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Did you mean lsulforaphane Nrf2 (13 results)?
Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling.
Ma C, Gu C, Lian P, Wazir J, Lu R, Ruan B, Wei L, Li L, Pu W, Peng Z, Wang W, Zong Y, Huang Z, Wang H, Lu Y, Su Z. Ma C, et al. Cell Death Dis. 2023 Nov 25;14(11):768. doi: 10.1038/s41419-023-06234-9. Cell Death Dis. 2023. PMID: 38007430 Free PMC article.
Network pharmacology analysis suggested that the KEAP1-NRF2 pathway might be involved in the protective effects of SFN on psoriasis. We observed reduced NRF2 expression in human psoriatic lesions, and subsequent experiments showed that SFN activated KEAP1-NRF2 …
Network pharmacology analysis suggested that the KEAP1-NRF2 pathway might be involved in the protective effects of SFN on psoriasis. …
Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.
Uddin MS, Mamun AA, Jakaria M, Thangapandiyan S, Ahmad J, Rahman MA, Mathew B, Abdel-Daim MM, Aleya L. Uddin MS, et al. Sci Total Environ. 2020 Mar 10;707:135624. doi: 10.1016/j.scitotenv.2019.135624. Epub 2019 Nov 21. Sci Total Environ. 2020. PMID: 31784171 Review.
Neurological disorders are auspicious candidates for Nrf2-targeted treatment strategy. Sulforaphane protects various neurological disorders by regulating the Nrf2 pathway. In this article, we recapitulate current studies of sulforaphane-mediated Nrf …
Neurological disorders are auspicious candidates for Nrf2-targeted treatment strategy. Sulforaphane protects various neurologi …
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.
Russo M, Spagnuolo C, Russo GL, Skalicka-Woźniak K, Daglia M, Sobarzo-Sánchez E, Nabavi SF, Nabavi SM. Russo M, et al. Crit Rev Food Sci Nutr. 2018 May 24;58(8):1391-1405. doi: 10.1080/10408398.2016.1259983. Epub 2017 Jul 21. Crit Rev Food Sci Nutr. 2018. PMID: 28001083 Review.
Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. ...At molecular level, sulforaphane modu …
Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts again …
Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD.
Shah A, Varma M, Bhandari R. Shah A, et al. Metab Brain Dis. 2024 Mar;39(3):373-385. doi: 10.1007/s11011-023-01224-4. Epub 2023 May 30. Metab Brain Dis. 2024. PMID: 37249861 Review.
Sulforaphane, a sulfur-containing phytochemical present mainly in cruciferous plants like broccoli and cabbage, has shown efficacy in activating the Nrf2 signaling pathway, which in turn brings about a protective effect on neuronal cells, especially against mitochon …
Sulforaphane, a sulfur-containing phytochemical present mainly in cruciferous plants like broccoli and cabbage, has shown efficacy in …
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
Houghton CA, Fassett RG, Coombes JS. Houghton CA, et al. Oxid Med Cell Longev. 2016;2016:7857186. doi: 10.1155/2016/7857186. Epub 2016 Jan 6. Oxid Med Cell Longev. 2016. PMID: 26881038 Free PMC article. Review.
By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2. ...Both its high bioavailability and significant Nrf2 inducer capaci …
By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the poly …
Sulforaphane prevents diabetes-induced hepatic ferroptosis by activating Nrf2 signaling axis.
Savic N, Markelic M, Stancic A, Velickovic K, Grigorov I, Vucetic M, Martinovic V, Gudelj A, Otasevic V. Savic N, et al. Biofactors. 2024 Jul-Aug;50(4):810-827. doi: 10.1002/biof.2042. Epub 2024 Feb 1. Biofactors. 2024. PMID: 38299761
Recently, we characterized the ferroptotic phenotype in the liver of diabetic mice and revealed nuclear factor (erythroid-derived-2)-related factor 2 (Nrf2) inactivation as an integral part of hepatic injury. Here, we aim to investigate whether sulforaphane, an N …
Recently, we characterized the ferroptotic phenotype in the liver of diabetic mice and revealed nuclear factor (erythroid-derived-2)-related …
Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.
Yang L, Palliyaguru DL, Kensler TW. Yang L, et al. Semin Oncol. 2016 Feb;43(1):146-153. doi: 10.1053/j.seminoncol.2015.09.013. Epub 2015 Sep 8. Semin Oncol. 2016. PMID: 26970133 Free PMC article. Review.
For reasons of experimental exigency, preclinical studies have focused principally on sulforaphane itself, while clinical studies have relied on broccoli sprout preparations rich in either sulforaphane or its biogenic precursor, glucoraphanin. ...Sulforaphane …
For reasons of experimental exigency, preclinical studies have focused principally on sulforaphane itself, while clinical studies hav …
Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway.
Lu W. Lu W. Ren Fail. 2024 Dec;46(2):2416937. doi: 10.1080/0886022X.2024.2416937. Epub 2024 Oct 17. Ren Fail. 2024. PMID: 39417305 Free PMC article.
However, in the presence of sulforaphane, AngII failed to induce increases in Nrf2 and a decrease in Keap1 expression, as well as ROS levels. ...The binding score between sulforaphane and Nrf2 was -4.7. CONCLUSION: Sulforaphane alleviated AngII- …
However, in the presence of sulforaphane, AngII failed to induce increases in Nrf2 and a decrease in Keap1 expression, as well …
Eat Your Broccoli: Oxidative Stress, NRF2, and Sulforaphane in Chronic Kidney Disease.
Liebman SE, Le TH. Liebman SE, et al. Nutrients. 2021 Jan 18;13(1):266. doi: 10.3390/nu13010266. Nutrients. 2021. PMID: 33477669 Free PMC article. Review.
Here, we review the influence of oxidative stress in CKD, and discuss regarding the role of the Nrf2 pathway in kidney disease from studies using genetic and pharmacologic approaches in animal models and clinical trials. We will then focus on the promising therapeutic pote …
Here, we review the influence of oxidative stress in CKD, and discuss regarding the role of the Nrf2 pathway in kidney disease from s …
Protective Effects of NRF2 Activator Sulforaphane in Polyinosinic:Polycytidylic Acid-Induced In Vitro and In Vivo Model.
Matsagar SV, Singh RK. Matsagar SV, et al. J Biochem Mol Toxicol. 2024 Dec;38(12):e70086. doi: 10.1002/jbt.70086. J Biochem Mol Toxicol. 2024. PMID: 39635763
Sulforaphane is a known NRF2 activator used for its strong antioxidant and anti-inflammatory activity through regulation of Keap-1-HO-1 pathway. However, there is a limited exploration about the role of NRF2 activator, sulforaphane in regulation of pol …
Sulforaphane is a known NRF2 activator used for its strong antioxidant and anti-inflammatory activity through regulation of Ke …
1,180 results