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Broadly neutralizing antibodies in HIV-1 treatment and prevention.

Kumar R, Qureshi H, Deshpande S, Bhattacharya J. Kumar R, et al. Among authors: deshpande s. Ther Adv Vaccines Immunother. 2018 Oct 12;6(4):61-68. doi: 10.1177/2515135518800689. eCollection 2018 Aug. Ther Adv Vaccines Immunother. 2018. PMID: 30345419 Free PMC article. Review.

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Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8.

Sutar J, Padwal V, Sonawani A, Nagar V, Patil P, Kulkarni B, Hingankar N, Deshpande S, Idicula-Thomas S, Jagtap D, Bhattacharya J, Bandivdekar A, Patel V. Sutar J, et al. Among authors: deshpande s. Virus Res. 2019 Nov;273:197763. doi: 10.1016/j.virusres.2019.197763. Epub 2019 Sep 22. Virus Res. 2019. PMID: 31553924

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Broad neutralization response in a subset of HIV-1 subtype C-infected viraemic non-progressors from southern India.

Nandagopal P, Bhattacharya J, Srikrishnan AK, Goyal R, Ravichandran Swathirajan C, Patil S, Saravanan S, Deshpande S, Vignesh R, Solomon SS, Singla N, Mukherjee J, Murugavel KG. Nandagopal P, et al. Among authors: deshpande s. J Gen Virol. 2018 Mar;99(3):379-392. doi: 10.1099/jgv.0.001016. J Gen Virol. 2018. PMID: 29458681

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HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms.

Deshpande S, Patil S, Kumar R, Hermanus T, Murugavel KG, Srikrishnan AK, Solomon S, Morris L, Bhattacharya J. Deshpande S, et al. Retrovirology. 2016 Aug 30;13(1):60. doi: 10.1186/s12977-016-0297-2. Retrovirology. 2016. PMID: 27576440 Free PMC article.

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Characterization of a stable HIV-1 B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes.

Kumar R, Ozorowski G, Kumar V, Holden LG, Shrivastava T, Patil S, Deshpande S, Ward AB, Bhattacharya J. Kumar R, et al. Among authors: deshpande s. J Biol Chem. 2017 Sep 22;292(38):15849-15858. doi: 10.1074/jbc.M117.803056. Epub 2017 Jul 25. J Biol Chem. 2017. PMID: 28743743 Free PMC article.

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Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities.

Mullick R, Sutar J, Hingankar N, Deshpande S, Thakar M, Sahay S, Ringe RP, Mukhopadhyay S, Patil A, Bichare S, Murugavel KG, Srikrishnan AK, Goyal R, Sok D, Bhattacharya J. Mullick R, et al. Among authors: deshpande s. Retrovirology. 2021 May 14;18(1):12. doi: 10.1186/s12977-021-00556-2. Retrovirology. 2021. PMID: 33990195 Free PMC article.

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Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category.

Boliar S, Patil S, Shukla BN, Ghobbeh A, Deshpande S, Chen W, Guenaga J, Dimitrov DS, Wyatt RT, Chakrabarti BK. Boliar S, et al. Among authors: deshpande s. Virology. 2018 Jun;519:99-105. doi: 10.1016/j.virol.2018.04.002. Epub 2018 May 11. Virology. 2018. PMID: 29684630 Free article.

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Geospatial HIV-1 subtype C gp120 sequence diversity and its predicted impact on broadly neutralizing antibody sensitivity.

Sutar J, Deshpande S, Mullick R, Hingankar N, Patel V, Bhattacharya J. Sutar J, et al. Among authors: deshpande s. PLoS One. 2021 May 24;16(5):e0251969. doi: 10.1371/journal.pone.0251969. eCollection 2021. PLoS One. 2021. PMID: 34029329 Free PMC article.

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Genetic attributes of blood-derived subtype-C HIV-1 tat and env in India and neurocognitive function.

Tilghman MW, Bhattacharya J, Deshpande S, Ghate M, Espitia S, Grant I, Marcotte TD, Smith D, Mehendale S. Tilghman MW, et al. Among authors: deshpande s. J Med Virol. 2014 Jan;86(1):88-96. doi: 10.1002/jmv.23816. Epub 2013 Oct 22. J Med Virol. 2014. PMID: 24150902 Free PMC article.

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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.

Kumar R, Deshpande S, Sewall LM, Ozorowski G, Cottrell CA, Lee WH, Holden LG, Richey ST, Chandrawacar AS, Dhiman K, Ashish, Kumar V, Ahmed S, Hingankar N, Kumar N, Murugavel KG, Srikrishnan AK, Sok D, Ward AB, Bhattacharya J. Kumar R, et al. Among authors: deshpande s. PLoS Pathog. 2021 Apr 7;17(4):e1008977. doi: 10.1371/journal.ppat.1008977. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826683 Free PMC article.

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