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72 results
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Filters applied: Clinical Trial. Clear all
Page 1
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW. Singh K, et al. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313065 Free PMC article. Clinical Trial.
Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvemen …
Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants …
Bioavailability of Glucoraphanin and Sulforaphane from High-Glucoraphanin Broccoli.
Sivapalan T, Melchini A, Saha S, Needs PW, Traka MH, Tapp H, Dainty JR, Mithen RF. Sivapalan T, et al. Mol Nutr Food Res. 2018 Sep;62(18):e1700911. doi: 10.1002/mnfr.201700911. Epub 2018 Mar 8. Mol Nutr Food Res. 2018. PMID: 29266773 Free PMC article. Clinical Trial.
This study seeks to quantify the exposure of human tissues to glucoraphanin and sulforaphane following consumption of broccoli with contrasting Myb28 genotypes. ...CONCLUSION: This is the first study to report the bioavailability of glucoraphanin and sulforaphane fr …
This study seeks to quantify the exposure of human tissues to glucoraphanin and sulforaphane following consumption of broccoli with c …
Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.
Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Bauman JE, et al. Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. Epub 2016 Jun 23. Cancer Prev Res (Phila). 2016. PMID: 27339168 Free PMC article. Clinical Trial.
Ingestion of sulforaphane-rich BSE demonstrated the greatest, most consistent bioavailability. Mucosal bioactivity, defined as 2-fold or greater upregulation of NQO1 mRNA, was observed in 6 of 9 evaluable participants ingesting glucoraphanin-rich BSE; 3 of 6 ingesting s
Ingestion of sulforaphane-rich BSE demonstrated the greatest, most consistent bioavailability. Mucosal bioactivity, defined as 2-fold …
Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.
Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley A, Melnyk S, Singh IN, James SJ, Frye RE, Fahey JW. Zimmerman AW, et al. Mol Autism. 2021 May 25;12(1):38. doi: 10.1186/s13229-021-00447-5. Mol Autism. 2021. PMID: 34034808 Free PMC article. Clinical Trial.
BACKGROUND: Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. ...
BACKGROUND: Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) throu …
Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension.
Langston-Cox AG, Anderson D, Creek DJ, Palmer KR, Marshall SA, Wallace EM. Langston-Cox AG, et al. Reprod Sci. 2021 May;28(5):1489-1497. doi: 10.1007/s43032-020-00439-5. Epub 2021 Jan 6. Reprod Sci. 2021. PMID: 33409874 Clinical Trial.
Sulforaphane, an isothiocyanate found in cruciferous vegetables such as broccoli, shows promise as an adjuvant therapy for preeclampsia. ...Sulforaphane may improve endothelial function and blood pressure in women with pregnancy hypertension....
Sulforaphane, an isothiocyanate found in cruciferous vegetables such as broccoli, shows promise as an adjuvant therapy for preeclamps
Accumulation of Sulforaphane and Alliin in Human Prostate Tissue.
Livingstone TL, Saha S, Bernuzzi F, Savva GM, Troncoso-Rey P, Traka MH, Mills RD, Ball RY, Mithen RF. Livingstone TL, et al. Nutrients. 2022 Aug 10;14(16):3263. doi: 10.3390/nu14163263. Nutrients. 2022. PMID: 36014767 Free PMC article. Clinical Trial.
Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transiti …
Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for all …
Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial.
Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Momtazmanesh S, et al. Psychiatry Clin Neurosci. 2020 Jul;74(7):398-405. doi: 10.1111/pcn.13016. Epub 2020 May 26. Psychiatry Clin Neurosci. 2020. PMID: 32347624 Free article. Clinical Trial.
In this randomized, double-blind, placebo-controlled clinical trial, we aimed to investigate the beneficial effects of adjuvant treatment with risperidone and sulforaphane in alleviating the irritability of children with ASD. METHODS: Sixty drug-free patients aged 4-12 yea …
In this randomized, double-blind, placebo-controlled clinical trial, we aimed to investigate the beneficial effects of adjuvant treatment wi …
Oral chronic sulforaphane effects on heavy resistance exercise: Implications for inflammatory and muscle damage parameters in young practitioners.
Sato K, Kihara H, Kumazawa Y, Tatara K. Sato K, et al. Nutrition. 2021 Oct;90:111266. doi: 10.1016/j.nut.2021.111266. Epub 2021 Apr 7. Nutrition. 2021. PMID: 34004418 Clinical Trial.
OBJECTIVE: Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulforaphane ingestion suppresses heavy resistance exercise-induced muscle damage parameters in humans remains unknown. ...
OBJECTIVE: Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulfo
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.
Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW. Brown RH, et al. Respir Res. 2015 Sep 15;16(1):106. doi: 10.1186/s12931-015-0253-z. Respir Res. 2015. PMID: 26369337 Free PMC article. Clinical Trial.
Interestingly, in 20 % of the asthmatics, sulforaphane aggravated the bronchoconstrictor effects of MCh and in a similar number was without effect, documenting the great heterogeneity of the responsiveness of these individuals to sulforaphane. Moreover, in individua …
Interestingly, in 20 % of the asthmatics, sulforaphane aggravated the bronchoconstrictor effects of MCh and in a similar number was w …
72 results