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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1941 1
1958 1
1959 4
1961 2
1962 2
1963 1
1965 1
1966 2
1967 3
1968 1
1969 6
1970 5
1971 7
1972 2
1973 3
1974 4
1975 35
1976 26
1977 23
1978 35
1979 26
1980 35
1981 44
1982 41
1983 51
1984 63
1985 64
1986 75
1987 82
1988 97
1989 116
1990 113
1991 132
1992 143
1993 136
1994 142
1995 215
1996 239
1997 212
1998 268
1999 299
2000 364
2001 343
2002 420
2003 429
2004 503
2005 580
2006 679
2007 715
2008 802
2009 795
2010 964
2011 1052
2012 1212
2013 1307
2014 1450
2015 1464
2016 1569
2017 1602
2018 1710
2019 1754
2020 1920
2021 2017
2022 1773
2023 1839
2024 2128
2025 2577
2026 1789

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32,909 results

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Page 1
Analyzing Prescription Drug to Over-the-Counter Drug Switch Rejections: Understanding Regulatory Concerns, A Global Overview.
Uliana T, Lassoued Z, Restrepo SM, Rahman S, Kolati S, Ateka A, Sourial K. Uliana T, et al. Clin Ther. 2026 Feb;48(2):148-158. doi: 10.1016/j.clinthera.2025.12.012. Epub 2026 Jan 22. Clin Ther. 2026. PMID: 41571519 Free article. Review.
PURPOSE: Prescription-to-over-the-counter (Rx-to-OTC) switch applications face significant barriers, with many experiencing rejections despite potential public health benefits. The purpose of this article was to investigate the regulatory landscape and challenges associate …
PURPOSE: Prescription-to-over-the-counter (Rx-to-OTC) switch applications face significant barriers, with many experiencing rejection …
Strategies for Switching between Oral Postsynaptic Antidopaminergic Antipsychotics in Patients with Schizophrenia: A Systematic Review.
Correll CU. Correll CU. CNS Drugs. 2025 Oct;39(10):913-935. doi: 10.1007/s40263-025-01206-3. Epub 2025 Jul 23. CNS Drugs. 2025. PMID: 40699529 Free PMC article.
BACKGROUND: Antipsychotic switching is common in the treatment of schizophrenia. Pharmacokinetic and pharmacodynamic properties of antipsychotics can inform switch strategies, as switching from shorter to longer half-life antipsychotics and switching f …
BACKGROUND: Antipsychotic switching is common in the treatment of schizophrenia. Pharmacokinetic and pharmacodynamic properties of an …
Real-world Data and Evidence to support a switch in status from Prescription drug to Over the Counter drug as applied by the EMA, the US FDA, the MHRA, and the BfArM.
Kühler TC, Ateka A, Lassoued Z, Routhier FX, Mékary-Sawaya S. Kühler TC, et al. Clin Ther. 2024 Mar;46(3):208-216. doi: 10.1016/j.clinthera.2023.12.013. Epub 2024 Jan 25. Clin Ther. 2024. PMID: 38278703 Free article.
PURPOSE: We studied under which circumstances and to what extent Real-World Data (RWD) and Real-World Evidence (RWE) were used in regulatory decisions when switching products from Prescription-only (Rx) to Over-the-Counter (OTC) status with the aim of extracting learnings …
PURPOSE: We studied under which circumstances and to what extent Real-World Data (RWD) and Real-World Evidence (RWE) were used in regulatory …
SMC motor proteins extrude DNA asymmetrically and can switch directions.
Barth R, Davidson IF, van der Torre J, Taschner M, Gruber S, Peters JM, Dekker C. Barth R, et al. Cell. 2025 Feb 6;188(3):749-763.e21. doi: 10.1016/j.cell.2024.12.020. Epub 2025 Jan 16. Cell. 2025. PMID: 39824185 Free article.
For cohesin, direction switches strongly correlate with the turnover of the subunit NIPBL, during which DNA strand switching may occur. ...The findings reveal that SMCs, surprisingly, can switch directions....
For cohesin, direction switches strongly correlate with the turnover of the subunit NIPBL, during which DNA strand switching m …
Switch mode capacitive pressure sensors.
Shalabi N, Searles K, Takahata K. Shalabi N, et al. Microsyst Nanoeng. 2022 Dec 23;8:132. doi: 10.1038/s41378-022-00469-w. eCollection 2022. Microsyst Nanoeng. 2022. PMID: 36568136 Free PMC article.
Switch mode capacitive pressure sensors are proposed as a new class of microfabricated devices that transform pressure into a mechanically switching capacitance to form an analog-to-digital signal with zero power, high sensitivity, and a high signal-to-noise ratio. …
Switch mode capacitive pressure sensors are proposed as a new class of microfabricated devices that transform pressure into a mechani …
Switch from fingolimod to ozanimod for safety or intolerance reasons.
Signoriello E, Romano G, Foschi M, Zanghì A, D'Amico E, Fantozzi R, Centonze D, Lus G. Signoriello E, et al. Ther Adv Neurol Disord. 2025 Jul 9;18:17562864251328191. doi: 10.1177/17562864251328191. eCollection 2025. Ther Adv Neurol Disord. 2025. PMID: 40655996 Free PMC article.
OBJECTIVES: We aimed to compare the adherence and persistence on treatment in MS patients switched to ozanimod from fingolimod for safety reasons (mainly lymphopenia or liver enzymes increase). METHODS: We retrospectively recruited patients treated with fingolimod who s …
OBJECTIVES: We aimed to compare the adherence and persistence on treatment in MS patients switched to ozanimod from fingolimod for sa …
Switch acceptance and persistence of adalimumab biosimilars in IBD patients: a prospective observational study.
D'Abbundo G, Nachury M, Wartski A, Blondeaux A, Hambli S, Gérard R, Desreumaux P, Duveau N, Wils P. D'Abbundo G, et al. Ther Adv Gastroenterol. 2025 Apr 23;18:17562848251332025. doi: 10.1177/17562848251332025. eCollection 2025. Ther Adv Gastroenterol. 2025. PMID: 40297206 Free PMC article.
Among respondents, 65.8% reported a positive experience with the switch. CONCLUSION: The study demonstrates high acceptance and favorable outcomes for switching to ADA biosimilars in IBD patients, including sustained efficacy and good treatment persistence. ...Addit …
Among respondents, 65.8% reported a positive experience with the switch. CONCLUSION: The study demonstrates high acceptance and favor …
Thiol-disulfide exchange in signaling: disulfide bonds as a switch.
Messens J, Collet JF. Messens J, et al. Antioxid Redox Signal. 2013 May 1;18(13):1594-6. doi: 10.1089/ars.2012.5156. Epub 2013 Feb 25. Antioxid Redox Signal. 2013. PMID: 23330837
However, in spite of the fundamental cell biological and medical importance of the thiol-disulfide exchange switches, we are only beginning to understand their principles of specificity, their mechanism of action, and their role in signal transduction. Our further progress …
However, in spite of the fundamental cell biological and medical importance of the thiol-disulfide exchange switches, we are only beg …
Switch from depression to mania--a record study over decades between 1920 and 1982.
Angst J. Angst J. Psychopathology. 1985;18(2-3):140-54. doi: 10.1159/000284227. Psychopathology. 1985. PMID: 4059486
A representative sample of 908 hospital records covering admissions between 1920 and 1982 for depression was analyzed in order to assess the switch rate to hypomania/mania. The results are the following: (1) Over the decades of this century there has been a substantial inc …
A representative sample of 908 hospital records covering admissions between 1920 and 1982 for depression was analyzed in order to assess the …
New molecular switch architectures.
Harris JD, Moran MJ, Aprahamian I. Harris JD, et al. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9414-9422. doi: 10.1073/pnas.1714499115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012601 Free PMC article.
In this paper we elaborate on recently developed molecular switch architectures and how these new systems can help with the realization of new functions and advancement of artificial molecular machines. ...Many of these systems offer distinct advantages over commonly emplo …
In this paper we elaborate on recently developed molecular switch architectures and how these new systems can help with the realizati …
32,909 results
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