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Year Number of Results
2000 1
2001 4
2002 4
2003 4
2004 5
2005 12
2006 11
2007 10
2008 16
2009 24
2010 38
2011 45
2012 45
2013 58
2014 40
2015 44
2016 49
2017 50
2018 55
2019 68
2020 30
2021 3
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525 results
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The emerging role of Nrf2 in mitochondrial function.
Dinkova-Kostova AT, Abramov AY. Dinkova-Kostova AT, et al. Free Radic Biol Med. 2015 Nov;88(Pt B):179-188. doi: 10.1016/j.freeradbiomed.2015.04.036. Epub 2015 May 11. Free Radic Biol Med. 2015. PMID: 25975984 Free PMC article. Review.
Under homeostatic conditions, Nrf2 affects the mitochondrial membrane potential, fatty acid oxidation, availability of substrates (NADH and FADH2/succinate) for respiration, and ATP synthesis. ...Pharmacological Nrf2 activators, such as the naturally occurrin …
Under homeostatic conditions, Nrf2 affects the mitochondrial membrane potential, fatty acid oxidation, availability of substra …
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Yagishita Y, et al. Molecules. 2019 Oct 6;24(19):3593. doi: 10.3390/molecules24193593. Molecules. 2019. PMID: 31590459 Free PMC article. Review.
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the a …
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the …
Chemopreventive activity of sulforaphane.
Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G. Jiang X, et al. Drug Des Devel Ther. 2018 Sep 11;12:2905-2913. doi: 10.2147/DDDT.S100534. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30254420 Free PMC article. Review.
In this context, many bioactive dietary compounds from vegetables and fruits have been demonstrated to be effective in cancer prevention and intervention. Over the years, sulforaphane (SFN), found in cruciferous vegetables, has been shown to have chemopreventive activity i …
In this context, many bioactive dietary compounds from vegetables and fruits have been demonstrated to be effective in cancer prevention and …
Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers.
Soundararajan P, Kim JS. Soundararajan P, et al. Molecules. 2018 Nov 15;23(11):2983. doi: 10.3390/molecules23112983. Molecules. 2018. PMID: 30445746 Free PMC article. Review.
Benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane ([1-isothioyanato-4-(methyl-sulfinyl) butane], SFN) are potential ITCs with efficient therapeutic properties. ...Antagonistic activity of BITC, PEITC and SFN against cancer was re …
Benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane ([1-isothioyanato-4-(methyl-sulfinyl) b …
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.
Russo M, Spagnuolo C, Russo GL, Skalicka-Woźniak K, Daglia M, Sobarzo-Sánchez E, Nabavi SF, Nabavi SM. Russo M, et al. Crit Rev Food Sci Nutr. 2018 May 24;58(8):1391-1405. doi: 10.1080/10408398.2016.1259983. Epub 2017 Jul 21. Crit Rev Food Sci Nutr. 2018. PMID: 28001083 Review.
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. ...At molecular level, sulforaphane modulates cellu …
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate
Effects of sulforaphane in the central nervous system.
Huang C, Wu J, Chen D, Jin J, Wu Y, Chen Z. Huang C, et al. Eur J Pharmacol. 2019 Jun 15;853:153-168. doi: 10.1016/j.ejphar.2019.03.010. Epub 2019 Mar 8. Eur J Pharmacol. 2019. PMID: 30858063 Review.
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. ...However, due to its peculiar ability in Nrf2 activation, SFN is recognized as an activator of Nrf2 and recommended as a supplementation for prevention and/or
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. ...However, due to its peculiar ab
Sulforaphane - role in aging and neurodegeneration.
Santín-Márquez R, Alarcón-Aguilar A, López-Diazguerrero NE, Chondrogianni N, Königsberg M. Santín-Márquez R, et al. Geroscience. 2019 Oct;41(5):655-670. doi: 10.1007/s11357-019-00061-7. Epub 2019 Apr 2. Geroscience. 2019. PMID: 30941620 Free PMC article. Review.
In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables. SFN activat …
In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, …
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.
Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. Zhang Y, et al. Phytomedicine. 2019 Aug 5:153062. doi: 10.1016/j.phymed.2019.153062. Online ahead of print. Phytomedicine. 2019. PMID: 31409554 Free article.
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor …
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fund …
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
Houghton CA, Fassett RG, Coombes JS. Houghton CA, et al. Oxid Med Cell Longev. 2016;2016:7857186. doi: 10.1155/2016/7857186. Epub 2016 Jan 6. Oxid Med Cell Longev. 2016. PMID: 26881038 Free PMC article. Review.
By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2. ...Both its high bioavailability and significant Nrf2 inducer capaci …
By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the poly …
Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.
Cheng D, Gao L, Su S, Sargsyan D, Wu R, Raskin I, Kong AN. Cheng D, et al. AAPS J. 2019 Feb 19;21(2):31. doi: 10.1208/s12248-019-0301-6. AAPS J. 2019. PMID: 30783799 Free PMC article.
Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and traditional herbal medicine. ...MIC-1 showed little toxicity from 1.25-5 muM. MIC-1 activated Nrf2-ARE at similar levels to SFN. MIC-1 als …
Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and tradi …
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