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SV40 and human mesothelioma.
Carbone M, Gazdar A, Butel JS. Carbone M, et al. Transl Lung Cancer Res. 2020 Feb;9(Suppl 1):S47-S59. doi: 10.21037/tlcr.2020.02.03. Transl Lung Cancer Res. 2020. PMID: 32206570 Free PMC article. Review.
Simian virus 40 (SV40) is a DNA tumor virus capable of infecting and transforming human mesothelial (HM) cells in vitro. ...In addition to mesotheliomas, SV40 now is linked with brain cancers, osteosarcomas, and lymphomas in humans. Explanations are provided for the …
Simian virus 40 (SV40) is a DNA tumor virus capable of infecting and transforming human mesothelial (HM) cells in vitro. ...In additi …
SV40: A human pathogen?
Garcea RL. Garcea RL. Dis Markers. 2001;17(3):149-51. doi: 10.1155/2001/515039. Dis Markers. 2001. PMID: 11790879 Free PMC article. Review.
Over the past eight years an increasing number of investigators have found SV40 genomic sequences in a variety of human samples, both malignant and normal. Tumor types recurrently reported as SV40-positive include choroid plexus neoplasms, ependymomas, osteosarcomas …
Over the past eight years an increasing number of investigators have found SV40 genomic sequences in a variety of human samples, both …
SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier.
Kawano M, Matsui M, Handa H. Kawano M, et al. Expert Rev Vaccines. 2013 Feb;12(2):199-210. doi: 10.1586/erv.12.149. Expert Rev Vaccines. 2013. PMID: 23414410 Free article. Review.
The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. ...Insertion of a particular for …
The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established t …
SV40 and human cancer: a review of recent data.
Shah KV. Shah KV. Int J Cancer. 2007 Jan 15;120(2):215-23. doi: 10.1002/ijc.22425. Int J Cancer. 2007. PMID: 17131333 Review.
The low-level immunoreactivity of human sera to SV40 was very likely the result of cross-reactivity with antibodies to the SV40-related human polyomaviruses BKV and JCV, rather than of authentic SV40 infection. SV40 sero-reactivity in patients with the …
The low-level immunoreactivity of human sera to SV40 was very likely the result of cross-reactivity with antibodies to the SV40
Does SV40 infection contribute to the development of human cancers?
Shah KV. Shah KV. Rev Med Virol. 2000 Jan-Feb;10(1):31-43. doi: 10.1002/(sici)1099-1654(200001/02)10:1<31::aid-rmv260>3.0.co;2-i. Rev Med Virol. 2000. PMID: 10654003 Review.
The SV40 sequences reported from humans are essentially identical to those of wild-type SV40; it is difficult to conceive that a highly species-specific polyomavirus like SV40 would cross the species barrier, become a human infection, and acquire pathogenic p …
The SV40 sequences reported from humans are essentially identical to those of wild-type SV40; it is difficult to conceive that …
SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy.
Kimchi-Sarfaty C, Gottesman MM. Kimchi-Sarfaty C, et al. Curr Pharm Biotechnol. 2004 Oct;5(5):451-8. doi: 10.2174/1389201043376670. Curr Pharm Biotechnol. 2004. PMID: 15544493 Review.
The recombinant SV40 vectors can infect a wide variety of cells-dividing cells as well as non-cycling ones. ...SV40-based vectors carry some SV40 viral sequences, but the SV40 in vitro-packaged vectors are free of any SV40 wild-type viral DNA se …
The recombinant SV40 vectors can infect a wide variety of cells-dividing cells as well as non-cycling ones. ...SV40-based vect …
Is there a role for SV40 in human cancer?
Poulin DL, DeCaprio JA. Poulin DL, et al. J Clin Oncol. 2006 Sep 10;24(26):4356-65. doi: 10.1200/JCO.2005.03.7101. J Clin Oncol. 2006. PMID: 16963733 Review.
Concerns regarding the potential health risk of SV40 exposure were reinforced by studies demonstrating SV40's potential to transform human cells and promote tumor growth in animal models. ...However, inconsistent reports linking SV40 with various tumor types …
Concerns regarding the potential health risk of SV40 exposure were reinforced by studies demonstrating SV40's potential to tra …
Association between SV40 and non-Hodgkin's lymphoma.
Butel JS, Vilchez RA, Jorgensen JL, Kozinetz CA. Butel JS, et al. Leuk Lymphoma. 2003;44 Suppl 3:S33-9. doi: 10.1080/10428190310001623784. Leuk Lymphoma. 2003. PMID: 15202523 Review.
Millions of people worldwide were inadvertently exposed to live simian virus 40 (SV40) between 1955 and 1963 through immunization with SV40-contaminated polio vaccines. Although the prevalence of SV40 infections in humans is not known, numerous studies sugges …
Millions of people worldwide were inadvertently exposed to live simian virus 40 (SV40) between 1955 and 1963 through immunization wit …
SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen.
Lowe DB, Shearer MH, Jumper CA, Kennedy RC. Lowe DB, et al. Cell Mol Life Sci. 2007 Apr;64(7-8):803-14. doi: 10.1007/s00018-007-6414-6. Cell Mol Life Sci. 2007. PMID: 17260087 Free PMC article. Review.
Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality in these tumor types has yet to be established. ...This review will also explore how vaccination against SV40 protein products may be …
Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality i …
New developments about the association of SV40 with human mesothelioma.
Carbone M, Pass HI, Miele L, Bocchetta M. Carbone M, et al. Oncogene. 2003 Aug 11;22(33):5173-80. doi: 10.1038/sj.onc.1206552. Oncogene. 2003. PMID: 12910254 Review.
Simian virus 40 (SV40) has been detected in human tumors in over 40 different laboratories. Many of these reports linked SV40 to human mesotheliomas. ...Therefore, three independent scientific panels have all agreed that there is compelling evidence that SV40
Simian virus 40 (SV40) has been detected in human tumors in over 40 different laboratories. Many of these reports linked SV40
Epigenetic Analysis of SV40 Minichromosomes.
Balakrishnan L, Milavetz B. Balakrishnan L, et al. Curr Protoc Microbiol. 2017 Aug 11;46:14F.3.1-14F.3.26. doi: 10.1002/cpmc.35. Curr Protoc Microbiol. 2017. PMID: 28800155 Free PMC article.
Simian virus 40 (SV40) is one of the best-characterized members of the polyomavirus family of small DNA tumor viruses. ...These facts, combined with high yields of virus and minichromosomes following infection and ease of manipulation, have made SV40 an extremely us …
Simian virus 40 (SV40) is one of the best-characterized members of the polyomavirus family of small DNA tumor viruses. ...These facts …
SV40, genetic polymorphism and mesothelioma. pathological and epidemiological evidence.
Magnani C. Magnani C. Med Lav. 2005 Jul-Aug;96(4):347-53. Med Lav. 2005. PMID: 16457431 Review.
METHODS: The review on SV40 was based on scientific papers published since 1990 on association of SV40 with human cancer. ...Diffusion of SV40 in humans is linked to polio vaccines produced in 1955-63 from SV40-infected monkeys. ...
METHODS: The review on SV40 was based on scientific papers published since 1990 on association of SV40 with human cancer. ...D …
The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential oncogenic activity.
Šenigl F, Soikkeli A, Prost S, Schatz DG, Slavková M, Hejnar J, Alinikula J. Šenigl F, et al. bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574829. doi: 10.1101/2024.01.09.574829. bioRxiv. 2024. Update in: Tumour Virus Res. 2024 Dec;18:200293. doi: 10.1016/j.tvr.2024.200293. PMID: 38260396 Free PMC article. Updated. Preprint.
Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in mesotheliomas, brain and bone tumors and lymphomas, but the mechanism for SV40 tumorigenesis in humans is not clear. ...In this study, …
Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in m …
SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines.
Wong C, Zhang S, Adam E, Paszat L, Butel JS. Wong C, et al. J Infect. 2019 Jun;78(6):476-483. doi: 10.1016/j.jinf.2019.04.007. Epub 2019 Apr 6. J Infect. 2019. PMID: 30965068 Free PMC article.
RESULTS: Overall SV40 seroprevalence was 22.8% for Colombian subjects and 12.8% for Nicaraguans. Subgroups of Colombian subjects ranged in frequency of SV40 seropositivity from 10.0% to 38.6%. ...CONCLUSIONS: Inhabitants of both Colombia and Nicaragua had detectable …
RESULTS: Overall SV40 seroprevalence was 22.8% for Colombian subjects and 12.8% for Nicaraguans. Subgroups of Colombian subjects rang …
Association of SV40 with human tumours.
Jasani B, Cristaudo A, Emri SA, Gazdar AF, Gibbs A, Krynska B, Miller C, Mutti L, Radu C, Tognon M, Procopio A. Jasani B, et al. Semin Cancer Biol. 2001 Feb;11(1):49-61. doi: 10.1006/scbi.2000.0346. Semin Cancer Biol. 2001. PMID: 11243899 Review.
Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. ...Molecular data from these studies are reviewed to re-evaluate the potential role of SV40 as a human carcinogen....
Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. ...Molecu …
SV40 induces mesotheliomas in hamsters.
Cicala C, Pompetti F, Carbone M. Cicala C, et al. Am J Pathol. 1993 May;142(5):1524-33. Am J Pathol. 1993. PMID: 8388174 Free PMC article.
In the course of studies to elucidate the relative contribution of simian virus 40 (SV40) large T and small t proteins during oncogenesis, we observed the appearance of pericardial and pleural tumors in 100% of Syrian hamsters injected in the pleural space with wild type …
In the course of studies to elucidate the relative contribution of simian virus 40 (SV40) large T and small t proteins during oncogen …
SV40 in adenovirus vaccines and adenovirus-SV40 recombinants.
Lewis AM Jr. Lewis AM Jr. Dev Biol Stand. 1998;94:207-16. Dev Biol Stand. 1998. PMID: 9776241 Review.
During the development of adenovirus (Ad) vaccines in the 1950s, Ad strains 1-5 and 7 recombined with SV40 during adaptation to growth in rhesus monkey kidney cells. The recombination events between the Ad and SV40 genomes produced hybrid viruses that contained, wit …
During the development of adenovirus (Ad) vaccines in the 1950s, Ad strains 1-5 and 7 recombined with SV40 during adaptation to growt …
Low incidence of SV40-like sequences in ependymal tumours.
Reuther FJ, Löhler J, Herms J, Hugo HH, Schindler C, Leithäuser F, Melzner I, Möller P, Scheil S. Reuther FJ, et al. J Pathol. 2001 Dec;195(5):580-5. doi: 10.1002/path.1005. J Pathol. 2001. PMID: 11745694 Review.
Between 1955 and 1963, millions of children and adults were exposed to SV40-contaminated poliovirus vaccines. The oncogenic potential of this polyomavirus was revealed when intracerebral inoculation of SV40 into newborn hamsters resulted in the development of ependy …
Between 1955 and 1963, millions of children and adults were exposed to SV40-contaminated poliovirus vaccines. The oncogenic potential …
SV40 in human thyroid nodules.
Ozdarendeli A, Camci C, Aygen E, Kirkil C, Toroman ZA, Dogru O, Doymaz MZ. Ozdarendeli A, et al. J Clin Virol. 2004 Aug;30(4):337-40. doi: 10.1016/j.jcv.2003.12.008. J Clin Virol. 2004. PMID: 15163424
OBJECTIVES: SV40 has been found in a variety of human samples, both malignant and normal. Many independent studies have suggested that SV40 plays a role for some cancers. ...CONCLUSION: The possible role of SV40 in the development of thyroid nodules and the s …
OBJECTIVES: SV40 has been found in a variety of human samples, both malignant and normal. Many independent studies have suggested tha …
Potential of recombinant SV40-based vectors for gene therapy.
Buscail L, Cordelier P. Buscail L, et al. Recent Pat DNA Gene Seq. 2007;1(2):93-9. doi: 10.2174/187221507780887045. Recent Pat DNA Gene Seq. 2007. PMID: 19075921 Review.
Many reasons for these difficulties lie in the nature of the viral agents used to introduce the foreign gene(s) in question. SV40 (Simian Virus-40) has been demonstrated to provide a unique vector for gene therapy which has several advantages over any of the currently avai …
Many reasons for these difficulties lie in the nature of the viral agents used to introduce the foreign gene(s) in question. SV40 (Si …
SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction.
Reus JB, Trivino-Soto GS, Wu LI, Kokott K, Lim ES. Reus JB, et al. Viruses. 2020 Jan 24;12(2):137. doi: 10.3390/v12020137. Viruses. 2020. PMID: 31991682 Free PMC article.
Since SV40 LT also encodes the LxCxE motif, the lack of STING expression in 293T cells is commonly assumed to be due to SV40 large T antigen. We find that SV40 LT does not alter exogenously expressed and endogenous levels of STING protein. We show that STING …
Since SV40 LT also encodes the LxCxE motif, the lack of STING expression in 293T cells is commonly assumed to be due to SV40 l …
Host range analysis of simian virus 40, BK virus and chimaeric SV40/BKV: relative expression of large T-antigen and Vp1 in infected and transformed cells.
O'Neill FJ, Carney H, Hu Y. O'Neill FJ, et al. Dev Biol Stand. 1998;94:191-205. Dev Biol Stand. 1998. PMID: 9776240 Review.
We examined the growth of SV40, BKV and the chimaeric genome virus, SV40/RFV, in several types of human cells. We analysed replication, expression of T-Ag and Vp1 capsid proteins, and cytopathic effects (CPE). ...In HFF cells the Vp1/T-Ag ratio was approximately 200 …
We examined the growth of SV40, BKV and the chimaeric genome virus, SV40/RFV, in several types of human cells. We analysed rep …
Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas.
Schrump DS, Waheed I. Schrump DS, et al. Semin Cancer Biol. 2001 Feb;11(1):73-80. doi: 10.1006/scbi.2000.0348. Semin Cancer Biol. 2001. PMID: 11243901 Review.
The majority of mesothelioma cells which contain SV40 early region sequences exhibit extremely low basal expression of SV40 oncoproteins; however, T/t antigen expression can be induced under conditions of cellular stress. Abrogation of SV40 T/t expression by …
The majority of mesothelioma cells which contain SV40 early region sequences exhibit extremely low basal expression of SV40 on …
New molecular and epidemiological issues in mesothelioma: role of SV40.
Carbone M, Fisher S, Powers A, Pass HI, Rizzo P. Carbone M, et al. J Cell Physiol. 1999 Aug;180(2):167-72. doi: 10.1002/(SICI)1097-4652(199908)180:2<167::AID-JCP4>3.0.CO;2-Q. J Cell Physiol. 1999. PMID: 10395286 Review.
SV40 also transforms human cells in tissue culture, and these cells contain extensive DNA damage. In the United States, at least 60% of human mesotheliomas contain and express SV40. In these tumor cells, the SV40 tumor antigen binds and inhibits the cellular
SV40 also transforms human cells in tissue culture, and these cells contain extensive DNA damage. In the United States, at least 60%
SV40 and p53 as team players in childhood lymphoproliferative disorders.
Heinsohn S, Scholz R, Kabisch H. Heinsohn S, et al. Int J Oncol. 2011 May;38(5):1307-17. doi: 10.3892/ijo.2011.967. Epub 2011 Mar 10. Int J Oncol. 2011. PMID: 21399869
All specimens showing a p53 mutation, were SV40-positive. p53 mutaions found in LNs of B-NHL patients harbour high SV40 copy numbers. Our data strongly support an important role for SV40, as well as a strong association of SV40 and p53 in childhood lym …
All specimens showing a p53 mutation, were SV40-positive. p53 mutaions found in LNs of B-NHL patients harbour high SV40 copy n …
Simian virus 40 (SV40) and human cancer: a review of the serological data.
Shah KV, Galloway DA, Knowles WA, Viscidi RP. Shah KV, et al. Rev Med Virol. 2004 Jul-Aug;14(4):231-9. doi: 10.1002/rmv.432. Rev Med Virol. 2004. PMID: 15248251 Review.
The development of EIA with virus-like particles (VLPs) of SV40, BKV and JCV has facilitated serological studies. Sera from macaques naturally infected with SV40 cross-react unambiguously with BKV and JCV VLPs. ...Absorption with BKV and JCV VLPs decreases or abolis …
The development of EIA with virus-like particles (VLPs) of SV40, BKV and JCV has facilitated serological studies. Sera from macaques …
Simian virus 40 (SV40) - Fresh perspectives on a historic virus.
Milavetz BI, Balakrishnan L. Milavetz BI, et al. Virology. 2025 Feb 1;604:110427. doi: 10.1016/j.virol.2025.110427. Online ahead of print. Virology. 2025. PMID: 39913987 Review.
Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. ...This review discusses these recent advancements in SV40 biology....
Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. ... …
SV40 infection induces telomerase activity in human mesothelial cells.
Foddis R, De Rienzo A, Broccoli D, Bocchetta M, Stekala E, Rizzo P, Tosolini A, Grobelny JV, Jhanwar SC, Pass HI, Testa JR, Carbone M. Foddis R, et al. Oncogene. 2002 Feb 21;21(9):1434-42. doi: 10.1038/sj.onc.1205203. Oncogene. 2002. PMID: 11857086
SV40 infection of human fibroblasts did not cause detectable telomerase activity. We also determined that the SV40 small t-antigen (tag) plays an important role in inducing telomerase activity because this activity was undetectable or minimal in mesothelial cells in
SV40 infection of human fibroblasts did not cause detectable telomerase activity. We also determined that the SV40 small t-ant
SV40 large T antigen-specific human T cell memory responses.
Coleman S, Gibbs A, Butchart E, Mason MD, Jasani B, Tabi Z. Coleman S, et al. J Med Virol. 2008 Aug;80(8):1497-504. doi: 10.1002/jmv.21216. J Med Virol. 2008. PMID: 18551603
The aim of our experiments was to find cellular immunological evidence of SV40 infection in humans by testing memory T cell responses to SV40 large T antigen (Tag). ...Similarly, the relevant BKV and JCV Tag peptides did not generate T cell responses against SV40
The aim of our experiments was to find cellular immunological evidence of SV40 infection in humans by testing memory T cell responses …
Increasing evidence for involvement of SV40 in human cancer.
Butel JS. Butel JS. Dis Markers. 2001;17(3):167-72. doi: 10.1155/2001/857621. Dis Markers. 2001. PMID: 11790883 Free PMC article. Review.
SV40, a small DNA virus, is known to possess strong oncogenic potential. Millions of people were exposed to SV40 as an unknown contaminant of some early poliovaccines. This article briefly summarizes the increasing evidence of the association of SV40 with cer
SV40, a small DNA virus, is known to possess strong oncogenic potential. Millions of people were exposed to SV40 as an unknown
SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes.
Lednicky JA, Stewart AR, Jenkins JJ 3rd, Finegold MJ, Butel JS. Lednicky JA, et al. Int J Cancer. 1997 Sep 4;72(5):791-800. doi: 10.1002/(sici)1097-0215(19970904)72:5<791::aid-ijc15>3.0.co;2-c. Int J Cancer. 1997. PMID: 9311596
Authentic simian virus 40 (SV40) has been detected in association with human choroid plexus and ependymoma tumors, and SV40-like DNA sequences have been found in some human osteosarcomas. ...Authentic SV40 DNA sequences were detected in 5 of 10 osteosarcoma t …
Authentic simian virus 40 (SV40) has been detected in association with human choroid plexus and ependymoma tumors, and SV40-li …
Does Simian Virus 40 (SV40) Have a Role in UK Malignant Pleural Mesothelioma? No Role is Identified in a Sensitive RNA In Situ Hybridization Study on Potentially Affected Birth Cohorts.
Alchami FS, Attanoos RL, Gibbs A, Morgan F, Jasani B. Alchami FS, et al. Appl Immunohistochem Mol Morphol. 2020 Jul;28(6):444-447. doi: 10.1097/PAI.0000000000000779. Appl Immunohistochem Mol Morphol. 2020. PMID: 31205069
SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogenic protein large T antigen (SV40 Tag) has been shown to cause malignant transformation of asbestos-treated human pleural mesothelial c
SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogeni
Discovery of simian virus 40 (SV40) and its relationship to poliomyelitis virus vaccines.
Hilleman MR. Hilleman MR. Dev Biol Stand. 1998;94:183-90. Dev Biol Stand. 1998. PMID: 9776239 Review.
There has been no evidence to implicate SV40 virus of vaccine origin in long- or short-term consequences in human subjects. Of importance, SV40 virus provided a new model for basic studies of viral pathogenesis and for cell transformation and neoplasia. ...Numerous …
There has been no evidence to implicate SV40 virus of vaccine origin in long- or short-term consequences in human subjects. Of import …
SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids.
Nakanishi A, Chapellier B, Maekawa N, Hiramoto M, Kuge T, Takahashi RU, Handa H, Imai T. Nakanishi A, et al. Virology. 2008 Sep 15;379(1):110-7. doi: 10.1016/j.virol.2008.06.032. Epub 2008 Jul 29. Virology. 2008. PMID: 18667220 Free article.
Polyomaviral vectors are generated by transfecting 293T cells with three sets of DNAs: DNA for the expression of simian virus 40 (SV40) T antigen; DNA for the expression of SV40 capsid proteins, and vector DNA harboring a reporter gene expression cassette carrying a …
Polyomaviral vectors are generated by transfecting 293T cells with three sets of DNAs: DNA for the expression of simian virus 40 (SV40
SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study.
Cristaudo A, Foddis R, Vivaldi A, Buselli R, Gattini V, Guglielmi G, Cosentino F, Ottenga F, Ciancia E, Libener R, Filiberti R, Neri M, Betta P, Tognon M, Mutti L, Puntoni R. Cristaudo A, et al. Cancer Res. 2005 Apr 15;65(8):3049-52. doi: 10.1158/0008-5472.CAN-04-2219. Cancer Res. 2005. PMID: 15833832
PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and …
PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and …
Detection of SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma and other pulmonary diseases.
Galateau-Salle F, Bidet P, Iwatsubo Y, Gennetay E, Renier A, Letourneux M, Pairon JC, Moritz S, Brochard P, Jaurand MC, Freymuth F. Galateau-Salle F, et al. Dev Biol Stand. 1998;94:147-52. Dev Biol Stand. 1998. PMID: 9776236 Review.
PCR amplification and hybridization with a probe specific for SV40 Tag revealed that 47.6% of mesotheliomas, 28.6% of primary bronchopulmonary carcinomas and 16% of non-neoplasic lung diseases contained SV40-like DNA sequences. ...However, a significantly higher num …
PCR amplification and hybridization with a probe specific for SV40 Tag revealed that 47.6% of mesotheliomas, 28.6% of primary broncho …
Virion-mediated transfer of SV40 epigenetic information.
Milavetz B, Kallestad L, Gefroh A, Adams N, Woods E, Balakrishnan L. Milavetz B, et al. Epigenetics. 2012 Jun 1;7(6):528-34. doi: 10.4161/epi.20057. Epub 2012 Jun 1. Epigenetics. 2012. PMID: 22507897 Free PMC article.
In order to determine whether SV40 is capable of transgenerational epigenetic regulation, we have analyzed SV40 chromatin from minichromosomes and virions for the presence of modified histones using various ChIP techniques and correlated these modifications with spe …
In order to determine whether SV40 is capable of transgenerational epigenetic regulation, we have analyzed SV40 chromatin from …
SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma.
Cacciotti P, Libener R, Betta P, Martini F, Porta C, Procopio A, Strizzi L, Penengo L, Tognon M, Mutti L, Gaudino G. Cacciotti P, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12032-7. doi: 10.1073/pnas.211026798. Epub 2001 Sep 25. Proc Natl Acad Sci U S A. 2001. PMID: 11572935 Free PMC article.
In human mesothelial cells (HMC) transfected with full-length SV40 DNA (SV40-HMC), Met receptor activation was associated with S-phase entry, acquisition of a fibroblastoid morphology, and the assembly of viral particles. ...This, in turn, was causally related to Ta …
In human mesothelial cells (HMC) transfected with full-length SV40 DNA (SV40-HMC), Met receptor activation was associated with …
Manipulation of SV40 Vectors.
Hammurskjöld ML. Hammurskjöld ML. Methods Mol Biol. 1991;7:169-80. doi: 10.1385/0-89603-178-0:169. Methods Mol Biol. 1991. PMID: 21416355
ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). ...Fig. 1. Schematic diagrams of the genome of SV40 and the SV40 expression vectors p14, pBABY, and pSVEpR4. The detailed maps and constructions o …
ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). ...Fig. 1. Schematic …
Sera from Patients with Malignant Pleural Mesothelioma Tested Positive for IgG Antibodies against SV40 Large T Antigen: The Viral Oncoprotein.
Mazzoni E, Bononi I, Rotondo JC, Mazziotta C, Libener R, Guaschino R, Gafà R, Lanza G, Martini F, Tognon M. Mazzoni E, et al. J Oncol. 2022 Jul 15;2022:7249912. doi: 10.1155/2022/7249912. eCollection 2022. J Oncol. 2022. PMID: 35874636 Free PMC article.
Immunohistochemical staining (IHS) assays showed SV40 Tag expression in 8/20, 40% of MPM specimens. These results indicate that SV40 is linked to a large fraction of MPM. It is worth noting that the prevalence of SV40 Tag antibodies detected in sera from coho …
Immunohistochemical staining (IHS) assays showed SV40 Tag expression in 8/20, 40% of MPM specimens. These results indicate that SV
[Molecular biology of natural and constructed in vitro recombinants of human adenoviruses and SV40].
Miroshnichenko OI, Naroditskiĭ BS. Miroshnichenko OI, et al. Mol Gen Mikrobiol Virusol. 1985 Nov;(11):3-11. Mol Gen Mikrobiol Virusol. 1985. PMID: 3025687 Review. Russian.
This review is devoted to the molecular and biological properties of natural and artificial Ad-SV40 hybrids. The conditions of adenovirus and SV40 recombinant formations are discussed. ...The data about the structural and functional organization of the hybrid RNA an …
This review is devoted to the molecular and biological properties of natural and artificial Ad-SV40 hybrids. The conditions of adenov …
Evaluation of SV40 in osteosarcoma and healthy population: a Hungarian-German study.
Heinsohn S, Szendroi M, Bielack S, Stadt UZ, Kabisch H. Heinsohn S, et al. Oncol Rep. 2009 Feb;21(2):289-97. Oncol Rep. 2009. PMID: 19148498
To reach an appropriate detection level, we investigated a real-time quantitative PCR-based assay for the detection and quantification of SV40 <10 copies in 500 ng of genomic DNA. We detected SV40 in 52% (143/277) of the OS samples analysed. In detail, we saw dif …
To reach an appropriate detection level, we investigated a real-time quantitative PCR-based assay for the detection and quantification of …
Isolation of a SV40-like Papovavirus from a human glioblastoma.
Scherneck S, Rudolph M, Geissler E, Vogel F, Lübbe L, Wählte H, Nisch G, Weickmann F, Zimmermann W. Scherneck S, et al. Int J Cancer. 1979 Nov 15;24(5):523-31. doi: 10.1002/ijc.2910240502. Int J Cancer. 1979. PMID: 93581
Serological tests (hemagglutination, neutralization, fluorescent antibody) revealed that the virus is indistinguishable from SV40. Despite this apparent antigenic identity SV40-GBM differs slightly from SV40 wild type. ...Therefore the virus SV40-GBM o …
Serological tests (hemagglutination, neutralization, fluorescent antibody) revealed that the virus is indistinguishable from SV40. De …
Oral polio vaccine and human cancer: a reassessment of SV40 as a contaminant based upon legal documents.
Kops SP. Kops SP. Anticancer Res. 2000 Nov-Dec;20(6C):4745-9. Anticancer Res. 2000. PMID: 11205211 Review.
To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that SV40 was not present in any poliovirus vaccine administered in the United States and was removed from the killed polio vaccine by 1963. …
To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that …
SV40 transfection of human kidney epithelial cells and stability of chromosome 11.
Poirier V, Tyler SJ, Brown KW, Shaw AP, Maitland NJ. Poirier V, et al. Int J Cancer. 1988 Dec 15;42(6):887-94. doi: 10.1002/ijc.2910420617. Int J Cancer. 1988. PMID: 2903852
We transfected normal kidney WT/NK, tumoral WT/T cells and human foetal kidney HFK cells with 2 SV40-derived plasmids SV3neo (pBR322-SV40-containing neomycin bacterial gene) and SVori- (pMK-origin mutated SV40). ...We looked at different markers associated wi …
We transfected normal kidney WT/NK, tumoral WT/T cells and human foetal kidney HFK cells with 2 SV40-derived plasmids SV3neo (pBR322- …
SV40-immortalized human fibroblasts as a source of SV40 infectious virions.
Morelli C, Barbisan F, Iaccheri L, Tognon M. Morelli C, et al. Mol Med. 2004 Jul-Dec;10(7-12):112-6. doi: 10.2119/2004-00037.Morelli. Mol Med. 2004. PMID: 15702218 Free PMC article.
Human fibroblasts immortalized by Simian Virus 40 (SV40) are widely employed for cell and molecular biology model of study. Indeed, SV40 transmission to humans was believed to occur only under exceptional situations. ...These data indicate that SV40-immortali …
Human fibroblasts immortalized by Simian Virus 40 (SV40) are widely employed for cell and molecular biology model of study. Indeed, …
Experimental tumour induction by SV40 transformed cells.
Cook JL, Routes BA, Sompayrac L. Cook JL, et al. Dev Biol Stand. 1998;94:303-9. Dev Biol Stand. 1998. PMID: 9776251 Review.
However, secondary manipulations of SV40-transformed cells can result in increased tumorigenicity. Some early observations on tumour induction by SV40 and transformed cells will be followed by a selected review of evidence suggesting that tumorigenicity of SV40
However, secondary manipulations of SV40-transformed cells can result in increased tumorigenicity. Some early observations on tumour …
Evidence against a role for SV40 in human mesothelioma.
Manfredi JJ, Dong J, Liu WJ, Resnick-Silverman L, Qiao R, Chahinian P, Saric M, Gibbs AR, Phillips JI, Murray J, Axten CW, Nolan RP, Aaronson SA. Manfredi JJ, et al. Cancer Res. 2005 Apr 1;65(7):2602-9. doi: 10.1158/0008-5472.CAN-04-2461. Cancer Res. 2005. PMID: 15805256
Kidney, a known reservoir of SV40 in monkeys, from some of these individuals were also negative for SV40 large T antigen sequences. A subset of mesotheliomas was analyzed for SV40 large T antigen expression by immunostaining with a highly specific SV40
Kidney, a known reservoir of SV40 in monkeys, from some of these individuals were also negative for SV40 large T antigen seque …
SV40-transformed simian cells support the replication of early SV40 mutants.
Gluzman Y. Gluzman Y. Cell. 1981 Jan;23(1):175-82. doi: 10.1016/0092-8674(81)90282-8. Cell. 1981. PMID: 6260373
CV-1, an established line of simian cells permissive for lytic growth of SV40, were transformed by an origin-defective mutant of SV40 which codes for wild-type T antigen. ...One of the lines (COS-1) contains a single integrated copy of the complete early region of …
CV-1, an established line of simian cells permissive for lytic growth of SV40, were transformed by an origin-defective mutant of S
Consideration of PCR methods for the detection of SV40 in tissue and DNA specimens.
Lednicky JA, Butel JS. Lednicky JA, et al. Dev Biol Stand. 1998;94:155-64. Dev Biol Stand. 1998. PMID: 9776238 Review.
SV40 is capable of infecting humans, although its association with human diseases remains controversial. Recently, a subgenomic SV40 DNA sequence was detected by polymerase chain reaction (PCR) in certain types of human tumour tissue as well as in normal pituitary t
SV40 is capable of infecting humans, although its association with human diseases remains controversial. Recently, a subgenomic SV
Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples.
Kjaerheim K, Røe OD, Waterboer T, Sehr P, Rizk R, Dai HY, Sandeck H, Larsson E, Andersen A, Boffetta P, Pawlita M. Kjaerheim K, et al. Int J Cancer. 2007 Jun 1;120(11):2459-65. doi: 10.1002/ijc.22592. Int J Cancer. 2007. PMID: 17315193
BKV and JCV specific antibodies cross- reactive with SV40 were preabsorbed with the respective VP1 proteins. Sera showing SV40 reactivity after preabsorption with BKV and JCV VP1 were further analyzed in SV40 neutralization assays. SV40 DNA was analyze …
BKV and JCV specific antibodies cross- reactive with SV40 were preabsorbed with the respective VP1 proteins. Sera showing SV40
Detection of authentic SV40 DNA sequences in human brain and bone tumours.
Butel JS, Jafar S, Stewart AR, Lednicky JA. Butel JS, et al. Dev Biol Stand. 1998;94:23-32. Dev Biol Stand. 1998. PMID: 9776222 Review.
This report summarizes our follow-up studies of SV40 DNA sequences in human brain tumors of early childhood and our confirmation of the presence of SV40 DNA in human osteosarcomas. ...Infectious SV40 was recovered from one brain tumor. We sequenced the entire …
This report summarizes our follow-up studies of SV40 DNA sequences in human brain tumors of early childhood and our confirmation of t …
Helpers for efficient encapsidation of SV40 pseudovirions.
Oppenheim A, Peleg A. Oppenheim A, et al. Gene. 1989 Apr 15;77(1):79-86. doi: 10.1016/0378-1119(89)90361-2. Gene. 1989. PMID: 2545539
Plasmid DNA that carries the simian virus 40 (SV40) ori can be packaged as SV40 pseudovirions. The pseudovirions are very efficient in gene transmission into a variety of cell types, including human hemopoietic cells. ...However, it underwent extensive recombination …
Plasmid DNA that carries the simian virus 40 (SV40) ori can be packaged as SV40 pseudovirions. The pseudovirions are very effi …
Serological evidence of SV40 infections in HIV-infected and HIV-negative adults.
Jafar S, Rodriguez-Barradas M, Graham DY, Butel JS. Jafar S, et al. J Med Virol. 1998 Apr;54(4):276-84. doi: 10.1002/(sici)1096-9071(199804)54:4<276::aid-jmv7>3.0.co;2-1. J Med Virol. 1998. PMID: 9557293
As individuals born between 1941 and 1962 had the highest chance of having received SV40-contaminated poliovaccines, we analyzed SV40 seropositivity rates based on year of birth. ...The SV40 seropositivity rates in the patients born between 1941 and 1962 may …
As individuals born between 1941 and 1962 had the highest chance of having received SV40-contaminated poliovaccines, we analyzed S
Expression of SV40 T antigen polypeptides in cells biochemically transformed by plasmids containing the herpes simplex virus thymidine kinase gene and the genome of an SV40tsA mutant.
Kit S, Otsuka H, Qavi H, Trkula D, Dubbs DR. Kit S, et al. Int J Cancer. 1981 Oct 15;28(4):485-96. doi: 10.1002/ijc.2910280415. Int J Cancer. 1981. PMID: 6273334
Molecular hybridization experiments showed that transformed clonal lines TF pSB10 C7 and TF pSB15 C10 had integrated intact SV40 genomes at one integration site, TF pSB10 C3 had integrated an SV40 genome with a small deletion near the BamH I site, but TF pSB15 Cl ha …
Molecular hybridization experiments showed that transformed clonal lines TF pSB10 C7 and TF pSB15 C10 had integrated intact SV40 geno …
Association Between Simian Virus 40 and Human Tumors.
Rotondo JC, Mazzoni E, Bononi I, Tognon M, Martini F. Rotondo JC, et al. Front Oncol. 2019 Jul 25;9:670. doi: 10.3389/fonc.2019.00670. eCollection 2019. Front Oncol. 2019. PMID: 31403031 Free PMC article. Review.
Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently from earlier SV40-contaminated vaccines. ...The main data on (i) the biology and genetics of SV40; (ii) the epidemiology of …
Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently …
SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals.
Martini F, Iaccheri L, Lazzarin L, Carinci P, Corallini A, Gerosa M, Iuzzolino P, Barbanti-Brodano G, Tognon M. Martini F, et al. Cancer Res. 1996 Oct 15;56(20):4820-5. Cancer Res. 1996. PMID: 8841004
DNA sequence analysis, performed in four positive samples, confirmed that the amplified PCR products belong to the SV40 early region. Sixty-one % of the neoplastic patients positive for SV40 sequences had an age excluding exposure to SV40-contaminated polio v …
DNA sequence analysis, performed in four positive samples, confirmed that the amplified PCR products belong to the SV40 early region. …
SV40 large T-antigen and human pleural mesothelioma. Screening by polymerase chain reaction and tyramine-amplified immunohistochemistry.
Dhaene K, Verhulst A, Van Marck E. Dhaene K, et al. Virchows Arch. 1999 Jul;435(1):1-7. doi: 10.1007/s004280050387. Virchows Arch. 1999. PMID: 10431839
Depending on the antibody used, different results have been observed regarding the subcellular expression of SV40 LTag in mesotheliomas with SV40 LTag-like DNA sequences. In this study, we screened 28 Belgian mesothelioma tumour samples for the presence of SV40
Depending on the antibody used, different results have been observed regarding the subcellular expression of SV40 LTag in mesotheliom …
Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters.
Zhang S, Sroller V, Zanwar P, Chen CJ, Halvorson SJ, Ajami NJ, Hecksel CW, Swain JL, Wong C, Sullivan CS, Butel JS. Zhang S, et al. PLoS Pathog. 2014 Feb 6;10(2):e1003912. doi: 10.1371/journal.ppat.1003912. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24516384 Free PMC article.
Effects of polyomavirus SV40 microRNA on pathogenesis of viral infections in vivo are not known. Syrian golden hamsters are the small animal model for studies of SV40. We report here effects of SV40 microRNA and influence of the structure of the regulatory re …
Effects of polyomavirus SV40 microRNA on pathogenesis of viral infections in vivo are not known. Syrian golden hamsters are the small …
SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival.
Wong NA, Rae F, Herriot MM, Mayer NJ, Brewster DH, Harrison DJ. Wong NA, et al. J Clin Pathol. 2003 Dec;56(12):904-9. doi: 10.1136/jcp.56.12.904. J Clin Pathol. 2003. PMID: 14645347 Free PMC article.
PCR to detect SV40 regulatory sequence and SV40 Tag immunohistochemistry were performed on selected cases from cohorts A and B. ...Neither SV40 regulatory sequence nor SV40 Tag protein were demonstrated in Tag DNA positive HCCs. ...
PCR to detect SV40 regulatory sequence and SV40 Tag immunohistochemistry were performed on selected cases from cohorts A and B …
Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication.
Dean FB, Bullock P, Murakami Y, Wobbe CR, Weissbach L, Hurwitz J. Dean FB, et al. Proc Natl Acad Sci U S A. 1987 Jan;84(1):16-20. doi: 10.1073/pnas.84.1.16. Proc Natl Acad Sci U S A. 1987. PMID: 3025851 Free PMC article.
The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP, catalyzed the conversion of a circular duplex DNA molecule containing the SV40 origin of replication to a form with unusual electro …
The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP …
Transcription enhancers as major determinants of SV40 polyomavirus growth efficiency and host cell tropism.
Schmidt K, Keiser S, Günther V, Georgiev O, Hirsch HH, Schaffner W, Bethge T. Schmidt K, et al. J Gen Virol. 2016 Jul;97(7):1597-1603. doi: 10.1099/jgv.0.000487. Epub 2016 Apr 21. J Gen Virol. 2016. PMID: 27100458 Free PMC article.
Using an SV40-based model system we provide evidence that duplications of enhancer elements, whether from SV40 itself or from the related BKPyV and JCPyV, increase early gene transcription and replicative capacity. SV40 harbouring subsegments of the strong cy …
Using an SV40-based model system we provide evidence that duplications of enhancer elements, whether from SV40 itself or from …
Causality of mesothelioma: SV40 question.
Shah KV. Shah KV. Thorac Surg Clin. 2004 Nov;14(4):497-504. doi: 10.1016/S1547-4127(04)00112-4. Thorac Surg Clin. 2004. PMID: 15559056
The fragility of the evidence for SV40 association with human cancer is seen in studies of NHL. A publication in 1999 stated that SV40 is rarely present in NHL. ...The weaknesses in the evidence linking SV40 with mesothelioma are summarized in Box 11 It seems …
The fragility of the evidence for SV40 association with human cancer is seen in studies of NHL. A publication in 1999 stated that …
Integration of SV40 in human osteosarcoma DNA.
Mendoza SM, Konishi T, Miller CW. Mendoza SM, et al. Oncogene. 1998 Nov 12;17(19):2457-62. doi: 10.1038/sj.onc.1202179. Oncogene. 1998. PMID: 9824156
Analysis by Southern blotting of total DNA from ten osteosarcomas, positive for SV40 by PCR, found viral integration in half of these. Analysis showed integration of one to four copies per cell of rearranged SV40. No SV40 was detectable on blots of the remain …
Analysis by Southern blotting of total DNA from ten osteosarcomas, positive for SV40 by PCR, found viral integration in half of these …
Investigation of the SV40--human cancer association: look for the full signature of the virus.
Shah KV, Rollison DE. Shah KV, et al. Dis Markers. 2001;17(3):159-61. doi: 10.1155/2001/630740. Dis Markers. 2001. PMID: 11790881 Free PMC article.
In the controversy about the association of simian virus 40 with human cancers, the greatest problem is the ascertainment of SV40 exposure. This difficulty would be resolved if one were to look for all components of SV40 infection. How does SV 40 circulate in the hu …
In the controversy about the association of simian virus 40 with human cancers, the greatest problem is the ascertainment of SV40 exp …
A colinear map relating the simian virus 40 (SV40) DNA segments of six adenovirus-SV40 hybrids to the DNA fragments produced by restriction endonuclease cleavage of SV40 DNA.
Lebowitz P, Kelly TJ Jr, Nathans D, Lee TN, Lewis AM Jr. Lebowitz P, et al. Proc Natl Acad Sci U S A. 1974 Feb;71(2):441-5. doi: 10.1073/pnas.71.2.441. Proc Natl Acad Sci U S A. 1974. PMID: 4131276 Free PMC article.
The simian virus 40 (SV40) DNA segments present in a series of adenovirus-SV40 hybrids have been mapped with respect to the sites of cleavage of SV40 DNA by restriction endonucleases. ...The two sets of data were consistent and have permitted alignment of the …
The simian virus 40 (SV40) DNA segments present in a series of adenovirus-SV40 hybrids have been mapped with respect to the si …
Examination of poliovirus vaccine preparations for SV40 sequences.
Sangar D, Pipkin PA, Wood DJ, Minor PD. Sangar D, et al. Biologicals. 1999 Mar;27(1):1-10. doi: 10.1006/biol.1998.0170. Biologicals. 1999. PMID: 10441397
Contamination of earlier materials with the monkey virus SV40, particularly inactivated Salk type poliovaccines, is well documented. Precautions have been in place for more than 30 years to prevent SV40 contamination of oral poliovaccines based on screening of donor …
Contamination of earlier materials with the monkey virus SV40, particularly inactivated Salk type poliovaccines, is well documented. …
Association of SV40 with human tumors.
Klein G, Powers A, Croce C. Klein G, et al. Oncogene. 2002 Feb 14;21(8):1141-9. doi: 10.1038/sj.onc.1205173. Oncogene. 2002. PMID: 11850833
Sequence analysis confirmed that the sequences were homologous to SV40. One year later, SV40 was also found in 5/9 human mesotheliomas, and in 1996 SV40 was also reported to be present in 1/3 of the tumor specimens examined. These reports, in combination with …
Sequence analysis confirmed that the sequences were homologous to SV40. One year later, SV40 was also found in 5/9 human mesot …
Immunodetection of SV40 T/t-antigens in human osteosrcoma in a series of Tunisian patients.
Ziadi S, Boughamoura H, Ben Maitig M, Ben Gacem R, Mestiri S, Chaabani L, Trimeche M. Ziadi S, et al. Pathol Oncol Res. 2012 Jul;18(3):691-6. doi: 10.1007/s12253-012-9496-x. Pathol Oncol Res. 2012. PMID: 22286959 Free article.
The etiology of osteosarcoma is not well understood. Recent investigations have identified SV40 DNA sequences in osteosarcomas, suggesting that SV40 may contribute to tumor development. ...This study documents the presence SV40 T/t-antigens in a proportion of …
The etiology of osteosarcoma is not well understood. Recent investigations have identified SV40 DNA sequences in osteosarcomas, sugge …
Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors.
Yang Z, Chen S, Xue S, Li X, Hu J, Sun Z, Cui H. Yang Z, et al. Onco Targets Ther. 2018 Aug 17;11:4945-4953. doi: 10.2147/OTT.S153576. eCollection 2018. Onco Targets Ther. 2018. PMID: 30154663 Free PMC article.
MATERIALS AND METHODS: A 122 bp SV40 terminator fragment (10 ng/L) was microinjected into zebrafish zygotes. SV40 fragment integration into the zebrafish embryonic genome was detected by Southern blot using a DNA probe for the SV40 terminator. ...RESULTS: Mic …
MATERIALS AND METHODS: A 122 bp SV40 terminator fragment (10 ng/L) was microinjected into zebrafish zygotes. SV40 fragment int …
Low prevalence of SV40 in Swiss mesothelioma patients after elimination of false-positive PCR results.
Ziegler A, Seemayer CA, Hinterberger M, Vogt P, Bigosch C, Gautschi O, Tornillo L, Betticher DC, Moch H, Stahel RA. Ziegler A, et al. Lung Cancer. 2007 Sep;57(3):282-91. doi: 10.1016/j.lungcan.2007.03.025. Epub 2007 May 21. Lung Cancer. 2007. PMID: 17513005
To characterize the prevalence of SV40 in Swiss mesothelioma patients, we optimized a real-time PCR for quantitative detection of SV40 DNA in plasma, and used a monoclonal antibody for immunohistochemical detection of SV40 in mesothelioma tissue microarrays. …
To characterize the prevalence of SV40 in Swiss mesothelioma patients, we optimized a real-time PCR for quantitative detection of …
Detection and quantification of SV40 large T-antigen DNA in mesothelioma tissues and cell lines.
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To this end, we investigated the efficacy of real time quantitative PCR in detecting low copy number SV40 DNA sequences, then we quantified SV40 copy number in MPM tissues and cell lines at our institution. Quantitative PCR demonstrated consistent precision and accu …
To this end, we investigated the efficacy of real time quantitative PCR in detecting low copy number SV40 DNA sequences, then we quan …
Expression of SV40 T antigen under control of adenovirus promoters.
Thummel C, Tjian R, Grodzicker T. Thummel C, et al. Cell. 1981 Mar;23(3):825-36. doi: 10.1016/0092-8674(81)90447-5. Cell. 1981. PMID: 7226231
We have obtained novel adenovirus-SV40 recombinant viruses that express wild-type SV40 large T and small t antigens under the control of different adenovirus promoters. ...Biochemical characterization of SV40 T antigens overproduced by the hybrid viruses indi …
We have obtained novel adenovirus-SV40 recombinant viruses that express wild-type SV40 large T and small t antigens under the …
SV40 sequences in human osteosarcoma of German origin.
Heinsohn S, Scholz RB, Weber B, Wittenstein B, Werner M, Delling G, Kempf-Bielack B, Setlak P, Bielack S, Kabisch H. Heinsohn S, et al. Anticancer Res. 2000 Nov-Dec;20(6B):4539-45. Anticancer Res. 2000. PMID: 11205301
Osteosarcoma is a bone malignancy with multiple molecular lesions underlining progression from normal bone to osteosarcoma. Recent investigations have identified SV40 DNA sequences in osteosarcomas, suggesting that SV40 may contribute to tumor development. ...These …
Osteosarcoma is a bone malignancy with multiple molecular lesions underlining progression from normal bone to osteosarcoma. Recent investiga …
SV40 gene activity during lytic infection and in a series of SV40 transformed mouse cells.
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Transcription of SV40 DNA was measured during lytic infection and in five SV40 transformed mouse cell lines. ...The RNA from the SV40 transformed cell line, which saturated 50 per cent of the viral DNA, could not be distinguished from SV40 lytic RNA in …
Transcription of SV40 DNA was measured during lytic infection and in five SV40 transformed mouse cell lines. ...The RNA from t …
Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.
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Some polio vaccines prepared from 1954 to 1961 were contaminated with infectious SV40. It has been assumed that all polio vaccines were SV40 free in the United States after 1961 and in other countries after 1962. Following a WHO requirement that was prompted by the …
Some polio vaccines prepared from 1954 to 1961 were contaminated with infectious SV40. It has been assumed that all polio vaccines we …
Characterization of SV40 T antigen associated with the nuclear matrix.
Mann K. Mann K. Virology. 1990 Nov;179(1):437-45. doi: 10.1016/0042-6822(90)90312-f. Virology. 1990. PMID: 2171215
Simian virus 40 (SV40) T antigen associated with the nuclear matrix of SV40-infected TC7 cells has been characterized. ...In contrast, turnover of SV40 T antigen in its association with the other subcellular fractions is not detected during the same period of …
Simian virus 40 (SV40) T antigen associated with the nuclear matrix of SV40-infected TC7 cells has been characterized. ...In c …
SV40-like sequences in human bone tumors.
Carbone M, Rizzo P, Procopio A, Giuliano M, Pass HI, Gebhardt MC, Mangham C, Hansen M, Malkin DF, Bushart G, Pompetti F, Picci P, Levine AS, Bergsagel JD, Garcea RL. Carbone M, et al. Oncogene. 1996 Aug 1;13(3):527-35. Oncogene. 1996. PMID: 8760294
PCR amplification and Southern blot hybridization with a probe specific for SV40 Tag revealed that 18/200 samples contained SV40-like sequences and, unexpectedly, 11/18 were from patients with osteosarcomas. ...The extent of SV40 genome sequences present in t …
PCR amplification and Southern blot hybridization with a probe specific for SV40 Tag revealed that 18/200 samples contained SV40
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.
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SV40 infection or transformation of murine cells stimulated the production of a 54K dalton protein that was specifically immunoprecipitated, along with SV40 large T and small t antigens, with sera from mice or hamsters bearing SV40-induced tumors. ...This pro
SV40 infection or transformation of murine cells stimulated the production of a 54K dalton protein that was specifically immunoprecip
Fanconi anemia patients are more susceptible to infection with tumor virus SV40.
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DNA tumor polyomavirus simian virus 40 (SV40) transforms FA fibroblasts at high efficiency suggesting that FA patients could be highly susceptible to SV40 infection. ...From the analysis of family pedigrees, 60% of the parents of SV40-positive probands were p …
DNA tumor polyomavirus simian virus 40 (SV40) transforms FA fibroblasts at high efficiency suggesting that FA patients could be highl …
Absence of SV40 large T-antigen expression in human mesothelioma cell lines.
Pilatte Y, Vivo C, Renier A, Kheuang L, Greffard A, Jaurand MC. Pilatte Y, et al. Am J Respir Cell Mol Biol. 2000 Dec;23(6):788-93. doi: 10.1165/ajrcmb.23.6.4251. Am J Respir Cell Mol Biol. 2000. PMID: 11104732
Simian virus (SV) 40 and SV40-like DNA sequences have recently been detected in several types of human tumors, including malignant mesothelioma. ...In this study we investigated SV40 large T antigen (SV40 Tag) protein expression in mesothelioma cell lines, es …
Simian virus (SV) 40 and SV40-like DNA sequences have recently been detected in several types of human tumors, including malignant me …
Immunoprecipitation of SV40 replicating minichromosomes complexed with bacteriophage T4 gene 32 protein.
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Late after infection SV40 replicating DNA molecules represent about 5% of total viral minichromosomes. Since gene 32 protein (P32) from bacteriophage T4 interacts with single-stranded DNA and SV40 replication complexes are expected to contain single-stranded regions …
Late after infection SV40 replicating DNA molecules represent about 5% of total viral minichromosomes. Since gene 32 protein (P32) fr …
Polyomavirus SV40 infections in Kazakhstan.
Nurgalieva ZZ, Wong C, Zhangabylov AK, Omarbekova ZE, Graham DY, Vilchez RA, Butel JS. Nurgalieva ZZ, et al. J Infect. 2005 Feb;50(2):142-8. doi: 10.1016/j.jinf.2004.03.001. J Infect. 2005. PMID: 15667916
OBJECTIVES: To examine the prevalence of polyomavirus SV40 infections in Kazakhstan, a central Asian country known to have used potentially contaminated SV40 poliovaccines before 1962. ...As increasing evidence indicates an association of SV40 with selected t …
OBJECTIVES: To examine the prevalence of polyomavirus SV40 infections in Kazakhstan, a central Asian country known to have used poten …
Evidence of SV40 infections in hospitalized children.
Butel JS, Jafar S, Wong C, Arrington AS, Opekun AR, Finegold MJ, Adam E. Butel JS, et al. Hum Pathol. 1999 Dec;30(12):1496-502. doi: 10.1016/s0046-8177(99)90173-9. Hum Pathol. 1999. PMID: 10667429
Simian virus 40 (SV40) is known to have contaminated poliovirus vaccines used between 1955 and 1963. Accumulating reports have described the presence of SV40 DNA in human tumors and normal tissues, although the significance of human infections by SV40 is unkn …
Simian virus 40 (SV40) is known to have contaminated poliovirus vaccines used between 1955 and 1963. Accumulating reports have descri …
Investigation of the simian polyomavirus SV40 as a potential causative agent of human neurological disorders in AIDS patients.
Tognon M, Martini F, Iaccheri L, Cultrera R, Contini C. Tognon M, et al. J Med Microbiol. 2001 Feb;50(2):165-172. doi: 10.1099/0022-1317-50-2-165. J Med Microbiol. 2001. PMID: 11211224
Three of the 12 CSF samples were positive for JCV (one sample) or SV40 (one) DNA, or both (one). No sample was positive for BKV DNA. JCV- and SV40-specific genomic regions were confirmed by DNA sequencing. ...These results suggest that SV40 may be involved in …
Three of the 12 CSF samples were positive for JCV (one sample) or SV40 (one) DNA, or both (one). No sample was positive for BKV DNA. …
Serum deprivation induces SV40 early promoter activity.
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The results show that serum deprivation of growing cells induces SV40 promoter activity while serum stimulation of quiescent G0 cells suppresses it. Kinetic analyses show a significant induction of the SV40 promoter activity during the first 2 days of serum deprivat …
The results show that serum deprivation of growing cells induces SV40 promoter activity while serum stimulation of quiescent G0 cells …
Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors.
Arad U, Axelrod J, Ben-nun-Shaul O, Oppenheim A, Galun E. Arad U, et al. J Hepatol. 2004 Mar;40(3):520-6. doi: 10.1016/j.jhep.2003.11.028. J Hepatol. 2004. PMID: 15123369
METHODS: A SV40-vector carrying the luciferase gene, and wild-type SV40, were used to assess transduction efficiency of human HBV-positive and HBV-negative hepatic cells. ...The level of MHC-I, the cellular receptor for SV40, was comparable in all the cell-li …
METHODS: A SV40-vector carrying the luciferase gene, and wild-type SV40, were used to assess transduction efficiency of human …
Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies.
Toscano MG, van der Velden J, van der Werf S, Odijk M, Roque A, Camacho-Garcia RJ, Herrera-Gomez IG, Mancini I, de Haan P. Toscano MG, et al. Mol Ther Methods Clin Dev. 2017 Jul 5;6:124-134. doi: 10.1016/j.omtm.2017.06.007. eCollection 2017 Sep 15. Mol Ther Methods Clin Dev. 2017. PMID: 28791314 Free PMC article.
SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the absence of contaminating RC SV40 particles. Our unique SV40 vector platform named SVac paves the way to clinically test a whole …
SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the a …
The role of plasmid constructs containing the SV40 DNA nuclear-targeting sequence in cationic lipid-mediated DNA delivery.
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Recently, via microinjection into the cytoplasm and in situ hybridizations into a few cell types, it was shown that a region of Simian virus 40(SV40), specifically a c. 372-bp fragment of SV40 genomic DNA encompassing the SV40 promoter-enhancer-origin of repl …
Recently, via microinjection into the cytoplasm and in situ hybridizations into a few cell types, it was shown that a region of Simian virus …
Constraints in simian virus 40 (SV40) encapsidation, as determined by SV40-based shuttle viruses.
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Simian virus 40 (SV40)-based shuttle vectors, containing the SV40 late genes, can be packaged as infectious pseudovirions. In terms of their function as bacterial plasmids, modifications in the overall size of these plasmids can be tolerated within a very wide range …
Simian virus 40 (SV40)-based shuttle vectors, containing the SV40 late genes, can be packaged as infectious pseudovirions. In …
Expression of chimeric genes in the early region of SV40.
Horowitz M, Cepko CL, Sharp PA. Horowitz M, et al. J Mol Appl Genet. 1983;2(2):147-59. J Mol Appl Genet. 1983. PMID: 6192195
RNA mapping demonstrated the following: (a) The SV40-rat preproinsulin chimeric RNA was initiated at the SV40 early promoter, spliced from the SV40 5' SS to the rat preproinsulin 3' SS, and polyadenylated solely at the SV40 poly(A) addition signal. ... …
RNA mapping demonstrated the following: (a) The SV40-rat preproinsulin chimeric RNA was initiated at the SV40 early promoter, …
Structural relationship between the 100,000- and 17,000- molecular-weight T antigens of simian virus 40 (SV40) as deduced by comparison with the SV40-specific proteins coded by the nondefective adenovirus type 2-SV40 hybrid viruses.
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The peptide maps of the 100 K and 17K T antigens were also compared with those of the SV40-specific proteins found in cells infected by the nondefective adenovirus type 2-SV40 hybrid viruses, which we have previously shown are encoded by defined sequences within the …
The peptide maps of the 100 K and 17K T antigens were also compared with those of the SV40-specific proteins found in cells infected …
Mapping the transcription site of the SV40-specific late 16 S mRNA.
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This paper describes the purification of polysomal RNA from SV40-lytically infected CV1 (monkey) cells and separation of the two distinct classes of SV40-specific mRNA sedimenting at 16 S and 19 S. These classes have been hybridized with the whole SV40 DNA ge …
This paper describes the purification of polysomal RNA from SV40-lytically infected CV1 (monkey) cells and separation of the two dist …
Emergent human pathogen simian virus 40 and its role in cancer.
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Experimental data strongly suggest that SV40 may be functionally important in the development of some of those human malignancies. Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain …
Experimental data strongly suggest that SV40 may be functionally important in the development of some of those human malignancies. Th …
Evidence for simian virus 40 (SV40) coding of SV40 T-antigen and the SV40-specific proteins in HeLa cells infected with nondefective adenovirus type 2-SV40 hybrid viruses.
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From the in vitro synthesis experiments with SV40-selected RNA, we further conclude that the SV40-specific proteins must be SV40 coded and not host coded. Since SV40 T-antigen is related to the SV40-specific proteins, it must also be SV40
From the in vitro synthesis experiments with SV40-selected RNA, we further conclude that the SV40-specific proteins must be …
Disassociation of the SV40 genome from capsid proteins prior to nuclear entry.
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Then, in the cytoplasm, disassembly progresses further to also make the genomic DNA accessible to immune detection, as well as to detection by an ethynyl-2-deoxyuridine (EdU)-based chemical reaction. The cytoplasmic partially disassembled SV40 particles retain some of the …
Then, in the cytoplasm, disassembly progresses further to also make the genomic DNA accessible to immune detection, as well as to detection …
Sequence analyses of human tumor-associated SV40 DNAs and SV40 viral isolates from monkeys and humans.
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SV40 DNA has been found associated with several types of human tumors. We now report a sequence comparison of SV40 DNAs from pediatric brain tumors and from osteosarcomas with viral isolates from monkeys and from humans. ...There was no compelling evidence for human
SV40 DNA has been found associated with several types of human tumors. We now report a sequence comparison of SV40 DNAs from p
Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts.
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BACKGROUND: Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however gene-level interactions between 3-MC and SV40
BACKGROUND: Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to e …
Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants.
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Immunol. 130:490-492, 1983) by using two independently isolated SV40-specific cytotoxic T-lymphocyte (CTL) clones, K11 and K19. We identified amino acids in the amino-terminal half of SV40 T antigen that are essential for the recognition of antigenic sites by these …
Immunol. 130:490-492, 1983) by using two independently isolated SV40-specific cytotoxic T-lymphocyte (CTL) clones, K11 and K19. We id …
Late coding region sequences required for competition by SV40 defectives.
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SV40 defectives containing the complete early coding region (E-SV40) or the complete late region (L-SV40) were separately transfected into green monkey cells. ...It also replicated continuously rather than transiently in Cosl cells. Next, we determined whethe
SV40 defectives containing the complete early coding region (E-SV40) or the complete late region (L-SV40) were separate
Transcription inhibition of SV40 by in vitro DNA methylation.
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SV40 DNA was methylated in vitro with prokaryotic or eukaryotic DNA cytosine-5-methyltransferases and the inhibition of transcription by methylation was studied in Xenopus oocytes. Methylation with the prokaryotic HhaI or HpaII methyltransferases did essentially not inhibi
SV40 DNA was methylated in vitro with prokaryotic or eukaryotic DNA cytosine-5-methyltransferases and the inhibition of transcription
Detection of SV40 like viral DNA and viral antigens in malignant pleural mesothelioma.
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Immunohistochemistry with an SV40-specific antibody was applied for detection of the SV40 viral antigen in the same material. SV40 DNA and expression of one of the viral proteins (small t-antigen) was found in approximately 60% of the investigated mesotheliom …
Immunohistochemistry with an SV40-specific antibody was applied for detection of the SV40 viral antigen in the same material. …
Conventional epidemiology and the link between SV40 and human cancers.
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Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror the human cancers that have been found to contain SV40 DNA or the viral oncoprotein. Increasing amounts of data support the notion t …
Simian virus 40 (SV40) is known to cause tumourigenesis. The main types of tumour induced by SV40 in laboratory animals mirror …
SV40 tumor rejection induced by vesicular stomatitis virus bearing SV40 tumor-specific transplantation antigen (SV40-TSTA). II. Association of SV40-TSTA activity with liposomes containing VSV glycolipids.
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When the glycolipids were extracted from VSV grown on cell lines (TSV5-cl2 and EHSVi-cl1) which contained the SV40 tumor-specific transplantation antigen (SV40-TSTA), it was possible either to induce a tumor rejection or at least to slow the growth of the tumor in S …
When the glycolipids were extracted from VSV grown on cell lines (TSV5-cl2 and EHSVi-cl1) which contained the SV40 tumor-specific tra …
Functional characterization of SV40-transformed adherent synovial cells from rheumatoid arthritis.
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A total of 14 transformed cell clones were obtained by micro-injecting origin-defective SV40 DNA into three types of cloned adherent synovial cells (ASC) (dendritic cells (DCs), macrophage-like cells (MCs), and fibroblast-like cells (FCs)) from two rheumatoid arthritis pat …
A total of 14 transformed cell clones were obtained by micro-injecting origin-defective SV40 DNA into three types of cloned adherent …
Absence of SV40 in Austrian tumors correlates with low incidence of mesotheliomas.
Leithner A, Weinhaeusel A, Windhager R, Schlegl R, Waldner P, Lang S, Dominkus M, Zoubek A, Popper HH, Haas OA. Leithner A, et al. Cancer Biol Ther. 2002 Jul-Aug;1(4):375-9. Cancer Biol Ther. 2002. PMID: 12432250
In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free British vaccine. Thus, we hypothesized that the Austrian population should be SV40-free. ...SV40 was easily detected in two bone tumor DNAs from Italy, and one from the U …
In Austria, polio mass vaccination started in winter 1961/62 with a presumably SV40-free British vaccine. Thus, we hypothesized that …
Two adenovirus type 2-simian virus 40 hybrid populations that contain the entire SV40 genome differ in their ability to induce SV40 transplantation immunity in hamsters but not in mice.
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Ad2++ HEY and Ad2++ LEY are two adenovirus 2(Ad2)-simian virus 40 (SV40) hybrids distinguished by differences in the efficiency with which they produce SV40 progeny in lytically infected African green monkey kidney cells. ...Only Ad2++ HEY induces SV40 transp …
Ad2++ HEY and Ad2++ LEY are two adenovirus 2(Ad2)-simian virus 40 (SV40) hybrids distinguished by differences in the efficiency with …
HPV-16 E6 and E7 genes, like SV40 early region genes, are insufficient for immortalization of human mesothelial and bronchial epithelial cells.
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Mesothelial cells expressing SV40 or HPV-16 genes mostly entered crisis (4/4 SV40- and 3/4 HPV-transfected clones). Similarly, 1/3 SV40- and 2/3 HPV-transfected bronchial epithelial cell cultures entered crisis. For these two types of epithelial cells, we the …
Mesothelial cells expressing SV40 or HPV-16 genes mostly entered crisis (4/4 SV40- and 3/4 HPV-transfected clones). Similarly, …
Studies of adenovirus SV40 hybrid viruses. I. Assay system and further evidence for hybridization.
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The titers of adenovirus and SV40 genetic carriers in hybrid preparations (E46(+)) can be quantitated by determining the percentage of cells showing neoantigens stainable with fluorescent antibody (FA) at 21 to 24 hours; both titers can be obtained with a single coverslip. …
The titers of adenovirus and SV40 genetic carriers in hybrid preparations (E46(+)) can be quantitated by determining the percentage o …
Herpes simplex virus-induced "rolling circle" amplification of SV40 DNA sequences in a transformed hamster cell line correlates with tandem integration of the SV40 genome.
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Infection with herpes simplex virus leads to amplification of SV40 DNA in various SV40-transformed cells. In earlier studies with the SV40-transformed hamster cell line Elona two different types of DNA amplification could be identified: (i) Bidirectional over …
Infection with herpes simplex virus leads to amplification of SV40 DNA in various SV40-transformed cells. In earlier studies w …
SV40 virus transformation down-regulates endothelin receptor.
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This report examines the effect of SV40 transformation on the expression of ET receptors. Results from receptor binding and reverse transcription (RT)-polymerase chain reaction (PCR) studies show that human lung fibroblasts IMR90 and WI38 express both ETA and ETB receptors …
This report examines the effect of SV40 transformation on the expression of ET receptors. Results from receptor binding and reverse t …
A packaging system for SV40 vectors without viral coding sequences.
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Here we described a system for packaging SV40 vectors without viral coding sequences. Recombinant adenovirus-expressing SV40 capsids can effectively package plasmids that contain the SV40 replication origin. The final yield of infectious SV40 vector is …
Here we described a system for packaging SV40 vectors without viral coding sequences. Recombinant adenovirus-expressing SV40 c …
Inhibition of SV40 DNA replication by Rous sarcoma virus LTR enhancer.
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Simian virus 40 (SV40) late region recombinant constructs containing the Rous sarcoma virus (RSV) src gene along with RSV enhancer stimulated expression but completely abolished SV40 DNA replication. Constructs, in which the heterologous enhancer sequences were omit …
Simian virus 40 (SV40) late region recombinant constructs containing the Rous sarcoma virus (RSV) src gene along with RSV enhancer st …
Serological cross reactivity between polyomavirus capsids.
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Similarly, the reactivity of the majority of human sera to SV40 was blocked by both SV40 and BK or JC, demonstrating that the SV40 reactivity of human sera is largely due to cross reacting BK and JC antibodies. In contrast, the reactivity of human sera to LPV …
Similarly, the reactivity of the majority of human sera to SV40 was blocked by both SV40 and BK or JC, demonstrating that the …
Unique strains of SV40 in commercial poliovaccines from 1955 not readily identifiable with current testing for SV40 infection.
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SV40 was first identified as a contaminant of poliovaccines used from 1955 until 1963. ...Our data demonstrate that humans were exposed to SV40 viruses with both one 72-bp enhancer and two 72-bp enhancers SV40 through contaminated vaccines. ...
SV40 was first identified as a contaminant of poliovaccines used from 1955 until 1963. ...Our data demonstrate that humans were expos
Isolation of double lysogens from 3T3 cells transformed by plaque morphology mutants of SV40.
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Simian virus 40 (SV40) rescued from 3T3 lines transformed independently by fuzzy plaque strain, SV40 (mKS-U4), and small-clear plaque strain, SV40 (mKS-U88), resembled the virus used to initiate the transformation. ...When these infectious centers were picked …
Simian virus 40 (SV40) rescued from 3T3 lines transformed independently by fuzzy plaque strain, SV40 (mKS-U4), and small-clear …
Simian virus 40 and human tumors: It is time to study mechanisms.
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Using the microdissection technique, they found SV40 in 54% of 93 mesotheliomas of the epithelial type. The surrounding reactive stromal cells, (20 lung cancers and 14 mesotheliomas of the sarcomatoid/fibrous type) did not contain SV40, confirming the specificity of …
Using the microdissection technique, they found SV40 in 54% of 93 mesotheliomas of the epithelial type. The surrounding reactive stro …
Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.
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BACKGROUND: A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progen …
BACKGROUND: A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a n …
Identification in human brain tumors of DNA sequences specific for SV40 large T antigen.
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In 8 tumor biopsies with SV40 sequences, the adjacent normal brain tissue was also analyzed but was devoid of viral DNA in all but one case. ...It remains to be shown whether the presence of SV40 contributes significantly to malignant transformation or whether certa …
In 8 tumor biopsies with SV40 sequences, the adjacent normal brain tissue was also analyzed but was devoid of viral DNA in all but on …
Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas.
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Animals given SV40 and ENU showed increased mortality and increased metastatic tumors (54.2% vs 30.8%) compared with those given SV40 alone. ...No difference in primary tumor size, histology, and SV40 T-antigen content was detected between SV40- and …
Animals given SV40 and ENU showed increased mortality and increased metastatic tumors (54.2% vs 30.8%) compared with those given S
Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IX. Analysis of TrAg in mouse cells synthesizing truncated SV40 large T antigen.
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The TK+ transformants were analyzed for SV40 transplantation rejection antigen (TrAg) at the cell surface by reacting them with cytotoxic lymphocytes (CTL) generated to SV40 TrAg in C3H/HeJ (H-2k) mice. ...However, LTK+ cells that were transformed with the plasmid p …
The TK+ transformants were analyzed for SV40 transplantation rejection antigen (TrAg) at the cell surface by reacting them with cytot …
A domain of SV40 capsid polypeptide VP1 that specifies migration into the cell nucleus.
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In order to identify the determinants responsible for the nuclear migration of simian virus 40 (SV40) polypeptide VP1, the 5'-terminal portion of the SV40 VP1 gene was fused with the complete cDNA sequence of poliovirus capsid polypeptide VP1 and the hybrid gene was …
In order to identify the determinants responsible for the nuclear migration of simian virus 40 (SV40) polypeptide VP1, the 5'-termina …
Enhanced induction of SV40 replication from transformed mammalian cells by fusion with UV-irradiated untransformed cells.
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DNA-damaging agents such as ultraviolet (UV) light are known to cause stimulation of virus replication in SV40-transformed hamster and human cells. The dose-response curves of UV-induced SV40 replication in transformed hamster cells resemble that obtained for UV-enh …
DNA-damaging agents such as ultraviolet (UV) light are known to cause stimulation of virus replication in SV40-transformed hamster an …
No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden.
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The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantitative real time polymerase chain reaction (PCR) with a sensitivity of 10 copies of viral DNA per sample. ...Eighteen tumors were amplifiable, …
The presence of SV40 in 26 consecutive cases of malignant mesothelioma of biphasic type was investigated using a SV40 quantita …
Polio vaccines, Simian Virus 40, and human cancer: the epidemiologic evidence for a causal association.
Dang-Tan T, Mahmud SM, Puntoni R, Franco EL. Dang-Tan T, et al. Oncogene. 2004 Aug 23;23(38):6535-40. doi: 10.1038/sj.onc.1207877. Oncogene. 2004. PMID: 15322523 Review.
In 1960, it was discovered that Simian Virus 40 (SV40) contaminated up to 30% of the poliovirus vaccines in the US. This contamination arose because the vaccines were produced in monkey kidney cell cultures harboring SV40 between 1955 and 1963. ...Productive SV40
In 1960, it was discovered that Simian Virus 40 (SV40) contaminated up to 30% of the poliovirus vaccines in the US. This contaminatio …
Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids.
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During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we became concerned by inconsistent results and therefore used several independent techniques to investigate SV40 in these tumours. ...Studies of SV40 based on PCR methods r …
During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we became concerned by inconsistent results and …
Construction of an adenovirus-SV40 recombinant producing SV40 T antigen from an adenovirus late promoter.
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An adenovirus-SV40 recombinant has been constructed in which the SV40 early region, joined to a copy of the adenovirus major late promoter, was substituted for a small portion of the adenovirus late region and all of early region 3. The inserted sequence functions a …
An adenovirus-SV40 recombinant has been constructed in which the SV40 early region, joined to a copy of the adenovirus major l …
Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research.
Engels EA. Engels EA. Expert Rev Vaccines. 2005 Apr;4(2):197-206. doi: 10.1586/14760584.4.2.197. Expert Rev Vaccines. 2005. PMID: 15889993 Free article. Review.
Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955-1962. Exposure to SV40 via contaminated vaccines has led to concern as SV40 causes cancer in laboratory animals. ...This article reviews the d …
Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955-1962. Exposure t …
Effect of human cytomegalovirus on replication of SV40 origin and the expression of T antigen.
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Human cytomegalovirus (HCMV) induces replication of the cloned SV40 origin of DNA replication in both productive and nonproductive infections. HCMV-induced replication of the SV40 DNA origin required the presence of T antigen. ...Cotransfection of the SV40-cl …
Human cytomegalovirus (HCMV) induces replication of the cloned SV40 origin of DNA replication in both productive and nonproductive in …
DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.
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With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in each of five cell lines, derived from four mammalian species, transformed by SV40 virus. Essentially all nuclei, including those of mult …
With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in eac …
Cell and molecular biology of simian virus 40: implications for human infections and disease.
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SV40 can replicate in certain types of simian and human cells. SV40-neutralizing antibodies have been detected in individuals not exposed to contaminated polio vaccines. SV40 DNA has been identified in some normal human tissues, and there are accumulating rep
SV40 can replicate in certain types of simian and human cells. SV40-neutralizing antibodies have been detected in individuals
Simian virus 40 infection in humans and association with human diseases: results and hypotheses.
Barbanti-Brodano G, Sabbioni S, Martini F, Negrini M, Corallini A, Tognon M. Barbanti-Brodano G, et al. Virology. 2004 Jan 5;318(1):1-9. doi: 10.1016/j.virol.2003.09.004. Virology. 2004. PMID: 15015494 Free article. Review.
Simian virus 40 (SV40) is a monkey virus that was introduced in the human population by contaminated poliovaccines, produced in SV40-infected monkey cells, between 1955 and 1963. ...This evidence includes detection of SV40 DNA sequences in human tissues and o …
Simian virus 40 (SV40) is a monkey virus that was introduced in the human population by contaminated poliovaccines, produced in SV
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus.
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The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expression. ...Although there is no detectable sequence homology to SV40, the MSV repeats can substitute functionally for the SV40
The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expr …
Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.
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SV40 Tag sequences were detected in 29% of buffy coats of blood donors. However, only four brain tumor cell lines showed all the five regions of the SV40 genome investigated. Expression of SV40 Tag sequences was found in 11 of 27 (41%) human tumor samples. DN
SV40 Tag sequences were detected in 29% of buffy coats of blood donors. However, only four brain tumor cell lines showed all the five
SUCCESSIVE TRANSFORMATIONS OF AN ESTABLISHED CELL LINE BY POLYOMA VIRUS AND SV40.
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Two different oncogenic viruses, polyoma and SV40, are capable of transforming mouse cell line 3T3. The properties of the transformed cells produced by the two viruses are in some ways similar, but in other ways they are specific for the infecting virus. ...Two different c …
Two different oncogenic viruses, polyoma and SV40, are capable of transforming mouse cell line 3T3. The properties of the transformed …
Molecular cloning and characterization of endogenous SV40 DNA from human HBL-100 cells.
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The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned …
The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cel …
Sequence of the junction in adenovirus 2-SV40 hybrids: examples of illegitimate recombination.
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The nucleotide sequences of six Ad2-SV40 junctions from three Ad2-SV40 hybrid viruses (Ad2++HEY, Ad2++LEY and Ad2+D1) were determined. ...Ad2++HEY and Ad2+D1 right junctions are identical and Ad2++LEY and Ad2+ND4 left junctions are identical, a result that strongly …
The nucleotide sequences of six Ad2-SV40 junctions from three Ad2-SV40 hybrid viruses (Ad2++HEY, Ad2++LEY and Ad2+D1) were det …
Host range determinant in the late region of SV40 and RF virus affecting growth in human cells.
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In human cells wtSV40 was also complemented by wtBKV DNA, but after two serial passages SV40 DNA disappeared. These findings indicate that SV40 late or capsid gene sequences, but not SV40 early sequences, generate a block to SV40 growth in human cells. …
In human cells wtSV40 was also complemented by wtBKV DNA, but after two serial passages SV40 DNA disappeared. These findings indicate …
SV40 DNA injected into Xenopus oocyte nuclei is transcribed by RNA polymerase B.
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SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients as do viral RNAs formed in infected green monkey cells but a variable proportion of RNA sequences complementary to SV40 DNA is also fo
SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients a
The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulum.
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For that reason, and because the caveosome and Golgi may have some common markers, we revisited the issue of whether SV40 might access the endoplasmic reticulum via the Golgi. RESULTS: We confirmed our earlier finding that SV40 co localizes with the Golgi marker bet …
For that reason, and because the caveosome and Golgi may have some common markers, we revisited the issue of whether SV40 might acces …
Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells.
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When ECCs are exposed to simian virus 40 (SV40), the SV40 tumour (T) antigen is not expressed, although the virus genome reaches the nucleus, and a primary transcript of the SV40 A gene is made. However, following exposure to retinoic acid, the differentiated …
When ECCs are exposed to simian virus 40 (SV40), the SV40 tumour (T) antigen is not expressed, although the virus genome reach …
Does simian virus 40 cause non-Hodgkin lymphoma? A review of the laboratory and epidemiological evidence.
Engels EA. Engels EA. Cancer Invest. 2005;23(6):529-36. doi: 10.1080/07357900500202820. Cancer Invest. 2005. PMID: 16203661 Review.
A link between SV40 and NHL is biologically plausible because SV40 causes hematological malignancies in laboratory rodents. However, detection of SV40 DNA in human NHL tumors has not been confirmed by other laboratories. Casting doubt on an association betwee …
A link between SV40 and NHL is biologically plausible because SV40 causes hematological malignancies in laboratory rodents. Ho …
Electrophoretic analysis of covalently closed SV40 DNA: Boltzmann distributions of DNA species.
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Covalently closed relaxed SV40 DNA [SV40(I')] generated by polynucleotide ligase closure of nicked circular SV40 DNA was analyzed by agarose gel electrophoresis. ...Densitometric analysis of native supercoiled SV40 DNA, partially unwound in the presenc …
Covalently closed relaxed SV40 DNA [SV40(I')] generated by polynucleotide ligase closure of nicked circular SV40 DNA wa …
Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen.
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An SV40-adenovirus 7 hybrid virus, PARA(cT), has been described that is defective for the nuclear transport of SV40 large tumor antigen. An SV40(cT) mutant was constructed using SV40 early and late region DNA fragments derived from PARA(cT) and wild-ty …
An SV40-adenovirus 7 hybrid virus, PARA(cT), has been described that is defective for the nuclear transport of SV40 large tumo …
A comparison of methods for the extraction of nucleoprotein complexes from SV40-infected cells.
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There was no disruption of mature SV40 virions with either of these extraction procedures. There was, however, considerably more effective extraction of SV40 NPCs, known to contain large tumor (T) antigen, using the low-salt hypotonic method as opposed to the deterg …
There was no disruption of mature SV40 virions with either of these extraction procedures. There was, however, considerably more effe …
Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.
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Furthermore, these results suggest that alterations in SV40 T antigen may be important in stabilizing human cells immortalized by SV40 genes that contain the wild-type SV40 ori, thus contributing to tumorigenic transformation. This is the first report of a su …
Furthermore, these results suggest that alterations in SV40 T antigen may be important in stabilizing human cells immortalized by …
Simian virus 40 and its association with human lymphomas.
Vilchez RA, Butel JS. Vilchez RA, et al. Curr Oncol Rep. 2003 Sep;5(5):372-9. doi: 10.1007/s11912-003-0021-y. Curr Oncol Rep. 2003. PMID: 12895387 Review.
Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain SV40 markers. ...This review examines the data implicating SV40 in the pathogenesis of human lymphomas and discusses future di …
Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain …
Simian virus 40 infection via MHC class I molecules and caveolae.
Norkin LC. Norkin LC. Immunol Rev. 1999 Apr;168:13-22. doi: 10.1111/j.1600-065x.1999.tb01279.x. Immunol Rev. 1999. PMID: 10399061 Review.
Nevertheless, although class I molecules bind SV40, they do not enter with SV40, nor do they enter spontaneously into uninfected SV40 host cells. ...These results imply the existence of a putative secondary receptor for SV40 that might mediate SV40
Nevertheless, although class I molecules bind SV40, they do not enter with SV40, nor do they enter spontaneously into uninfect …
Isolation of a papovavirus with a bipartite genome containing unlinked SV40 and BKV sequences.
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Wild-type (wt) BK virus was introduced into permissive BSC-1 cells along with either early or late defective SV40 genomes. The defectives contained all of the late (L-SV40) or all of the early (E-SV40) coding sequences. ...Also, DNase I digestion of virus sto …
Wild-type (wt) BK virus was introduced into permissive BSC-1 cells along with either early or late defective SV40 genomes. The defect …
Short and long range activation by the SV40 enhancer.
Wasylyk B, Wasylyk C, Chambon P. Wasylyk B, et al. Nucleic Acids Res. 1984 Jul 25;12(14):5589-608. doi: 10.1093/nar/12.14.5589. Nucleic Acids Res. 1984. PMID: 6087293 Free PMC article.
Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between the SV40 enhancer and either the homologous SV40 early or the heterologous conalbumin promoter elements. ...This short range …
Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between …
Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes.
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These are the same tumor types that are specifically induced by SV40 when injected into hamsters, a finding that has raised concerns about the possible pathogenic role of SV40 in humans. Two different SV40 isolates differing in the number of 72-bp elements in …
These are the same tumor types that are specifically induced by SV40 when injected into hamsters, a finding that has raised concerns …
Biology of simian virus 40 (SV40) transplantation antigen (TrAg). X. Tumorigenic potential of mouse cells transformed by SV40 in high responder C57BL/6 mice and correlation with the persistence of SV40 TrAg, early proteins and sequences.
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Primary mouse embryo fibroblasts of C57Bl/6 origin and cells derived from a tumor induced by polyoma virus in a C57Bl/6 mouse were transformed with SV40. The tumorigenic potential of these cells in normal adult and SV40-immunized mice was correlated with the synthes …
Primary mouse embryo fibroblasts of C57Bl/6 origin and cells derived from a tumor induced by polyoma virus in a C57Bl/6 mouse were transform …
In vivo transcription on oligomeric simian virus 40 (SV40) DNA.
Shani M, Seidman M, Salzman NP. Shani M, et al. Virology. 1977 Nov;83(1):110-9. doi: 10.1016/0042-6822(77)90214-8. Virology. 1977. PMID: 18625479
A simian virus 40 nucleoprotein complex containing an endogenous RNA polymerase activity was extracted from infected BSC-1 nuclei with Triton X-100 in low ionic strength buffer. About 30% of both SV40 DNA and total SV40 transcriptional activity in isolated nuclei ar …
A simian virus 40 nucleoprotein complex containing an endogenous RNA polymerase activity was extracted from infected BSC-1 nuclei with Trito …
c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
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All the plasmids possessing SV40 ori sequences could replicate, even in the absence of SV40 T antigen, in human HL-60 and Raji cells which are expressing c-myc gene at high level. ...These results indicate that the c-myc protein can be substituted for SV40 T …
All the plasmids possessing SV40 ori sequences could replicate, even in the absence of SV40 T antigen, in human HL-60 and Raji …
Simian virus 40 (SV40)-like DNA sequences not detectable in finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines.
Hirvonen A, Mattson K, Karjalainen A, Ollikainen T, Tammilehto L, Hovi T, Vainio H, Pass HI, Di Resta I, Carbone M, Linnainmaa K. Hirvonen A, et al. Mol Carcinog. 1999 Oct;26(2):93-9. Mol Carcinog. 1999. PMID: 10506753
It is also known that expression of SV40 large T antigen inhibits cellular Rb and p53. This suggests that SV40 might render infected cells more susceptible to asbestos carcinogenicity. ...All of the Finnish tumor tissues tested negative for SV40-like sequence …
It is also known that expression of SV40 large T antigen inhibits cellular Rb and p53. This suggests that SV40 might render in …
Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas.
Mayall FG, Jacobson G, Wilkins R. Mayall FG, et al. J Clin Pathol. 1999 Apr;52(4):291-3. doi: 10.1136/jcp.52.4.291. J Clin Pathol. 1999. PMID: 10474522 Free PMC article.
The DNA from the paraffin sections was also used to search for SV40 sequences. A 105 base pair segment at the 3' of the SV40 large T antigen (Tag) was targeted and any PCR amplification products were sequenced to confirm that they were of SV40 origin. ...Of t …
The DNA from the paraffin sections was also used to search for SV40 sequences. A 105 base pair segment at the 3' of the SV40 l …
Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells.
Bocchetta M, Miele L, Pass HI, Carbone M. Bocchetta M, et al. Oncogene. 2003 Jan 9;22(1):81-9. doi: 10.1038/sj.onc.1206097. Oncogene. 2003. PMID: 12527910
Notch-1 induction is achieved at the transcriptional level and requires both the SV40 large T-antigen and the small t-antigen. Notch-1 upregulation is maintained in SV40-transformed human mesothelial clones and in SV40-positive mesotheliomas and derived cell …
Notch-1 induction is achieved at the transcriptional level and requires both the SV40 large T-antigen and the small t-antigen. Notch- …
Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.
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The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 transgenic lines derived from injection of the same gene construct. Our studies demonstrate functional immune tolerance to SV40 T antig …
The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 tr …
SV40 DNA amplification and reintegration in surviving hamster cells after 60Co gamma-irradiation.
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SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 sequences was pursued over a period of 20 days following radiation exposure. As shown by colony hybridization, integrated SV40 sequences w
SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 seque
COS Cell Expression.
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COS-1 cells were created by transforming an established line of monkey epithelial cells, CV-1, with a defective mutant of SV40 (1). The SV40 mutant used carried a small deletion within the origin of replication and, although this construct transformed CV-1 cells, wh …
COS-1 cells were created by transforming an established line of monkey epithelial cells, CV-1, with a defective mutant of SV40 (1). T …
Simian virus 40 and human cancer.
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Deoxyribonucleic acid (DNA) oncoviruses can induce neoplastic transformation by interfering with proliferative proteins. Simian virus 40 (SV40) has been shown to induce brain tumors, osteosarcoma, lymphoid tumors and malignant mesothelioma in hamsters and SV40-like …
Deoxyribonucleic acid (DNA) oncoviruses can induce neoplastic transformation by interfering with proliferative proteins. Simian virus 40 ( …
Detection of antibodies to polyomavirus SV40 in two central European countries.
Butel JS, Wong C, Vilchez RA, Szücs G, Dömök I, Kríz B, Slonim D, Adam E. Butel JS, et al. Cent Eur J Public Health. 2003 Mar;11(1):3-8. Cent Eur J Public Health. 2003. PMID: 12690795
Simian virus 40 (SV40) is significantly associated with some human cancers. However, the frequency of tumor-associated virus detection differs by geographic regions, so it is important to understand the status of SV40 infections in different populations. ...Females …
Simian virus 40 (SV40) is significantly associated with some human cancers. However, the frequency of tumor-associated virus detectio …
Endogenous butyrylcholinesterase in SV40 transformed cell lines: COS-1, COS-7, MRC-5 SV40, and WI-38 VA13.
Kris M, Jbilo O, Bartels CF, Masson P, Rhode S, Lockridge O. Kris M, et al. In Vitro Cell Dev Biol Anim. 1994 Oct;30A(10):680-9. doi: 10.1007/BF02631271. In Vitro Cell Dev Biol Anim. 1994. PMID: 7842168
Comparison of proteins expressed by SV40 transformed cell lines and untransformed cell lines is of interest because SV40 transformed cells are immortal, whereas untransformed cells senesce after about 50 doublings. In MRC-5 SV40 cells, only seven proteins hav …
Comparison of proteins expressed by SV40 transformed cell lines and untransformed cell lines is of interest because SV40 trans …
A nondefective (competent) adenovirus-SV40 hybrid isolated from the AD.2-SV40 hybrid population.
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A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with one-hit kinetics in both human embryonic kidney and African green monkey kidney cells, induces an SV40 specific antigen which is det …
A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with …
Complementation between SV40 and RFV defectives and acquisition of SV40 origins by late RFV genomes.
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EL SV40 and RFV are variants of SV40 and BKV which contain bipartite or dual genomes. One molecule contains all the early viral sequences (E-SV40, E-RFV) and the other all the late viral sequences (L-SV40, L-RFV). ...E-SV40/rL-RFV demonstrated a …
EL SV40 and RFV are variants of SV40 and BKV which contain bipartite or dual genomes. One molecule contains all the early vira …
Simultaneous immunostaining with anti-S100P and anti-SV40 antibodies revealed the origin of BK virus-infected decoy cells in voided urine samples.
Ariyasu S, Yanai H, Sato M, Shinno Y, Taniguchi K, Yamadori I, Miki Y, Sato Y, Yoshino T, Takahashi K. Ariyasu S, et al. Cytopathology. 2015 Aug;26(4):250-5. doi: 10.1111/cyt.12213. Epub 2014 Oct 17. Cytopathology. 2015. PMID: 25323691
METHODS: We performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine samples exhibiting SV40 positivity and a decoy-cell appearance on Papanicolaou staining. ...RESULTS: BKV-infected cells were categor …
METHODS: We performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine …
Molecular analysis of a novel simian virus 40 (SV40) type in rhesus macaques and evidence for double infections with the classical SV40 type.
Fagrouch Z, Karremans K, Deuzing I, van Gessel S, Niphuis H, Bogers W, Verschoor EJ. Fagrouch Z, et al. J Clin Microbiol. 2011 Apr;49(4):1280-6. doi: 10.1128/JCM.01005-10. Epub 2011 Feb 9. J Clin Microbiol. 2011. PMID: 21307214 Free PMC article.
Sequence analysis of PCR amplicons revealed that they form two genetic clusters, one containing the majority of known SV40 strains and the other formed by variants with 7% genetic difference. Based on this difference, we propose two SV40 types: "type 1" or "classica …
Sequence analysis of PCR amplicons revealed that they form two genetic clusters, one containing the majority of known SV40 strains an …
Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens.
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A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S …
A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 D …
Transformation of human keratinocytes by SV40 virus alters their response to the tumor promoter TPA.
Delescluse C, Bernard BA, Bailly J, Darmon YM. Delescluse C, et al. Carcinogenesis. 1986 Apr;7(4):551-8. doi: 10.1093/carcin/7.4.551. Carcinogenesis. 1986. PMID: 2421937
However, TPA and SV40 transformation had specific non-overlapping effects. For example, TPA did not prevent terminal differentiation and stratification, as SV40-transformation did, but stimulated these processes. ...These observations lead to the conclusion that TPA …
However, TPA and SV40 transformation had specific non-overlapping effects. For example, TPA did not prevent terminal differentiation …
Simian virus 40 and malignant mesothelioma (Review).
Cerrano PG, Jasani B, Filiberti R, Neri M, Merlo F, De Flora S, Mutti L, Puntoni R. Cerrano PG, et al. Int J Oncol. 2003 Jan;22(1):187-94. Int J Oncol. 2003. PMID: 12469203 Review.
In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, SV40 DNA sequences were detected with significative frequency in human pleural mesotheliomas by using polymerase chain reaction (PCR) …
In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, …
SV40 tumor rejection induced by vesicular stomatitis virus bearing SV40 tumor-specific transplantation antigen (SV40-TSTA). I. Specificity of immunoprotection and effect of enzyme treatment on TSTA activity.
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Highly purified vesicular stomatitis virus (VSV) was obtained from VSV-infected SV40-transformed hamster cell lines. Immunization with this virus protected hamsters against challenge with SV40-transformed cells (TSV5-cl2). This protection was obtained regardless of …
Highly purified vesicular stomatitis virus (VSV) was obtained from VSV-infected SV40-transformed hamster cell lines. Immunization wit …
UV-reactivation, virus production and mutagenesis of SV40 in VU-irradiated monkey kidney cells.
Cornelis JJ, Lupker JH, van der Eb AJ. Cornelis JJ, et al. Mutat Res. 1980 Jun;71(1):139-46. doi: 10.1016/0027-5107(80)90014-7. Mutat Res. 1980. PMID: 6248777
The survival of UV-irradiated simian virus 40 (SV40) is higher in VU-irradiated than in non-irradiated monolayers of BSC-1 monkey cells. A similar reactivation is found when cells are infected with SV40-DNA, suggesting that reactivation acts on viral DNA. The enhanc …
The survival of UV-irradiated simian virus 40 (SV40) is higher in VU-irradiated than in non-irradiated monolayers of BSC-1 monkey cel …
Simian virus 40 (SV40)-specific proteins associated with the nuclear matrix isolated from adenovirus type 2-SV40 hybrid virus-infected HeLa cells carry SV40 U-antigen determinants.
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The distribution of simian virus 40 (SV40)-specific proteins in nuclear subfractions of pulse-chase-labeled HeLa cells infected with nondefective adenovirus type 2 (Ad2)-SV40 hybrid viruses was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. . …
The distribution of simian virus 40 (SV40)-specific proteins in nuclear subfractions of pulse-chase-labeled HeLa cells infected with …
Expression of p53 after sv40 virus-infection of quiescent cells.
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SV40 infection of quiescent mouse cells leads to a re-entry of the cells into the cell cycle and to cellular DNA synthesis. ...At late time after virus infection wild-type p53 is complexed to the SV40 large T antigen. SV40 infection of quiescent cells in the
SV40 infection of quiescent mouse cells leads to a re-entry of the cells into the cell cycle and to cellular DNA synthesis. ...At lat
Determination of the DNA conformation of the simian virus 40 (SV40) enhancer in SV40 minichromosomes.
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The simian virus 40 (SV40) enhancer contains three 8-bp purine-pyrimidine alternating sequences which are known to adopt the left-handed Z-DNA conformation in vitro. ...Our results indicate that, regardless of the precise moment of the viral lytic cycle at which minichromo …
The simian virus 40 (SV40) enhancer contains three 8-bp purine-pyrimidine alternating sequences which are known to adopt the left-han …
H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes.
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T cytotoxic cells generated to syngeneic SV40 virus transformants lyse only SV40 target cells that are syngeneic at the H-2 locus. In contrast, SV40-specific tumor transplantation immunity shows no requirements for syngeneic H-2. ...
T cytotoxic cells generated to syngeneic SV40 virus transformants lyse only SV40 target cells that are syngeneic at the H-2 lo …
Identification of SV40 in brain, kidney and urine of healthy and SIV-infected rhesus monkeys.
Newman JS, Baskin GB, Frisque RJ. Newman JS, et al. J Neurovirol. 1998 Aug;4(4):394-406. doi: 10.3109/13550289809114538. J Neurovirol. 1998. PMID: 9718131
In the present study we have used PCR to analyze tissues from 20 monkeys for the presence of SV40. Five of the animals, which were infected with simian immunodeficiency virus (SIV), were found to exhibit SV40-induced lesions and to have SV40 sequences present …
In the present study we have used PCR to analyze tissues from 20 monkeys for the presence of SV40. Five of the animals, which were in …
DNA replication in SV40-infected cells. XI. The properties of SV40 DNA and nucleoprotein complex synthesized in the presence of cycloheximide.
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The superhelical density of SV40 DNA synthesized in the presence of cycloheximide is about one half that of viral DNA produced in the absence of this drug. Ribonuclease H and alkali treatment were employed to determine if ribonucleotides could be detected in closed circula …
The superhelical density of SV40 DNA synthesized in the presence of cycloheximide is about one half that of viral DNA produced in the …
Dibutyryl cyclic AMP treatment of 3T3 and SV40 virus-transformed 3T3 cells in aggregates. Effects on mobility and cell contact ultrastructure.
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The 3T3 cells penetrated into 3T3 aggregates an average of 0.89 cell diameter in 1.5 days, whereas the SV40-3T3 cells penetrated into SV40-3T3 aggregates an average of 3.20 cell diameters in the same time. ...Treatment with theophylline plus dibutyryl cyclic AMP res …
The 3T3 cells penetrated into 3T3 aggregates an average of 0.89 cell diameter in 1.5 days, whereas the SV40-3T3 cells penetrated into …
Transformation mediated by the SV40 T antigens: separation of the overlapping SV40 early genes with a retroviral vector.
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We placed the SV40 early region within this DNA and after transfection of cells producing helper Moloney murine leukemia virus, SV40 retroviruses (MV40) could be rescued. ...There is little difference in transformation either by agar assay or focus formation between …
We placed the SV40 early region within this DNA and after transfection of cells producing helper Moloney murine leukemia virus, SV
Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promoters.
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To determine whether trans activation by small t might be involved in the SV40 productive infection cycle, we examined the effects of cotransfecting plasmids encoding small t with plasmids containing the chloramphenicol acetyltransferase (CAT) gene linked to the SV40
To determine whether trans activation by small t might be involved in the SV40 productive infection cycle, we examined the effects of …
Live oral poliovirus vaccines do not contain detectable simian virus 40 (SV40) DNA.
Sierra-Honigmann A, Krause PR. Sierra-Honigmann A, et al. Biologicals. 2000 Mar;28(1):1-4. doi: 10.1006/biol.1999.0233. Biologicals. 2000. PMID: 10799049
Prior to 1962, poliovirus vaccines produced in rhesus monkey kidney cells were contaminated with SV40. Recent studies reporting the detection of SV40 in human tumours raised concern that SV40 may be oncogenic in humans. ...SV40 DNA sequences were not f …
Prior to 1962, poliovirus vaccines produced in rhesus monkey kidney cells were contaminated with SV40. Recent studies reporting the d …
Markers of past infection with simian virus 40 (SV40) and risk of incident non-Hodgkin lymphoma in a Maryland cohort.
Rollison DE, Helzlsouer KJ, Halsey NA, Shah KV, Viscidi RP. Rollison DE, et al. Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1448-52. doi: 10.1158/1055-9965.EPI-04-0674. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15941954
Simian virus 40 (SV40) genome sequences have been detected in human non-Hodgkin lymphoma (NHL) tissues, and past infection with SV40 may be a risk factor for NHL. ...Whereas SV40 antibodies were detected by VLP ELISA in 15% of cases and 10% of controls [match …
Simian virus 40 (SV40) genome sequences have been detected in human non-Hodgkin lymphoma (NHL) tissues, and past infection with SV
Re-evaluation of a case of progressive multifocal leukoencephalopathy previously diagnosed as simian virus 40 (SV40) etiology.
Eizuru Y, Sakihama K, Minamishima Y, Hayashi T, Sumiyoshi A. Eizuru Y, et al. Acta Pathol Jpn. 1993 Jun;43(6):327-32. doi: 10.1111/j.1440-1827.1993.tb02575.x. Acta Pathol Jpn. 1993. PMID: 8394043
Restriction endonuclease cleavage analysis revealed that this viral DNA was different from SV40 DNA, but similar to JC virus DNA. After cloning of this viral DNA into pBR322 at the BamHI site, DNA homology of this virus and of SV40 was investigated. ...Therefore, th …
Restriction endonuclease cleavage analysis revealed that this viral DNA was different from SV40 DNA, but similar to JC virus DNA. Aft …
Simian virus 40 in humans.
Martini F, Corallini A, Balatti V, Sabbioni S, Pancaldi C, Tognon M. Martini F, et al. Infect Agent Cancer. 2007 Jul 9;2:13. doi: 10.1186/1750-9378-2-13. Infect Agent Cancer. 2007. PMID: 17620119 Free PMC article.
Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. ...In the present review we consider the main results obtained by different groups investigating …
Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in …
High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences.
Kimchi-Sarfaty C, Arora M, Sandalon Z, Oppenheim A, Gottesman MM. Kimchi-Sarfaty C, et al. Hum Gene Ther. 2003 Jan 20;14(2):167-77. doi: 10.1089/104303403321070865. Hum Gene Ther. 2003. PMID: 12614568
In vitro packaging of plasmid DNA using recombinant SV40 capsid proteins is a potentially useful procedure that overcomes some restrictions of the other SV40 systems such as the requirement for SV40 sequences and the limitation in size of DNA that can be pack …
In vitro packaging of plasmid DNA using recombinant SV40 capsid proteins is a potentially useful procedure that overcomes some restri …
Mammalian genomic sequences can substitute for the SV40 AT stretch in sustaining replication of the SV40 origin of replication.
Galli I, Iguchi-Ariga SM, Ariga H. Galli I, et al. FEBS Lett. 1993 Mar 8;318(3):335-40. doi: 10.1016/0014-5793(93)80541-2. FEBS Lett. 1993. PMID: 8382635 Free article.
The core of the SV40 origin of replication (ori) contains a stretch of adenine (A) and thymine (T) residues. ...We reasoned that, in this light, there might exist cellular DNA sequences that can substitute for the SV40 AT stretch. To study this possibility, we diges …
The core of the SV40 origin of replication (ori) contains a stretch of adenine (A) and thymine (T) residues. ...We reasoned that, in …
Porcine vascular smooth muscle cells immortalized with SV40 ori-defective DNA: characteristics of cell growth and collagen synthesis.
Fujimitsu K, Sakata N, Jimi S, Takebayashi S, Sasaguri Y, Morimatsu M. Fujimitsu K, et al. Acta Pathol Jpn. 1993 Sep;43(9):481-9. doi: 10.1111/j.1440-1827.1993.tb01161.x. Acta Pathol Jpn. 1993. PMID: 8237368
SV40-SMC expressed SV40 large T antigen, c-myc and c-myb encoded proteins in the nuclei. ...By immunofluorescent (IF) staining, collagen phenotypes I, III, IV and V were detected in both SV40-SMC and SMC. However, protein synthesis including collagen and non-
SV40-SMC expressed SV40 large T antigen, c-myc and c-myb encoded proteins in the nuclei. ...By immunofluorescent (IF) staining
Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.
Zerrahn J, Knippschild U, Winkler T, Deppert W. Zerrahn J, et al. EMBO J. 1993 Dec;12(12):4739-46. doi: 10.1002/j.1460-2075.1993.tb06162.x. EMBO J. 1993. PMID: 8223482 Free PMC article.
We found that simian virus 40 (SV40), in addition to the SV40 early proteins large T antigen (large T) and small antigen (small t), codes for a third early protein with a molecular weight of 17 kDa. This protein (17kT) is expressed from an alternatively spliced thir …
We found that simian virus 40 (SV40), in addition to the SV40 early proteins large T antigen (large T) and small antigen (smal …
Immunotherapy of SV40 induced tumours in mice: a model for vaccine development.
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Various vaccination strategies were compared for their ability to elicit antigen-specific tumour immunity, using the SV40-BALB/c murine tumour system. Specifically, mice were injected with baculovirus-derived recombinant SV40 Tag (rTag), synthetic peptides correspon …
Various vaccination strategies were compared for their ability to elicit antigen-specific tumour immunity, using the SV40-BALB/c muri …
Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen.
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The distribution of antigenic sites recognized by cytotoxic T lymphocytes (CTL) in the amino terminal half of SV40 T antigen was studied using SV40-specific CTL clones. Spleen cells of C57BL/6 (B6) mice immunized with B6/pSV3T3-20GV cells, which synthesize a truncat …
The distribution of antigenic sites recognized by cytotoxic T lymphocytes (CTL) in the amino terminal half of SV40 T antigen was stud …
Hyperacetylation and differential deacetylation of histones H4 and H3 define two distinct classes of acetylated SV40 chromosomes early in infection.
Milavetz B. Milavetz B. Virology. 2004 Feb 20;319(2):324-36. doi: 10.1016/j.virol.2003.11.010. Virology. 2004. PMID: 14980492 Free article.
SV40 chromosomes undergoing encapsidation late in infection and SV40 chromatin in virions are hyperacetylated on histones H4 and H3. However, the fate of the SV40 chromosomes containing hyperacetylated histones in a subsequent round of infection has not been
SV40 chromosomes undergoing encapsidation late in infection and SV40 chromatin in virions are hyperacetylated on histones H4 a
DNA synthesis and multinucleation of mouse cells infected with SV40 in the presence of cytochalasin B.
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DNA synthesis and nuclear division of mouse cells, BALB/3T3, infected with SV40 were studied and were compared with those of SV40-transformed mouse cells, mKS-A TU-7. Both SV40-infected and SV40-transformed cells behaved similarly in the presence of cy …
DNA synthesis and nuclear division of mouse cells, BALB/3T3, infected with SV40 were studied and were compared with those of SV40
Similar regulation of the synthesis of adenovirus fiber and of simian virus 40-specific proteins encoded by the helper-defective Ad2+SV40 hybrid viruses Ad2+ND5 and Ad2+ND4del.
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The SV40 helper-defective Ad2+SV40 hybrid viruses Ad2+ND5 and Ad2+ND4del were analyzed to determine why they are unable to grow efficiently in monkey cells even though they contain the appropriate SV40 genetic information. ...This suggests that the synthesis …
The SV40 helper-defective Ad2+SV40 hybrid viruses Ad2+ND5 and Ad2+ND4del were analyzed to determine why they are unable to gro …
Characterization of the surface proteins of SV40-transformed mouse and human cells: absence of SV40-specific proteins.
Rose TM, Weil R. Rose TM, et al. Int J Cancer. 1983 May 15;31(5):639-48. doi: 10.1002/ijc.2910310517. Int J Cancer. 1983. PMID: 6303969
The proteins of a number of SV40- and spontaneously transformed mouse and human cell lines were compared in an effort to identify a surface protein which would correspond to the SV40 tumor-specific transplantation antigen (TSTA). ...We were not able to obtain serolo …
The proteins of a number of SV40- and spontaneously transformed mouse and human cell lines were compared in an effort to identify a s …
Influence of SV40 Genome on the Replication of an Adenovirus-SV40 "Hybrid" Population.
Feldman LA, Melnick JL, Rapp F. Feldman LA, et al. J Bacteriol. 1965 Sep;90(3):778-82. doi: 10.1128/jb.90.3.778-782.1965. J Bacteriol. 1965. PMID: 16562080 Free PMC article.
(Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an adenovirus-SV40 "hybrid" population. J. Bacteriol. 90:778-782. 1965....These results suggest that the population of the adenovirus- …
(Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an …
Immune control of SV40-induced tumors in mice.
Pan S, Abramczuk J, Knowles BB. Pan S, et al. Int J Cancer. 1987 Jun 15;39(6):722-8. doi: 10.1002/ijc.2910390612. Int J Cancer. 1987. PMID: 3034805
Mice of these 3 H-2 haplotypes were challenged with SV40 and their ability to generate and sustain an antibody response to SV40 T-antigen was found to be equivalent. ...Although interaction between the various immune effector mechanisms may play a role in the recogn …
Mice of these 3 H-2 haplotypes were challenged with SV40 and their ability to generate and sustain an antibody response to SV40