sv40 - Search Results

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1

Carbone M, Gazdar A, Butel JS. Carbone M, et al. Transl Lung Cancer Res. 2020 Feb;9(Suppl 1):S47-S59. doi: 10.21037/tlcr.2020.02.03. Transl Lung Cancer Res. 2020. PMID: 32206570 Free PMC article. Review.

Simian virus 40 (SV40) is a DNA tumor virus capable of infecting and transforming human mesothelial (HM) cells in vitro. ...In addition to mesotheliomas, SV40 now is linked with brain cancers, osteosarcomas, and lymphomas in humans. Explanations are provided for the …

Simian virus 40 (SV40) is a DNA tumor virus capable of infecting and transforming human mesothelial (HM) cells in vitro. ...In additi …

2

SV40: A human pathogen?

Garcea RL. Garcea RL. Dis Markers. 2001;17(3):149-51. doi: 10.1155/2001/515039. Dis Markers. 2001. PMID: 11790879 Free PMC article. Review.

Over the past eight years an increasing number of investigators have found SV40 genomic sequences in a variety of human samples, both malignant and normal. Tumor types recurrently reported as SV40-positive include choroid plexus neoplasms, ependymomas, osteosarcomas …

Over the past eight years an increasing number of investigators have found SV40 genomic sequences in a variety of human samples, both …

3

Simian virus 40 (SV40) - Fresh perspectives on a historic virus.

Milavetz BI, Balakrishnan L. Milavetz BI, et al. Virology. 2025 Mar;604:110427. doi: 10.1016/j.virol.2025.110427. Epub 2025 Feb 1. Virology. 2025. PMID: 39913987 Free PMC article. Review.

Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. ...This review discusses these recent advancements in SV40 biology....

Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. ... …

4

SV40 and human cancer: a review of recent data.

Shah KV. Shah KV. Int J Cancer. 2007 Jan 15;120(2):215-23. doi: 10.1002/ijc.22425. Int J Cancer. 2007. PMID: 17131333 Review.

The low-level immunoreactivity of human sera to SV40 was very likely the result of cross-reactivity with antibodies to the SV40-related human polyomaviruses BKV and JCV, rather than of authentic SV40 infection. SV40 sero-reactivity in patients with the …

The low-level immunoreactivity of human sera to SV40 was very likely the result of cross-reactivity with antibodies to the SV40 …

5

SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier.

Kawano M, Matsui M, Handa H. Kawano M, et al. Expert Rev Vaccines. 2013 Feb;12(2):199-210. doi: 10.1586/erv.12.149. Expert Rev Vaccines. 2013. PMID: 23414410 Review.

The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. ...Insertion of a particular for …

The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established t …

6

Does SV40 infection contribute to the development of human cancers?

Shah KV. Shah KV. Rev Med Virol. 2000 Jan-Feb;10(1):31-43. doi: 10.1002/(sici)1099-1654(200001/02)10:1<31::aid-rmv260>3.0.co;2-i. Rev Med Virol. 2000. PMID: 10654003 Review.

The SV40 sequences reported from humans are essentially identical to those of wild-type SV40; it is difficult to conceive that a highly species-specific polyomavirus like SV40 would cross the species barrier, become a human infection, and acquire pathogenic p …

The SV40 sequences reported from humans are essentially identical to those of wild-type SV40; it is difficult to conceive that …

7

Is there a role for SV40 in human cancer?

Poulin DL, DeCaprio JA. Poulin DL, et al. J Clin Oncol. 2006 Sep 10;24(26):4356-65. doi: 10.1200/JCO.2005.03.7101. J Clin Oncol. 2006. PMID: 16963733 Review.

Concerns regarding the potential health risk of SV40 exposure were reinforced by studies demonstrating SV40's potential to transform human cells and promote tumor growth in animal models. ...However, inconsistent reports linking SV40 with various tumor types …

Concerns regarding the potential health risk of SV40 exposure were reinforced by studies demonstrating SV40's potential to tra …

8

Association between SV40 and non-Hodgkin's lymphoma.

Butel JS, Vilchez RA, Jorgensen JL, Kozinetz CA. Butel JS, et al. Leuk Lymphoma. 2003;44 Suppl 3:S33-9. doi: 10.1080/10428190310001623784. Leuk Lymphoma. 2003. PMID: 15202523 Review.

Millions of people worldwide were inadvertently exposed to live simian virus 40 (SV40) between 1955 and 1963 through immunization with SV40-contaminated polio vaccines. Although the prevalence of SV40 infections in humans is not known, numerous studies sugges …

Millions of people worldwide were inadvertently exposed to live simian virus 40 (SV40) between 1955 and 1963 through immunization wit …

9

Association of SV40 with human tumours.

Jasani B, Cristaudo A, Emri SA, Gazdar AF, Gibbs A, Krynska B, Miller C, Mutti L, Radu C, Tognon M, Procopio A. Jasani B, et al. Semin Cancer Biol. 2001 Feb;11(1):49-61. doi: 10.1006/scbi.2000.0346. Semin Cancer Biol. 2001. PMID: 11243899 Review.

Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. ...Molecular data from these studies are reviewed to re-evaluate the potential role of SV40 as a human carcinogen....

Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. ...Molecu …

10

SV40 in human brain cancers and non-Hodgkin's lymphoma.

Vilchez RA, Butel JS. Vilchez RA, et al. Oncogene. 2003 Aug 11;22(33):5164-72. doi: 10.1038/sj.onc.1206547. Oncogene. 2003. PMID: 12910253 Review.

Simian virus 40 (SV40) is a potent DNA tumor virus that is known to induce primary brain cancers and lymphomas in laboratory animals. ...In addition, recent large independent studies showed that SV40 T-ag DNA is significantly associated with human non-Hodgkin's lymp …

Simian virus 40 (SV40) is a potent DNA tumor virus that is known to induce primary brain cancers and lymphomas in laboratory animals. …

11

SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen.

Lowe DB, Shearer MH, Jumper CA, Kennedy RC. Lowe DB, et al. Cell Mol Life Sci. 2007 Apr;64(7-8):803-14. doi: 10.1007/s00018-007-6414-6. Cell Mol Life Sci. 2007. PMID: 17260087 Free PMC article. Review.

Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality in these tumor types has yet to be established. ...This review will also explore how vaccination against SV40 protein products may be …

Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality i …

12

Patterns of polyomavirus SV40 infections and associated cancers in humans: a model.

Butel JS. Butel JS. Curr Opin Virol. 2012 Aug;2(4):508-14. doi: 10.1016/j.coviro.2012.06.004. Epub 2012 Jul 6. Curr Opin Virol. 2012. PMID: 22771310 Free PMC article. Review.

Predictions from the model include that SV40 infections and virus-associated malignancies will be restricted geographically and demographically and that in developed countries, such as the US, SV40 prevalence rates will be generally very low. The model highlights th …

Predictions from the model include that SV40 infections and virus-associated malignancies will be restricted geographically and demog …

13

Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas.

Schrump DS, Waheed I. Schrump DS, et al. Semin Cancer Biol. 2001 Feb;11(1):73-80. doi: 10.1006/scbi.2000.0348. Semin Cancer Biol. 2001. PMID: 11243901 Review.

The majority of mesothelioma cells which contain SV40 early region sequences exhibit extremely low basal expression of SV40 oncoproteins; however, T/t antigen expression can be induced under conditions of cellular stress. Abrogation of SV40 T/t expression by …

The majority of mesothelioma cells which contain SV40 early region sequences exhibit extremely low basal expression of SV40 on …

14

SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy.

Kimchi-Sarfaty C, Gottesman MM. Kimchi-Sarfaty C, et al. Curr Pharm Biotechnol. 2004 Oct;5(5):451-8. doi: 10.2174/1389201043376670. Curr Pharm Biotechnol. 2004. PMID: 15544493 Review.

The recombinant SV40 vectors can infect a wide variety of cells-dividing cells as well as non-cycling ones. ...SV40-based vectors carry some SV40 viral sequences, but the SV40 in vitro-packaged vectors are free of any SV40 wild-type viral DNA se …

The recombinant SV40 vectors can infect a wide variety of cells-dividing cells as well as non-cycling ones. ...SV40-based vect …

15

Epigenetic Analysis of SV40 Minichromosomes.

Balakrishnan L, Milavetz B. Balakrishnan L, et al. Curr Protoc Microbiol. 2017 Aug 11;46:14F.3.1-14F.3.26. doi: 10.1002/cpmc.35. Curr Protoc Microbiol. 2017. PMID: 28800155 Free PMC article.

Simian virus 40 (SV40) is one of the best-characterized members of the polyomavirus family of small DNA tumor viruses. ...These facts, combined with high yields of virus and minichromosomes following infection and ease of manipulation, have made SV40 an extremely us …

Simian virus 40 (SV40) is one of the best-characterized members of the polyomavirus family of small DNA tumor viruses. ...These facts …

16

Low incidence of SV40-like sequences in ependymal tumours.

Reuther FJ, Löhler J, Herms J, Hugo HH, Schindler C, Leithäuser F, Melzner I, Möller P, Scheil S. Reuther FJ, et al. J Pathol. 2001 Dec;195(5):580-5. doi: 10.1002/path.1005. J Pathol. 2001. PMID: 11745694 Review.

Between 1955 and 1963, millions of children and adults were exposed to SV40-contaminated poliovirus vaccines. The oncogenic potential of this polyomavirus was revealed when intracerebral inoculation of SV40 into newborn hamsters resulted in the development of ependy …

Between 1955 and 1963, millions of children and adults were exposed to SV40-contaminated poliovirus vaccines. The oncogenic potential …

17

Establishment and Characterization of SV40 T-Antigen Immortalized Porcine Muscle Satellite Cell.

Ni M, He J, Li T, Zhao G, Ji Z, Ren F, Leng J, Wu M, Huang R, Li P, Hou L. Ni M, et al. Cells. 2024 Apr 18;13(8):703. doi: 10.3390/cells13080703. Cells. 2024. PMID: 38667318 Free PMC article.

To address this conundrum and maintain the normal function of pMuSCs during in vitro passaging, we generated an immortalized pMuSCs (SV40 T-pMuSCs) by stably expressing SV40 T-antigen (SV40 T) using a lentiviral-based vector system. The SV40 T-pMuSCs c …

To address this conundrum and maintain the normal function of pMuSCs during in vitro passaging, we generated an immortalized pMuSCs (SV40 …

18

SV40, genetic polymorphism and mesothelioma. pathological and epidemiological evidence.

Magnani C. Magnani C. Med Lav. 2005 Jul-Aug;96(4):347-53. Med Lav. 2005. PMID: 16457431 Review.

METHODS: The review on SV40 was based on scientific papers published since 1990 on association of SV40 with human cancer. ...Diffusion of SV40 in humans is linked to polio vaccines produced in 1955-63 from SV40-infected monkeys. ...

METHODS: The review on SV40 was based on scientific papers published since 1990 on association of SV40 with human cancer. ...D …

19

SV40 in adenovirus vaccines and adenovirus-SV40 recombinants.

Lewis AM Jr. Lewis AM Jr. Dev Biol Stand. 1998;94:207-16. Dev Biol Stand. 1998. PMID: 9776241 Review.

During the development of adenovirus (Ad) vaccines in the 1950s, Ad strains 1-5 and 7 recombined with SV40 during adaptation to growth in rhesus monkey kidney cells. The recombination events between the Ad and SV40 genomes produced hybrid viruses that contained, wit …

During the development of adenovirus (Ad) vaccines in the 1950s, Ad strains 1-5 and 7 recombined with SV40 during adaptation to growt …

20

Detection of SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma and other pulmonary diseases.

Galateau-Salle F, Bidet P, Iwatsubo Y, Gennetay E, Renier A, Letourneux M, Pairon JC, Moritz S, Brochard P, Jaurand MC, Freymuth F. Galateau-Salle F, et al. Dev Biol Stand. 1998;94:147-52. Dev Biol Stand. 1998. PMID: 9776236 Review.

PCR amplification and hybridization with a probe specific for SV40 Tag revealed that 47.6% of mesotheliomas, 28.6% of primary bronchopulmonary carcinomas and 16% of non-neoplasic lung diseases contained SV40-like DNA sequences. ...However, a significantly higher num …

PCR amplification and hybridization with a probe specific for SV40 Tag revealed that 47.6% of mesotheliomas, 28.6% of primary broncho …

21

SV40 induces mesotheliomas in hamsters.

Cicala C, Pompetti F, Carbone M. Cicala C, et al. Am J Pathol. 1993 May;142(5):1524-33. Am J Pathol. 1993. PMID: 8388174 Free PMC article.

In the course of studies to elucidate the relative contribution of simian virus 40 (SV40) large T and small t proteins during oncogenesis, we observed the appearance of pericardial and pleural tumors in 100% of Syrian hamsters injected in the pleural space with wild type …

In the course of studies to elucidate the relative contribution of simian virus 40 (SV40) large T and small t proteins during oncogen …

22

SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines.

Wong C, Zhang S, Adam E, Paszat L, Butel JS. Wong C, et al. J Infect. 2019 Jun;78(6):476-483. doi: 10.1016/j.jinf.2019.04.007. Epub 2019 Apr 6. J Infect. 2019. PMID: 30965068 Free PMC article.

RESULTS: Overall SV40 seroprevalence was 22.8% for Colombian subjects and 12.8% for Nicaraguans. Subgroups of Colombian subjects ranged in frequency of SV40 seropositivity from 10.0% to 38.6%. ...CONCLUSIONS: Inhabitants of both Colombia and Nicaragua had detectable …

RESULTS: Overall SV40 seroprevalence was 22.8% for Colombian subjects and 12.8% for Nicaraguans. Subgroups of Colombian subjects rang …

23

Discovery of simian virus 40 (SV40) and its relationship to poliomyelitis virus vaccines.

Hilleman MR. Hilleman MR. Dev Biol Stand. 1998;94:183-90. Dev Biol Stand. 1998. PMID: 9776239 Review.

There has been no evidence to implicate SV40 virus of vaccine origin in long- or short-term consequences in human subjects. Of importance, SV40 virus provided a new model for basic studies of viral pathogenesis and for cell transformation and neoplasia. ...Numerous …

There has been no evidence to implicate SV40 virus of vaccine origin in long- or short-term consequences in human subjects. Of import …

24

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential oncogenic activity.

Šenigl F, Soikkeli A, Prost S, Schatz DG, Slavková M, Hejnar J, Alinikula J. Šenigl F, et al. bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574829. doi: 10.1101/2024.01.09.574829. bioRxiv. 2024. Update in: Tumour Virus Res. 2024 Dec;18:200293. doi: 10.1016/j.tvr.2024.200293. PMID: 38260396 Free PMC article. Updated. Preprint.

Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in mesotheliomas, brain and bone tumors and lymphomas, but the mechanism for SV40 tumorigenesis in humans is not clear. ...In this study, …

Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in m …

25

New developments about the association of SV40 with human mesothelioma.

Carbone M, Pass HI, Miele L, Bocchetta M. Carbone M, et al. Oncogene. 2003 Aug 11;22(33):5173-80. doi: 10.1038/sj.onc.1206552. Oncogene. 2003. PMID: 12910254 Review.

Simian virus 40 (SV40) has been detected in human tumors in over 40 different laboratories. Many of these reports linked SV40 to human mesotheliomas. ...Therefore, three independent scientific panels have all agreed that there is compelling evidence that SV40 …

Simian virus 40 (SV40) has been detected in human tumors in over 40 different laboratories. Many of these reports linked SV40 …

26

SV40 in human thyroid nodules.

Ozdarendeli A, Camci C, Aygen E, Kirkil C, Toroman ZA, Dogru O, Doymaz MZ. Ozdarendeli A, et al. J Clin Virol. 2004 Aug;30(4):337-40. doi: 10.1016/j.jcv.2003.12.008. J Clin Virol. 2004. PMID: 15163424

OBJECTIVES: SV40 has been found in a variety of human samples, both malignant and normal. Many independent studies have suggested that SV40 plays a role for some cancers. ...CONCLUSION: The possible role of SV40 in the development of thyroid nodules and the s …

OBJECTIVES: SV40 has been found in a variety of human samples, both malignant and normal. Many independent studies have suggested tha …

27

Potential of recombinant SV40-based vectors for gene therapy.

Buscail L, Cordelier P. Buscail L, et al. Recent Pat DNA Gene Seq. 2007;1(2):93-9. doi: 10.2174/187221507780887045. Recent Pat DNA Gene Seq. 2007. PMID: 19075921 Review.

Many reasons for these difficulties lie in the nature of the viral agents used to introduce the foreign gene(s) in question. SV40 (Simian Virus-40) has been demonstrated to provide a unique vector for gene therapy which has several advantages over any of the currently avai …

Many reasons for these difficulties lie in the nature of the viral agents used to introduce the foreign gene(s) in question. SV40 (Si …

28

Simian virus 40 (SV40) and human cancer: a review of the serological data.

Shah KV, Galloway DA, Knowles WA, Viscidi RP. Shah KV, et al. Rev Med Virol. 2004 Jul-Aug;14(4):231-9. doi: 10.1002/rmv.432. Rev Med Virol. 2004. PMID: 15248251 Review.

The development of EIA with virus-like particles (VLPs) of SV40, BKV and JCV has facilitated serological studies. Sera from macaques naturally infected with SV40 cross-react unambiguously with BKV and JCV VLPs. ...Absorption with BKV and JCV VLPs decreases or abolis …

The development of EIA with virus-like particles (VLPs) of SV40, BKV and JCV has facilitated serological studies. Sera from macaques …

29

Host range analysis of simian virus 40, BK virus and chimaeric SV40/BKV: relative expression of large T-antigen and Vp1 in infected and transformed cells.

O'Neill FJ, Carney H, Hu Y. O'Neill FJ, et al. Dev Biol Stand. 1998;94:191-205. Dev Biol Stand. 1998. PMID: 9776240 Review.

We examined the growth of SV40, BKV and the chimaeric genome virus, SV40/RFV, in several types of human cells. We analysed replication, expression of T-Ag and Vp1 capsid proteins, and cytopathic effects (CPE). ...In HFF cells the Vp1/T-Ag ratio was approximately 200 …

We examined the growth of SV40, BKV and the chimaeric genome virus, SV40/RFV, in several types of human cells. We analysed rep …

30

New molecular and epidemiological issues in mesothelioma: role of SV40.

Carbone M, Fisher S, Powers A, Pass HI, Rizzo P. Carbone M, et al. J Cell Physiol. 1999 Aug;180(2):167-72. doi: 10.1002/(SICI)1097-4652(199908)180:2<167::AID-JCP4>3.0.CO;2-Q. J Cell Physiol. 1999. PMID: 10395286 Review.

SV40 also transforms human cells in tissue culture, and these cells contain extensive DNA damage. In the United States, at least 60% of human mesotheliomas contain and express SV40. In these tumor cells, the SV40 tumor antigen binds and inhibits the cellular …

SV40 also transforms human cells in tissue culture, and these cells contain extensive DNA damage. In the United States, at least 60% …

31

SV40 infection induces telomerase activity in human mesothelial cells.

Foddis R, De Rienzo A, Broccoli D, Bocchetta M, Stekala E, Rizzo P, Tosolini A, Grobelny JV, Jhanwar SC, Pass HI, Testa JR, Carbone M. Foddis R, et al. Oncogene. 2002 Feb 21;21(9):1434-42. doi: 10.1038/sj.onc.1205203. Oncogene. 2002. PMID: 11857086

SV40 infection of human fibroblasts did not cause detectable telomerase activity. We also determined that the SV40 small t-antigen (tag) plays an important role in inducing telomerase activity because this activity was undetectable or minimal in mesothelial cells in …

SV40 infection of human fibroblasts did not cause detectable telomerase activity. We also determined that the SV40 small t-ant …

32

Increasing evidence for involvement of SV40 in human cancer.

Butel JS. Butel JS. Dis Markers. 2001;17(3):167-72. doi: 10.1155/2001/857621. Dis Markers. 2001. PMID: 11790883 Free PMC article. Review.

SV40, a small DNA virus, is known to possess strong oncogenic potential. Millions of people were exposed to SV40 as an unknown contaminant of some early poliovaccines. This article briefly summarizes the increasing evidence of the association of SV40 with cer …

SV40, a small DNA virus, is known to possess strong oncogenic potential. Millions of people were exposed to SV40 as an unknown …

33

SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction.

Reus JB, Trivino-Soto GS, Wu LI, Kokott K, Lim ES. Reus JB, et al. Viruses. 2020 Jan 24;12(2):137. doi: 10.3390/v12020137. Viruses. 2020. PMID: 31991682 Free PMC article.

Since SV40 LT also encodes the LxCxE motif, the lack of STING expression in 293T cells is commonly assumed to be due to SV40 large T antigen. We find that SV40 LT does not alter exogenously expressed and endogenous levels of STING protein. We show that STING …

Since SV40 LT also encodes the LxCxE motif, the lack of STING expression in 293T cells is commonly assumed to be due to SV40 l …

34

SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes.

Lednicky JA, Stewart AR, Jenkins JJ 3rd, Finegold MJ, Butel JS. Lednicky JA, et al. Int J Cancer. 1997 Sep 4;72(5):791-800. doi: 10.1002/(sici)1097-0215(19970904)72:5<791::aid-ijc15>3.0.co;2-c. Int J Cancer. 1997. PMID: 9311596

Authentic simian virus 40 (SV40) has been detected in association with human choroid plexus and ependymoma tumors, and SV40-like DNA sequences have been found in some human osteosarcomas. ...Authentic SV40 DNA sequences were detected in 5 of 10 osteosarcoma t …

Authentic simian virus 40 (SV40) has been detected in association with human choroid plexus and ependymoma tumors, and SV40-li …

35

Oral polio vaccine and human cancer: a reassessment of SV40 as a contaminant based upon legal documents.

Kops SP. Kops SP. Anticancer Res. 2000 Nov-Dec;20(6C):4745-9. Anticancer Res. 2000. PMID: 11205211 Review.

To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that SV40 was not present in any poliovirus vaccine administered in the United States and was removed from the killed polio vaccine by 1963. …

To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that …

36

Does Simian Virus 40 (SV40) Have a Role in UK Malignant Pleural Mesothelioma? No Role is Identified in a Sensitive RNA In Situ Hybridization Study on Potentially Affected Birth Cohorts.

Alchami FS, Attanoos RL, Gibbs A, Morgan F, Jasani B. Alchami FS, et al. Appl Immunohistochem Mol Morphol. 2020 Jul;28(6):444-447. doi: 10.1097/PAI.0000000000000779. Appl Immunohistochem Mol Morphol. 2020. PMID: 31205069

SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogenic protein large T antigen (SV40 Tag) has been shown to cause malignant transformation of asbestos-treated human pleural mesothelial c …

SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogeni …

37

Detection of authentic SV40 DNA sequences in human brain and bone tumours.

Butel JS, Jafar S, Stewart AR, Lednicky JA. Butel JS, et al. Dev Biol Stand. 1998;94:23-32. Dev Biol Stand. 1998. PMID: 9776222 Review.

This report summarizes our follow-up studies of SV40 DNA sequences in human brain tumors of early childhood and our confirmation of the presence of SV40 DNA in human osteosarcomas. ...Infectious SV40 was recovered from one brain tumor. We sequenced the entire …

This report summarizes our follow-up studies of SV40 DNA sequences in human brain tumors of early childhood and our confirmation of t …

38

Experimental tumour induction by SV40 transformed cells.

Cook JL, Routes BA, Sompayrac L. Cook JL, et al. Dev Biol Stand. 1998;94:303-9. Dev Biol Stand. 1998. PMID: 9776251 Review.

However, secondary manipulations of SV40-transformed cells can result in increased tumorigenicity. Some early observations on tumour induction by SV40 and transformed cells will be followed by a selected review of evidence suggesting that tumorigenicity of SV40 …

However, secondary manipulations of SV40-transformed cells can result in increased tumorigenicity. Some early observations on tumour …

39

SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study.

Cristaudo A, Foddis R, Vivaldi A, Buselli R, Gattini V, Guglielmi G, Cosentino F, Ottenga F, Ciancia E, Libener R, Filiberti R, Neri M, Betta P, Tognon M, Mutti L, Puntoni R. Cristaudo A, et al. Cancer Res. 2005 Apr 15;65(8):3049-52. doi: 10.1158/0008-5472.CAN-04-2219. Cancer Res. 2005. PMID: 15833832

PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and …

PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and …

40

Consideration of PCR methods for the detection of SV40 in tissue and DNA specimens.

Lednicky JA, Butel JS. Lednicky JA, et al. Dev Biol Stand. 1998;94:155-64. Dev Biol Stand. 1998. PMID: 9776238 Review.

SV40 is capable of infecting humans, although its association with human diseases remains controversial. Recently, a subgenomic SV40 DNA sequence was detected by polymerase chain reaction (PCR) in certain types of human tumour tissue as well as in normal pituitary t …

SV40 is capable of infecting humans, although its association with human diseases remains controversial. Recently, a subgenomic SV …

41

Evidence against a role for SV40 in human mesothelioma.

Manfredi JJ, Dong J, Liu WJ, Resnick-Silverman L, Qiao R, Chahinian P, Saric M, Gibbs AR, Phillips JI, Murray J, Axten CW, Nolan RP, Aaronson SA. Manfredi JJ, et al. Cancer Res. 2005 Apr 1;65(7):2602-9. doi: 10.1158/0008-5472.CAN-04-2461. Cancer Res. 2005. PMID: 15805256

Kidney, a known reservoir of SV40 in monkeys, from some of these individuals were also negative for SV40 large T antigen sequences. A subset of mesotheliomas was analyzed for SV40 large T antigen expression by immunostaining with a highly specific SV40 …

Kidney, a known reservoir of SV40 in monkeys, from some of these individuals were also negative for SV40 large T antigen seque …

42

SV40-like sequences in human bone tumors.

Carbone M, Rizzo P, Procopio A, Giuliano M, Pass HI, Gebhardt MC, Mangham C, Hansen M, Malkin DF, Bushart G, Pompetti F, Picci P, Levine AS, Bergsagel JD, Garcea RL. Carbone M, et al. Oncogene. 1996 Aug 1;13(3):527-35. Oncogene. 1996. PMID: 8760294

PCR amplification and Southern blot hybridization with a probe specific for SV40 Tag revealed that 18/200 samples contained SV40-like sequences and, unexpectedly, 11/18 were from patients with osteosarcomas. ...The extent of SV40 genome sequences present in t …

PCR amplification and Southern blot hybridization with a probe specific for SV40 Tag revealed that 18/200 samples contained SV40 …

43

SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma.

Cacciotti P, Libener R, Betta P, Martini F, Porta C, Procopio A, Strizzi L, Penengo L, Tognon M, Mutti L, Gaudino G. Cacciotti P, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12032-7. doi: 10.1073/pnas.211026798. Epub 2001 Sep 25. Proc Natl Acad Sci U S A. 2001. PMID: 11572935 Free PMC article.

In human mesothelial cells (HMC) transfected with full-length SV40 DNA (SV40-HMC), Met receptor activation was associated with S-phase entry, acquisition of a fibroblastoid morphology, and the assembly of viral particles. ...This, in turn, was causally related to Ta …

In human mesothelial cells (HMC) transfected with full-length SV40 DNA (SV40-HMC), Met receptor activation was associated with …

44

SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals.

Martini F, Iaccheri L, Lazzarin L, Carinci P, Corallini A, Gerosa M, Iuzzolino P, Barbanti-Brodano G, Tognon M. Martini F, et al. Cancer Res. 1996 Oct 15;56(20):4820-5. Cancer Res. 1996. PMID: 8841004

DNA sequence analysis, performed in four positive samples, confirmed that the amplified PCR products belong to the SV40 early region. Sixty-one % of the neoplastic patients positive for SV40 sequences had an age excluding exposure to SV40-contaminated polio v …

DNA sequence analysis, performed in four positive samples, confirmed that the amplified PCR products belong to the SV40 early region. …

45

SV40-transformed simian cells support the replication of early SV40 mutants.

Gluzman Y. Gluzman Y. Cell. 1981 Jan;23(1):175-82. doi: 10.1016/0092-8674(81)90282-8. Cell. 1981. PMID: 6260373

CV-1, an established line of simian cells permissive for lytic growth of SV40, were transformed by an origin-defective mutant of SV40 which codes for wild-type T antigen. ...One of the lines (COS-1) contains a single integrated copy of the complete early region of …

CV-1, an established line of simian cells permissive for lytic growth of SV40, were transformed by an origin-defective mutant of S …

46

Conventional epidemiology and the link between SV40 and human cancers.

Vilchez RA, Kozinetz CA, Butel JS. Vilchez RA, et al. Lancet Oncol. 2003 Mar;4(3):188-91. doi: 10.1016/s1470-2045(03)01024-6. Lancet Oncol. 2003. PMID: 12623365

Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror the human cancers that have been found to contain SV40 DNA or the viral oncoprotein. Increasing amounts of data support the notion t …

Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror …

47

SV40 large T antigen-specific human T cell memory responses.

Coleman S, Gibbs A, Butchart E, Mason MD, Jasani B, Tabi Z. Coleman S, et al. J Med Virol. 2008 Aug;80(8):1497-504. doi: 10.1002/jmv.21216. J Med Virol. 2008. PMID: 18551603

The aim of our experiments was to find cellular immunological evidence of SV40 infection in humans by testing memory T cell responses to SV40 large T antigen (Tag). ...Similarly, the relevant BKV and JCV Tag peptides did not generate T cell responses against SV40 …

The aim of our experiments was to find cellular immunological evidence of SV40 infection in humans by testing memory T cell responses …

48

[Molecular biology of natural and constructed in vitro recombinants of human adenoviruses and SV40].

Miroshnichenko OI, Naroditskiĭ BS. Miroshnichenko OI, et al. Mol Gen Mikrobiol Virusol. 1985 Nov;(11):3-11. Mol Gen Mikrobiol Virusol. 1985. PMID: 3025687 Review. Russian.

This review is devoted to the molecular and biological properties of natural and artificial Ad-SV40 hybrids. The conditions of adenovirus and SV40 recombinant formations are discussed. ...The data about the structural and functional organization of the hybrid RNA an …

This review is devoted to the molecular and biological properties of natural and artificial Ad-SV40 hybrids. The conditions of adenov …

49

Investigation of the SV40--human cancer association: look for the full signature of the virus.

Shah KV, Rollison DE. Shah KV, et al. Dis Markers. 2001;17(3):159-61. doi: 10.1155/2001/630740. Dis Markers. 2001. PMID: 11790881 Free PMC article.

In the controversy about the association of simian virus 40 with human cancers, the greatest problem is the ascertainment of SV40 exposure. This difficulty would be resolved if one were to look for all components of SV40 infection. How does SV 40 circulate in the hu …

In the controversy about the association of simian virus 40 with human cancers, the greatest problem is the ascertainment of SV40 exp …

50

Disassociation of the SV40 genome from capsid proteins prior to nuclear entry.

Kuksin D, Norkin LC. Kuksin D, et al. Virol J. 2012 Aug 10;9:158. doi: 10.1186/1743-422X-9-158. Virol J. 2012. PMID: 22882793 Free PMC article.

Then, in the cytoplasm, disassembly progresses further to also make the genomic DNA accessible to immune detection, as well as to detection by an ethynyl-2-deoxyuridine (EdU)-based chemical reaction. The cytoplasmic partially disassembled SV40 particles retain some of the …

Then, in the cytoplasm, disassembly progresses further to also make the genomic DNA accessible to immune detection, as well as to detection …

51

Evaluation of SV40 in osteosarcoma and healthy population: a Hungarian-German study.

Heinsohn S, Szendroi M, Bielack S, Stadt UZ, Kabisch H. Heinsohn S, et al. Oncol Rep. 2009 Feb;21(2):289-97. Oncol Rep. 2009. PMID: 19148498

To reach an appropriate detection level, we investigated a real-time quantitative PCR-based assay for the detection and quantification of SV40 <10 copies in 500 ng of genomic DNA. We detected SV40 in 52% (143/277) of the OS samples analysed. In detail, we saw dif …

To reach an appropriate detection level, we investigated a real-time quantitative PCR-based assay for the detection and quantification of …

52

Manipulation of SV40 Vectors.

Hammurskjöld ML. Hammurskjöld ML. Methods Mol Biol. 1991;7:169-80. doi: 10.1385/0-89603-178-0:169. Methods Mol Biol. 1991. PMID: 21416355

ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). ...Fig. 1. Schematic diagrams of the genome of SV40 and the SV40 expression vectors p14, pBABY, and pSVEpR4. The detailed maps and constructions o …

ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). ...Fig. 1. Schematic …

53

Sera from Patients with Malignant Pleural Mesothelioma Tested Positive for IgG Antibodies against SV40 Large T Antigen: The Viral Oncoprotein.

Mazzoni E, Bononi I, Rotondo JC, Mazziotta C, Libener R, Guaschino R, Gafà R, Lanza G, Martini F, Tognon M. Mazzoni E, et al. J Oncol. 2022 Jul 15;2022:7249912. doi: 10.1155/2022/7249912. eCollection 2022. J Oncol. 2022. PMID: 35874636 Free PMC article.

Immunohistochemical staining (IHS) assays showed SV40 Tag expression in 8/20, 40% of MPM specimens. These results indicate that SV40 is linked to a large fraction of MPM. It is worth noting that the prevalence of SV40 Tag antibodies detected in sera from coho …

Immunohistochemical staining (IHS) assays showed SV40 Tag expression in 8/20, 40% of MPM specimens. These results indicate that SV …

54

SV40 transfection of human kidney epithelial cells and stability of chromosome 11.

Poirier V, Tyler SJ, Brown KW, Shaw AP, Maitland NJ. Poirier V, et al. Int J Cancer. 1988 Dec 15;42(6):887-94. doi: 10.1002/ijc.2910420617. Int J Cancer. 1988. PMID: 2903852

We transfected normal kidney WT/NK, tumoral WT/T cells and human foetal kidney HFK cells with 2 SV40-derived plasmids SV3neo (pBR322-SV40-containing neomycin bacterial gene) and SVori- (pMK-origin mutated SV40). ...We looked at different markers associated wi …

We transfected normal kidney WT/NK, tumoral WT/T cells and human foetal kidney HFK cells with 2 SV40-derived plasmids SV3neo (pBR322- …

55

Immunoprecipitation of SV40 replicating minichromosomes complexed with bacteriophage T4 gene 32 protein.

Miranda EI, Garrido-Guerrero E, Garcia-Carranca A, Gariglio P. Miranda EI, et al. Nucleic Acids Res. 1992 Feb 25;20(4):903-7. doi: 10.1093/nar/20.4.903. Nucleic Acids Res. 1992. PMID: 1311833 Free PMC article.

Late after infection SV40 replicating DNA molecules represent about 5% of total viral minichromosomes. Since gene 32 protein (P32) from bacteriophage T4 interacts with single-stranded DNA and SV40 replication complexes are expected to contain single-stranded regions …

Late after infection SV40 replicating DNA molecules represent about 5% of total viral minichromosomes. Since gene 32 protein (P32) fr …

56

Carcinogen-mediated induction of SV40 DNA amplification is enhanced by acrylamide in Chinese hamster CO60 cells.

Vanhorick M, Moens W. Vanhorick M, et al. Carcinogenesis. 1983 Nov;4(11):1459-63. doi: 10.1093/carcin/4.11.1459. Carcinogenesis. 1983. PMID: 6315255

The exposure of SV40-transformed Chinese hamster cells (line CO60) to 50-150 micrograms/ml of monomeric acrylamide for 24 h resulted in a very weak induction of the amplification of the SV40 DNA inserts as measured by in situ hybridization with radioactive SV40 …

The exposure of SV40-transformed Chinese hamster cells (line CO60) to 50-150 micrograms/ml of monomeric acrylamide for 24 h resulted …

57

Construction of an adenovirus-SV40 recombinant producing SV40 T antigen from an adenovirus late promoter.

Solnick D. Solnick D. Cell. 1981 Apr;24(1):135-43. doi: 10.1016/0092-8674(81)90509-2. Cell. 1981. PMID: 6263482

An adenovirus-SV40 recombinant has been constructed in which the SV40 early region, joined to a copy of the adenovirus major late promoter, was substituted for a small portion of the adenovirus late region and all of early region 3. The inserted sequence functions a …

An adenovirus-SV40 recombinant has been constructed in which the SV40 early region, joined to a copy of the adenovirus major l …

58

Detection and quantification of SV40 large T-antigen DNA in mesothelioma tissues and cell lines.

Gordon GJ, Chen CJ, Jaklitsch MT, Richards WG, Sugarbaker DJ, Bueno R. Gordon GJ, et al. Oncol Rep. 2002 May-Jun;9(3):631-4. Oncol Rep. 2002. PMID: 11956641

To this end, we investigated the efficacy of real time quantitative PCR in detecting low copy number SV40 DNA sequences, then we quantified SV40 copy number in MPM tissues and cell lines at our institution. Quantitative PCR demonstrated consistent precision and accu …

To this end, we investigated the efficacy of real time quantitative PCR in detecting low copy number SV40 DNA sequences, then we quan …

59

Immunodetection of SV40 T/t-antigens in human osteosrcoma in a series of Tunisian patients.

Ziadi S, Boughamoura H, Ben Maitig M, Ben Gacem R, Mestiri S, Chaabani L, Trimeche M. Ziadi S, et al. Pathol Oncol Res. 2012 Jul;18(3):691-6. doi: 10.1007/s12253-012-9496-x. Pathol Oncol Res. 2012. PMID: 22286959 Free article.

The etiology of osteosarcoma is not well understood. Recent investigations have identified SV40 DNA sequences in osteosarcomas, suggesting that SV40 may contribute to tumor development. ...This study documents the presence SV40 T/t-antigens in a proportion of …

The etiology of osteosarcoma is not well understood. Recent investigations have identified SV40 DNA sequences in osteosarcomas, sugge …

60

Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication.

Dean FB, Bullock P, Murakami Y, Wobbe CR, Weissbach L, Hurwitz J. Dean FB, et al. Proc Natl Acad Sci U S A. 1987 Jan;84(1):16-20. doi: 10.1073/pnas.84.1.16. Proc Natl Acad Sci U S A. 1987. PMID: 3025851 Free PMC article.

The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP, catalyzed the conversion of a circular duplex DNA molecule containing the SV40 origin of replication to a form with unusual electro …

The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP …

61

Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters.

Zhang S, Sroller V, Zanwar P, Chen CJ, Halvorson SJ, Ajami NJ, Hecksel CW, Swain JL, Wong C, Sullivan CS, Butel JS. Zhang S, et al. PLoS Pathog. 2014 Feb 6;10(2):e1003912. doi: 10.1371/journal.ppat.1003912. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24516384 Free PMC article.

Effects of polyomavirus SV40 microRNA on pathogenesis of viral infections in vivo are not known. Syrian golden hamsters are the small animal model for studies of SV40. We report here effects of SV40 microRNA and influence of the structure of the regulatory re …

Effects of polyomavirus SV40 microRNA on pathogenesis of viral infections in vivo are not known. Syrian golden hamsters are the small …

62

Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40.

McNees AL, Harrigal LJ, Kelly A, Minard CG, Wong C, Butel JS. McNees AL, et al. PLoS One. 2018 Feb 12;13(2):e0192799. doi: 10.1371/journal.pone.0192799. eCollection 2018. PLoS One. 2018. PMID: 29432481 Free PMC article.

BACKGROUND: Polyomaviruses, including simian virus 40 (SV40), display evidence of lymphotropic properties. This study analyzed the nature of SV40-human lymphocyte interactions in established cell lines and in primary lymphocytes. ...Following infection of primary ly …

BACKGROUND: Polyomaviruses, including simian virus 40 (SV40), display evidence of lymphotropic properties. This study analyzed the na …

63

SV40 and p53 as team players in childhood lymphoproliferative disorders.

Heinsohn S, Scholz R, Kabisch H. Heinsohn S, et al. Int J Oncol. 2011 May;38(5):1307-17. doi: 10.3892/ijo.2011.967. Epub 2011 Mar 10. Int J Oncol. 2011. PMID: 21399869

All specimens showing a p53 mutation, were SV40-positive. p53 mutaions found in LNs of B-NHL patients harbour high SV40 copy numbers. Our data strongly support an important role for SV40, as well as a strong association of SV40 and p53 in childhood lym …

All specimens showing a p53 mutation, were SV40-positive. p53 mutaions found in LNs of B-NHL patients harbour high SV40 copy n …

64

SV40 large tumor antigen associated synthetic peptides define native antigenic determinants and induce protective tumor immunity in mice.

Bright RK, Shearer MH, Kennedy RC. Bright RK, et al. Mol Immunol. 1994 Oct;31(14):1077-87. doi: 10.1016/0161-5890(94)90103-1. Mol Immunol. 1994. PMID: 7523865

Synthetic peptides were utilized to define antigenic determinants on simian virus 40 (SV40) large tumor antigen (T-ag). Six synthetic peptides representing predicted B-cell epitopes on SV40 T-ag were used to immunize mice to compare the humoral immune responses and …

Synthetic peptides were utilized to define antigenic determinants on simian virus 40 (SV40) large tumor antigen (T-ag). Six synthetic …

65

Influence of SV40 Genome on the Replication of an Adenovirus-SV40 "Hybrid" Population.

Feldman LA, Melnick JL, Rapp F. Feldman LA, et al. J Bacteriol. 1965 Sep;90(3):778-82. doi: 10.1128/jb.90.3.778-782.1965. J Bacteriol. 1965. PMID: 16562080 Free PMC article.

(Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an adenovirus-SV40 "hybrid" population. J. Bacteriol. 90:778-782. 1965....These results suggest that the population of the adenovirus- …

(Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an …

66

Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.

Cutrone R, Lednicky J, Dunn G, Rizzo P, Bocchetta M, Chumakov K, Minor P, Carbone M. Cutrone R, et al. Cancer Res. 2005 Nov 15;65(22):10273-9. doi: 10.1158/0008-5472.CAN-05-2028. Cancer Res. 2005. PMID: 16288015

Some polio vaccines prepared from 1954 to 1961 were contaminated with infectious SV40. It has been assumed that all polio vaccines were SV40 free in the United States after 1961 and in other countries after 1962. Following a WHO requirement that was prompted by the …

Some polio vaccines prepared from 1954 to 1961 were contaminated with infectious SV40. It has been assumed that all polio vaccines we …

67

SV40 large T-antigen and human pleural mesothelioma. Screening by polymerase chain reaction and tyramine-amplified immunohistochemistry.

Dhaene K, Verhulst A, Van Marck E. Dhaene K, et al. Virchows Arch. 1999 Jul;435(1):1-7. doi: 10.1007/s004280050387. Virchows Arch. 1999. PMID: 10431839

Depending on the antibody used, different results have been observed regarding the subcellular expression of SV40 LTag in mesotheliomas with SV40 LTag-like DNA sequences. In this study, we screened 28 Belgian mesothelioma tumour samples for the presence of SV40 …

Depending on the antibody used, different results have been observed regarding the subcellular expression of SV40 LTag in mesotheliom …

68

SV40 sequences in human osteosarcoma of German origin.

Heinsohn S, Scholz RB, Weber B, Wittenstein B, Werner M, Delling G, Kempf-Bielack B, Setlak P, Bielack S, Kabisch H. Heinsohn S, et al. Anticancer Res. 2000 Nov-Dec;20(6B):4539-45. Anticancer Res. 2000. PMID: 11205301

Osteosarcoma is a bone malignancy with multiple molecular lesions underlining progression from normal bone to osteosarcoma. Recent investigations have identified SV40 DNA sequences in osteosarcomas, suggesting that SV40 may contribute to tumor development. ...These …

Osteosarcoma is a bone malignancy with multiple molecular lesions underlining progression from normal bone to osteosarcoma. Recent investiga …

69

The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulum.

Norkin LC, Kuksin D. Norkin LC, et al. Virol J. 2005 Apr 19;2:38. doi: 10.1186/1743-422X-2-38. Virol J. 2005. PMID: 15840166 Free PMC article.

For that reason, and because the caveosome and Golgi may have some common markers, we revisited the issue of whether SV40 might access the endoplasmic reticulum via the Golgi. RESULTS: We confirmed our earlier finding that SV40 co localizes with the Golgi marker bet …

For that reason, and because the caveosome and Golgi may have some common markers, we revisited the issue of whether SV40 might acces …

70

Virion-mediated transfer of SV40 epigenetic information.

Milavetz B, Kallestad L, Gefroh A, Adams N, Woods E, Balakrishnan L. Milavetz B, et al. Epigenetics. 2012 Jun 1;7(6):528-34. doi: 10.4161/epi.20057. Epub 2012 Jun 1. Epigenetics. 2012. PMID: 22507897 Free PMC article.

In order to determine whether SV40 is capable of transgenerational epigenetic regulation, we have analyzed SV40 chromatin from minichromosomes and virions for the presence of modified histones using various ChIP techniques and correlated these modifications with spe …

In order to determine whether SV40 is capable of transgenerational epigenetic regulation, we have analyzed SV40 chromatin from …

71

Expression of chimeric genes in the early region of SV40.

Horowitz M, Cepko CL, Sharp PA. Horowitz M, et al. J Mol Appl Genet. 1983;2(2):147-59. J Mol Appl Genet. 1983. PMID: 6192195

RNA mapping demonstrated the following: (a) The SV40-rat preproinsulin chimeric RNA was initiated at the SV40 early promoter, spliced from the SV40 5' SS to the rat preproinsulin 3' SS, and polyadenylated solely at the SV40 poly(A) addition signal. ... …

RNA mapping demonstrated the following: (a) The SV40-rat preproinsulin chimeric RNA was initiated at the SV40 early promoter, …

72

Association of SV40 with human tumors.

Klein G, Powers A, Croce C. Klein G, et al. Oncogene. 2002 Feb 14;21(8):1141-9. doi: 10.1038/sj.onc.1205173. Oncogene. 2002. PMID: 11850833

Sequence analysis confirmed that the sequences were homologous to SV40. One year later, SV40 was also found in 5/9 human mesotheliomas, and in 1996 SV40 was also reported to be present in 1/3 of the tumor specimens examined. These reports, in combination with …

Sequence analysis confirmed that the sequences were homologous to SV40. One year later, SV40 was also found in 5/9 human mesot …

73

Molecular identification of SV40 infection in human subjects and possible association with kidney disease.

Li RM, Branton MH, Tanawattanacharoen S, Falk RA, Jennette JC, Kopp JB. Li RM, et al. J Am Soc Nephrol. 2002 Sep;13(9):2320-30. doi: 10.1097/01.asn.0000028249.06596.cf. J Am Soc Nephrol. 2002. PMID: 12191976

If indeed SV40 is endemic within the human population, the route of transmission is unknown. It was therefore hypothesized that SV40 might be renotropic in humans and be detected more frequently in samples obtained from patients with kidney diseases. ...This study d …

If indeed SV40 is endemic within the human population, the route of transmission is unknown. It was therefore hypothesized that SV …

74

Immune control of SV40-induced tumors in mice.

Pan S, Abramczuk J, Knowles BB. Pan S, et al. Int J Cancer. 1987 Jun 15;39(6):722-8. doi: 10.1002/ijc.2910390612. Int J Cancer. 1987. PMID: 3034805

Mice of these 3 H-2 haplotypes were challenged with SV40 and their ability to generate and sustain an antibody response to SV40 T-antigen was found to be equivalent. ...Although interaction between the various immune effector mechanisms may play a role in the recogn …

Mice of these 3 H-2 haplotypes were challenged with SV40 and their ability to generate and sustain an antibody response to SV40 …

75

Replicative functions of the SV40(cT)-3 mutant defective for nuclear transport of T antigen.

Lanford RE, Butel JS. Lanford RE, et al. Virology. 1985 Nov;147(1):72-80. doi: 10.1016/0042-6822(85)90228-4. Virology. 1985. PMID: 2998072

The SV40(cT)-3 mutant is defective in transport of SV40 large tumor antigen (T-ag) to the nucleus. ...The cT mutation sufficiently suppressed the nuclear transport of wild-type (WT) T-ag in SV40(cT)-3-infected COS-1 cells to result in the cessation of WT-T-ag …

The SV40(cT)-3 mutant is defective in transport of SV40 large tumor antigen (T-ag) to the nucleus. ...The cT mutation sufficie …

76

A colinear map relating the simian virus 40 (SV40) DNA segments of six adenovirus-SV40 hybrids to the DNA fragments produced by restriction endonuclease cleavage of SV40 DNA.

Lebowitz P, Kelly TJ Jr, Nathans D, Lee TN, Lewis AM Jr. Lebowitz P, et al. Proc Natl Acad Sci U S A. 1974 Feb;71(2):441-5. doi: 10.1073/pnas.71.2.441. Proc Natl Acad Sci U S A. 1974. PMID: 4131276 Free PMC article.

The simian virus 40 (SV40) DNA segments present in a series of adenovirus-SV40 hybrids have been mapped with respect to the sites of cleavage of SV40 DNA by restriction endonucleases. ...The two sets of data were consistent and have permitted alignment of the …

The simian virus 40 (SV40) DNA segments present in a series of adenovirus-SV40 hybrids have been mapped with respect to the si …

77

Evidence of SV40 infections in hospitalized children.

Butel JS, Jafar S, Wong C, Arrington AS, Opekun AR, Finegold MJ, Adam E. Butel JS, et al. Hum Pathol. 1999 Dec;30(12):1496-502. doi: 10.1016/s0046-8177(99)90173-9. Hum Pathol. 1999. PMID: 10667429

Simian virus 40 (SV40) is known to have contaminated poliovirus vaccines used between 1955 and 1963. Accumulating reports have described the presence of SV40 DNA in human tumors and normal tissues, although the significance of human infections by SV40 is unkn …

Simian virus 40 (SV40) is known to have contaminated poliovirus vaccines used between 1955 and 1963. Accumulating reports have descri …

78

Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts.

Crosby LM, Moore TM, George M, Yoon LW, Easton MJ, Ni H, Morgan KT, DeAngelo AB. Crosby LM, et al. Cancer Cell Int. 2010 Feb 23;10:4. doi: 10.1186/1475-2867-10-4. Cancer Cell Int. 2010. PMID: 20178601 Free PMC article.

BACKGROUND: Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however gene-level interactions between 3-MC and SV40 …

BACKGROUND: Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to e …

79

SV40-immortalized human fibroblasts as a source of SV40 infectious virions.

Morelli C, Barbisan F, Iaccheri L, Tognon M. Morelli C, et al. Mol Med. 2004 Jul-Dec;10(7-12):112-6. doi: 10.2119/2004-00037.Morelli. Mol Med. 2004. PMID: 15702218 Free PMC article.

Human fibroblasts immortalized by Simian Virus 40 (SV40) are widely employed for cell and molecular biology model of study. Indeed, SV40 transmission to humans was believed to occur only under exceptional situations. ...These data indicate that SV40-immortali …

Human fibroblasts immortalized by Simian Virus 40 (SV40) are widely employed for cell and molecular biology model of study. Indeed, …

80

Detection of SV40 like viral DNA and viral antigens in malignant pleural mesothelioma.

Ramael M, Nagels J, Heylen H, De Schepper S, Paulussen J, De Maeyer M, Van Haesendonck C. Ramael M, et al. Eur Respir J. 1999 Dec;14(6):1381-6. doi: 10.1183/09031936.99.14613819. Eur Respir J. 1999. PMID: 10624771 Free article.

Immunohistochemistry with an SV40-specific antibody was applied for detection of the SV40 viral antigen in the same material. SV40 DNA and expression of one of the viral proteins (small t-antigen) was found in approximately 60% of the investigated mesotheliom …

Immunohistochemistry with an SV40-specific antibody was applied for detection of the SV40 viral antigen in the same material. …

81

Polyomavirus SV40 infections in Kazakhstan.

Nurgalieva ZZ, Wong C, Zhangabylov AK, Omarbekova ZE, Graham DY, Vilchez RA, Butel JS. Nurgalieva ZZ, et al. J Infect. 2005 Feb;50(2):142-8. doi: 10.1016/j.jinf.2004.03.001. J Infect. 2005. PMID: 15667916

OBJECTIVES: To examine the prevalence of polyomavirus SV40 infections in Kazakhstan, a central Asian country known to have used potentially contaminated SV40 poliovaccines before 1962. ...As increasing evidence indicates an association of SV40 with selected t …

OBJECTIVES: To examine the prevalence of polyomavirus SV40 infections in Kazakhstan, a central Asian country known to have used poten …

82

Inverse relationship between anti-SV40 TASA and anti-H-2 cytotoxic responses.

De Giovanni C, Grilli S, Lollini PL, Nicoletti G, Prodi G, Nanni P. De Giovanni C, et al. J Cancer Res Clin Oncol. 1983;106(2):117-22. doi: 10.1007/BF00395389. J Cancer Res Clin Oncol. 1983. PMID: 6313694 Free PMC article.

The in vitro cytotoxic response against H-2d and H-2b SV40-transformed fibroblasts was studied in a 40-h 3H-proline assay. A very low response against SV40 TASA is associated with the H-2d antigens on target cells: however, SV40-transformed H-2d cells are as …

The in vitro cytotoxic response against H-2d and H-2b SV40-transformed fibroblasts was studied in a 40-h 3H-proline assay. A very low …

83

Sequence of the junction in adenovirus 2-SV40 hybrids: examples of illegitimate recombination.

Ling LE, Manos MM, Gluzman Y. Ling LE, et al. Nucleic Acids Res. 1982 Dec 20;10(24):8099-112. doi: 10.1093/nar/10.24.8099. Nucleic Acids Res. 1982. PMID: 6298708 Free PMC article.

The nucleotide sequences of six Ad2-SV40 junctions from three Ad2-SV40 hybrid viruses (Ad2++HEY, Ad2++LEY and Ad2+D1) were determined. ...Ad2++HEY and Ad2+D1 right junctions are identical and Ad2++LEY and Ad2+ND4 left junctions are identical, a result that strongly …

The nucleotide sequences of six Ad2-SV40 junctions from three Ad2-SV40 hybrid viruses (Ad2++HEY, Ad2++LEY and Ad2+D1) were det …

84

SV40 virus transformation down-regulates endothelin receptor.

Chiou WJ, Wang J, Berg CE, Wu-Wong JR. Chiou WJ, et al. Biochim Biophys Acta. 1999 May 6;1450(1):35-44. doi: 10.1016/s0167-4889(99)00030-0. Biochim Biophys Acta. 1999. PMID: 10231553 Free article.

This report examines the effect of SV40 transformation on the expression of ET receptors. Results from receptor binding and reverse transcription (RT)-polymerase chain reaction (PCR) studies show that human lung fibroblasts IMR90 and WI38 express both ETA and ETB receptors …

This report examines the effect of SV40 transformation on the expression of ET receptors. Results from receptor binding and reverse t …

85

Evaluation of cellular immune response and biosafety of SV40 virus-like particle in tumor immunotherapy.

He T, Hei R, Liu C, Wang H, Gao Z, Dong K, Zhang J. He T, et al. J Mater Sci Mater Med. 2025 Dec 24;37(1):15. doi: 10.1007/s10856-025-06986-0. J Mater Sci Mater Med. 2025. PMID: 41441896 Free PMC article.

In vivo imaging of mice demonstrated the migration of SV40 VLP between lymph nodes. Flow cytometry revealed that SV40 VLP significantly increased the numbers of CD4(+) T cells and NK cells in the spleen, along with elevated levels of CD4(+) T cells in mesenteric lym …

In vivo imaging of mice demonstrated the migration of SV40 VLP between lymph nodes. Flow cytometry revealed that SV40 VLP sign …

86

Serological evidence of SV40 infections in HIV-infected and HIV-negative adults.

Jafar S, Rodriguez-Barradas M, Graham DY, Butel JS. Jafar S, et al. J Med Virol. 1998 Apr;54(4):276-84. doi: 10.1002/(sici)1096-9071(199804)54:4<276::aid-jmv7>3.0.co;2-1. J Med Virol. 1998. PMID: 9557293

As individuals born between 1941 and 1962 had the highest chance of having received SV40-contaminated poliovaccines, we analyzed SV40 seropositivity rates based on year of birth. ...The SV40 seropositivity rates in the patients born between 1941 and 1962 may …

As individuals born between 1941 and 1962 had the highest chance of having received SV40-contaminated poliovaccines, we analyzed S …

87

Studies of adenovirus SV40 hybrid viruses. I. Assay system and further evidence for hybridization.

Rowe WP, Baum SG, Pugh E, Hoggan MD. Rowe WP, et al. J Exp Med. 1965 Nov 1;122(5):943-54. doi: 10.1084/jem.122.5.943. J Exp Med. 1965. PMID: 4285252 Free PMC article.

The titers of adenovirus and SV40 genetic carriers in hybrid preparations (E46(+)) can be quantitated by determining the percentage of cells showing neoantigens stainable with fluorescent antibody (FA) at 21 to 24 hours; both titers can be obtained with a single coverslip. …

The titers of adenovirus and SV40 genetic carriers in hybrid preparations (E46(+)) can be quantitated by determining the percentage o …

88

SV40 tumor rejection induced by vesicular stomatitis virus bearing SV40 tumor-specific transplantation antigen (SV40-TSTA). I. Specificity of immunoprotection and effect of enzyme treatment on TSTA activity.

Ansel S, Huet C, Tournier P. Ansel S, et al. Int J Cancer. 1977 Jul 15;20(1):51-60. doi: 10.1002/ijc.2910200110. Int J Cancer. 1977. PMID: 71274

Highly purified vesicular stomatitis virus (VSV) was obtained from VSV-infected SV40-transformed hamster cell lines. Immunization with this virus protected hamsters against challenge with SV40-transformed cells (TSV5-cl2). This protection was obtained regardless of …

Highly purified vesicular stomatitis virus (VSV) was obtained from VSV-infected SV40-transformed hamster cell lines. Immunization wit …

89

SV40 in human tumors: new documents shed light on the apparent controversy.

MacLachlan DS. MacLachlan DS. Anticancer Res. 2002 Nov-Dec;22(6B):3495-9. Anticancer Res. 2002. PMID: 12552945

The first study, Testa et al., 1998, confirmed the presence of SV40 in mesothelioma. The second study, Strickler et al., produced irregular results indicating that: (a) though never reporting SV40 detection to date, Dr. ...Shah's laboratory had the most sensitive te …

The first study, Testa et al., 1998, confirmed the presence of SV40 in mesothelioma. The second study, Strickler et al., produced irr …

90

Helpers for efficient encapsidation of SV40 pseudovirions.

Oppenheim A, Peleg A. Oppenheim A, et al. Gene. 1989 Apr 15;77(1):79-86. doi: 10.1016/0378-1119(89)90361-2. Gene. 1989. PMID: 2545539

Plasmid DNA that carries the simian virus 40 (SV40) ori can be packaged as SV40 pseudovirions. The pseudovirions are very efficient in gene transmission into a variety of cell types, including human hemopoietic cells. ...However, it underwent extensive recombination …

Plasmid DNA that carries the simian virus 40 (SV40) ori can be packaged as SV40 pseudovirions. The pseudovirions are very effi …

91

Serum deprivation induces SV40 early promoter activity.

Tzen CY, Scott RE, Robinson FD. Tzen CY, et al. Cell Prolif. 1997 Feb;30(2):53-60. doi: 10.1046/j.1365-2184.1997.00067.x. Cell Prolif. 1997. PMID: 9332495 Free PMC article.

The results show that serum deprivation of growing cells induces SV40 promoter activity while serum stimulation of quiescent G0 cells suppresses it. Kinetic analyses show a significant induction of the SV40 promoter activity during the first 2 days of serum deprivat …

The results show that serum deprivation of growing cells induces SV40 promoter activity while serum stimulation of quiescent G0 cells …

92

Live oral poliovirus vaccines do not contain detectable simian virus 40 (SV40) DNA.

Sierra-Honigmann A, Krause PR. Sierra-Honigmann A, et al. Biologicals. 2000 Mar;28(1):1-4. doi: 10.1006/biol.1999.0233. Biologicals. 2000. PMID: 10799049

Prior to 1962, poliovirus vaccines produced in rhesus monkey kidney cells were contaminated with SV40. Recent studies reporting the detection of SV40 in human tumours raised concern that SV40 may be oncogenic in humans. ...SV40 DNA sequences were not f …

Prior to 1962, poliovirus vaccines produced in rhesus monkey kidney cells were contaminated with SV40. Recent studies reporting the d …

93

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells.

Bocchetta M, Miele L, Pass HI, Carbone M. Bocchetta M, et al. Oncogene. 2003 Jan 9;22(1):81-9. doi: 10.1038/sj.onc.1206097. Oncogene. 2003. PMID: 12527910

Notch-1 induction is achieved at the transcriptional level and requires both the SV40 large T-antigen and the small t-antigen. Notch-1 upregulation is maintained in SV40-transformed human mesothelial clones and in SV40-positive mesotheliomas and derived cell …

Notch-1 induction is achieved at the transcriptional level and requires both the SV40 large T-antigen and the small t-antigen. Notch- …

94

Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.

Faas SJ, Pan S, Pinkert CA, Brinster RL, Knowles BB. Faas SJ, et al. J Exp Med. 1987 Feb 1;165(2):417-27. doi: 10.1084/jem.165.2.417. J Exp Med. 1987. PMID: 3029269 Free PMC article.

The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 transgenic lines derived from injection of the same gene construct. Our studies demonstrate functional immune tolerance to SV40 T antig …

The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 tr …

95

Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

Linzer DI, Levine AJ. Linzer DI, et al. Cell. 1979 May;17(1):43-52. doi: 10.1016/0092-8674(79)90293-9. Cell. 1979. PMID: 222475

SV40 infection or transformation of murine cells stimulated the production of a 54K dalton protein that was specifically immunoprecipitated, along with SV40 large T and small t antigens, with sera from mice or hamsters bearing SV40-induced tumors. ...This pro …

SV40 infection or transformation of murine cells stimulated the production of a 54K dalton protein that was specifically immunoprecip …

96

Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes.

Zhang L, Qi F, Gaudino G, Strianese O, Yang H, Morris P, Pass HI, Nerurkar VR, Bocchetta M, Carbone M. Zhang L, et al. Genes Cancer. 2010 Oct;1(10):1008-20. doi: 10.1177/1947601910395580. Genes Cancer. 2010. PMID: 21779427 Free PMC article.

These are the same tumor types that are specifically induced by SV40 when injected into hamsters, a finding that has raised concerns about the possible pathogenic role of SV40 in humans. Two different SV40 isolates differing in the number of 72-bp elements in …

These are the same tumor types that are specifically induced by SV40 when injected into hamsters, a finding that has raised concerns …

97

Association Between Simian Virus 40 and Human Tumors.

Rotondo JC, Mazzoni E, Bononi I, Tognon M, Martini F. Rotondo JC, et al. Front Oncol. 2019 Jul 25;9:670. doi: 10.3389/fonc.2019.00670. eCollection 2019. Front Oncol. 2019. PMID: 31403031 Free PMC article. Review.

Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently from earlier SV40-contaminated vaccines. ...The main data on (i) the biology and genetics of SV40; (ii) the epidemiology of …

Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently …

98

Evidence for simian virus 40 (SV40) coding of SV40 T-antigen and the SV40-specific proteins in HeLa cells infected with nondefective adenovirus type 2-SV40 hybrid viruses.

Mann K, Hunter T, Walter G, Linke H. Mann K, et al. J Virol. 1977 Oct;24(1):151-69. doi: 10.1128/JVI.24.1.151-169.1977. J Virol. 1977. PMID: 198574 Free PMC article.

From the in vitro synthesis experiments with SV40-selected RNA, we further conclude that the SV40-specific proteins must be SV40 coded and not host coded. Since SV40 T-antigen is related to the SV40-specific proteins, it must also be SV40 …

From the in vitro synthesis experiments with SV40-selected RNA, we further conclude that the SV40-specific proteins must be …

99

Expression of SV40 T antigen under control of adenovirus promoters.

Thummel C, Tjian R, Grodzicker T. Thummel C, et al. Cell. 1981 Mar;23(3):825-36. doi: 10.1016/0092-8674(81)90447-5. Cell. 1981. PMID: 7226231

We have obtained novel adenovirus-SV40 recombinant viruses that express wild-type SV40 large T and small t antigens under the control of different adenovirus promoters. ...Biochemical characterization of SV40 T antigens overproduced by the hybrid viruses indi …

We have obtained novel adenovirus-SV40 recombinant viruses that express wild-type SV40 large T and small t antigens under the …

100

The role of plasmid constructs containing the SV40 DNA nuclear-targeting sequence in cationic lipid-mediated DNA delivery.

Prasad TK, Rao NM. Prasad TK, et al. Cell Mol Biol Lett. 2005;10(2):203-15. Cell Mol Biol Lett. 2005. PMID: 16010286 Free article.

Recently, via microinjection into the cytoplasm and in situ hybridizations into a few cell types, it was shown that a region of Simian virus 40(SV40), specifically a c. 372-bp fragment of SV40 genomic DNA encompassing the SV40 promoter-enhancer-origin of repl …

Recently, via microinjection into the cytoplasm and in situ hybridizations into a few cell types, it was shown that a region of Simian virus …

101

SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival.

Wong NA, Rae F, Herriot MM, Mayer NJ, Brewster DH, Harrison DJ. Wong NA, et al. J Clin Pathol. 2003 Dec;56(12):904-9. doi: 10.1136/jcp.56.12.904. J Clin Pathol. 2003. PMID: 14645347 Free PMC article.

PCR to detect SV40 regulatory sequence and SV40 Tag immunohistochemistry were performed on selected cases from cohorts A and B. ...Neither SV40 regulatory sequence nor SV40 Tag protein were demonstrated in Tag DNA positive HCCs. ...

PCR to detect SV40 regulatory sequence and SV40 Tag immunohistochemistry were performed on selected cases from cohorts A and B …

102

Causality of mesothelioma: SV40 question.

Shah KV. Shah KV. Thorac Surg Clin. 2004 Nov;14(4):497-504. doi: 10.1016/S1547-4127(04)00112-4. Thorac Surg Clin. 2004. PMID: 15559056

The fragility of the evidence for SV40 association with human cancer is seen in studies of NHL. A publication in 1999 stated that SV40 is rarely present in NHL. ...The weaknesses in the evidence linking SV40 with mesothelioma are summarized in Box 11 It seems …

The fragility of the evidence for SV40 association with human cancer is seen in studies of NHL. A publication in 1999 stated that …

103

Replication of SV40 chromatin in extracts from eggs of Xenopus laevis.

Richter A, Otto B, Knippers R. Richter A, et al. Nucleic Acids Res. 1981 Aug 11;9(15):3793-807. doi: 10.1093/nar/9.15.3793. Nucleic Acids Res. 1981. PMID: 6269093 Free PMC article.

We found that nucleoprotein containing replicating SV40 DNA served as primer-template while nucleoprotein with nonreplicating SV40 DNA was ineffective. ...This conclusion is supported by a restriction enzyme analysis showing that in vitro DNA synthesis occurs in fra …

We found that nucleoprotein containing replicating SV40 DNA served as primer-template while nucleoprotein with nonreplicating SV40 …

104

Low prevalence of SV40 in Swiss mesothelioma patients after elimination of false-positive PCR results.

Ziegler A, Seemayer CA, Hinterberger M, Vogt P, Bigosch C, Gautschi O, Tornillo L, Betticher DC, Moch H, Stahel RA. Ziegler A, et al. Lung Cancer. 2007 Sep;57(3):282-91. doi: 10.1016/j.lungcan.2007.03.025. Epub 2007 May 21. Lung Cancer. 2007. PMID: 17513005

To characterize the prevalence of SV40 in Swiss mesothelioma patients, we optimized a real-time PCR for quantitative detection of SV40 DNA in plasma, and used a monoclonal antibody for immunohistochemical detection of SV40 in mesothelioma tissue microarrays. …

To characterize the prevalence of SV40 in Swiss mesothelioma patients, we optimized a real-time PCR for quantitative detection of …

105

Biology of simian virus 40 (SV40) transplantation antigen (TrAg). X. Tumorigenic potential of mouse cells transformed by SV40 in high responder C57BL/6 mice and correlation with the persistence of SV40 TrAg, early proteins and sequences.

Flyer DC, Pretell J, Campbell AE, Liao WS, Tevethia MJ, Taylor JM, Tevethia SS. Flyer DC, et al. Virology. 1983 Nov;131(1):207-20. doi: 10.1016/0042-6822(83)90546-9. Virology. 1983. PMID: 6316651

Primary mouse embryo fibroblasts of C57Bl/6 origin and cells derived from a tumor induced by polyoma virus in a C57Bl/6 mouse were transformed with SV40. The tumorigenic potential of these cells in normal adult and SV40-immunized mice was correlated with the synthes …

Primary mouse embryo fibroblasts of C57Bl/6 origin and cells derived from a tumor induced by polyoma virus in a C57Bl/6 mouse were transform …

106

SV40 DNA injected into Xenopus oocyte nuclei is transcribed by RNA polymerase B.

Rungger D, Huber JP, Türler H. Rungger D, et al. Cell Biol Int Rep. 1979 Mar;3(2):183-8. doi: 10.1016/0309-1651(79)90125-5. Cell Biol Int Rep. 1979. PMID: 222491

SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients as do viral RNAs formed in infected green monkey cells but a variable proportion of RNA sequences complementary to SV40 DNA is also fo …

SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients a …

107

A domain of SV40 capsid polypeptide VP1 that specifies migration into the cell nucleus.

Wychowski C, Benichou D, Girard M. Wychowski C, et al. EMBO J. 1986 Oct;5(10):2569-76. doi: 10.1002/j.1460-2075.1986.tb04536.x. EMBO J. 1986. PMID: 3023047 Free PMC article.

In order to identify the determinants responsible for the nuclear migration of simian virus 40 (SV40) polypeptide VP1, the 5'-terminal portion of the SV40 VP1 gene was fused with the complete cDNA sequence of poliovirus capsid polypeptide VP1 and the hybrid gene was …

In order to identify the determinants responsible for the nuclear migration of simian virus 40 (SV40) polypeptide VP1, the 5'-termina …

108

Simian virus 40 (SV40)-like DNA sequences not detectable in finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines.

Hirvonen A, Mattson K, Karjalainen A, Ollikainen T, Tammilehto L, Hovi T, Vainio H, Pass HI, Di Resta I, Carbone M, Linnainmaa K. Hirvonen A, et al. Mol Carcinog. 1999 Oct;26(2):93-9. Mol Carcinog. 1999. PMID: 10506753

It is also known that expression of SV40 large T antigen inhibits cellular Rb and p53. This suggests that SV40 might render infected cells more susceptible to asbestos carcinogenicity. ...All of the Finnish tumor tissues tested negative for SV40-like sequence …

It is also known that expression of SV40 large T antigen inhibits cellular Rb and p53. This suggests that SV40 might render in …

109

Simultaneous immunostaining with anti-S100P and anti-SV40 antibodies revealed the origin of BK virus-infected decoy cells in voided urine samples.

Ariyasu S, Yanai H, Sato M, Shinno Y, Taniguchi K, Yamadori I, Miki Y, Sato Y, Yoshino T, Takahashi K. Ariyasu S, et al. Cytopathology. 2015 Aug;26(4):250-5. doi: 10.1111/cyt.12213. Epub 2014 Oct 17. Cytopathology. 2015. PMID: 25323691

METHODS: We performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine samples exhibiting SV40 positivity and a decoy-cell appearance on Papanicolaou staining. ...RESULTS: BKV-infected cells were categor …

METHODS: We performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine …

110

Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies.

Toscano MG, van der Velden J, van der Werf S, Odijk M, Roque A, Camacho-Garcia RJ, Herrera-Gomez IG, Mancini I, de Haan P. Toscano MG, et al. Mol Ther Methods Clin Dev. 2017 Jul 5;6:124-134. doi: 10.1016/j.omtm.2017.06.007. eCollection 2017 Sep 15. Mol Ther Methods Clin Dev. 2017. PMID: 28791314 Free PMC article.

SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the absence of contaminating RC SV40 particles. Our unique SV40 vector platform named SVac paves the way to clinically test a whole …

SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the a …

111

Examination of poliovirus vaccine preparations for SV40 sequences.

Sangar D, Pipkin PA, Wood DJ, Minor PD. Sangar D, et al. Biologicals. 1999 Mar;27(1):1-10. doi: 10.1006/biol.1998.0170. Biologicals. 1999. PMID: 10441397

Contamination of earlier materials with the monkey virus SV40, particularly inactivated Salk type poliovaccines, is well documented. Precautions have been in place for more than 30 years to prevent SV40 contamination of oral poliovaccines based on screening of donor …

Contamination of earlier materials with the monkey virus SV40, particularly inactivated Salk type poliovaccines, is well documented. …

112

SUCCESSIVE TRANSFORMATIONS OF AN ESTABLISHED CELL LINE BY POLYOMA VIRUS AND SV40.

TODARO GJ, GREEN H. TODARO GJ, et al. Science. 1965 Jan 29;147(3657):513-4. doi: 10.1126/science.147.3657.513. Science. 1965. PMID: 14241404

Two different oncogenic viruses, polyoma and SV40, are capable of transforming mouse cell line 3T3. The properties of the transformed cells produced by the two viruses are in some ways similar, but in other ways they are specific for the infecting virus. ...Two different c …

Two different oncogenic viruses, polyoma and SV40, are capable of transforming mouse cell line 3T3. The properties of the transformed …

113

DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.

POPE JH, ROWE WP. POPE JH, et al. J Exp Med. 1964 Aug 1;120(2):121-8. doi: 10.1084/jem.120.2.121. J Exp Med. 1964. PMID: 14206435 Free PMC article.

With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in each of five cell lines, derived from four mammalian species, transformed by SV40 virus. Essentially all nuclei, including those of mult …

With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in eac …

114

Extended lifespan of normal human B lymphocytes experimentally infected by SV40 or transfected by SV40 large T antigen expression vector.

Alaribe FN, Mazzoni E, Rigolin GM, Rizzotto L, Maniero S, Pancaldi C, Manfrini M, Martini F, Tognon MG. Alaribe FN, et al. Leuk Res. 2013 Jun;37(6):681-9. doi: 10.1016/j.leukres.2013.02.003. Epub 2013 Mar 7. Leuk Res. 2013. PMID: 23473917

SV40 footprints were detected in different lymphoproliferative disorders and in blood specimens of healthy donors. However, little is known on the ability of SV40 to infect/transform normal human B-lymphocytes. In this in vitro study, experimental SV40 infect …

SV40 footprints were detected in different lymphoproliferative disorders and in blood specimens of healthy donors. However, little is …

115

Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples.

Kjaerheim K, Røe OD, Waterboer T, Sehr P, Rizk R, Dai HY, Sandeck H, Larsson E, Andersen A, Boffetta P, Pawlita M. Kjaerheim K, et al. Int J Cancer. 2007 Jun 1;120(11):2459-65. doi: 10.1002/ijc.22592. Int J Cancer. 2007. PMID: 17315193

BKV and JCV specific antibodies cross- reactive with SV40 were preabsorbed with the respective VP1 proteins. Sera showing SV40 reactivity after preabsorption with BKV and JCV VP1 were further analyzed in SV40 neutralization assays. SV40 DNA was analyze …

BKV and JCV specific antibodies cross- reactive with SV40 were preabsorbed with the respective VP1 proteins. Sera showing SV40 …

116

Identification in human brain tumors of DNA sequences specific for SV40 large T antigen.

Huang H, Reis R, Yonekawa Y, Lopes JM, Kleihues P, Ohgaki H. Huang H, et al. Brain Pathol. 1999 Jan;9(1):33-42. doi: 10.1111/j.1750-3639.1999.tb00207.x. Brain Pathol. 1999. PMID: 9989448 Free PMC article.

In 8 tumor biopsies with SV40 sequences, the adjacent normal brain tissue was also analyzed but was devoid of viral DNA in all but one case. ...It remains to be shown whether the presence of SV40 contributes significantly to malignant transformation or whether certa …

In 8 tumor biopsies with SV40 sequences, the adjacent normal brain tissue was also analyzed but was devoid of viral DNA in all but on …

117

Electrophoretic analysis of covalently closed SV40 DNA: Boltzmann distributions of DNA species.

DeLeys RJ, Jackson DA. DeLeys RJ, et al. Nucleic Acids Res. 1976 Mar;3(3):641-52. doi: 10.1093/nar/3.3.641. Nucleic Acids Res. 1976. PMID: 179058 Free PMC article.

Covalently closed relaxed SV40 DNA [SV40(I')] generated by polynucleotide ligase closure of nicked circular SV40 DNA was analyzed by agarose gel electrophoresis. ...Densitometric analysis of native supercoiled SV40 DNA, partially unwound in the presenc …

Covalently closed relaxed SV40 DNA [SV40(I')] generated by polynucleotide ligase closure of nicked circular SV40 DNA wa …

118

Specific aggregation of SV40-transformed cells by ornithine, leucine copolymers.

Duksin D, Katchalski E, Sachs L. Duksin D, et al. Proc Natl Acad Sci U S A. 1970 Sep;67(1):185-92. doi: 10.1073/pnas.67.1.185. Proc Natl Acad Sci U S A. 1970. PMID: 4318776 Free PMC article.

In addition to the aggregation of cells transformed by SV40, cells transformed by adenovirus 12, which did not contain detectable SV40-specific nuclear tumor (T) antigen, were also aggregated by the basic copolymer in the presence of serum. This indicates that the o …

In addition to the aggregation of cells transformed by SV40, cells transformed by adenovirus 12, which did not contain detectable …

119

Frequency of SV40-specific cytotoxic T-lymphocyte precursors in two SV40 T-antigen transgenic mouse lines.

Juretic A, Knowles BB. Juretic A, et al. APMIS. 1991 Mar;99(3):213-8. doi: 10.1111/j.1699-0463.1991.tb05141.x. APMIS. 1991. PMID: 1850285

Cytotoxic T-lymphocyte precursors (CTL-P) from control C57BL/6 mice and from mice of two simian virus 40 (SV40) T-antigen transgenic lines, 427 and 419, specifically nonresponsive and responsive, respectively, to SV40 T antigen, were quantitated by limiting dilution …

Cytotoxic T-lymphocyte precursors (CTL-P) from control C57BL/6 mice and from mice of two simian virus 40 (SV40) T-antigen transgenic …

120

Markers of past infection with simian virus 40 (SV40) and risk of incident non-Hodgkin lymphoma in a Maryland cohort.

Rollison DE, Helzlsouer KJ, Halsey NA, Shah KV, Viscidi RP. Rollison DE, et al. Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1448-52. doi: 10.1158/1055-9965.EPI-04-0674. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15941954

Simian virus 40 (SV40) genome sequences have been detected in human non-Hodgkin lymphoma (NHL) tissues, and past infection with SV40 may be a risk factor for NHL. ...Whereas SV40 antibodies were detected by VLP ELISA in 15% of cases and 10% of controls [match …

Simian virus 40 (SV40) genome sequences have been detected in human non-Hodgkin lymphoma (NHL) tissues, and past infection with SV …

121

Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants.

Anderson RW, Tevethia MJ, Kalderon D, Smith AE, Tevethia SS. Anderson RW, et al. J Virol. 1988 Jan;62(1):285-96. doi: 10.1128/JVI.62.1.285-296.1988. J Virol. 1988. PMID: 2446015 Free PMC article.

Immunol. 130:490-492, 1983) by using two independently isolated SV40-specific cytotoxic T-lymphocyte (CTL) clones, K11 and K19. We identified amino acids in the amino-terminal half of SV40 T antigen that are essential for the recognition of antigenic sites by these …

Immunol. 130:490-492, 1983) by using two independently isolated SV40-specific cytotoxic T-lymphocyte (CTL) clones, K11 and K19. We id …

122

Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors.

Yang Z, Chen S, Xue S, Li X, Hu J, Sun Z, Cui H. Yang Z, et al. Onco Targets Ther. 2018 Aug 17;11:4945-4953. doi: 10.2147/OTT.S153576. eCollection 2018. Onco Targets Ther. 2018. PMID: 30154663 Free PMC article.

MATERIALS AND METHODS: A 122 bp SV40 terminator fragment (10 ng/ L) was microinjected into zebrafish zygotes. SV40 fragment integration into the zebrafish embryonic genome was detected by Southern blot using a DNA probe for the SV40 terminator. ...RESULTS: Mi …

MATERIALS AND METHODS: A 122 bp SV40 terminator fragment (10 ng/ L) was microinjected into zebrafish zygotes. SV40 fragment in …

123

Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen.

Lanford RE, Butel JS. Lanford RE, et al. Cell. 1984 Jul;37(3):801-13. doi: 10.1016/0092-8674(84)90415-x. Cell. 1984. PMID: 6086146

An SV40-adenovirus 7 hybrid virus, PARA(cT), has been described that is defective for the nuclear transport of SV40 large tumor antigen. An SV40(cT) mutant was constructed using SV40 early and late region DNA fragments derived from PARA(cT) and wild-ty …

An SV40-adenovirus 7 hybrid virus, PARA(cT), has been described that is defective for the nuclear transport of SV40 large tumo …

124

Complementation between SV40 and RFV defectives and acquisition of SV40 origins by late RFV genomes.

O'Neill FJ, Miller TH, Stevens R. O'Neill FJ, et al. Virology. 1986 Oct 30;154(2):344-56. doi: 10.1016/0042-6822(86)90460-5. Virology. 1986. PMID: 3020784

EL SV40 and RFV are variants of SV40 and BKV which contain bipartite or dual genomes. One molecule contains all the early viral sequences (E-SV40, E-RFV) and the other all the late viral sequences (L-SV40, L-RFV). ...E-SV40/rL-RFV demonstrated a …

EL SV40 and RFV are variants of SV40 and BKV which contain bipartite or dual genomes. One molecule contains all the early vira …

125

Isolation of a SV40-like Papovavirus from a human glioblastoma.

Scherneck S, Rudolph M, Geissler E, Vogel F, Lübbe L, Wählte H, Nisch G, Weickmann F, Zimmermann W. Scherneck S, et al. Int J Cancer. 1979 Nov 15;24(5):523-31. doi: 10.1002/ijc.2910240502. Int J Cancer. 1979. PMID: 93581

Serological tests (hemagglutination, neutralization, fluorescent antibody) revealed that the virus is indistinguishable from SV40. Despite this apparent antigenic identity SV40-GBM differs slightly from SV40 wild type. ...Therefore the virus SV40-GBM o …

Serological tests (hemagglutination, neutralization, fluorescent antibody) revealed that the virus is indistinguishable from SV40. De …

126

Analysis of mechanisms controlling the interactions of SV40 large T antigen with the SV40 ORI region.

Schirmbeck R, Deppert W. Schirmbeck R, et al. Virology. 1988 Aug;165(2):527-38. doi: 10.1016/0042-6822(88)90597-1. Virology. 1988. PMID: 2841799

We have characterized the interactions of simian virus 40 (SV40) large tumor antigen (large T) with the control region of the SV40 genome, the SV40 ORI, by analyzing the specific binding of large T antigen to SV40 wild-type origin DNA and to isolated b …

We have characterized the interactions of simian virus 40 (SV40) large tumor antigen (large T) with the control region of the SV40 …

127

Late coding region sequences required for competition by SV40 defectives.

O'Neill FJ, Miller TH, Stevens R. O'Neill FJ, et al. Virology. 1987 Dec;161(2):293-304. doi: 10.1016/0042-6822(87)90121-8. Virology. 1987. PMID: 2825404

SV40 defectives containing the complete early coding region (E-SV40) or the complete late region (L-SV40) were separately transfected into green monkey cells. ...It also replicated continuously rather than transiently in Cosl cells. Next, we determined whethe …

SV40 defectives containing the complete early coding region (E-SV40) or the complete late region (L-SV40) were separate …

128

SV40 gene activity during lytic infection and in a series of SV40 transformed mouse cells.

Martin MA, Axelrod D. Martin MA, et al. Proc Natl Acad Sci U S A. 1969 Dec;64(4):1203-10. doi: 10.1073/pnas.64.4.1203. Proc Natl Acad Sci U S A. 1969. PMID: 4318346 Free PMC article.

Transcription of SV40 DNA was measured during lytic infection and in five SV40 transformed mouse cell lines. ...The RNA from the SV40 transformed cell line, which saturated 50 per cent of the viral DNA, could not be distinguished from SV40 lytic RNA in …

Transcription of SV40 DNA was measured during lytic infection and in five SV40 transformed mouse cell lines. ...The RNA from t …

129

Structural relationship between the 100,000- and 17,000- molecular-weight T antigens of simian virus 40 (SV40) as deduced by comparison with the SV40-specific proteins coded by the nondefective adenovirus type 2-SV40 hybrid viruses.

Linke HK, Hunter T, Walter G. Linke HK, et al. J Virol. 1979 Jan;29(1):390-4. doi: 10.1128/JVI.29.1.390-394.1979. J Virol. 1979. PMID: 219231 Free PMC article.

The peptide maps of the 100 K and 17K T antigens were also compared with those of the SV40-specific proteins found in cells infected by the nondefective adenovirus type 2-SV40 hybrid viruses, which we have previously shown are encoded by defined sequences within the …

The peptide maps of the 100 K and 17K T antigens were also compared with those of the SV40-specific proteins found in cells infected …

130

An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.

Weisshart K, Bradley MK, Weiner BM, Schneider C, Moarefi I, Fanning E, Arthur AK. Weisshart K, et al. J Virol. 1996 Jun;70(6):3509-16. doi: 10.1128/JVI.70.6.3509-3516.1996. J Virol. 1996. PMID: 8648684 Free PMC article.

A peptide encompassing the N-terminal 82 amino acids of simian virus 40 (SV40) large T antigen was previously shown to bind to the large subunit of DNA polymerase alpha-primase (I. ...The mutant protein also retained ATPase, helicase, and SV40 origin DNA-binding act …

A peptide encompassing the N-terminal 82 amino acids of simian virus 40 (SV40) large T antigen was previously shown to bind to the la …

131

Simian virus 40 transformation, malignant mesothelioma and brain tumors.

Qi F, Carbone M, Yang H, Gaudino G. Qi F, et al. Expert Rev Respir Med. 2011 Oct;5(5):683-97. doi: 10.1586/ers.11.51. Expert Rev Respir Med. 2011. PMID: 21955238 Free PMC article. Review.

It appears unlikely that SV40 infection alone is sufficient to cause human malignancy, as we did not observe an epidemic of cancers following the administration of SV40-contaminated vaccines. However, it seems possible that SV40 may act as a cofactor in the p …

It appears unlikely that SV40 infection alone is sufficient to cause human malignancy, as we did not observe an epidemic of cancers f …

132

Simian virus 40 and malignant mesothelioma (Review).

Cerrano PG, Jasani B, Filiberti R, Neri M, Merlo F, De Flora S, Mutti L, Puntoni R. Cerrano PG, et al. Int J Oncol. 2003 Jan;22(1):187-94. Int J Oncol. 2003. PMID: 12469203 Review.

In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, SV40 DNA sequences were detected with significative frequency in human pleural mesotheliomas by using polymerase chain reaction (PCR) …

In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, …

133

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.

Martini F, Lazzarin L, Iaccheri L, Vignocchi B, Finocchiaro G, Magnani I, Serra M, Scotlandi K, Barbanti-Brodano G, Tognon M. Martini F, et al. Cancer. 2002 Feb 15;94(4):1037-48. Cancer. 2002. PMID: 11920474 Free article.

SV40 Tag sequences were detected in 29% of buffy coats of blood donors. However, only four brain tumor cell lines showed all the five regions of the SV40 genome investigated. Expression of SV40 Tag sequences was found in 11 of 27 (41%) human tumor samples. DN …

SV40 Tag sequences were detected in 29% of buffy coats of blood donors. However, only four brain tumor cell lines showed all the five …

134

Enhanced induction of SV40 replication from transformed mammalian cells by fusion with UV-irradiated untransformed cells.

van der Lubbe JL, van Drunen CM, Hertoghs JJ, Cornelis JJ, Rommelaere J, van der Eb AJ. van der Lubbe JL, et al. Mutat Res. 1985 Aug;151(1):1-8. doi: 10.1016/0027-5107(85)90175-7. Mutat Res. 1985. PMID: 2991760

DNA-damaging agents such as ultraviolet (UV) light are known to cause stimulation of virus replication in SV40-transformed hamster and human cells. The dose-response curves of UV-induced SV40 replication in transformed hamster cells resemble that obtained for UV-enh …

DNA-damaging agents such as ultraviolet (UV) light are known to cause stimulation of virus replication in SV40-transformed hamster an …

135

SV40 DNA amplification and reintegration in surviving hamster cells after 60Co gamma-irradiation.

Lücke-Huhle C, Pech M, Herrlich P. Lücke-Huhle C, et al. Int J Radiat Biol. 1990 Oct;58(4):577-88. doi: 10.1080/09553009014551941. Int J Radiat Biol. 1990. PMID: 1976719

SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 sequences was pursued over a period of 20 days following radiation exposure. As shown by colony hybridization, integrated SV40 sequences w …

SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 seque …

136

Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.

Kao C, Hauser P, Reznikoff WS, Reznikoff CA. Kao C, et al. J Virol. 1993 Apr;67(4):1987-95. doi: 10.1128/JVI.67.4.1987-1995.1993. J Virol. 1993. PMID: 8383222 Free PMC article.

Furthermore, these results suggest that alterations in SV40 T antigen may be important in stabilizing human cells immortalized by SV40 genes that contain the wild-type SV40 ori, thus contributing to tumorigenic transformation. This is the first report of a su …

Furthermore, these results suggest that alterations in SV40 T antigen may be important in stabilizing human cells immortalized by …

137

Simian virus 40 (SV40)-specific proteins associated with the nuclear matrix isolated from adenovirus type 2-SV40 hybrid virus-infected HeLa cells carry SV40 U-antigen determinants.

Deppert W. Deppert W. J Virol. 1978 Apr;26(1):165-78. doi: 10.1128/JVI.26.1.165-178.1978. J Virol. 1978. PMID: 77334 Free PMC article.

The distribution of simian virus 40 (SV40)-specific proteins in nuclear subfractions of pulse-chase-labeled HeLa cells infected with nondefective adenovirus type 2 (Ad2)-SV40 hybrid viruses was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. . …

The distribution of simian virus 40 (SV40)-specific proteins in nuclear subfractions of pulse-chase-labeled HeLa cells infected with …

138

Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids.

López-Ríos F, Illei PB, Rusch V, Ladanyi M. López-Ríos F, et al. Lancet. 2004 Sep 25-Oct 1;364(9440):1157-66. doi: 10.1016/S0140-6736(04)17102-X. Lancet. 2004. PMID: 15451223

During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we became concerned by inconsistent results and therefore used several independent techniques to investigate SV40 in these tumours. ...Studies of SV40 based on PCR methods r …

During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we became concerned by inconsistent results and …

139

Functional characterization of SV40-transformed adherent synovial cells from rheumatoid arthritis.

Goto M, Okamoto M, Sasano M, Nishizawa K, Aotsuka S, Yamaguchi N, Obinata M, Ikeda K. Goto M, et al. Clin Exp Immunol. 1991 Dec;86(3):387-92. doi: 10.1111/j.1365-2249.1991.tb02942.x. Clin Exp Immunol. 1991. PMID: 1660794 Free PMC article.

A total of 14 transformed cell clones were obtained by micro-injecting origin-defective SV40 DNA into three types of cloned adherent synovial cells (ASC) (dendritic cells (DCs), macrophage-like cells (MCs), and fibroblast-like cells (FCs)) from two rheumatoid arthritis pat …

A total of 14 transformed cell clones were obtained by micro-injecting origin-defective SV40 DNA into three types of cloned adherent …

140

COS Cell Expression.

Hancock JF. Hancock JF. Methods Mol Biol. 1992;8:153-8. doi: 10.1385/0-89603-191-8:153. Methods Mol Biol. 1992. PMID: 21390709

COS-1 cells were created by transforming an established line of monkey epithelial cells, CV-1, with a defective mutant of SV40 (1). The SV40 mutant used carried a small deletion within the origin of replication and, although this construct transformed CV-1 cells, wh …

COS-1 cells were created by transforming an established line of monkey epithelial cells, CV-1, with a defective mutant of SV40 (1). T …

141

Comparison of regulatory sequences and enhancer activities of SV40 variants isolated from patients with neurological diseases.

Martin JD, Li PN. Martin JD, et al. Virus Res. 1991 May;19(2-3):163-72. doi: 10.1016/0168-1702(91)90043-u. Virus Res. 1991. PMID: 1654014

The latter copy, together with its insertion, is inserted at nucleotide 4966 (SV40 number). SVMEN has an almost exact deletion of one of the 72-base-pair repeats of the natural SV40 enhancer. ...The enhancer activity in CV-1 cells of the lytic virus, SVPML, is 36% t …

The latter copy, together with its insertion, is inserted at nucleotide 4966 (SV40 number). SVMEN has an almost exact deletion of one …

142

Host range determinant in the late region of SV40 and RF virus affecting growth in human cells.

O'Neill FJ, Xu XL, Miller TH. O'Neill FJ, et al. Intervirology. 1990;31(2-4):175-87. doi: 10.1159/000150152. Intervirology. 1990. PMID: 2165043

In human cells wtSV40 was also complemented by wtBKV DNA, but after two serial passages SV40 DNA disappeared. These findings indicate that SV40 late or capsid gene sequences, but not SV40 early sequences, generate a block to SV40 growth in human cells. …

In human cells wtSV40 was also complemented by wtBKV DNA, but after two serial passages SV40 DNA disappeared. These findings indicate …

143

Immunization of mice with baculovirus-derived recombinant SV40 large tumour antigen induces protective tumour immunity to a lethal challenge with SV40-transformed cells.

Shearer MH, Bright RK, Lanford RE, Kennedy RC. Shearer MH, et al. Clin Exp Immunol. 1993 Feb;91(2):266-71. doi: 10.1111/j.1365-2249.1993.tb05893.x. Clin Exp Immunol. 1993. PMID: 7679059 Free PMC article.

Analysis of these anti-SV40 T-ag responses indicated that the antibodies recognized epitopes associated with both the carboxy and amino terminus of SV40 T-ag. This pattern of SV40 T-ag epitope recognition was similar to that observed in anti-SV40 T-ag …

Analysis of these anti-SV40 T-ag responses indicated that the antibodies recognized epitopes associated with both the carboxy and ami …

144

Endogenous butyrylcholinesterase in SV40 transformed cell lines: COS-1, COS-7, MRC-5 SV40, and WI-38 VA13.

Kris M, Jbilo O, Bartels CF, Masson P, Rhode S, Lockridge O. Kris M, et al. In Vitro Cell Dev Biol Anim. 1994 Oct;30A(10):680-9. doi: 10.1007/BF02631271. In Vitro Cell Dev Biol Anim. 1994. PMID: 7842168

Comparison of proteins expressed by SV40 transformed cell lines and untransformed cell lines is of interest because SV40 transformed cells are immortal, whereas untransformed cells senesce after about 50 doublings. In MRC-5 SV40 cells, only seven proteins hav …

Comparison of proteins expressed by SV40 transformed cell lines and untransformed cell lines is of interest because SV40 trans …

145

Fanconi anemia patients are more susceptible to infection with tumor virus SV40.

Comar M, De Rocco D, Cappelli E, Zanotta N, Bottega R, Svahn J, Farruggia P, Misuraca A, Corsolini F, Dufour C, Savoia A. Comar M, et al. PLoS One. 2013 Nov 18;8(11):e79683. doi: 10.1371/journal.pone.0079683. eCollection 2013. PLoS One. 2013. PMID: 24260277 Free PMC article.

DNA tumor polyomavirus simian virus 40 (SV40) transforms FA fibroblasts at high efficiency suggesting that FA patients could be highly susceptible to SV40 infection. ...From the analysis of family pedigrees, 60% of the parents of SV40-positive probands were p …

DNA tumor polyomavirus simian virus 40 (SV40) transforms FA fibroblasts at high efficiency suggesting that FA patients could be highl …

146

Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors.

Arad U, Axelrod J, Ben-nun-Shaul O, Oppenheim A, Galun E. Arad U, et al. J Hepatol. 2004 Mar;40(3):520-6. doi: 10.1016/j.jhep.2003.11.028. J Hepatol. 2004. PMID: 15123369

METHODS: A SV40-vector carrying the luciferase gene, and wild-type SV40, were used to assess transduction efficiency of human HBV-positive and HBV-negative hepatic cells. ...The level of MHC-I, the cellular receptor for SV40, was comparable in all the cell-li …

METHODS: A SV40-vector carrying the luciferase gene, and wild-type SV40, were used to assess transduction efficiency of human …

147

Short and long range activation by the SV40 enhancer.

Wasylyk B, Wasylyk C, Chambon P. Wasylyk B, et al. Nucleic Acids Res. 1984 Jul 25;12(14):5589-608. doi: 10.1093/nar/12.14.5589. Nucleic Acids Res. 1984. PMID: 6087293 Free PMC article.

Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between the SV40 enhancer and either the homologous SV40 early or the heterologous conalbumin promoter elements. ...This short range …

Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between …

148

Simian virus 40 in humans.

Martini F, Corallini A, Balatti V, Sabbioni S, Pancaldi C, Tognon M. Martini F, et al. Infect Agent Cancer. 2007 Jul 9;2:13. doi: 10.1186/1750-9378-2-13. Infect Agent Cancer. 2007. PMID: 17620119 Free PMC article.

Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. ...In the present review we consider the main results obtained by different groups investigating …

Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in …

149

Initiation of SV40 DNA replication after microinjection into Xenopus eggs.

McTiernan CF, Stambrook PJ. McTiernan CF, et al. Biochim Biophys Acta. 1984 Jul 18;782(3):295-303. doi: 10.1016/0167-4781(84)90065-4. Biochim Biophys Acta. 1984. PMID: 6329301

The radioactive DNA that eluted with NaCl was comprised mostly of supercoiled and open circular SV40 DNAs. The radioactive DNA eluted with caffeine was comprised mainly of endogenous DNA but also contained replicative forms of SV40 DNA. ...Digestion with BamH1, whic …

The radioactive DNA that eluted with NaCl was comprised mostly of supercoiled and open circular SV40 DNAs. The radioactive DNA eluted …

150

Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters.

Patel NC, Halvorson SJ, Sroller V, Arrington AS, Wong C, Smith EO, Vilchez RA, Butel JS. Patel NC, et al. Virology. 2009 Mar 30;386(1):94-101. doi: 10.1016/j.virol.2008.12.040. Epub 2009 Jan 31. Virology. 2009. PMID: 19181358 Free PMC article.

Viral strain differences influence the oncogenic potential of polyomavirus simian virus 40 (SV40). We hypothesized that viral strain differences might also affect vertical transmission of SV40 in susceptible hosts. Pregnant Syrian golden hamsters were inoculated int …

Viral strain differences influence the oncogenic potential of polyomavirus simian virus 40 (SV40). We hypothesized that viral strain …

151

Simian virus 40 (SV40) production from SV40-transformed human amnion cells of established lines.

Fogh J, Loveless J. Fogh J, et al. J Natl Cancer Inst. 1978 Apr;60(4):895-8. J Natl Cancer Inst. 1978. PMID: 204798

Sixteen established cell lines of simian virus 40 (SV40)-transformed human amnion cells were examined for SV40 production. Many of these lines produced SV40 for extensive periods. ...Virus was produced after heterokaryon formation of cells of the virus-free a …

Sixteen established cell lines of simian virus 40 (SV40)-transformed human amnion cells were examined for SV40 production. Man …

152

Characterization of SV40 T antigen associated with the nuclear matrix.

Mann K. Mann K. Virology. 1990 Nov;179(1):437-45. doi: 10.1016/0042-6822(90)90312-f. Virology. 1990. PMID: 2171215

Simian virus 40 (SV40) T antigen associated with the nuclear matrix of SV40-infected TC7 cells has been characterized. ...In contrast, turnover of SV40 T antigen in its association with the other subcellular fractions is not detected during the same period of …

Simian virus 40 (SV40) T antigen associated with the nuclear matrix of SV40-infected TC7 cells has been characterized. ...In c …

153

A packaging system for SV40 vectors without viral coding sequences.

Fang B, Koch P, Bouvet M, Ji L, Roth JA. Fang B, et al. Anal Biochem. 1997 Dec 1;254(1):139-43. doi: 10.1006/abio.1997.2417. Anal Biochem. 1997. PMID: 9398356

Here we described a system for packaging SV40 vectors without viral coding sequences. Recombinant adenovirus-expressing SV40 capsids can effectively package plasmids that contain the SV40 replication origin. The final yield of infectious SV40 vector is …

Here we described a system for packaging SV40 vectors without viral coding sequences. Recombinant adenovirus-expressing SV40 c …

154

Constraints in simian virus 40 (SV40) encapsidation, as determined by SV40-based shuttle viruses.

Menck CF, James M, Benoit A, Sarasin A. Menck CF, et al. J Gen Virol. 1990 Jan;71 ( Pt 1):143-50. doi: 10.1099/0022-1317-71-1-143. J Gen Virol. 1990. PMID: 2154531

Simian virus 40 (SV40)-based shuttle vectors, containing the SV40 late genes, can be packaged as infectious pseudovirions. In terms of their function as bacterial plasmids, modifications in the overall size of these plasmids can be tolerated within a very wide range …

Simian virus 40 (SV40)-based shuttle vectors, containing the SV40 late genes, can be packaged as infectious pseudovirions. In …

155

Detection of SV40 T antigen with labelled antibodies: radioimmunoassay and autoradiography.

Flügel RM, Crefeld T, Munk K. Flügel RM, et al. Int J Cancer. 1977 May 15;19(5):656-63. doi: 10.1002/ijc.2910190509. Int J Cancer. 1977. PMID: 68015

SV40 T antigen, partially purified from SV80, a human cell line, has been used to develop a sensitive solid phase radioimmunoassay. In this assay SV40 T antigen was immobilized on microtiter plates, reacted with hamster anti-SV40 T antibody and subsequently w …

SV40 T antigen, partially purified from SV80, a human cell line, has been used to develop a sensitive solid phase radioimmunoassay. I …

156

Immunotherapy of SV40 induced tumours in mice: a model for vaccine development.

Bright RK, Shearer MH, Pass HI, Kennedy RC. Bright RK, et al. Dev Biol Stand. 1998;94:341-53. Dev Biol Stand. 1998. PMID: 9776255

Various vaccination strategies were compared for their ability to elicit antigen-specific tumour immunity, using the SV40-BALB/c murine tumour system. Specifically, mice were injected with baculovirus-derived recombinant SV40 Tag (rTag), synthetic peptides correspon …

Various vaccination strategies were compared for their ability to elicit antigen-specific tumour immunity, using the SV40-BALB/c muri …

157

Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas.

Mayall FG, Jacobson G, Wilkins R. Mayall FG, et al. J Clin Pathol. 1999 Apr;52(4):291-3. doi: 10.1136/jcp.52.4.291. J Clin Pathol. 1999. PMID: 10474522 Free PMC article.

The DNA from the paraffin sections was also used to search for SV40 sequences. A 105 base pair segment at the 3' of the SV40 large T antigen (Tag) was targeted and any PCR amplification products were sequenced to confirm that they were of SV40 origin. ...Of t …

The DNA from the paraffin sections was also used to search for SV40 sequences. A 105 base pair segment at the 3' of the SV40 l …

158

Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas.

Choudhury S, Pegg AE, Kreider JW, Mayo DR, Howett MK. Choudhury S, et al. Proc Soc Exp Biol Med. 1989 Oct;192(1):72-7. doi: 10.3181/00379727-192-42958. Proc Soc Exp Biol Med. 1989. PMID: 2552456

Animals given SV40 and ENU showed increased mortality and increased metastatic tumors (54.2% vs 30.8%) compared with those given SV40 alone. ...No difference in primary tumor size, histology, and SV40 T-antigen content was detected between SV40- and …

Animals given SV40 and ENU showed increased mortality and increased metastatic tumors (54.2% vs 30.8%) compared with those given S …

159

UV-reactivation, virus production and mutagenesis of SV40 in VU-irradiated monkey kidney cells.

Cornelis JJ, Lupker JH, van der Eb AJ. Cornelis JJ, et al. Mutat Res. 1980 Jun;71(1):139-46. doi: 10.1016/0027-5107(80)90014-7. Mutat Res. 1980. PMID: 6248777

The survival of UV-irradiated simian virus 40 (SV40) is higher in VU-irradiated than in non-irradiated monolayers of BSC-1 monkey cells. A similar reactivation is found when cells are infected with SV40-DNA, suggesting that reactivation acts on viral DNA. The enhanc …

The survival of UV-irradiated simian virus 40 (SV40) is higher in VU-irradiated than in non-irradiated monolayers of BSC-1 monkey cel …

160

Expression of SV40 T antigen polypeptides in cells biochemically transformed by plasmids containing the herpes simplex virus thymidine kinase gene and the genome of an SV40tsA mutant.

Kit S, Otsuka H, Qavi H, Trkula D, Dubbs DR. Kit S, et al. Int J Cancer. 1981 Oct 15;28(4):485-96. doi: 10.1002/ijc.2910280415. Int J Cancer. 1981. PMID: 6273334

Molecular hybridization experiments showed that transformed clonal lines TF pSB10 C7 and TF pSB15 C10 had integrated intact SV40 genomes at one integration site, TF pSB10 C3 had integrated an SV40 genome with a small deletion near the BamH I site, but TF pSB15 Cl ha …

Molecular hybridization experiments showed that transformed clonal lines TF pSB10 C7 and TF pSB15 C10 had integrated intact SV40 geno …

161

An investigation of the occurrence of SV40 antibodies in South Africa.

Basetse HR, Lecatsas G, Gerber LJ. Basetse HR, et al. S Afr Med J. 2002 Oct;92(10):825-8. S Afr Med J. 2002. PMID: 12432810

We developed an enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to simian virus 40 (SV40) in human serum. We then used the ELISA to test for anti-SV40 antibodies in healthy individuals and patients suffering from cancer and renal diseases. …

We developed an enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to simian virus 40 (SV40) in human serum. W …

162

Primate's p53 inhibits SV40 DNA replication in vitro.

Miyamoto N, Kihara E, Inada T, Katsura S, Murakami Y. Miyamoto N, et al. Biochem Biophys Res Commun. 1990 Apr 30;168(2):604-8. doi: 10.1016/0006-291x(90)92363-5. Biochem Biophys Res Commun. 1990. PMID: 2159296

Here we report the evidence that p53 of primate origin also inhibits SV40 DNA replication in vitro. p53-SV40 large tumor antigen (T antigen) complex purified from SV40 infected COS-1 cells had little replication activity and inhibited SV40 DNA replicat …

Here we report the evidence that p53 of primate origin also inhibits SV40 DNA replication in vitro. p53-SV40 large tumor antig …

163

Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.

Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Shi J, et al. Oncotarget. 2017 Oct 9;8(58):98609-98622. doi: 10.18632/oncotarget.21694. eCollection 2017 Nov 17. Oncotarget. 2017. PMID: 29228714 Free PMC article.

In this study, a potent DNA tumor virus, simian virus 40 (SV40), was used as a model to investigate the viral influences on cellular circRNA transcriptome. ...A total of 134 significantly dysregulated circRNAs, including 103 upregulated and 31 downregulated circRNAs, were …

In this study, a potent DNA tumor virus, simian virus 40 (SV40), was used as a model to investigate the viral influences on cellular …

164

Absence of SV40 large T-antigen expression in human mesothelioma cell lines.

Pilatte Y, Vivo C, Renier A, Kheuang L, Greffard A, Jaurand MC. Pilatte Y, et al. Am J Respir Cell Mol Biol. 2000 Dec;23(6):788-93. doi: 10.1165/ajrcmb.23.6.4251. Am J Respir Cell Mol Biol. 2000. PMID: 11104732

Simian virus (SV) 40 and SV40-like DNA sequences have recently been detected in several types of human tumors, including malignant mesothelioma. ...In this study we investigated SV40 large T antigen (SV40 Tag) protein expression in mesothelioma cell lines, es …

Simian virus (SV) 40 and SV40-like DNA sequences have recently been detected in several types of human tumors, including malignant me …

165

Transcription inhibition of SV40 by in vitro DNA methylation.

Götz F, Schulze-Forster K, Wagner H, Kröger H, Simon D. Götz F, et al. Biochim Biophys Acta. 1990 Nov 30;1087(3):323-9. doi: 10.1016/0167-4781(90)90006-n. Biochim Biophys Acta. 1990. PMID: 2174269

SV40 DNA was methylated in vitro with prokaryotic or eukaryotic DNA cytosine-5-methyltransferases and the inhibition of transcription by methylation was studied in Xenopus oocytes. Methylation with the prokaryotic HhaI or HpaII methyltransferases did essentially not inhibi …

SV40 DNA was methylated in vitro with prokaryotic or eukaryotic DNA cytosine-5-methyltransferases and the inhibition of transcription …

166

The regulation of SV40 gene expression in nonpermissive cells.

Segal S, Khoury G. Segal S, et al. Prog Clin Biol Res. 1981;66 Pt B:409-15. Prog Clin Biol Res. 1981. PMID: 6273931

Both early and late transcripts can be detected in infected mouse cells. Both early and late SV40 transcriptional activities peak between 10 and 15 h post infection; by 24 h after infection SV40 RNA is almost undetectable. ...After differentiation of the F9 cells wi …

Both early and late transcripts can be detected in infected mouse cells. Both early and late SV40 transcriptional activities peak bet …

167

DNAaseI-hypersensitive minichromosomes of SV40 possess an elastic torsional strain in DNA.

Luchnik AN, Bakayev VV, Yugai AA, Zbarsky IB, Georgiev GP. Luchnik AN, et al. Nucleic Acids Res. 1985 Feb 25;13(4):1135-49. doi: 10.1093/nar/13.4.1135. Nucleic Acids Res. 1985. PMID: 2987817 Free PMC article.

Here we show that one and the same fraction of SV40 minichromosomes is hypersensitive to DNAase I and is relaxable by topoisomerase I. ...The possibility that this fraction of minichromosomes can be represented by naked DNA is ruled out by the results of studying the kinet …

Here we show that one and the same fraction of SV40 minichromosomes is hypersensitive to DNAase I and is relaxable by topoisomerase I …

168

SV40 tumor rejection induced by vesicular stomatitis virus bearing SV40 tumor-specific transplantation antigen (SV40-TSTA). II. Association of SV40-TSTA activity with liposomes containing VSV glycolipids.

Huet C, Ansel S. Huet C, et al. Int J Cancer. 1977 Jul 15;20(1):61-6. doi: 10.1002/ijc.2910200111. Int J Cancer. 1977. PMID: 71275

When the glycolipids were extracted from VSV grown on cell lines (TSV5-cl2 and EHSVi-cl1) which contained the SV40 tumor-specific transplantation antigen (SV40-TSTA), it was possible either to induce a tumor rejection or at least to slow the growth of the tumor in S …

When the glycolipids were extracted from VSV grown on cell lines (TSV5-cl2 and EHSVi-cl1) which contained the SV40 tumor-specific tra …

169

Absence of SV40 in Austrian tumors correlates with low incidence of mesotheliomas.

Leithner A, Weinhaeusel A, Windhager R, Schlegl R, Waldner P, Lang S, Dominkus M, Zoubek A, Popper HH, Haas OA. Leithner A, et al. Cancer Biol Ther. 2002 Jul-Aug;1(4):375-9. Cancer Biol Ther. 2002. PMID: 12432250

In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free British vaccine. Thus, we hypothesized that the Austrian population should be SV40-free. ...SV40 was easily detected in two bone tumor DNAs from Italy, and one from the U …

In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free British vaccine. Thus, we hypothesized that …

170

Regulation of SV40-induced cell division and tumor antigen by dibutyryl adenosine 3'-5'-monophosphate.

Robb JA. Robb JA. J Supramol Struct. 1976;4(2):271-8. doi: 10.1002/jss.400040213. J Supramol Struct. 1976. PMID: 177818

The addition of exogenous dibutyryl adenosine 3'-5'-monophosphate (dbcAMP) at the time of infection stimulates the SV40-induced cell division at all MOI and inhibits SV40-induced cell death at high MOI. ...The addition of dbcAMP to productively infected TC7 monkey c …

The addition of exogenous dibutyryl adenosine 3'-5'-monophosphate (dbcAMP) at the time of infection stimulates the SV40-induced cell …

171

Recognition by cytotoxic T lymphocytes of cells expressing fragments of the SV40 tumor antigen.

Gooding LR, O'Connell KA. Gooding LR, et al. J Immunol. 1983 Nov;131(5):2580-6. J Immunol. 1983. PMID: 6313808

Recognition by cytotoxic T lymphocytes (CTL) of syngeneic cells transformed with simian virus 40 (SV40) was examined by using cells expressing known portions of the SV40 early region both as sensitizing cells for stimulation of CTL development and as targets for lys …

Recognition by cytotoxic T lymphocytes (CTL) of syngeneic cells transformed with simian virus 40 (SV40) was examined by using cells e …

172

Isolation of a papovavirus with a bipartite genome containing unlinked SV40 and BKV sequences.

O'Neill FJ, Miller TH. O'Neill FJ, et al. Virology. 1985 May;143(1):75-87. doi: 10.1016/0042-6822(85)90098-4. Virology. 1985. PMID: 2998014

Wild-type (wt) BK virus was introduced into permissive BSC-1 cells along with either early or late defective SV40 genomes. The defectives contained all of the late (L-SV40) or all of the early (E-SV40) coding sequences. ...Also, DNase I digestion of virus sto …

Wild-type (wt) BK virus was introduced into permissive BSC-1 cells along with either early or late defective SV40 genomes. The defect …

173

Characterization of the surface proteins of SV40-transformed mouse and human cells: absence of SV40-specific proteins.

Rose TM, Weil R. Rose TM, et al. Int J Cancer. 1983 May 15;31(5):639-48. doi: 10.1002/ijc.2910310517. Int J Cancer. 1983. PMID: 6303969

The proteins of a number of SV40- and spontaneously transformed mouse and human cell lines were compared in an effort to identify a surface protein which would correspond to the SV40 tumor-specific transplantation antigen (TSTA). ...We were not able to obtain serolo …

The proteins of a number of SV40- and spontaneously transformed mouse and human cell lines were compared in an effort to identify a s …

174

Reactivity to SV40 T antigen in athymic (nude), anti-thymocyte serum-treated, and normal mice.

Knowles BB, Ford SR, Aden DP. Knowles BB, et al. J Immunol. 1977 Jul;119(1):79-82. J Immunol. 1977. PMID: 194983

Antisera prepared in syngeneic mice by hyperimmunization with intact SV40-transformed mouse cells or with somatic cell hybrids between SV40-transformed human and normal mouse cells exhibit anti-SV40 tumor (T) antigen reactivity. Athymic mice bearing tumors fo …

Antisera prepared in syngeneic mice by hyperimmunization with intact SV40-transformed mouse cells or with somatic cell hybrids betwee …

175

Expression of late viral functions in SV40-infected rat-monkey somatic cell hybrids.

Huebner K, Letofsky J, Linnenbach A, Croce CM. Huebner K, et al. Somatic Cell Genet. 1979 Nov;5(6):909-22. doi: 10.1007/BF01542650. Somatic Cell Genet. 1979. PMID: 232577

Somatic cell hybrids between a rat hepatoma cell line and an SV40-transformed African green monkey kidney cell line (T22 TK-) have been isolated and their response to infection by SV40 virus characterized. ...Capsid antigen-positive clones produced little or no form …

Somatic cell hybrids between a rat hepatoma cell line and an SV40-transformed African green monkey kidney cell line (T22 TK-) have be …

176

Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.

Elmishad AG, Bocchetta M, Pass HI, Carbone M. Elmishad AG, et al. Dev Biol (Basel). 2006;123:109-17; discussion 119-32. Dev Biol (Basel). 2006. PMID: 16566440

Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human tumours has been linked to the administration of SV40-contaminated polio vaccines from 1954 until 1963. Many of these reports linked …

Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human t …

177

The sv40 transcription complex. II. Non-dissociation of protein from SV40 chromatin during transcription.

Green MH, Brooks TL. Green MH, et al. Nucleic Acids Res. 1977 Dec;4(12):4279-89. doi: 10.1093/nar/4.12.4279. Nucleic Acids Res. 1977. PMID: 202929 Free PMC article.

A small fraction of the SV40 chromatin isolated from infected monkey cell cultures by the Triton method contains active RNA polymerase which had initiated transcription in vivo. ...The density of the VTC-3H-RNA complex indicated that less than 5% of the original protein di …

A small fraction of the SV40 chromatin isolated from infected monkey cell cultures by the Triton method contains active RNA polymeras …

178

Generation of cytotoxic lymphocytes by SV40-induced antigens.

Chang C, Chang R, Mora PT, Hu CP. Chang C, et al. J Immunol. 1982 May;128(5):2160-3. J Immunol. 1982. PMID: 6278025

In order to study the correlation of in vivo tumor transplantation immunity and in vitro immunologic assays, cell-mediated cytotoxicity against SV40-transformed cells was studied in AL/N strain mice by using 51Cr-release assay. Killing of SV40-transformed AL/N fibro …

In order to study the correlation of in vivo tumor transplantation immunity and in vitro immunologic assays, cell-mediated cytotoxicity agai …

179

Cell sorting but not serum starvation is effective for SV40 human corneal epithelial cell cycle synchronization.

Liliensiek SJ, Schell K, Howard E, Nealey P, Murphy CJ. Liliensiek SJ, et al. Exp Eye Res. 2006 Jul;83(1):61-8. doi: 10.1016/j.exer.2005.11.007. Epub 2006 Mar 20. Exp Eye Res. 2006. PMID: 16545370 Free PMC article.

In comparison, we achieved efficient synchronization of the SV40-HCECs with sterile cell sorting. SV40-HCEC cells gated into G1, S and G2M were synchronized up to 85% following the sort and maintained synchronization up to 24 h. Our findings indicate that serum star …

In comparison, we achieved efficient synchronization of the SV40-HCECs with sterile cell sorting. SV40-HCEC cells gated into G …

180

Effect of human cytomegalovirus on replication of SV40 origin and the expression of T antigen.

Pari GS, St Jeor SC. Pari GS, et al. Virology. 1990 Aug;177(2):824-8. doi: 10.1016/0042-6822(90)90558-9. Virology. 1990. PMID: 2164739

Human cytomegalovirus (HCMV) induces replication of the cloned SV40 origin of DNA replication in both productive and nonproductive infections. HCMV-induced replication of the SV40 DNA origin required the presence of T antigen. ...Cotransfection of the SV40-cl …

Human cytomegalovirus (HCMV) induces replication of the cloned SV40 origin of DNA replication in both productive and nonproductive in …

181

Interaction between SV40 DNA and camptothecin, an antitumor alkaloid.

Fukada M. Fukada M. J Biochem. 1980 Apr;87(4):1089-96. J Biochem. 1980. PMID: 6248502 Free article.

Camptothecin specifically interacted with closed superhelical circular SV40 DNA during incubation in 1.0 M NaCl at 37 degrees C and induced an alkali-labile linkage in the E strand. ...Analysis of the s20,0w value of SV40 DNA I after the interaction with camptotheci …

Camptothecin specifically interacted with closed superhelical circular SV40 DNA during incubation in 1.0 M NaCl at 37 degrees C and i …

182

Transformation mediated by the SV40 T antigens: separation of the overlapping SV40 early genes with a retroviral vector.

Kriegler M, Perez CF, Hardy C, Botchan M. Kriegler M, et al. Cell. 1984 Sep;38(2):483-91. doi: 10.1016/0092-8674(84)90503-8. Cell. 1984. PMID: 6088084

We placed the SV40 early region within this DNA and after transfection of cells producing helper Moloney murine leukemia virus, SV40 retroviruses (MV40) could be rescued. ...There is little difference in transformation either by agar assay or focus formation between …

We placed the SV40 early region within this DNA and after transfection of cells producing helper Moloney murine leukemia virus, SV …

183

Serologic response to BK Virus following human infection with SV40.

Brown P, Morris JA. Brown P, et al. Proc Soc Exp Biol Med. 1976 May;152(1):130-1. doi: 10.3181/00379727-152-39343. Proc Soc Exp Biol Med. 1976. PMID: 177991

A small group of human volunteers given live SV40 virus, and who sero-converted to SV40, did not develop any heterologous antibody response to BK virus, even when BK antibody was demonstrated in preinfection sera. SV40 infection does not appear to contribute …

A small group of human volunteers given live SV40 virus, and who sero-converted to SV40, did not develop any heterologous anti …

184

Sequence analyses of human tumor-associated SV40 DNAs and SV40 viral isolates from monkeys and humans.

Stewart AR, Lednicky JA, Butel JS. Stewart AR, et al. J Neurovirol. 1998 Apr;4(2):182-93. doi: 10.3109/13550289809114518. J Neurovirol. 1998. PMID: 9584955

SV40 DNA has been found associated with several types of human tumors. We now report a sequence comparison of SV40 DNAs from pediatric brain tumors and from osteosarcomas with viral isolates from monkeys and from humans. ...There was no compelling evidence for human …

SV40 DNA has been found associated with several types of human tumors. We now report a sequence comparison of SV40 DNAs from p …

185

Presence of simian virus 40 (SV40) is not frequent in Swedish malignant mesotheliomas.

Priftakis P, Bogdanovic G, Hjerpe A, Dalianis T. Priftakis P, et al. Anticancer Res. 2002 May-Jun;22(3):1357-60. Anticancer Res. 2002. PMID: 12168811

In Sweden, from 1958, due to production in Javanese macaque kidney cells and SV40 testing from 1961, only polio vaccine claimed to be free of SV40 has been used. Hence, we aimed to screen Swedish MM patients for the presence of SV40. ...CONCLUSION: The presen …

In Sweden, from 1958, due to production in Javanese macaque kidney cells and SV40 testing from 1961, only polio vaccine claimed to be …

186

Simian virus 40 and human cancer.

Mutti L, Carbone M, Giordano GG, Giordano A. Mutti L, et al. Monaldi Arch Chest Dis. 1998 Apr;53(2):198-201. Monaldi Arch Chest Dis. 1998. PMID: 9689809 Review.

Deoxyribonucleic acid (DNA) oncoviruses can induce neoplastic transformation by interfering with proliferative proteins. Simian virus 40 (SV40) has been shown to induce brain tumors, osteosarcoma, lymphoid tumors and malignant mesothelioma in hamsters and SV40-like …

Deoxyribonucleic acid (DNA) oncoviruses can induce neoplastic transformation by interfering with proliferative proteins. Simian virus 40 ( …

187

Integration of SV40 at 12q23 in SV40-immortalized human bronchial epithelial cells.

Lu YJ, Dong XY, Guo SP, Ke Y, Cheng SJ. Lu YJ, et al. Carcinogenesis. 1996 Sep;17(9):2089-91. doi: 10.1093/carcin/17.9.2089. Carcinogenesis. 1996. PMID: 8824541

In four SV40-immortalized human bronchial epithelia] cell lines established in our laboratory, we identified the SV40 integration sites by fluorescence in situ hybridization. We found that in the late passage of all the four cell lines, SV40 integrated at 12q …

In four SV40-immortalized human bronchial epithelia] cell lines established in our laboratory, we identified the SV40 integrat …

188

A comparison of methods for the extraction of nucleoprotein complexes from SV40-infected cells.

Springen B, Mann K. Springen B, et al. J Virol Methods. 1984 Oct;9(2):99-105. doi: 10.1016/0166-0934(84)90002-8. J Virol Methods. 1984. PMID: 6096391

There was no disruption of mature SV40 virions with either of these extraction procedures. There was, however, considerably more effective extraction of SV40 NPCs, known to contain large tumor (T) antigen, using the low-salt hypotonic method as opposed to the deterg …

There was no disruption of mature SV40 virions with either of these extraction procedures. There was, however, considerably more effe …

189

No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.

Lundstig A, Dejmek A, Eklund C, Filinic I, Dillner J. Lundstig A, et al. Anticancer Res. 2007 Nov-Dec;27(6B):4159-61. Anticancer Res. 2007. PMID: 18225586 Free article.

The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. ...Eighteen tumors were amplifiable, …

The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantita …

190

Cell and molecular biology of simian virus 40: implications for human infections and disease.

Butel JS, Lednicky JA. Butel JS, et al. J Natl Cancer Inst. 1999 Jan 20;91(2):119-34. doi: 10.1093/jnci/91.2.119. J Natl Cancer Inst. 1999. PMID: 9923853 Review.

SV40 can replicate in certain types of simian and human cells. SV40-neutralizing antibodies have been detected in individuals not exposed to contaminated polio vaccines. SV40 DNA has been identified in some normal human tissues, and there are accumulating rep …

SV40 can replicate in certain types of simian and human cells. SV40-neutralizing antibodies have been detected in individuals …

191

Inhibition of SV40 replicon function by engineered antisense RNA transcribed by RNA polymerase III.

Jennings PA, Molloy PL. Jennings PA, et al. EMBO J. 1987 Oct;6(10):3043-7. doi: 10.1002/j.1460-2075.1987.tb02610.x. EMBO J. 1987. PMID: 2446865 Free PMC article.

Promoters recognized by RNA polymerase III were used to direct synthesis of RNAs of opposite polarity to the 5' end of the mRNA for the large T-antigen of SV40. A construct was made utilizing the adenovirus (human type II) VA1 gene promoter linked to 163 bp of SV40 …

Promoters recognized by RNA polymerase III were used to direct synthesis of RNAs of opposite polarity to the 5' end of the mRNA for the larg …

192

High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences.

Kimchi-Sarfaty C, Arora M, Sandalon Z, Oppenheim A, Gottesman MM. Kimchi-Sarfaty C, et al. Hum Gene Ther. 2003 Jan 20;14(2):167-77. doi: 10.1089/104303403321070865. Hum Gene Ther. 2003. PMID: 12614568

In vitro packaging of plasmid DNA using recombinant SV40 capsid proteins is a potentially useful procedure that overcomes some restrictions of the other SV40 systems such as the requirement for SV40 sequences and the limitation in size of DNA that can be pack …

In vitro packaging of plasmid DNA using recombinant SV40 capsid proteins is a potentially useful procedure that overcomes some restri …

193

Molecular cloning and characterization of endogenous SV40 DNA from human HBL-100 cells.

Saint-Ruf C, Nardeux P, Cebrian J, Lacasa M, Lavialle C, Cassingena R. Saint-Ruf C, et al. Int J Cancer. 1989 Aug 15;44(2):367-72. doi: 10.1002/ijc.2910440230. Int J Cancer. 1989. PMID: 2547730

The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned …

The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cel …

194

Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus.

Levinson B, Khoury G, Vande Woude G, Gruss P. Levinson B, et al. Nature. 1982 Feb 18;295(5850):568-72. doi: 10.1038/295568a0. Nature. 1982. PMID: 6276775

The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expression. ...Although there is no detectable sequence homology to SV40, the MSV repeats can substitute functionally for the SV40 …

The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expr …

195

Transformation of human keratinocytes by SV40 virus alters their response to the tumor promoter TPA.

Delescluse C, Bernard BA, Bailly J, Darmon YM. Delescluse C, et al. Carcinogenesis. 1986 Apr;7(4):551-8. doi: 10.1093/carcin/7.4.551. Carcinogenesis. 1986. PMID: 2421937

However, TPA and SV40 transformation had specific non-overlapping effects. For example, TPA did not prevent terminal differentiation and stratification, as SV40-transformation did, but stimulated these processes. ...These observations lead to the conclusion that TPA …

However, TPA and SV40 transformation had specific non-overlapping effects. For example, TPA did not prevent terminal differentiation …

196

Herpes simplex virus-induced "rolling circle" amplification of SV40 DNA sequences in a transformed hamster cell line correlates with tandem integration of the SV40 genome.

Gerspach R, Matz B. Gerspach R, et al. Virology. 1989 Dec;173(2):723-7. doi: 10.1016/0042-6822(89)90586-2. Virology. 1989. PMID: 2556850

Infection with herpes simplex virus leads to amplification of SV40 DNA in various SV40-transformed cells. In earlier studies with the SV40-transformed hamster cell line Elona two different types of DNA amplification could be identified: (i) Bidirectional over …

Infection with herpes simplex virus leads to amplification of SV40 DNA in various SV40-transformed cells. In earlier studies w …

197

Dibutyryl cyclic AMP treatment of 3T3 and SV40 virus-transformed 3T3 cells in aggregates. Effects on mobility and cell contact ultrastructure.

Gershman H, Drumm J, Rosen JJ. Gershman H, et al. J Cell Biol. 1977 Feb;72(2):424-40. doi: 10.1083/jcb.72.2.424. J Cell Biol. 1977. PMID: 188830 Free PMC article.

The 3T3 cells penetrated into 3T3 aggregates an average of 0.89 cell diameter in 1.5 days, whereas the SV40-3T3 cells penetrated into SV40-3T3 aggregates an average of 3.20 cell diameters in the same time. ...Treatment with theophylline plus dibutyryl cyclic AMP res …

The 3T3 cells penetrated into 3T3 aggregates an average of 0.89 cell diameter in 1.5 days, whereas the SV40-3T3 cells penetrated into …

198

SV40 T antigen acts as a minor histocompatibility antigen of SV40 T antigen tolerant transgenic mice.

Juretic A, Knowles BB. Juretic A, et al. Immunogenetics. 1989;29(6):366-70. doi: 10.1007/BF00375864. Immunogenetics. 1989. PMID: 2786497

The ability of normal mice to mount an SV40 T antigen-specific cytolytic T lymphocytes response when immunized in vivo with splenocytes from the SV40 T antigen transgenic 427-line mice and restimulated in vitro with SV40-transformed fibroblasts, or when immun …

The ability of normal mice to mount an SV40 T antigen-specific cytolytic T lymphocytes response when immunized in vivo with splenocyt …

199

An embryo protein induced by SV40 virus transformation of mouse cells.

Mora PT, Chandrasekaran K, McFarland VW. Mora PT, et al. Nature. 1980 Dec 25;288(5792):722-4. doi: 10.1038/288722a0. Nature. 1980. PMID: 6256642

A specific protein of molecular weight (MW) approximately 55,000 (55K) was found recently by immunoprecipitation in all SV40 virus-transformed mammalian cells, in addition to the SV40 large T antigen (appoximately 94K) and small antigen (approximately 17K), which ar …

A specific protein of molecular weight (MW) approximately 55,000 (55K) was found recently by immunoprecipitation in all SV40 virus-tr …

200

Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replication in vivo.

Richter A, Strausfeld U, Knippers R. Richter A, et al. Nucleic Acids Res. 1987 Apr 24;15(8):3455-68. doi: 10.1093/nar/15.8.3455. Nucleic Acids Res. 1987. PMID: 3033604 Free PMC article.

The late replicative SV40 DNA intermediates which accumulate in VM26 treated cells contained essentially full length labeled DNA strands. ...Since VM26 is known to be a specific inhibitor of DNA topoisomerase II we conclude that this enzyme is dispensable for the chain elo …

The late replicative SV40 DNA intermediates which accumulate in VM26 treated cells contained essentially full length labeled DNA stra …

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