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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 4
2002 4
2003 4
2004 5
2005 12
2006 11
2007 10
2008 16
2009 24
2010 38
2011 45
2012 45
2013 58
2014 40
2015 44
2016 49
2017 50
2018 55
2019 68
2020 53
2021 46
2022 33
2023 2
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611 results
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Page 1
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J. Zhang Z, et al. Cell Death Dis. 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. Cell Death Dis. 2018. PMID: 29362432 Free PMC article.
Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2(-/-)) and wild-type (WT) mice. Meanwhile, rat type II alveolar epithelial cells line (RLE-6TN) and human epithelial cells line (A549) were both treated …
Here, we observed the effects of Nrf2 pathway and Numb on bleomycin(BLM)-induced PF in Nrf2-knockout (Nrf2(-/-)) and wi …
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.
Russo M, Spagnuolo C, Russo GL, Skalicka-Woźniak K, Daglia M, Sobarzo-Sánchez E, Nabavi SF, Nabavi SM. Russo M, et al. Crit Rev Food Sci Nutr. 2018 May 24;58(8):1391-1405. doi: 10.1080/10408398.2016.1259983. Epub 2017 Jul 21. Crit Rev Food Sci Nutr. 2018. PMID: 28001083 Review.
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. ...At molecular level, sulforaphane modulates cellu …
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate
Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers.
Soundararajan P, Kim JS. Soundararajan P, et al. Molecules. 2018 Nov 15;23(11):2983. doi: 10.3390/molecules23112983. Molecules. 2018. PMID: 30445746 Free PMC article. Review.
Benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane ([1-isothioyanato-4-(methyl-sulfinyl) butane], SFN) are potential ITCs with efficient therapeutic properties. ...Antagonistic activity of BITC, PEITC and SFN against cancer was re …
Benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane ([1-isothioyanato-4-(methyl-sulfinyl) b …
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Yagishita Y, et al. Molecules. 2019 Oct 6;24(19):3593. doi: 10.3390/molecules24193593. Molecules. 2019. PMID: 31590459 Free PMC article. Review.
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the a …
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the …
Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.
Li D, Shao R, Wang N, Zhou N, Du K, Shi J, Wang Y, Zhao Z, Ye X, Zhang X, Xu H. Li D, et al. Autophagy. 2021 Apr;17(4):872-887. doi: 10.1080/15548627.2020.1739442. Epub 2020 Mar 15. Autophagy. 2021. PMID: 32138578 Free PMC article.
NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), a transcriptional factor that controls the expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a proposed target of SFN. NFE2L2/NRF2 is a target gene of TFEB (transcription fac …
NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), a transcriptional factor that controls the expression of multiple detoxifying enzym …
Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy.
Gu J, Cheng Y, Wu H, Kong L, Wang S, Xu Z, Zhang Z, Tan Y, Keller BB, Zhou H, Wang Y, Xu Z, Cai L. Gu J, et al. Diabetes. 2017 Feb;66(2):529-542. doi: 10.2337/db15-1274. Epub 2016 Nov 30. Diabetes. 2017. PMID: 27903744 Free PMC article.
We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription factor erythroid 2-related factor 2 (Nrf2) and metallothionein (MT). ...SFN did not induc …
We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and type 2 diabetes (T2DM) animal models vi …
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.
Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. Zhang Y, et al. Phytomedicine. 2021 Jun;86:153062. doi: 10.1016/j.phymed.2019.153062. Epub 2019 Aug 5. Phytomedicine. 2021. PMID: 31409554 Free PMC article.
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor …
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fund …
Effects of sulforaphane in the central nervous system.
Huang C, Wu J, Chen D, Jin J, Wu Y, Chen Z. Huang C, et al. Eur J Pharmacol. 2019 Jun 15;853:153-168. doi: 10.1016/j.ejphar.2019.03.010. Epub 2019 Mar 8. Eur J Pharmacol. 2019. PMID: 30858063 Review.
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. ...However, due to its peculiar ability in Nrf2 activation, SFN is recognized as an activator of Nrf2 and recommended as a supplementation for prevention and/or
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. ...However, due to its peculiar ab
Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane.
Wang Y, Mandal AK, Son YO, Pratheeshkumar P, Wise JTF, Wang L, Zhang Z, Shi X, Chen Z. Wang Y, et al. Toxicol Appl Pharmacol. 2018 Aug 15;353:23-30. doi: 10.1016/j.taap.2018.06.003. Epub 2018 Jun 6. Toxicol Appl Pharmacol. 2018. PMID: 29885333 Free PMC article.
In untransformed BEAS-2BR cells, sulforaphane, a natural compound, increased autophagy, activated Nrf2, and decreased ROS. In cadmium-transformed BEAS-2BR cells, sulforaphane restored autophagy, decreased Nrf2, and decreased apoptosis resistance. ...
In untransformed BEAS-2BR cells, sulforaphane, a natural compound, increased autophagy, activated Nrf2, and decreased ROS. In …
Chemopreventive activity of sulforaphane.
Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G. Jiang X, et al. Drug Des Devel Ther. 2018 Sep 11;12:2905-2913. doi: 10.2147/DDDT.S100534. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30254420 Free PMC article. Review.
In this context, many bioactive dietary compounds from vegetables and fruits have been demonstrated to be effective in cancer prevention and intervention. Over the years, sulforaphane (SFN), found in cruciferous vegetables, has been shown to have chemopreventive activity i …
In this context, many bioactive dietary compounds from vegetables and fruits have been demonstrated to be effective in cancer prevention and …
611 results