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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1992 1
1994 3
1995 3
1996 4
1997 9
1998 6
1999 12
2000 12
2001 21
2002 23
2003 26
2004 42
2005 64
2006 68
2007 68
2008 80
2009 103
2010 122
2011 146
2012 162
2013 182
2014 181
2015 186
2016 203
2017 217
2018 258
2019 223
2020 218
2021 1
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2,288 results
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Isothiocyanate from Broccoli, Sulforaphane, and Its Properties.
Vanduchova A, Anzenbacher P, Anzenbacherova E. Vanduchova A, et al. J Med Food. 2019 Feb;22(2):121-126. doi: 10.1089/jmf.2018.0024. Epub 2018 Oct 27. J Med Food. 2019. PMID: 30372361 Review.
Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane
Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through me …
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.
Russo M, Spagnuolo C, Russo GL, Skalicka-Woźniak K, Daglia M, Sobarzo-Sánchez E, Nabavi SF, Nabavi SM. Russo M, et al. Crit Rev Food Sci Nutr. 2018 May 24;58(8):1391-1405. doi: 10.1080/10408398.2016.1259983. Epub 2017 Jul 21. Crit Rev Food Sci Nutr. 2018. PMID: 28001083 Review.
Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. ...At molecular level, sulforaphane modu
Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts again
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
Houghton CA, Fassett RG, Coombes JS. Houghton CA, et al. Oxid Med Cell Longev. 2016;2016:7857186. doi: 10.1155/2016/7857186. Epub 2016 Jan 6. Oxid Med Cell Longev. 2016. PMID: 26881038 Free PMC article. Review.
Broccoli-derived sulforaphane emerges as a phytochemical with this capability, with oral doses capable of favourably modifying genes associated with chemoprevention. ...Both its high bioavailability and significant Nrf2 inducer capacity contribute to the therapeutic potent …
Broccoli-derived sulforaphane emerges as a phytochemical with this capability, with oral doses capable of favourably modifying genes …
Chemopreventive activity of sulforaphane.
Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G. Jiang X, et al. Drug Des Devel Ther. 2018 Sep 11;12:2905-2913. doi: 10.2147/DDDT.S100534. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30254420 Free PMC article. Review.
Over the years, sulforaphane (SFN), found in cruciferous vegetables, has been shown to have chemopreventive activity in vitro and in vivo. ...
Over the years, sulforaphane (SFN), found in cruciferous vegetables, has been shown to have chemopreventive activity in vitro and in …
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW. Singh K, et al. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313065 Free PMC article. Clinical Trial.
Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvemen …
Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants …
Potential effects of sulforaphane to fight obesity.
Martins T, Colaço B, Venâncio C, Pires MJ, Oliveira PA, Rosa E, Antunes LM. Martins T, et al. J Sci Food Agric. 2018 Jun;98(8):2837-2844. doi: 10.1002/jsfa.8898. Epub 2018 Mar 7. J Sci Food Agric. 2018. PMID: 29363750 Review.
Simultaneously, in the last decade, the effects of sulforaphane as a potential treatment for obesity have been investigated, with promising results. ...Valorization of these co-products could be achieved through their exploitation for the extraction of bioactive compounds …
Simultaneously, in the last decade, the effects of sulforaphane as a potential treatment for obesity have been investigated, with pro …
Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.
Yang L, Palliyaguru DL, Kensler TW. Yang L, et al. Semin Oncol. 2016 Feb;43(1):146-153. doi: 10.1053/j.seminoncol.2015.09.013. Epub 2015 Sep 8. Semin Oncol. 2016. PMID: 26970133 Free PMC article. Review.
For reasons of experimental exigency, preclinical studies have focused principally on sulforaphane itself, while clinical studies have relied on broccoli sprout preparations rich in either sulforaphane or its biogenic precursor, glucoraphanin. ...Sulforaphane
For reasons of experimental exigency, preclinical studies have focused principally on sulforaphane itself, while clinical studies hav …
Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase.
Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P. Fahey JW, et al. PLoS One. 2015 Nov 2;10(11):e0140963. doi: 10.1371/journal.pone.0140963. eCollection 2015. PLoS One. 2015. PMID: 26524341 Free PMC article.
Sulforaphane is difficult to deliver in an enriched and stable form for purposes of direct human consumption. We have focused upon evaluating the bioavailability of sulforaphane, either by direct administration of glucoraphanin (a glucosinolate, or β-thioglucoside-N
Sulforaphane is difficult to deliver in an enriched and stable form for purposes of direct human consumption. We have focused upon ev
Effects of sulforaphane in the central nervous system.
Huang C, Wu J, Chen D, Jin J, Wu Y, Chen Z. Huang C, et al. Eur J Pharmacol. 2019 Jun 15;853:153-168. doi: 10.1016/j.ejphar.2019.03.010. Epub 2019 Mar 8. Eur J Pharmacol. 2019. PMID: 30858063 Review.
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is a common mechanism for the anti-oxidative and anti-inflammatory activity of some herb-derive
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. Activation of the nuclear factor (
Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.
Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Bauman JE, et al. Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. Epub 2016 Jun 23. Cancer Prev Res (Phila). 2016. PMID: 27339168 Free PMC article. Clinical Trial.
Sulforaphane also promoted NRF2-independent dephosphorylation/inactivation of pSTAT3, a key oncogenic factor in HNSCC. Compared with vehicle, sulforaphane significantly reduced the incidence and size of 4NQO-induced tongue tumors in mice. ...Ingestion of sulforap
Sulforaphane also promoted NRF2-independent dephosphorylation/inactivation of pSTAT3, a key oncogenic factor in HNSCC. Compared with
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