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Narcolepsy during Childhood: An Update.
Rocca FL, Pizza F, Ricci E, Plazzi G. Rocca FL, et al. Neuropediatrics. 2015 Jun;46(3):181-98. doi: 10.1055/s-0035-1550152. Epub 2015 May 11. Neuropediatrics. 2015. PMID: 25961600 Review.
Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations, and fragmented nocturnal sleep usually arising in adolescence or young adulthood. ...As in adults, the occurrenc …
Narcolepsy type 1 (NT1) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep …
Infancy narcolepsy: Streptococcus infection as a causal factor.
Lopes DA, Coelho FM, Pradella-Hallinan M, de Araújo Melo MH, Tufik S. Lopes DA, et al. Sleep Sci. 2015 Jan-Mar;8(1):49-52. doi: 10.1016/j.slsci.2015.02.002. Epub 2015 Feb 18. Sleep Sci. 2015. PMID: 26483943 Free PMC article.
Streptococcal infections are suggested as a risk factor for narcolepsy. This hypothesis is supported by the presence of anti-streptolysin antibodies in 65% of patients with narcolepsy. ...It has also been shown a significant association between birth order and na …
Streptococcal infections are suggested as a risk factor for narcolepsy. This hypothesis is supported by the presence of anti-streptol …
Anti-streptococcal antibodies in Chinese patients with type -1 narcolepsy.
Ding Q, Li J, Xiao F, Zhang C, Dong X, Han F. Ding Q, et al. Sleep Med. 2020 Aug;72:37-40. doi: 10.1016/j.sleep.2020.03.019. Epub 2020 Mar 31. Sleep Med. 2020. PMID: 32540635
However, previous studies from Asian narcolepsy patients did not reveal elevated anti-streptolysin O [ASO]. ...ASO and ADB positive rates had no significant differences among different disease duration groups (p = 0.55 and 0.9, respectively). CONCLUSION: Streptococcus …
However, previous studies from Asian narcolepsy patients did not reveal elevated anti-streptolysin O [ASO]. ...ASO and ADB positive r …
Genetic association, seasonal infections and autoimmune basis of narcolepsy.
Singh AK, Mahlios J, Mignot E. Singh AK, et al. J Autoimmun. 2013 Jun;43:26-31. doi: 10.1016/j.jaut.2013.02.003. Epub 2013 Mar 13. J Autoimmun. 2013. PMID: 23497937 Free PMC article. Review.
Narcolepsy is generally a sporadic disorder and is caused by the loss of hypocretin (orexin)-producing neurons in the hypothalamus region of the brain. ...More recently, narcolepsy was identified in association with seasonal streptococcus, H1N1 infections and …
Narcolepsy is generally a sporadic disorder and is caused by the loss of hypocretin (orexin)-producing neurons in the hypothalamus re …
Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.
Kornum BR, Faraco J, Mignot E. Kornum BR, et al. Curr Opin Neurobiol. 2011 Dec;21(6):897-903. doi: 10.1016/j.conb.2011.09.003. Epub 2011 Sep 30. Curr Opin Neurobiol. 2011. PMID: 21963829 Review.
The loss of hypothalamic hypocretin/orexin (hcrt) producing neurons causes narcolepsy with cataplexy. An autoimmune basis for the disease has long been suspected and recent results have greatly strengthened this hypothesis. ...We speculate that upper airway infections may …
The loss of hypothalamic hypocretin/orexin (hcrt) producing neurons causes narcolepsy with cataplexy. An autoimmune basis for the dis …
A coordinated cross-disciplinary research initiative to address an increased incidence of narcolepsy following the 2009-2010 Pandemrix vaccination programme in Sweden.
Feltelius N, Persson I, Ahlqvist-Rastad J, Andersson M, Arnheim-Dahlström L, Bergman P, Granath F, Adori C, Hökfelt T, Kühlmann-Berenzon S, Liljeström P, Maeurer M, Olsson T, Örtqvist Å, Partinen M, Salmonson T, Zethelius B. Feltelius N, et al. J Intern Med. 2015 Oct;278(4):335-53. doi: 10.1111/joim.12391. Epub 2015 Jun 30. J Intern Med. 2015. PMID: 26123389 Free article. Review.
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy. Furthermore, a number of studies using cellular and molecular experimental models investigated possible links between influenza vaccination and …
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy. Furthe …
Narcolepsy in Children: Sleep disorders in children, A rapidly evolving field seeking consensus.
Dye TJ, Simakajornboon N. Dye TJ, et al. Pediatr Pulmonol. 2022 Aug;57(8):1952-1962. doi: 10.1002/ppul.25512. Epub 2021 Jun 1. Pediatr Pulmonol. 2022. PMID: 34021733
Narcolepsy is a life-long sleep disorder with two distinct subtypes, narcolepsy type I and narcolepsy type II. ...There are limitations of using MSLT in young children such that a negative MSLT test cannot exclude narcolepsy. HLA markers have limited u …
Narcolepsy is a life-long sleep disorder with two distinct subtypes, narcolepsy type I and narcolepsy type II. ...There …
Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset.
Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Aran A, et al. Sleep. 2009 Aug;32(8):979-83. doi: 10.1093/sleep/32.8.979. Sleep. 2009. PMID: 19725248 Free PMC article.
STUDY OBJECTIVES: Narcolepsy-cataplexy has long been thought to have an autoimmune origin. ...This study evaluated whether Streptococcus pyogenes and Helicobacter pylori infections are triggers for narcolepsy. ...
STUDY OBJECTIVES: Narcolepsy-cataplexy has long been thought to have an autoimmune origin. ...This study evaluated whether Strepto …
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children.
Aran A, Einen M, Lin L, Plazzi G, Nishino S, Mignot E. Aran A, et al. Sleep. 2010 Nov;33(11):1457-64. doi: 10.1093/sleep/33.11.1457. Sleep. 2010. PMID: 21102987 Free PMC article.
MEASUREMENTS AND RESULTS: patients were separated into children with onset of narcolepsy prior to (53%), around (29%), and after (18%) puberty. None of the children had secondary narcolepsy. ...Streptococcus-positive throat infections were reported in 20% of …
MEASUREMENTS AND RESULTS: patients were separated into children with onset of narcolepsy prior to (53%), around (29%), and after (18% …
Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases.
Ambati A, Poiret T, Svahn BM, Valentini D, Khademi M, Kockum I, Lima I, Arnheim-Dahlström L, Lamb F, Fink K, Meng Q, Kumar A, Rane L, Olsson T, Maeurer M. Ambati A, et al. J Intern Med. 2015 Sep;278(3):264-76. doi: 10.1111/joim.12355. Epub 2015 Mar 22. J Intern Med. 2015. PMID: 25683265 Free article.
RESULTS: IFN-gamma production was significantly increased in whole blood from narcolepsy cases in response to streptococcus serotype M6 (P = 0.0065) and streptodornase B protein (P = 0.0050). ...Significantly, higher (P = 0.02) titres of serum antistreptolysin O wer …
RESULTS: IFN-gamma production was significantly increased in whole blood from narcolepsy cases in response to streptococcus se …