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Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking.
Ma R, Zhang W, Chen L, Tong L. Ma R, et al. BMC Complement Med Ther. 2025 Jun 6;25(1):204. doi: 10.1186/s12906-025-04939-2. BMC Complement Med Ther. 2025. PMID: 40481474 Free PMC article.
BACKGROUND: Depression is a prevalent and debilitating neuropsychiatric disorder, often associated with neuroinflammation, oxidative stress, and neuronal apoptosis. Jiawei Suanzaoren (JWSZR), a traditional Chinese medicine (TCM) formulation, has demonstrated potential in a …
BACKGROUND: Depression is a prevalent and debilitating neuropsychiatric disorder, often associated with neuroinflammation, oxidative stress, …
Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment.
Zhang L, Guo Z, Han Y, Yan H, Lv D, Yao P, Zhao J, Chen L, Guo W. Zhang L, et al. World J Biol Psychiatry. 2025 Jun;26(5):211-223. doi: 10.1080/15622975.2025.2503938. Epub 2025 May 18. World J Biol Psychiatry. 2025. PMID: 40384005 Clinical Trial.
Patients were assigned to receive either modified Suanzaoren decoction (MSZRD) or estazolam treatment for six weeks. Spontaneous brain activity was evaluated by amplitude of low-frequency fluctuations (ALFF), Wavelet-ALFF, and fractional ALFF (fALFF). ...
Patients were assigned to receive either modified Suanzaoren decoction (MSZRD) or estazolam treatment for six weeks. Spontaneous brai …
Prediction of treatment efficacy in the suanzaoren decoction and estazolam for chronic insomnia disorder, along with brain function and cognitive changes before and after treatment, and potential gene expression profiles.
Li T, Han Y, Yan H, Lv D, Yao P, Chen L, Yuan Y, Zhao J, Guo W, Guo Z, Lang B. Li T, et al. Asian J Psychiatr. 2025 May 28;110:104563. doi: 10.1016/j.ajp.2025.104563. Online ahead of print. Asian J Psychiatr. 2025. PMID: 40482291
OBJECTIVE: This study compared the brain function changes in chronic insomnia disorder (CID) before and after treatment by suanzaoren decoction (SZRD) and estazolam, to reveal their effects in cognition improvement, and to explore the potential genetic basis underpinning t …
OBJECTIVE: This study compared the brain function changes in chronic insomnia disorder (CID) before and after treatment by suanzaoren …
Exploring the mechanism of the potential effects of Liujunzi Tang combined with Suanzaoren Tang in the treatment of lung cancer with insomnia based on network pharmacology and molecular docking technology.
Wang Y, Zhao X, Wang X, Wang X, Zhang T, Wang Y. Wang Y, et al. Medicine (Baltimore). 2025 Apr 18;104(16):e42205. doi: 10.1097/MD.0000000000042205. Medicine (Baltimore). 2025. PMID: 40258725 Free PMC article.
This study explores the potential mechanisms of Liujunzi Tang combined with Suanzaoren Tang in treating lung cancer with insomnia through network pharmacology and molecular docking methods. ...A total of 185 effective active components and 241 targets were obtained for Liu …
This study explores the potential mechanisms of Liujunzi Tang combined with Suanzaoren Tang in treating lung cancer with insomnia thr …
Exploring natural therapy for chronic heart failure: experience in traditional Chinese medicine treatment before 2022.
Pan LP, Zhu L, Wang BX, Li YQ, Gao L, Zhao HH. Pan LP, et al. Front Med (Lausanne). 2025 Apr 7;12:1522163. doi: 10.3389/fmed.2025.1522163. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40265178 Free PMC article.
RESULT: Among 626 effective medical records, Fuling, Huangqi, and Danshen are the most commonly used herbs; The medication for chest tightness is closely related to Tinglizi; The medication for palpitations is closely related to Guizhi, Fuzi, Zhigancao, and Wuweizi; The medicatio …
RESULT: Among 626 effective medical records, Fuling, Huangqi, and Danshen are the most commonly used herbs; The medication for chest tightne …
Mechanistic insights into Suanzaoren Decoction's improvement of cardiac contractile function in anxiety-induced cardiac insufficiency.
Zhang Y, Jin Y, Zhao N, Wang T, Wang X, Li Z, Yan Y. Zhang Y, et al. J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118860. doi: 10.1016/j.jep.2024.118860. Epub 2024 Sep 26. J Ethnopharmacol. 2025. PMID: 39341264
ETHNOPHARMACOLOGICAL RELEVANCE: According to traditional Chinese medicine, Anxiety-induced cardiac blood insufficiency leads to palpitations and restlessness. Suanzaoren Decoction (SD) is effective in replenishing blood and promoting blood circulation. ...
ETHNOPHARMACOLOGICAL RELEVANCE: According to traditional Chinese medicine, Anxiety-induced cardiac blood insufficiency leads to palpitations …
Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study.
Chen LQ, Zhou YC, Ning F, Zhu MJ. Chen LQ, et al. Front Pharmacol. 2025 Jan 29;15:1495957. doi: 10.3389/fphar.2024.1495957. eCollection 2024. Front Pharmacol. 2025. PMID: 39944400 Free PMC article.
BACKGROUND: Traditional Chinese medicine has a good clinical therapeutic effect on perimenopausal insomnia, Jiawei Suanzaoren Tang (JW-SZRT) has a significant therapeutic effect on people with yin deficiency and fire excess type insomnia. ...The treatment group was treated …
BACKGROUND: Traditional Chinese medicine has a good clinical therapeutic effect on perimenopausal insomnia, Jiawei Suanzaoren Tang (J …
[Study on anti-depression effect of Suanzaoren Decoction based on liver metabolomics].
Li J, Tong YN, Wang HT, Zhao SH, Chen WY, Li ZW, Liu MY. Li J, et al. Zhongguo Zhong Yao Za Zhi. 2025 Jan;50(1):19-31. doi: 10.19540/j.cnki.cjcmm.20240902.703. Zhongguo Zhong Yao Za Zhi. 2025. PMID: 39929643 Chinese.
To explore the anti-depression effect of Suanzaoren Decoction(SZRD), the regulatory effects on endogenous metabolites in the liver of rats with depression induced by chronic unpredictable mild stress(CUMS) were analyzed by using LC-MS metabolomics. ...
To explore the anti-depression effect of Suanzaoren Decoction(SZRD), the regulatory effects on endogenous metabolites in the liver of …
Integrated gut microbiome and metabolomic analyses elucidate the therapeutic mechanisms of Suanzaoren decoction in insomnia and depression models.
Zhang H, Gao T, Zhao F, Wang N, Li Z, Qin X, Liu Y, Wang R. Zhang H, et al. Front Neurosci. 2024 Oct 11;18:1459141. doi: 10.3389/fnins.2024.1459141. eCollection 2024. Front Neurosci. 2024. PMID: 39464422 Free PMC article.
The gut microbiome and metabolomic pathways are increasingly recognized as key contributors to these conditions' pathophysiology. Suanzaoren Decoction (SZRD), a traditional Chinese herbal formulation, has demonstrated significant therapeutic benefits for both insomnia and …
The gut microbiome and metabolomic pathways are increasingly recognized as key contributors to these conditions' pathophysiology. Suanzao …
A comprehensive study on the regulation of Compound Zaoren Granules on cAMP/CREB signaling pathway and metabolic disorder in CUMS-PCPA induced insomnia rats.
Wang Z, Li D, Chen M, Yu X, Chen C, Chen Y, Zhang L, Shu Y. Wang Z, et al. J Ethnopharmacol. 2024 Oct 5;332:118401. doi: 10.1016/j.jep.2024.118401. Epub 2024 May 28. J Ethnopharmacol. 2024. PMID: 38815875 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Zaoren Granules (CZG), an optimized herbal formulation based on the traditional Chinese medicine prescription Suanzaoren decoction, are designed specifically for insomnia treatment. However, the mechanisms underlying its efficacy in …
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Zaoren Granules (CZG), an optimized herbal formulation based on the traditional Chinese medicine pr …
Suanzaoren decoction exerts its antidepressant effect via the CaMK signaling pathway.
Zhang X, Guo J, Zhang C, Wang W, Du S, Tian X. Zhang X, et al. Transl Neurosci. 2024 May 8;15(1):20220341. doi: 10.1515/tnsci-2022-0341. eCollection 2024 Jan 1. Transl Neurosci. 2024. PMID: 38736723 Free PMC article.
Calmodulin-dependent protein kinases (CaMKs) are widely regarded as "memory molecules" due to their role in controlling numerous neuronal functions in the brain, and the CaMK signaling pathway plays a crucial role in controlling synaptic plasticity. Suanzaoren decoction (S …
Calmodulin-dependent protein kinases (CaMKs) are widely regarded as "memory molecules" due to their role in controlling numerous neuronal fu …
Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.
Lv X, Bi A, Zhang Z, Li J, Wei Y, Wan M, Wang J, Yan T, Jia Y. Lv X, et al. J Pharm Biomed Anal. 2024 Apr 15;241:115980. doi: 10.1016/j.jpba.2024.115980. Epub 2024 Jan 12. J Pharm Biomed Anal. 2024. PMID: 38266455
GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui Yaolue" and Siwu Decoction in "Heji Jufang". ...
GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui …
SuanZaoRen decoction alleviates neuronal loss, synaptic damage and ferroptosis of AD via activating DJ-1/Nrf2 signaling pathway.
Long Q, Li T, Zhu Q, He L, Zhao B. Long Q, et al. J Ethnopharmacol. 2024 Apr 6;323:117679. doi: 10.1016/j.jep.2023.117679. Epub 2023 Dec 29. J Ethnopharmacol. 2024. PMID: 38160863 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positive therapeutic effects on insomnia, depression and Alzheimer's disease (AD). ...
ETHNOPHARMACOLOGICAL RELEVANCE: SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positiv …
Screening the components in multi-biological samples and the comparative pharmacokinetic study in healthy and depression model rats of Suan-Zao-Ren decoction combined with a network pharmacology.
Du Y, Wang J, Jiang L, Li J, Li J, Ren C, Yan T, Jia Y, He B. Du Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117360. doi: 10.1016/j.jep.2023.117360. Epub 2023 Oct 28. J Ethnopharmacol. 2024. PMID: 37898440
ETHNOPHARMACOLOGICAL RELEVANCE: Suanzaoren Decoction (SZRD) is a classic traditional Chinese prescription, which has been commonly used for treating insomnia, depression and other nerve system diseases for a long time. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Suanzaoren Decoction (SZRD) is a classic traditional Chinese prescription, which has been commonly us …
Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-kappaB pathway and Wnt/beta-catenin pathway.
Du Y, Yan T, Wu B, He B, Jia Y. Du Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117190. doi: 10.1016/j.jep.2023.117190. Epub 2023 Sep 20. J Ethnopharmacol. 2024. PMID: 37739105
Thus, these two aspects are conducive to the development of treatments for depression. Suanzaoren Decoction (SZRD) is a classic traditional Chinese medicine compound for the treatment of insomnia, which can clinically relieve depression symptoms, but its antidepressant pha …
Thus, these two aspects are conducive to the development of treatments for depression. Suanzaoren Decoction (SZRD) is a classic tradi …
Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of alzheimer's with diabetes.
Chen T, Lei Y, Li M, Liu X, Zhang L, Cai F, Gong X, Zhang R. Chen T, et al. Hereditas. 2024 Jan 3;161(1):2. doi: 10.1186/s41065-023-00301-z. Hereditas. 2024. PMID: 38167125 Free PMC article.
BACKGROUND: Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. ...
BACKGROUND: Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable co …
Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFkappaB/NLRP3 inflammation signal pathway.
Du Y, He B, Wu B, Yan T, Jia Y. Du Y, et al. J Chem Neuroanat. 2023 Dec;134:102349. doi: 10.1016/j.jchemneu.2023.102349. Epub 2023 Oct 23. J Chem Neuroanat. 2023. PMID: 37879571
The toll-like receptor 4 (TLR4)/ nuclear factor kappa-B kinase (NFkappaB)/ NOD-like receptor thermal protein domain associated protein 3 (NLRP3) pathway is closely associated with the regulation of microbiota-gut-brain axis. Suanzaoren Decoction (SZRD), which recorded in J …
The toll-like receptor 4 (TLR4)/ nuclear factor kappa-B kinase (NFkappaB)/ NOD-like receptor thermal protein domain associated protein 3 (NL …
Antidepressant effect of licorice total flavonoids and liquiritin: A review.
Wang R, Chen Y, Wang Z, Cao B, Du J, Deng T, Yang M, Han J. Wang R, et al. Heliyon. 2023 Nov 13;9(11):e22251. doi: 10.1016/j.heliyon.2023.e22251. eCollection 2023 Nov. Heliyon. 2023. PMID: 38074876 Free PMC article. Review.
Licorice, an excellent natural medicine with a long history of cultivation and application, is found in classical antidepressant prescriptions such as Chaihu Shugan Powder, Ganmai Dazao Decoction, Suanzaoren Decoction, etc. Licorice mainly contains triterpenoids and flavon …
Licorice, an excellent natural medicine with a long history of cultivation and application, is found in classical antidepressant prescriptio …
Research progress in the prevention and treatment of insomnia with classical prescriptions.
Shi X, Chen L, Li W, Wang R. Shi X, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Oct 28;48(10):1494-1505. doi: 10.11817/j.issn.1672-7347.2023.230200. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023. PMID: 38432879 Free PMC article. Chinese, English.
According to these 9 kinds of pathogenesis of insomnia, the corresponding classical prescriptions such as Longdanxiegan decoction, Suanzaoren decoction, Huanglian-Wendan decoction, Jiaotai pill and Guipi decoction were analyzed and summarized. ...According to these 9 kinds …
According to these 9 kinds of pathogenesis of insomnia, the corresponding classical prescriptions such as Longdanxiegan decoction, Suanza …
Modified Suanzaoren decoction in treating post-stroke cognitive impairment with comorbid insomnia symptoms: A clinical trial.
Zhu M, Pan G, Luo F, Sui S, Zhang Y. Zhu M, et al. Medicine (Baltimore). 2023 Oct 6;102(40):e35239. doi: 10.1097/MD.0000000000035239. Medicine (Baltimore). 2023. PMID: 37800827 Free PMC article. Clinical Trial.
BACKGROUND: Cognitive impairment and insomnia are common complications for stroke patients, and often coexist without effective therapy. Modified Suanzaoren decoction (M-SZRD), derived from a famous classic prescription, has been used as an alternative treatment for these …
BACKGROUND: Cognitive impairment and insomnia are common complications for stroke patients, and often coexist without effective therapy. Mod …
[Effect of Suanzaoren Decoction on expression of ionotropic glutamate receptors and synaptic plasticity in hippocampus of anxiety rats].
Wang HK, He JM, Yan YH, Wang ZH, Li RX, Wang YY. Wang HK, et al. Zhongguo Zhong Yao Za Zhi. 2023 Oct;48(20):5583-5591. doi: 10.19540/j.cnki.cjcmm.20230704.401. Zhongguo Zhong Yao Za Zhi. 2023. PMID: 38114151 Chinese.
The effect of Suanzaoren Decoction on rat behaviors were evaluated through open field experiment, elevated plus maze experiment, and light/dark box experiment. ...Furthermore, Suanzaoren Decoction significantly decreased the gene and protein expression of NMDAR(GluN …
The effect of Suanzaoren Decoction on rat behaviors were evaluated through open field experiment, elevated plus maze experiment, and …
Exploring the mechanism of Suanzaoren decoction in treatment of insomnia based on network pharmacology and molecular docking.
Wang S, Zhao Y, Hu X. Wang S, et al. Front Pharmacol. 2023 Aug 21;14:1145532. doi: 10.3389/fphar.2023.1145532. eCollection 2023. Front Pharmacol. 2023. PMID: 37670944 Free PMC article.
Objective: To explore the functional mechanisms of Suanzaoren decoction (SZRD) for treating insomnia using network pharmacology and molecular docking. ...
Objective: To explore the functional mechanisms of Suanzaoren decoction (SZRD) for treating insomnia using network pharmacology and m …
Interaction of Bmal1 and eIF2α/ATF4 pathway was involved in Shuxie compound alleviation of circadian rhythm disturbance-induced hepatic endoplasmic reticulum stress.
Zhang M, Wu W, Huang C, Cai T, Wang M, Zhao N, Liu S, Yang S. Zhang M, et al. J Ethnopharmacol. 2023 Aug 10;312:116446. doi: 10.1016/j.jep.2023.116446. Epub 2023 Apr 3. J Ethnopharmacol. 2023. PMID: 37019162
ETHNOPHARMACOLOGICAL RELEVANCE: Shuxie Compound (SX) combines the composition and efficacy of Suanzaoren decoction and Huanglian Wendan decoction. It can soothe the liver, regulate the qi, nourish the blood and calm the mind. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Shuxie Compound (SX) combines the composition and efficacy of Suanzaoren decoction and Huanglian Wend …
Screening the effective components of Suanzaoren decoction on the treatment of chronic restraint stress induced anxiety-like mice by integrated chinmedomics and network pharmacology.
Yan Y, Li J, Zhang Y, Wang H, Qin X, Zhai K, Du C. Yan Y, et al. Phytomedicine. 2023 Jul;115:154853. doi: 10.1016/j.phymed.2023.154853. Epub 2023 May 2. Phytomedicine. 2023. PMID: 37156059
BACKGROUND: Suanzaoren decoction (SZRD) is a classical traditional Chinese prescription. It is widely used to treat mental disorders, including insomnia, anxiety, and depression, in China and other Asian countries. ...
BACKGROUND: Suanzaoren decoction (SZRD) is a classical traditional Chinese prescription. It is widely used to treat mental disorders, …
[Clinical application of Chaihu Jia Longgu Muli Decoction based on modern pathophysiology mechanism].
Liu HL, Jin ZX, Su KL, Wang PQ, Xiong XJ. Liu HL, et al. Zhongguo Zhong Yao Za Zhi. 2023 May;48(10):2620-2624. doi: 10.19540/j.cnki.cjcmm.20230206.501. Zhongguo Zhong Yao Za Zhi. 2023. PMID: 37282922 Chinese.
This formula was found to be used in combination with other formulas, such as Gualou Xiebai Decoction, Wendan Decoction, Zhizhu Pills, Juzhijiang Decoction, Suanzaoren Decoction, and Banxia Baizhu Tianma Decoction....
This formula was found to be used in combination with other formulas, such as Gualou Xiebai Decoction, Wendan Decoction, Zhizhu Pills, Juzhi …
A systematic review with meta-analysis: Traditional Chinese tuina therapy for insomnia.
Wang Z, Xu H, Zhou H, Lei Y, Yang L, Guo J, Wang Y, Zhou Y. Wang Z, et al. Front Neurosci. 2023 Jan 25;16:1096003. doi: 10.3389/fnins.2022.1096003. eCollection 2022. Front Neurosci. 2023. PMID: 36760792 Free PMC article.

In terms of efficacy, tuina alone was superior to other treatments [odds ratio (OR), 3.46; 95% confidence interval (CI), 2.15, 5.55; P < 0.00001]; tuina combined with other treatments (acupuncture, scraping, auricular acupuncture, Suanzaoren decoction, estazolam) was mo

…
In terms of efficacy, tuina alone was superior to other treatments [odds ratio (OR), 3.46; 95% confidence interval (CI), 2.15, 5.55; P < …
Anxiolytic-like effect of Suanzaoren-Wuweizi herb-pair and evidence for the involvement of the monoaminergic system in mice based on network pharmacology.
Liu J, Shi JL, Guo JY, Chen Y, Ma XJ, Wang SN, Zheng ZQ, Lin MX, He S. Liu J, et al. BMC Complement Med Ther. 2023 Jan 9;23(1):7. doi: 10.1186/s12906-022-03829-1. BMC Complement Med Ther. 2023. PMID: 36624423 Free PMC article.
BACKGROUND: Suanzaoren-Wuweizi herb-pair (SWHP), composed of Zizyphi Spinosi Semen (Suanzaoren in Chinese) and Schisandrae Chinensis Fructus (Wuweizi in Chinese), is a traditional herbal formula that has been extensively used for the treatment of insomnia. The study …
BACKGROUND: Suanzaoren-Wuweizi herb-pair (SWHP), composed of Zizyphi Spinosi Semen (Suanzaoren in Chinese) and Schisandrae Chi …
The Herbal Medicine Suanzaoren (Ziziphi Spinosae Semen) for Sleep Quality Improvements: A Systematic Review and Meta-analysis.
Yang M, Wang H, Zhang YL, Zhang F, Li X, Kim SD, Chen Y, Chen J, Chimonas S, Korenstein D, Mao JJ. Yang M, et al. Integr Cancer Ther. 2023 Jan-Dec;22:15347354231162080. doi: 10.1177/15347354231162080. Integr Cancer Ther. 2023. PMID: 37014010 Free PMC article.
METHODS: We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized trials of Suanzaoren. We included randomized trials comparing Suanzaoren to placebo, medications, cognitive behavioral therapy (CB …
METHODS: We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized tria …
[Mechanism of Suanzaoren Decoction in improving insomnia rats by integrating metabolomics and intestinal flora analysis].
DU H, Liu JX, Yan Y, DU CH. DU H, et al. Zhongguo Zhong Yao Za Zhi. 2022 Dec;47(24):6741-6752. doi: 10.19540/j.cnki.cjcmm.20220902.701. Zhongguo Zhong Yao Za Zhi. 2022. PMID: 36604924 Chinese.
To explore the mechanism of Suanzaoren Decoction(SZRD) in improving the insomnia rat model induced by DL-4-chlorophenylalanine(PCPA). ...
To explore the mechanism of Suanzaoren Decoction(SZRD) in improving the insomnia rat model induced by DL-4-chlorophenylalanine(PCPA). …
Suanzaoren Decoction for the treatment of chronic insomnia: a systematic review and meta-analysis.
Liu XX, Ma YQ, Wang YG, Zhong FX, Yin XP, Zhang QM. Liu XX, et al. Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8523-8533. doi: 10.26355/eurrev_202211_30388. Eur Rev Med Pharmacol Sci. 2022. PMID: 36459033 Free article.
OBJECTIVE: Suanzaoren decoction (SZRD) in Traditional Chinese Medicine is a common prescription for chronic insomnia. ...
OBJECTIVE: Suanzaoren decoction (SZRD) in Traditional Chinese Medicine is a common prescription for chronic insomnia. ...
Study on the active components and mechanism of Suanzaoren decoction in improving cognitive impairment caused by sleep deprivation.
Cheng L, Wang F, Li ZH, Wen C, Ding L, Zhang SB, You QY. Cheng L, et al. J Ethnopharmacol. 2022 Oct 5;296:115502. doi: 10.1016/j.jep.2022.115502. Epub 2022 Jun 28. J Ethnopharmacol. 2022. PMID: 35777606
ETHNOPHARMACOLOGICAL RELEVANCE: Suanzaoren Decoction (SZRD) is a traditional and classic prescription for the treatment of insomnia, with a history of more than 1,000 years. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Suanzaoren Decoction (SZRD) is a traditional and classic prescription for the treatment of insomnia, …
Mechanisms of Action of Semen Ziziphi spinosae in the Treatment of Tourette Syndrome.
Fan F, Han F, Hao L. Fan F, et al. Degener Neurol Neuromuscul Dis. 2022 Jul 15;12:85-96. doi: 10.2147/DNND.S370278. eCollection 2022. Degener Neurol Neuromuscul Dis. 2022. PMID: 35875687 Free PMC article.
BACKGROUND: Semen Ziziphi spinosae, known as Suanzaoren (SZR) in Chinese, is a Chinese herbal medicine widely used in sedatives and tranquilizers. ...
BACKGROUND: Semen Ziziphi spinosae, known as Suanzaoren (SZR) in Chinese, is a Chinese herbal medicine widely used in sedatives and t …
Biomedical Analytics of Four Chinese Medicinals in Treatment of Insomnia Based on Network Pharmacology.
Deng Q, Huang L, Yu F, Lin J, Hu L, Zhao J, Pan L, Kui Y, Wu S. Deng Q, et al. Biomed Res Int. 2022 May 31;2022:9414262. doi: 10.1155/2022/9414262. eCollection 2022. Biomed Res Int. 2022. PMID: 35769674 Free PMC article.
AIM: Our aim is to recommend the appropriate Chinese medicinals in clinical treatment of insomnia, which are suanzaoren (Semen Ziziphi Spinosae), chuanxiong (Rhizoma Chuanxiong), fuling (Poria), and baishao (Radix Paeoniae Alba). ...
AIM: Our aim is to recommend the appropriate Chinese medicinals in clinical treatment of insomnia, which are suanzaoren (Semen Ziziph …
[Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction].
Liu JX, Li JH, DU CH, Yan Y. Liu JX, et al. Zhongguo Zhong Yao Za Zhi. 2022 Mar;47(6):1632-1641. doi: 10.19540/j.cnki.cjcmm.20211204.701. Zhongguo Zhong Yao Za Zhi. 2022. PMID: 35347962 Chinese.
Suanzaoren Decoction(SZRD) is a classical formula for the clinical treatment of insomnia. ...
Suanzaoren Decoction(SZRD) is a classical formula for the clinical treatment of insomnia. ...
[Effect of Suanzaoren Decoction on molecular levels of bile acids in serum, liver, and ileum of insomnia mice].
Zhang Z, Huang YF, Zhao WW, Sun XR, Han HC, Wang X, Jing ZQ, Ma PK, Zhang YJ. Zhang Z, et al. Zhongguo Zhong Yao Za Zhi. 2022 Jan;47(1):159-166. doi: 10.19540/j.cnki.cjcmm.20210802.402. Zhongguo Zhong Yao Za Zhi. 2022. PMID: 35178923 Chinese.
To explore the mechanism of Suanzaoren Decoction in the treatment of insomnia from endogenous bile acid regulation, the present study investigated the hepatoprotective effect of Suanzaoren Decoction and the molecular changes of bile acids in the serum, liver, and il …
To explore the mechanism of Suanzaoren Decoction in the treatment of insomnia from endogenous bile acid regulation, the present study …
Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis.
Dong YJ, Jiang NH, Zhan LH, Teng X, Fang X, Lin MQ, Xie ZY, Luo R, Li LZ, Li B, Zhang BB, Lv GY, Chen SH. Dong YJ, et al. Biomed Pharmacother. 2021 Nov;143:112141. doi: 10.1016/j.biopha.2021.112141. Epub 2021 Sep 10. Biomed Pharmacother. 2021. PMID: 34509822 Free article.
AIM: Modified Suanzaoren Decoction (MSZRD) is obtained by improving Suanzaoren Decoction (SZRT), a traditional Chinese herbal prescription that has been used to treat insomnia for more than thousands of years. ...
AIM: Modified Suanzaoren Decoction (MSZRD) is obtained by improving Suanzaoren Decoction (SZRT), a traditional Chinese herbal …
Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder.
Liu YY, Yu LH, Zhang J, Xie DJ, Zhang XX, Yu JM. Liu YY, et al. Biomed Res Int. 2021 Oct 8;2021:1752570. doi: 10.1155/2021/1752570. eCollection 2021. Biomed Res Int. 2021. PMID: 34660782 Free PMC article.
This study is aimed at exploring the possible mechanism of action of the Suanzaoren decoction (SZRD) in the treatment of Parkinson's disease with sleep disorder (PDSD) based on network pharmacology and molecular docking. ...
This study is aimed at exploring the possible mechanism of action of the Suanzaoren decoction (SZRD) in the treatment of Parkinson's …
Efficacy and safety of electroacupuncture combined with Suanzaoren decoction for insomnia following stroke: study protocol for a randomized controlled trial.
Huang HL, Yang SB, Mei ZG, Huang YG, Chen MH, Mei QL, Lei HP, Mei QX, Chen JH. Huang HL, et al. Trials. 2021 Jul 24;22(1):485. doi: 10.1186/s13063-021-05399-y. Trials. 2021. PMID: 34496928 Free PMC article.
Traditional Chinese medicine (TCM), including acupuncture and the Chinese herbal medication (CHM) Suanzaoren decoction (SZRD), has been reported as an alternative option for insomnia relief after stroke in China for thousands of years. ...
Traditional Chinese medicine (TCM), including acupuncture and the Chinese herbal medication (CHM) Suanzaoren decoction (SZRD), has be …
From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors.
Ma K, Wang X, Feng S, Xia X, Zhang H, Rahaman A, Dong Z, Lu Y, Li X, Zhou X, Zhao H, Wang Y, Wang S, Baloch Z. Ma K, et al. Biomed Pharmacother. 2020 Dec;132:110810. doi: 10.1016/j.biopha.2020.110810. Epub 2020 Sep 30. Biomed Pharmacother. 2020. PMID: 33053508 Free PMC article. Review.
CONCLUSION: Lily Bulb, Rhizoma Anemarrhena Decoction and Ganmai Dazao Decoction were used to treat depression. Suanzaoren Decoction, Huanglian Ejiao Decoction and Zhizi Chi Decoction were suggested for anxiety. ...
CONCLUSION: Lily Bulb, Rhizoma Anemarrhena Decoction and Ganmai Dazao Decoction were used to treat depression. Suanzaoren Decoction, …
Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.
Zhao CB, Liu J, Shi JL, Wang SN, Ding YS, He S, Lin MX, Luo J, Jiang YN, Bian LH, Yao ZW, Li QY, Wang XM, Guo JY. Zhao CB, et al. Evid Based Complement Alternat Med. 2020 Jun 17;2020:2078932. doi: 10.1155/2020/2078932. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32655658 Free PMC article.
Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs. The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer. SWHP has bee …
Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consist …
Soporific Effect of Modified Suanzaoren Decoction and Its Effects on the Expression of CCK-8 and Orexin-A.
Zhan LH, Dong YJ, Yang K, Lei SS, Li B, Teng X, Zhou C, Luo R, Yu QX, Jin HY, Lv GY, Chen SH. Zhan LH, et al. Evid Based Complement Alternat Med. 2020 Jun 16;2020:6984087. doi: 10.1155/2020/6984087. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32617111 Free PMC article.
Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousand years. ...Herein, we studied the effects of modified Suanzaoren decoction (MSZRD) on gastrointestinal disorder-related insomnia. Th …
Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousan …
[Review of chemical constituents, pharmacological effects and clinical applications of Suanzaoren Decoction and prediction and analysis of its Q-markers].
Wang Y, Yang X, Xia PF, Ma X, Yang RJ, Wang YX, Fan Q, Zhao L. Wang Y, et al. Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2765-2771. doi: 10.19540/j.cnki.cjcmm.20190812.201. Zhongguo Zhong Yao Za Zhi. 2020. PMID: 32627449 Chinese.
Suanzaoren Decoction is a classic prescription for nourishing the heart and liver, nourishing blood and tranquilizing the mind. ...The results indicated that jujuboside, spinosin, ferulic acid, senkyunolide , sarsasapogenin, mangiferin, liquiritoside and glycyrrhizic acid …
Suanzaoren Decoction is a classic prescription for nourishing the heart and liver, nourishing blood and tranquilizing the mind. ...Th …
Efficacy and Safety of Jiawei Suanzaoren Decoction Combined with Lorazepam for Chronic Insomnia: A Parallel-Group Randomized Controlled Trial.
Song MF, Chen LQ, Shao QY, Hu LL, Liu WJ, Zhang YH. Song MF, et al. Evid Based Complement Alternat Med. 2020 Feb 8;2020:3450989. doi: 10.1155/2020/3450989. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32089719 Free PMC article.
BACKGROUND: Chronic insomnia is a major public health problem, but there are limited effective therapies. Jiawei Suanzaoren Decoction (JW-SZRD) has been used as an alternative option for treating insomnia. ...
BACKGROUND: Chronic insomnia is a major public health problem, but there are limited effective therapies. Jiawei Suanzaoren Decoction …
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Gu M, He P, Lyu C, Liu X, Xu Y, Cheng S, Gu Y, Jia Y. Gu M, et al. Mol Med Rep. 2019 Nov;20(5):4253-4261. doi: 10.3892/mmr.2019.10686. Epub 2019 Sep 16. Mol Med Rep. 2019. PMID: 31545438 Free PMC article.
Several herbal formulae that containing Semen Ziziphi Spinosae (SZS), also called Suanzaoren in Chinese, are clinically effective in the treatment of patients with acute myocardial infarction (AMI). ...
Several herbal formulae that containing Semen Ziziphi Spinosae (SZS), also called Suanzaoren in Chinese, are clinically effective in …
In Silico Study of Anti-Insomnia Mechanism for Suanzaoren Prescription.
Gao J, Wang Q, Huang Y, Tang K, Yang X, Cao Z. Gao J, et al. Front Pharmacol. 2019 Aug 22;10:925. doi: 10.3389/fphar.2019.00925. eCollection 2019. Front Pharmacol. 2019. PMID: 31507421 Free PMC article.
As an alternative treatment, Chinese herbal formula Suanzaoren prescription (SZRP), composed of Suanzaoren [seeds of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F.Chow] and four additional herbs, has been reported with significant anti-insomnia effects. ...The resu …
As an alternative treatment, Chinese herbal formula Suanzaoren prescription (SZRP), composed of Suanzaoren [seeds of Ziziphus …
The investigation of immunoprotective and sedative hypnotic effect of total polysaccharide from Suanzaoren decoction by serum metabonomics approach.
Niu X, He B, Du Y, Sui Z, Rong W, Wang X, Li Q, Bi K. Niu X, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:29-37. doi: 10.1016/j.jchromb.2018.04.004. Epub 2018 Apr 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29654984
Suanzaoren decoction, as one of the traditional Chinese medicine prescriptions, has been most commonly used in Asian countries and reported to inhibit the process of immunodeficiency insomnia. ...This study provides a useful approach for exploring the mechanism and evaluat …
Suanzaoren decoction, as one of the traditional Chinese medicine prescriptions, has been most commonly used in Asian countries and re …
Suanzaoren Formulae for Insomnia: Updated Clinical Evidence and Possible Mechanisms.
Zhou QH, Zhou XL, Xu MB, Jin TY, Rong PQ, Zheng GQ, Lin Y. Zhou QH, et al. Front Pharmacol. 2018 Feb 9;9:76. doi: 10.3389/fphar.2018.00076. eCollection 2018. Front Pharmacol. 2018. PMID: 29479317 Free PMC article. Review.
Insomnia disorder is a widespread and refractory disease. Semen Ziziphi Spinosae, Suanzaoren, a well-known Chinese herbal medicine, has been used for treating insomnia for thousands of years. Here, we aimed to assess the available evidence of Chinese herbal formulae that c …
Insomnia disorder is a widespread and refractory disease. Semen Ziziphi Spinosae, Suanzaoren, a well-known Chinese herbal medicine, h …
Simultaneous quantitative determination of 13 active components in the traditional Chinese medicinal preparation Suanzaoren oral liquid by HPLC coupled with diode array detection and evaporative light scattering detection.
Zhu L, Wang Z, Zhai X, Sui Z, Wang D, Li Q, Bi K, He B, Wang T. Zhu L, et al. J Sep Sci. 2017 Jun;40(11):2320-2325. doi: 10.1002/jssc.201700061. Epub 2017 Apr 24. J Sep Sci. 2017. PMID: 28371233
To control the quality of different forms of Suanzaoren decoction, an effective and reliable method for the simultaneous determination of 13 major components (neomangiferin, mangiferin, spinosin, liquiritin apioside, liquiritin, 6'''-feruloylspinosin, senkyunolide I, timos …
To control the quality of different forms of Suanzaoren decoction, an effective and reliable method for the simultaneous determinatio …
Efficacy and safety of suanzaoren decoction for chronic insomnia disorder in adults: study protocol for randomised, double-blind, double-dummy, placebo-controlled trial.
Zhou QH, Wang HL, Zhou XL, Xu MB, Zhang HF, Huang LB, Zheng GQ, Lin Y. Zhou QH, et al. BMJ Open. 2017 Apr 4;7(4):e014280. doi: 10.1136/bmjopen-2016-014280. BMJ Open. 2017. PMID: 28377394 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of suanzaoren decoction (SZRD), a classic Chinese herbal prescription, for adult chronic insomnia disorder. ...
OBJECTIVE: To evaluate the efficacy and safety of suanzaoren decoction (SZRD), a classic Chinese herbal prescription, for adult chron …
Treatment of Insomnia With Traditional Chinese Herbal Medicine.
Singh A, Zhao K. Singh A, et al. Int Rev Neurobiol. 2017;135:97-115. doi: 10.1016/bs.irn.2017.02.006. Epub 2017 Apr 3. Int Rev Neurobiol. 2017. PMID: 28807167 Review.
This brought complexity and difficulties to identify which are the essential key herbs or formulas. It was found Suanzaoren decoction (Ziziphus spinose decoction ) is the most frequently used formula for the treatment of insomnia. Based on the clinical data, several herbs …
This brought complexity and difficulties to identify which are the essential key herbs or formulas. It was found Suanzaoren decoction …
Efficacy and safety of the Chaihuguizhiganjiang-suanzaoren granule on primary insomnia: study protocol for a randomised controlled trial.
Liu QQ, Zhang J, Guo RJ, Xie YZ, Fu QN, He T, Zhu XQ, Du J, Yang J, Wang JL, Wei MM, Li QQ, Shi GX, Liu CZ. Liu QQ, et al. BMJ Open. 2016 Feb 2;6(2):e008459. doi: 10.1136/bmjopen-2015-008459. BMJ Open. 2016. PMID: 26839010 Free PMC article. Clinical Trial.
We aim to evaluate the efficacy and safety of the Chaihuguizhiganjiang-suanzaoren granule (CSG), a Chinese herbal medicine treatment, in patients with primary insomnia. ...
We aim to evaluate the efficacy and safety of the Chaihuguizhiganjiang-suanzaoren granule (CSG), a Chinese herbal medicine treatment, …
Simultaneous Determinations of Eleven Bioactive Components in Suanzaoren Decoction Granules by High-Performance Liquid Chromatography and Its Application to the Quality Control in Productive Processes.
Kuang Y, He B, DU Y, Li J, Wang D, Bi K, Li Q. Kuang Y, et al. Anal Sci. 2016;32(9):931-6. doi: 10.2116/analsci.32.931. Anal Sci. 2016. PMID: 27682396 Free article.
A simple and reliable method using high-performance liquid chromatography coupled with a photodiode array detector (HPLC-PDA) was firstly established for the determinations of eleven bioactive compounds (neomangiferin, mangiferin, spinosin, liquiritin apioside, liquiritin, fumali …
A simple and reliable method using high-performance liquid chromatography coupled with a photodiode array detector (HPLC-PDA) was firstly es …
Efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder: a randomized, double-blind, controlled trial.
Ye Q, Zhou J, Yuan X, Yuan C, Yang X. Ye Q, et al. J Tradit Chin Med. 2015 Aug;35(4):381-8. doi: 10.1016/s0254-6272(15)30113-8. J Tradit Chin Med. 2015. PMID: 26427106 Free article. Clinical Trial.
The treatment group was given Zhenjingdingzhi decoction, while the control group was treated with Suanzaoren decoction. The pharmacological treatment lasted for 8 weeks. The clinical efficacy was assessed by using Spiegel scale, Pittsburgh sleep quality index (PSQ) and Tra …
The treatment group was given Zhenjingdingzhi decoction, while the control group was treated with Suanzaoren decoction. The pharmacol …
[Identification of constituents in Suanzaoren tang by LC-Q-TOF-MS and LC-IT-MS].
Zhu YX, Chen LL, Gong JR, Wang SF. Zhu YX, et al. Zhongguo Zhong Yao Za Zhi. 2014 Feb;39(3):457-65. Zhongguo Zhong Yao Za Zhi. 2014. PMID: 24946548 Chinese.
LC-Q-TOF-MS and LC-IT-MS in positive and negative ion mode were applied to simultaneously characterize the constituents in Suanzaoren tang. Analysis was performed on an Agilent Zorbax SB-C18, Rapid Resolution HT column(4.6 mmx 50 mm, 1. 8 micro m) with gradient elution of …
LC-Q-TOF-MS and LC-IT-MS in positive and negative ion mode were applied to simultaneously characterize the constituents in Suanzaoren …
[Study on quality control method of suanzaoren hehuan formula and fingerprint of its saponins parts].
Liang Y, Zhang QW, Sun Y, Meng F, Qiao W, Chen C. Liang Y, et al. Zhong Yao Cai. 2014 Jan;37(1):126-9. Zhong Yao Cai. 2014. PMID: 25090716 Chinese.
OBJECTIVE: To establish the method for determining total saponins and paeoniflorin in Suanzaoren Hehuan Formula (SHF) and an HPLC fingerprint of its saponins parts. METHODS: The total saponins in SHF was determined by ultraviolet spectrophotometry at 545 nm. ...
OBJECTIVE: To establish the method for determining total saponins and paeoniflorin in Suanzaoren Hehuan Formula (SHF) and an HPLC fin …
Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials.
Xie CL, Gu Y, Wang WW, Lu L, Fu DL, Liu AJ, Li HQ, Li JH, Lin Y, Tang WJ, Zheng GQ. Xie CL, et al. BMC Complement Altern Med. 2013 Jan 22;13:18. doi: 10.1186/1472-6882-13-18. BMC Complement Altern Med. 2013. PMID: 23336848 Free PMC article.
BACKGROUND: Insomnia is a widespread human health problem, but there currently are the limitations of conventional therapies available. Suanzaoren decoction (SZRD) is a well known classic Chinese herbal prescription for insomnia and has been treating people's insomnia for …
BACKGROUND: Insomnia is a widespread human health problem, but there currently are the limitations of conventional therapies available. S …
Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry.
Yang B, Zhang A, Sun H, Dong W, Yan G, Li T, Wang X. Yang B, et al. J Pharm Biomed Anal. 2012 Jan 25;58:113-24. doi: 10.1016/j.jpba.2011.09.033. Epub 2011 Oct 4. J Pharm Biomed Anal. 2012. PMID: 22019702
Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context, and its property consists with the global view of traditional Chinese medicine (TCM). Suanzaoren decoction (SZRD), an ancient TCM formulae, has been used fo …
Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context, and its property consis …
Prescription of chinese herbal medicine and selection of acupoints in pattern-based traditional chinese medicine treatment for insomnia: a systematic review.
Yeung WF, Chung KF, Poon MM, Ho FY, Zhang SP, Zhang ZJ, Ziea ET, Wong Taam V. Yeung WF, et al. Evid Based Complement Alternat Med. 2012;2012:902578. doi: 10.1155/2012/902578. Epub 2012 Nov 28. Evid Based Complement Alternat Med. 2012. PMID: 23259001 Free PMC article.
Except for Gui Pi Tang, An Shen Ding Zhi Wan, and Wen Dan Tang which were used more commonly for deficiency of both the heart and spleen, internal disturbance of phlegm-heat, and qi deficiency of the heart and gallbladder, respectively, the selection of herbal formula for other p …
Except for Gui Pi Tang, An Shen Ding Zhi Wan, and Wen Dan Tang which were used more commonly for deficiency of both the heart and spleen, in …
Ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction.
Yang B, Dong W, Zhang A, Sun H, Wu F, Wang P, Wang X. Yang B, et al. J Sep Sci. 2011 Nov;34(22):3208-15. doi: 10.1002/jssc.201100632. Epub 2011 Oct 12. J Sep Sci. 2011. PMID: 21994021
A rapid, sensitive, specific and reliable ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS) method with MassLynx MassFragment was developed for the analysis of Suanzaoren decoction ( …
A rapid, sensitive, specific and reliable ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-fl …
[Discussion of related problems in herbal prescription science based on objective indications of herbs].
Xiong XJ, Wang J. Xiong XJ, et al. Zhong Xi Yi Jie He Xue Bao. 2010 Jan;8(1):20-4. doi: 10.3736/jcim20100104. Zhong Xi Yi Jie He Xue Bao. 2010. PMID: 20082753 Chinese.
In studying the doctrines in the general textbook Herbal Prescription Science and applying them to clinical practice, it was found that they are imprecise and inapplicable. Based on the analysis of Suanzaoren Decoction, Xiaoqinglong Decoction, Jichuan Decoction, etc., the …
In studying the doctrines in the general textbook Herbal Prescription Science and applying them to clinical practice, it was found that they …
Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suanzaoren) and Radix et Rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations.
Fang XSh, Hao JF, Zhou HY, Zhu LX, Wang JH, Song FQ. Fang XSh, et al. Phytomedicine. 2010 Jan;17(1):75-80. doi: 10.1016/j.phymed.2009.07.004. Epub 2009 Aug 13. Phytomedicine. 2010. PMID: 19682877
Semen Ziziphi spinosae (Suanzaoren in China) and Radix et Rhizoma Salviae miltiorrhizae (Danshen in China) are conventional herbal drugs in traditional Chinese medicine and have been used widely for the treatment of insomnia. In the present study, the sedative-hypnotic act …
Semen Ziziphi spinosae (Suanzaoren in China) and Radix et Rhizoma Salviae miltiorrhizae (Danshen in China) are conventional herbal dr …
What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation.
Chen CY, Chen YF, Tsai HY. Chen CY, et al. J Biomol Struct Dyn. 2008 Aug;26(1):57-64. doi: 10.1080/07391102.2008.10507223. J Biomol Struct Dyn. 2008. PMID: 18533726
Investigation of the major effective constituents from suanzaoren to modulate the GABA-A was the aim of the study. Jujuboside A, which was indicated to be the effective constituent from suanzaoren, had no blood-brain barrier (BBB) penetration and was unable to bind …
Investigation of the major effective constituents from suanzaoren to modulate the GABA-A was the aim of the study. Jujuboside A, whic …
[Study on the factors of Suanzaoren decoction action by correspondence analysis combined with uniform design].
Li R. Li R. Zhong Yao Cai. 2007 Jun;30(6):694-6. Zhong Yao Cai. 2007. PMID: 17918444 Chinese.
METHODS: The number of spontaneous activities was determined to study the influence of the factors Suanzaoren decoction action by correspondence analysis combined with uniform design. RESULTS: According to the correlation degree of each factors, there was positive correlat …
METHODS: The number of spontaneous activities was determined to study the influence of the factors Suanzaoren decoction action by cor …
[Effect of Suanzaoren decoction on acute hepatic failure in mice].
Zhu HP, Gao ZL, Tan DM, Zhong YD. Zhu HP, et al. Zhongguo Zhong Yao Za Zhi. 2007 Apr;32(8):718-21. Zhongguo Zhong Yao Za Zhi. 2007. PMID: 17608229 Chinese.
Suanzaoren decoction inhibited the serum the levels of ALT, AST, TNF-alpha and IL-1, and reduced the levels of MDA, NO and NOS and increased the levels of GR and SOD in the liver. CONCLUSION: Treatment with Suanzaoren decoction can suppress the D-Gal-N/LPS-induced a …
Suanzaoren decoction inhibited the serum the levels of ALT, AST, TNF-alpha and IL-1, and reduced the levels of MDA, NO and NOS and in …
[Clinical observation on auxiliary treatment with suanzaoren decoction for chronic severe hepatitis].
Zhu HP, Gao ZL, Tan DM. Zhu HP, et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Apr;27(4):303-5. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007. PMID: 17526166 Clinical Trial. Chinese.
OBJECTIVE: To investigate the curative effect and safety of auxiliary treatment with Suanzaoren Decoction (SZRD) on patients with chronic severe hepatitis (CSH). METHODS: Sixty patients, with the diagnosis in accordance with the diagnostic criterion of CSH, were assigned t …
OBJECTIVE: To investigate the curative effect and safety of auxiliary treatment with Suanzaoren Decoction (SZRD) on patients with chr …
Study on the therapeutic material basis of traditional chinese medicinal preparation Suanzaoren decoction.
Li YJ, Bi KS. Li YJ, et al. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):847-51. doi: 10.1248/cpb.54.847. Chem Pharm Bull (Tokyo). 2006. PMID: 16755056 Free article.
Methodology for elucidating the therapeutic material basis and quality control indices of Traditional Chinese Medicinal Preparation Suanzaoren decoction was developed. Combination of Suanzaoren decoction was designed and sixteen groups were obtained. Effects on freq …
Methodology for elucidating the therapeutic material basis and quality control indices of Traditional Chinese Medicinal Preparation Suanz …
[Clinical features of Wei Yuheng].
Yu ZY. Yu ZY. Zhonghua Yi Shi Za Zhi. 2006 Apr;36(2):79-82. Zhonghua Yi Shi Za Zhi. 2006. PMID: 17096983 Chinese.
If the yin blood is insufficient, Semen Ziziphi Spinosae (Suanzaoren) should be added. In order to prepare a out way for phlegm-heat caused dy liver yin deficiency, a lubricative, Semen Trichosanthis (Gualouren) was always used and raw Semen Coicis Recens (Shengyiyiren) to …
If the yin blood is insufficient, Semen Ziziphi Spinosae (Suanzaoren) should be added. In order to prepare a out way for phlegm-heat …
Simultaneous determination of saponins and fatty acids in Ziziphus jujuba (Suanzaoren) by high performance liquid chromatography-evaporative light scattering detection and pressurized liquid extraction.
Zhao J, Li SP, Yang FQ, Li P, Wang YT. Zhao J, et al. J Chromatogr A. 2006 Mar 10;1108(2):188-94. doi: 10.1016/j.chroma.2005.12.104. Epub 2006 Feb 3. J Chromatogr A. 2006. PMID: 16458908
The seed of Ziziphus jujube Mill. var. spinosa (Bunge) Hu ex H. F. Chou, Suanzaoren in Chinese, is one of commonly used Chinese medicines. Saponins and fatty oil contains several fatty acids in Suanzaoren are responsible for its therapeutic activities. ...The valida …
The seed of Ziziphus jujube Mill. var. spinosa (Bunge) Hu ex H. F. Chou, Suanzaoren in Chinese, is one of commonly used Chinese medic …
Pharmacokinetics of mangiferin in rat plasma after oral administration of a single dose of suanzaoren decoction.
Li YJ, Bi KS. Li YJ, et al. Yao Xue Xue Bao. 2005 Feb;40(2):164-7. Yao Xue Xue Bao. 2005. PMID: 15875675
AIM: To study the pharmacokinetics of mangiferin in rats after oral administration of a single dose of Suanzaoren decoction. METHODS: An HPLC method was established using puerain as internal standard. ...CONCLUSION: The validated HPLC method developed has been applied to t …
AIM: To study the pharmacokinetics of mangiferin in rats after oral administration of a single dose of Suanzaoren decoction. METHODS: …
HPLC determination of ferulic acid in rat plasma after oral administration of Rhizoma Chuanxiong and its compound preparation.
Li Y, Bi K. Li Y, et al. Biomed Chromatogr. 2003 Dec;17(8):543-6. doi: 10.1002/bmc.274. Biomed Chromatogr. 2003. PMID: 14648613
The method was successfully applied to the determination of pharmacokinetic parameters in rat plasma after oral administration of Rhizoma Chuanxiong and and its compound preparation Suanzaoren decoctions. The calibration curve was linear over the range 0.0510-4.08 micro g/ …
The method was successfully applied to the determination of pharmacokinetic parameters in rat plasma after oral administration of Rhizoma Ch …
Pharmacokinetic study on spinosin in rat plasma after oral administration of suanzaoren extract at a single dose.
Li YJ, Liang XM, Xiao HB, Bi KS. Li YJ, et al. Yao Xue Xue Bao. 2003 Jun;38(6):448-50. Yao Xue Xue Bao. 2003. PMID: 14513806
AIM: To study the pharmacokinetics of spinosin in rat plasma after oral administration of Suanzaoren extract using sulfamethoxazole (SMZ) as internal standard by RP-HPLC method. METHODS: Plasma samples were deproteined with acetonitrile, followed by evaporation of the acet …
AIM: To study the pharmacokinetics of spinosin in rat plasma after oral administration of Suanzaoren extract using sulfamethoxazole ( …
Determination of spinosin in rat plasma by reversed-phase high-performance chromatography after oral administration of Suanzaoren decoction.
Li Y, Liang X, Xiao H, Bi K. Li Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 25;787(2):421-5. doi: 10.1016/s1570-0232(02)01001-2. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12650764
The HPLC method developed has been applied to determine the pharmacokinetics of spinosin in rat plasma after having taken Suanzaoren decoction....
The HPLC method developed has been applied to determine the pharmacokinetics of spinosin in rat plasma after having taken Suanzaoren …
[Pharmacodynamics study of suanzaoren decoction extracted by different technological process].
Li Y, Wang R, Chen M, Wang Z, Bi K. Li Y, et al. Zhong Yao Cai. 2001 Dec;24(12):884-5. Zhong Yao Cai. 2001. PMID: 11917848 Chinese.
OBJECTIVE: To select the optimal technological process for Suanzaoren decoction. METHOD: The effects of extracts from different technological processes on spontaneous motion and sleep time in mice induced by pentobarbital sodium (subthreshold dosage) were studied. RESULTS: …
OBJECTIVE: To select the optimal technological process for Suanzaoren decoction. METHOD: The effects of extracts from different techn …
Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs.
Liao JF, Jan YM, Huang SY, Wang HH, Yu LL, Chen CF. Liao JF, et al. Proc Natl Sci Counc Repub China B. 1995 Jul;19(3):151-8. Proc Natl Sci Counc Repub China B. 1995. PMID: 7480361
These ten herbal drugs are Chaihu (Radix Bupleuri), Chuanxiong (Rhizoma Chuanxiong), Danggui (Radix Angelicae sinensis), Danshen (Radix Salviae miltiorrhizae), Duhuo (Radix Angelicae pubescentis), Hangqin (Radix Scutellariae), Qinjiao (Radix Gentianae macrophyllae), Shengma (Rhiz …
These ten herbal drugs are Chaihu (Radix Bupleuri), Chuanxiong (Rhizoma Chuanxiong), Danggui (Radix Angelicae sinensis), Danshen (Radix Salv …
[Observation on the efficacy and experimental study of compound suanzaoren ansen capsules in insomnia].
Ma YD, Li RH. Ma YD, et al. Zhong Xi Yi Jie He Za Zhi. 1989 Feb;9(2):85-7, 68-9. Zhong Xi Yi Jie He Za Zhi. 1989. PMID: 2736692 Chinese.
374 patients suffering from insomnia were divided into three groups by random: 202 cases in group I were treated with compound Suanzaoren Ansen capsules (SAC); 85 cases in group II were treated with Zhusha Ansen pills (ZAP) as control; 87 cases in group III were treated wi …
374 patients suffering from insomnia were divided into three groups by random: 202 cases in group I were treated with compound Suanzaoren …