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Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters.
Pondeljak N, Lugović-Mihić L. Pondeljak N, et al. Clin Ther. 2020 May;42(5):757-770. doi: 10.1016/j.clinthera.2020.03.008. Epub 2020 Apr 7. Clin Ther. 2020. PMID: 32276734 Review.
The skin actively responds to psychological stress, with involvement of skin immune cells, hormones, neurotransmitters. ...IMPLICATIONS: Psychoneuroimmunology provides an understanding that the skin is target and source of stress mediators. This …
The skin actively responds to psychological stress, with involvement of skin immune cells, hormones, neurotransmitters. …
Impact of Chronic Moderate Psychological Stress on Skin Aging: Exploratory Clinical Study and Cellular Functioning.
Pujos M, Chamayou-Robert C, Parat M, Bonnet M, Couret S, Robiolo A, Doucet O. Pujos M, et al. J Cosmet Dermatol. 2025 Jan;24(1):e16634. doi: 10.1111/jocd.16634. Epub 2024 Nov 6. J Cosmet Dermatol. 2025. PMID: 39506493 Free PMC article.
INTRODUCTION: Skin is continuously exposed to environmental external and internal factors, including psychological stress (PS). ...METHODS: In vitro stress tests with cortisol and epinephrine, and with cortisol only on extracellular matrix (ECM) …
INTRODUCTION: Skin is continuously exposed to environmental external and internal factors, including psychological stress (PS) …
The brain-skin connection: A narrative review of neuroendocrine and immune pathways.
Tan CC, Soh KV, Wang E, Choi EC. Tan CC, et al. JAAD Int. 2025 Oct 28;24:112-123. doi: 10.1016/j.jdin.2025.10.008. eCollection 2026 Feb. JAAD Int. 2025. PMID: 41393358 Free PMC article.
BACKGROUND: Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood. OBJECTIVE: To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how st …
BACKGROUND: Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood. …
Pathogenetic peculiarities of neuroendocrine and metabolic disorders in patients with acne associated with chronic stress.
Dashko MO, Syzon OO, Chaplyk-Chyzho IO, Turkevych SA. Dashko MO, et al. Wiad Lek. 2019;72(5 cz 2):997-1001. Wiad Lek. 2019. PMID: 31175732
OBJECTIVE: Introduction: Acne is a chronic relapsing skin condition with multifactorial nature associated with disorders of sebaceous glands activity, psycho-emotional disorders and slow response to treatment. The aim: To study a pathogenic role of chronic stress …
OBJECTIVE: Introduction: Acne is a chronic relapsing skin condition with multifactorial nature associated with disorders of se …
Role of Lactium in Psychodermatology: The CERTAIN Trial(#) on Patients with Acne Vulgaris.
Kerure AS, Udare S, Vispute C. Kerure AS, et al. Dermatol Res Pract. 2022 May 4;2022:2916317. doi: 10.1155/2022/2916317. eCollection 2022. Dermatol Res Pract. 2022. PMID: 35573814 Free PMC article.
Stress plays an important role in the causation and aggravation of psychodermatological conditions such as acne vulgaris. Alpha casein hydrolysate (alphas1-casein hydrolysate; Lactium) has been shown to decrease serum cortisol levels, reduce stress …
Stress plays an important role in the causation and aggravation of psychodermatological conditions such as acne vulgaris …
On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders.
Slominski A. Slominski A. Br J Dermatol. 2009 Feb;160(2):229-32. doi: 10.1111/j.1365-2133.2008.08958.x. Br J Dermatol. 2009. PMID: 19187344 Free PMC article.
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body's response to stress.- Stress induces the hypothalamic produc …
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pitui …
Endocrine parameters in acne vulgaris.
Schmidt JB, Lindmaier A, Spona J. Schmidt JB, et al. Endocrinol Exp. 1990 Dec;24(4):457-64. Endocrinol Exp. 1990. PMID: 2151388
In addition, sex hormone binding globulin (SHBG), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), 17 beta-estradiol (E2) and cortisol (F) were evaluated. Moreover, the counts of acne lesions in the face were performed in 34 males and f …
In addition, sex hormone binding globulin (SHBG), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), 17 beta-est …
A randomized comparative trial of a combined oral contraceptive and azelaic acid to assess their effect on sleep quality in adult female acne patients.
Albuquerque RG, da Rocha MA, Hirotsu C, Hachul H, Bagatin E, Tufik S, Andersen ML. Albuquerque RG, et al. Arch Dermatol Res. 2015 Dec;307(10):905-15. doi: 10.1007/s00403-015-1600-0. Epub 2015 Oct 15. Arch Dermatol Res. 2015. PMID: 26472098 Clinical Trial.
Several studies have reported an increase in the prevalence of adult female acne. This subtype of acne presents particular characteristics, and can be triggered by several factors such as smoking, stress, the use of oily cosmetics and even by poor sleep. ...W …
Several studies have reported an increase in the prevalence of adult female acne. This subtype of acne presents particular cha …
Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.
Bender A, Zapolanski T, Watkins S, Khosraviani A, Seiffert K, Ding W, Wagner JA, Granstein RD. Bender A, et al. Exp Dermatol. 2008 Sep;17(9):752-60. doi: 10.1111/j.1600-0625.2008.00716.x. Epub 2008 Mar 13. Exp Dermatol. 2008. PMID: 18341570 Free PMC article.
ATP released by the sympathetic nerves during stress may stimulate release of pro-inflammatory chemokines by dermal vessel endothelial cells, resulting in recruitment of inflammatory cells and exacerbation of inflammatory skin disease. ...Inhibition of production of …
ATP released by the sympathetic nerves during stress may stimulate release of pro-inflammatory chemokines by dermal vessel endothelia …
Striae and acne following cardiac surgery in a child.
Goggin N, Enright F, Costigan C, Duff D, Oslizlok P, Wood AE, Watson R. Goggin N, et al. Br J Dermatol. 1999 Apr;140(4):734-6. doi: 10.1046/j.1365-2133.1999.02781.x. Br J Dermatol. 1999. PMID: 10233332
We conclude that the cause of steroid excess in our patient was stress induced by the cardiac surgery and a complicated and protracted postoperative course. To our knowledge, this is the first report in the English language literature of skin changes due to endogeno …
We conclude that the cause of steroid excess in our patient was stress induced by the cardiac surgery and a complicated and protracte …