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Page 1
Sulforaphane's Multifaceted Potential: From Neuroprotection to Anticancer Action.
Otoo RA, Allen AR. Otoo RA, et al. Molecules. 2023 Oct 1;28(19):6902. doi: 10.3390/molecules28196902. Molecules. 2023. PMID: 37836745 Free PMC article. Review.
Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. ...SFN has been shown to exert neuroprotective effects through the activation of the Nrf2 pathway, the modulation of neuroinflammation, and epigene …
Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. ...SFN has bee …
Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis.
Zhang Y, Wu Q, Liu J, Zhang Z, Ma X, Zhang Y, Zhu J, Thring RW, Wu M, Gao Y, Tong H. Zhang Y, et al. Biomed Pharmacother. 2022 Aug;152:113273. doi: 10.1016/j.biopha.2022.113273. Epub 2022 Jun 14. Biomed Pharmacother. 2022. PMID: 35709656 Free article.
SFN also led to increased expression of antioxidant genes downstream of Nrf2 and decreased accumulation of lipid peroxides MDA and 4-HNE, both in vivo and in vitro. ...Taken together, SFN ameliorated HFD-induced insulin resistance by activating the AMPK-Nrf2-GPx4 pa …
SFN also led to increased expression of antioxidant genes downstream of Nrf2 and decreased accumulation of lipid peroxides MDA and 4- …
Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.
Li D, Shao R, Wang N, Zhou N, Du K, Shi J, Wang Y, Zhao Z, Ye X, Zhang X, Xu H. Li D, et al. Autophagy. 2021 Apr;17(4):872-887. doi: 10.1080/15548627.2020.1739442. Epub 2020 Mar 15. Autophagy. 2021. PMID: 32138578 Free PMC article.
NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), a transcriptional factor that controls the expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a proposed target of SFN. NFE2L2/NRF2 is a target gene of TFEB (transcription fac …
NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), a transcriptional factor that controls the expression of multiple detoxifying enzym …
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.
Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. Zhang Y, et al. Phytomedicine. 2021 Jun;86:153062. doi: 10.1016/j.phymed.2019.153062. Epub 2019 Aug 5. Phytomedicine. 2021. PMID: 31409554 Free PMC article.
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor …
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fund …
Protective role of sulphoraphane against vascular complications in diabetes.
Yamagishi S, Matsui T. Yamagishi S, et al. Pharm Biol. 2016 Oct;54(10):2329-39. doi: 10.3109/13880209.2016.1138314. Epub 2016 Feb 3. Pharm Biol. 2016. PMID: 26841240 Free article. Review.
We reviewed here the protective role of sulphoraphane against diabetic vascular complications. Methods In this review, literature searches were undertaken in Medline and in CrossRef. ...Results There is accumulating evidence that sulphoraphane exerts beneficial effe …
We reviewed here the protective role of sulphoraphane against diabetic vascular complications. Methods In this review, literature sea …
A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway.
Zhang X, Zhang D, Fan A, Zhou X, Yang C, Zhou J, Shen M, Liu H, Zou K, Tao J. Zhang X, et al. J Adv Res. 2025 Aug;74:25-41. doi: 10.1016/j.jare.2024.09.020. Epub 2024 Sep 27. J Adv Res. 2025. PMID: 39341455 Free PMC article.
Gene interference, overexpression, CUT&TAG technology, and transcriptome analyses were performed to elucidate the underlying mechanisms of the nuclear factor E2-related factor 2 (NRF2)-transketolase (TKT) axis in mediating GCs proliferation. RESULTS: Our research revea …
Gene interference, overexpression, CUT&TAG technology, and transcriptome analyses were performed to elucidate the underlying mechanisms …
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD. Nioi P, et al. Biochem J. 2003 Sep 1;374(Pt 2):337-48. doi: 10.1042/BJ20030754. Biochem J. 2003. PMID: 12816537 Free PMC article.
Electrophoretic mobility-shift and chromatin immunoprecipitation assays revealed that Nrf2 associates, in low amounts, with the nqo1 ARE under constitutive conditions, and following sulphoraphane challenge of cells, Nrf2 is recruited to the ARE in substantial …
Electrophoretic mobility-shift and chromatin immunoprecipitation assays revealed that Nrf2 associates, in low amounts, with the nqo1 …
Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.
Cheng D, Gao L, Su S, Sargsyan D, Wu R, Raskin I, Kong AN. Cheng D, et al. AAPS J. 2019 Feb 19;21(2):31. doi: 10.1208/s12248-019-0301-6. AAPS J. 2019. PMID: 30783799 Free PMC article.
Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and traditional herbal medicine. ...MIC-1 activated Nrf2-ARE at similar levels to SFN. MIC-1 also increased gene expression of downstream N …
Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and tradi …
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.
Ernst IM, Wagner AE, Schuemann C, Storm N, Höppner W, Döring F, Stocker A, Rimbach G. Ernst IM, et al. Pharmacol Res. 2011 Mar;63(3):233-40. doi: 10.1016/j.phrs.2010.11.005. Epub 2010 Nov 23. Pharmacol Res. 2011. PMID: 21109004
The isothiocyanate sulforaphane (SFN) has been shown to induce phase 2 and antioxidant enzymes in cultured cells and in vivo via a Nrf2 dependent signal transduction pathway. However, little is known regarding the effect of structurally related compounds such …
The isothiocyanate sulforaphane (SFN) has been shown to induce phase 2 and antioxidant enzymes in cultured cells and in vivo v …
Exploring the anti-inflammatory activity of sulforaphane.
Treasure K, Harris J, Williamson G. Treasure K, et al. Immunol Cell Biol. 2023 Oct;101(9):805-828. doi: 10.1111/imcb.12686. Epub 2023 Aug 31. Immunol Cell Biol. 2023. PMID: 37650498 Review.
Therefore, alternative drug options with improved safety profiles are urgently needed. Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification enzymes via nuclear factor-erythroid factor 2-related factor 2 ( …
Therefore, alternative drug options with improved safety profiles are urgently needed. Sulforaphane, a phytochemical derived from pla …
713 results