (53%), around (29%), and after (18% …
Anti-streptococcal antibodies in Chinese patients with type -1 narcolepsy.
Ding Q, Li J, Xiao F, Zhang C, Dong X, Han F. Ding Q, et al. Sleep Med. 2020 Aug;72:37-40. doi: 10.1016/j.sleep.2020.03.019. Epub 2020 Mar 31. Sleep Med. 2020. PMID: 32540635
BACKGROUND: Narcolepsy type 1 (NT1) is considered to be an autoimmune disease, and streptococcal infection may be an environmental trigger. ...CONCLUSION: Streptococcus infection reflected by increase of ASO and ADB levels was not found in Chinese patients with type …
BACKGROUND: Narcolepsy type 1 (NT1) is considered to be an autoimmune disease, and streptococcal infection may be an environmental tr …
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