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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1923 1
1928 1
1938 2
1941 1
1947 1
1949 1
1952 1
1953 2
1954 3
1955 1
1956 2
1957 4
1959 1
1960 8
1961 2
1962 2
1963 2
1964 3
1965 7
1966 9
1967 14
1968 15
1969 24
1970 17
1971 22
1972 40
1973 55
1974 78
1975 316
1976 335
1977 297
1978 270
1979 283
1980 318
1981 358
1982 410
1983 538
1984 575
1985 658
1986 695
1987 698
1988 765
1989 916
1990 981
1991 1065
1992 1162
1993 1270
1994 1487
1995 1461
1996 1603
1997 1586
1998 1675
1999 1750
2000 1946
2001 2191
2002 2466
2003 2532
2004 3097
2005 3109
2006 3452
2007 3504
2008 3845
2009 3840
2010 4057
2011 4510
2012 4691
2013 4910
2014 5453
2015 5539
2016 5553
2017 6080
2018 6620
2019 7149
2020 7804
2021 8356
2022 7909
2023 7653
2024 8302
2025 9029
2026 5045

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147,175 results

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Page 1
Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience.
Yan L, Wang Y, Hu H, Yang D, Wang W, Luo Z, Wang Y, Yang F, So KF, Zhang L. Yan L, et al. Cell Metab. 2024 Sep 3;36(9):2104-2117.e4. doi: 10.1016/j.cmet.2024.07.018. Epub 2024 Aug 19. Cell Metab. 2024. PMID: 39163863 Free article.
Here, we report that exercise-induced lactate markedly potentiates the lactylation of multiple synaptic proteins, among which synaptosome-associated protein 91 (SNAP91) is the critical molecule for synaptic functions. Both anatomical evidence and in vivo recording d …
Here, we report that exercise-induced lactate markedly potentiates the lactylation of multiple synaptic proteins, among which synapto …
FNDC5/Irisin: Physiology and Pathophysiology.
Waseem R, Shamsi A, Mohammad T, Hassan MI, Kazim SN, Chaudhary AA, Rudayni HA, Al-Zharani M, Ahmad F, Islam A. Waseem R, et al. Molecules. 2022 Feb 8;27(3):1118. doi: 10.3390/molecules27031118. Molecules. 2022. PMID: 35164383 Free PMC article. Review.
A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases. Physical exercise helps improve quality of life and reduces the risk o …
A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart disea …
Molecular insights of exercise therapy in disease prevention and treatment.
Walzik D, Wences Chirino TY, Zimmer P, Joisten N. Walzik D, et al. Signal Transduct Target Ther. 2024 May 29;9(1):138. doi: 10.1038/s41392-024-01841-0. Signal Transduct Target Ther. 2024. PMID: 38806473 Free PMC article. Review.
Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle, cardiac muscle, adipose, and liver tissue. These signaling molecules, which are collectively t …
Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by diff …
EXERCISE AND MICRORNA.
Pala M. Pala M. Georgian Med News. 2023 Dec;(345):146-153. Georgian Med News. 2023. PMID: 38325314 Review.
Physical activity stimulates numerous structural, metabolic, and morphological adaptations. These adaptations are vital for maintaining human health throughout life. ...This review describes miRNAs whose activities change in the heart, skeletal muscle, and ci …
Physical activity stimulates numerous structural, metabolic, and morphological adaptations. These adaptations are vital for ma …
Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review.
Mielgo-Ayuso J, Pietrantonio L, Viribay A, Calleja-González J, González-Bernal J, Fernández-Lázaro D. Mielgo-Ayuso J, et al. Nutrients. 2021 Dec 3;13(12):4359. doi: 10.3390/nu13124359. Nutrients. 2021. PMID: 34959912 Free PMC article.
The main aim of the present systematic review was to determine the effects of oral l-C supplementation on moderate- (50-79% V O(2 max)) and high-intensity ( 80% V O(2 max)) exercise performance and to show the effective doses and ideal timing of its intake. A structured …
The main aim of the present systematic review was to determine the effects of oral l-C supplementation on moderate- (50-79% V O(2 max)) and …
Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways.
Barghash MM, Mabanglo MF, Hoff SE, Brozdnychenko D, Wong KS, Binepal G, Ip P, Shen J, Furukawa T, Katayama H, Trudel V, Tan J, Yudin AK, Gray-Owen SD, Sakuda S, Batey RA, Vahidi S, Bonomi M, Houry WA. Barghash MM, et al. Structure. 2025 Oct 2;33(10):1700-1716.e6. doi: 10.1016/j.str.2025.07.013. Epub 2025 Aug 11. Structure. 2025. PMID: 40795847 Free article.
Here, we investigate the mechanism of ClpP activation by these compounds using an integrative approach combining structural, biochemical, and computational tools. We identified small molecules that activate ClpP through binding at internal catalytic si …
Here, we investigate the mechanism of ClpP activation by these compounds using an integrative approach combining structural, b …
Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli.
El Zahed SS, French S, Farha MA, Kumar G, Brown ED. El Zahed SS, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01925-20. doi: 10.1128/AAC.01925-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468483 Free PMC article.
Herein, we address the contribution of efflux using a novel approach that applies multivariate analysis, machine learning, and structure-based clustering to some 4,500 molecules (actives) from a small-molecule screen in efflux-compromised Escherichia c …
Herein, we address the contribution of efflux using a novel approach that applies multivariate analysis, machine learning, and structure …
Activity-annotated molecular networking accelerates active molecule screening from natural products.
Wang W, Li A, He F, Dai J, He L, Zou D. Wang W, et al. J Chromatogr A. 2025 Aug 30;1757:466170. doi: 10.1016/j.chroma.2025.466170. Epub 2025 Jun 24. J Chromatogr A. 2025. PMID: 40582026
AAMN was developed by annotating activity data, defined as the correlation relationship between a molecule's relative abundance and the corresponding activity data, onto molecular networks to accelerate the active molecule screening from …
AAMN was developed by annotating activity data, defined as the correlation relationship between a molecule's relative a …
[Marfan syndrome].
Jondeau G, Boileau C, Chevallier B, Delorme G, Digne F, Guiti C, Milleron O, de SaintJean M, Le Parc JM, Moura B. Jondeau G, et al. Arch Mal Coeur Vaiss. 2003 Nov;96(11):1081-8. Arch Mal Coeur Vaiss. 2003. PMID: 14694784 Review. French.
Marfan's syndrome is a monogenetic disease with an autosomal dominant transmission generally accompanied by type I fibrillin abnormality. This widely-distributed molecule participates in the structure of connective tissues so that any aberration may result in diseas …
Marfan's syndrome is a monogenetic disease with an autosomal dominant transmission generally accompanied by type I fibrillin abnormality. Th …
Making PI3K superfamily enzymes run faster.
Gong GQ, Anandapadamanaban M, Islam MS, Hay IM, Bourguet M, Špokaitė S, Dessus AN, Ohashi Y, Perisic O, Williams RL. Gong GQ, et al. Adv Biol Regul. 2025 Jan;95:101060. doi: 10.1016/j.jbior.2024.101060. Epub 2024 Nov 19. Adv Biol Regul. 2025. PMID: 39592347 Free PMC article. Review.
A recent report of a small-molecule activator of PI3Kalpha for application in nerve regeneration suggests that flexibility of these regulatory elements might be exploited to develop specific activators of all PI3K superfamily members. ...We review common s …
A recent report of a small-molecule activator of PI3Kalpha for application in nerve regeneration suggests that flexibility of …
147,175 results
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