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1993 3
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2002 5
2004 4
2005 3
2006 4
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2010 1
2011 1
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59 results

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Page 1
C. elegans Apical Extracellular Matrices Shape Epithelia.
Cohen JD, Sundaram MV. Cohen JD, et al. J Dev Biol. 2020 Oct 6;8(4):23. doi: 10.3390/jdb8040023. J Dev Biol. 2020. PMID: 33036165 Free PMC article. Review.
Despite their widespread importance for human health, aECMs are poorly understood compared to basal and stromal ECMs. The nematode Caenorhabditis elegans contains a variety of distinct aECMs, some of which share many of the same types of components (lipids, lipoproteins, c …
Despite their widespread importance for human health, aECMs are poorly understood compared to basal and stromal ECMs. The nematode Caenorhab …
RTK/Ras/MAPK signaling.
Sundaram MV. Sundaram MV. WormBook. 2006 Feb 11:1-19. doi: 10.1895/wormbook.1.80.1. WormBook. 2006. PMID: 18050474 Free PMC article. Review.
Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known …
Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control ma …
The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity.
Sundaram MV, Buechner M. Sundaram MV, et al. Genetics. 2016 May;203(1):35-63. doi: 10.1534/genetics.116.189357. Genetics. 2016. PMID: 27183565 Free PMC article. Review.
The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular organogenesis involving a minimum of cells. ...
The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular organogenesis involving a minimum of cells. …
Auto-fusion and the shaping of neurons and tubes.
Soulavie F, Sundaram MV. Soulavie F, et al. Semin Cell Dev Biol. 2016 Dec;60:136-145. doi: 10.1016/j.semcdb.2016.07.018. Epub 2016 Jul 18. Semin Cell Dev Biol. 2016. PMID: 27436685 Free PMC article. Review.
In contrast to cell-cell fusion or macropinocytic fission, which result in the merging or formation of two separate membrane bound compartments, auto-fusion preserves one compartment, but changes its shape. The discovery of auto-fusion in C. elegans was enabled by identifi …
In contrast to cell-cell fusion or macropinocytic fission, which result in the merging or formation of two separate membrane bound compartme …
Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene.
Young AF, Schmidt HF, Sundaram MV. Young AF, et al. MicroPubl Biol. 2022 Jun 20;2022:10.17912/micropub.biology.000589. doi: 10.17912/micropub.biology.000589. eCollection 2022. MicroPubl Biol. 2022. PMID: 35800971 Free PMC article.
The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. ...
The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple …
Canonical RTK-Ras-ERK signaling and related alternative pathways.
Sundaram MV. Sundaram MV. WormBook. 2013 Jul 11:1-38. doi: 10.1895/wormbook.1.80.2. WormBook. 2013. PMID: 23908058 Free PMC article. Review.
Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling pathways control many aspects of C. elegans development and behavior. Studies in C. elegans helped elucidate the basic framework of the RTK-Ras-ERK pathway and continue to provi …
Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling pathways control many aspects of C. elegans …
A C. elegans Zona Pellucida domain protein functions via its ZPc domain.
Cohen JD, Bermudez JG, Good MC, Sundaram MV. Cohen JD, et al. PLoS Genet. 2020 Nov 3;16(11):e1009188. doi: 10.1371/journal.pgen.1009188. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33141826 Free PMC article.
Current models suggest that ZP proteins polymerize via their ZPn subdomains, while ZPc subdomains modulate ZPn behavior. Using the model organism C. elegans, we investigated the aECM assembly of one ZP protein, LET-653, which shapes several tubes. ...
Current models suggest that ZP proteins polymerize via their ZPn subdomains, while ZPc subdomains modulate ZPn behavior. Using the model org …
Time to make the doughnuts: Building and shaping seamless tubes.
Sundaram MV, Cohen JD. Sundaram MV, et al. Semin Cell Dev Biol. 2017 Jul;67:123-131. doi: 10.1016/j.semcdb.2016.05.006. Epub 2016 May 10. Semin Cell Dev Biol. 2017. PMID: 27178486 Free PMC article. Review.
Seamless tubes also are found in invertebrate organs, including the Drosophila trachea and the Caenorhabditis elegans excretory system. Seamless tube cells can be less than a micron in diameter, and they can adopt very simple "doughnut-like" shapes or very complex, branche …
Seamless tubes also are found in invertebrate organs, including the Drosophila trachea and the Caenorhabditis elegans excretory syste …
Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva.
Barker TJ, Chan FY, Carvalho AX, Sundaram MV. Barker TJ, et al. MicroPubl Biol. 2023 Jun 14;2023:10.17912/micropub.biology.000863. doi: 10.17912/micropub.biology.000863. eCollection 2023. MicroPubl Biol. 2023. PMID: 37396793 Free PMC article.
The C. elegans vulva is a polarized epithelial tube that has been studied extensively as a model for cell-cell signaling, cell fate specification, and tubulogenesis. ...
The C. elegans vulva is a polarized epithelial tube that has been studied extensively as a model for cell-cell signaling, cell fate s …
Lethargus is a Caenorhabditis elegans sleep-like state.
Raizen DM, Zimmerman JE, Maycock MH, Ta UD, You YJ, Sundaram MV, Pack AI. Raizen DM, et al. Nature. 2008 Jan 31;451(7178):569-72. doi: 10.1038/nature06535. Epub 2008 Jan 9. Nature. 2008. PMID: 18185515
We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sensory neurons to promote the C. elegans sleep-like state. Conserved effects on sleep-like behaviour of homologous genes in C. elegan …
We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sens …
59 results