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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
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1938 1
1939 1
1942 1
1945 9
1946 8
1947 13
1948 12
1949 9
1950 19
1951 44
1952 81
1953 81
1954 71
1955 75
1956 80
1957 93
1958 120
1959 108
1960 111
1961 158
1962 172
1963 335
1964 430
1965 378
1966 525
1967 630
1968 763
1969 833
1970 805
1971 1049
1972 1033
1973 1111
1974 1068
1975 1154
1976 1250
1977 1310
1978 1323
1979 1489
1980 1571
1981 1544
1982 1745
1983 1804
1984 1685
1985 1678
1986 1678
1987 1676
1988 1769
1989 1744
1990 1970
1991 2102
1992 2205
1993 2409
1994 2197
1995 2225
1996 2338
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1998 2507
1999 2612
2000 2808
2001 2737
2002 2987
2003 3047
2004 3067
2005 3127
2006 3588
2007 3553
2008 3605
2009 3639
2010 3996
2011 4074
2012 4249
2013 4301
2014 4074
2015 4015
2016 3968
2017 4128
2018 4140
2019 3995
2020 4212
2021 4533
2022 3852
2023 4023
2024 4253
2025 4642
2026 2641

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147,774 results

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Page 1
The cell biology of synapse formation.
Südhof TC. Südhof TC. J Cell Biol. 2021 Jul 5;220(7):e202103052. doi: 10.1083/jcb.202103052. Epub 2021 Jun 4. J Cell Biol. 2021. PMID: 34086051 Free PMC article. Review.
Here, I posit that synaptic adhesion molecules (SAMs) organize synapse formation. Diverse SAMs collaborate to achieve the astounding specificity and plasticity of synapses, with each SAM contributing different facets. In orchestrating synapse assembly, SAMs l …
Here, I posit that synaptic adhesion molecules (SAMs) organize synapse formation. Diverse SAMs collaborate to achieve the astounding …
Synapse pathology in Alzheimer's disease.
Griffiths J, Grant SGN. Griffiths J, et al. Semin Cell Dev Biol. 2023 Apr;139:13-23. doi: 10.1016/j.semcdb.2022.05.028. Epub 2022 Jun 9. Semin Cell Dev Biol. 2023. PMID: 35690535 Free article. Review.
We consider the emerging view that synapse pathology may operate at a further level, that of synapse diversity, and discuss the prospects for leveraging new synaptome mapping methods to comprehensively understand the molecular properties of vulnerable and resilient …
We consider the emerging view that synapse pathology may operate at a further level, that of synapse diversity, and discuss th …
Synapse organizers as molecular codes for synaptic plasticity.
Connor SA, Siddiqui TJ. Connor SA, et al. Trends Neurosci. 2023 Nov;46(11):971-985. doi: 10.1016/j.tins.2023.08.001. Epub 2023 Aug 29. Trends Neurosci. 2023. PMID: 37652840 Review.
Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at the level of individual synapses. ...Therefore, synapse organizers regulate how synapses adapt to ongoing activity, a pr …
Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at t …
Astrocyte-secreted neurocan controls inhibitory synapse formation and function.
Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino FP, Bindu DS, Savage JT, Eroglu C. Irala D, et al. Neuron. 2024 May 15;112(10):1657-1675.e10. doi: 10.1016/j.neuron.2024.03.007. Epub 2024 Apr 3. Neuron. 2024. PMID: 38574730 Free PMC article.
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusiv …
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic pr …
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Dejanovic B, Wu T, Tsai MC, Graykowski D, Gandham VD, Rose CM, Bakalarski CE, Ngu H, Wang Y, Pandey S, Rezzonico MG, Friedman BA, Edmonds R, De Mazière A, Rakosi-Schmidt R, Singh T, Klumperman J, Foreman O, Chang MC, Xie L, Sheng M, Hanson JE. Dejanovic B, et al. Nat Aging. 2022 Sep;2(9):837-850. doi: 10.1038/s43587-022-00281-1. Epub 2022 Sep 20. Nat Aging. 2022. PMID: 37118504 Free PMC article.
C1q deletion reduced astrocyte-synapse association and decreased astrocytic and microglial synapses engulfment in Tau(P301S) mice and rescued synapse density. Finally, in an AD mouse model that combines beta-amyloid and Tau pathologies, deletion of the AD ris …
C1q deletion reduced astrocyte-synapse association and decreased astrocytic and microglial synapses engulfment in Tau(P301S) m …
Synapse vulnerability and resilience across the clinical spectrum of dementias.
Taddei RN, Duff KE. Taddei RN, et al. Nat Rev Neurol. 2025 Jul;21(7):353-369. doi: 10.1038/s41582-025-01094-7. Epub 2025 May 22. Nat Rev Neurol. 2025. PMID: 40404832 Review.
Preservation of synapses is crucial for healthy cognitive ageing, and synapse loss is one of the closest anatomical correlates of cognitive decline in Alzheimer disease, dementia with Lewy bodies and frontotemporal dementia. ...Evidence has highlighted that vulnerab …
Preservation of synapses is crucial for healthy cognitive ageing, and synapse loss is one of the closest anatomical correlates …
Synapse vulnerability and resilience underlying Alzheimer's disease.
Taddei RN, E Duff K. Taddei RN, et al. EBioMedicine. 2025 Feb;112:105557. doi: 10.1016/j.ebiom.2025.105557. Epub 2025 Jan 31. EBioMedicine. 2025. PMID: 39891995 Free PMC article. Review.
Synapse preservation is key for healthy cognitive ageing, and synapse loss represents a critical anatomical basis of cognitive dysfunction in Alzheimer's disease (AD), predicting dementia onset, severity, and progression. ...The synapse loss in AD is highly s …
Synapse preservation is key for healthy cognitive ageing, and synapse loss represents a critical anatomical basis of cognitive …
Astrocyte-dependent circuit remodeling by synapse phagocytosis.
Park J, Chung WS. Park J, et al. Curr Opin Neurobiol. 2023 Aug;81:102732. doi: 10.1016/j.conb.2023.102732. Epub 2023 May 27. Curr Opin Neurobiol. 2023. PMID: 37247606 Review.
In the past 15 years, pioneering works have demonstrated that different types of glial cells regulate the number of synapses by selectively eliminating them through phagocytic molecular machinery. Although a majority of findings have been focused on microglia, it is increa …
In the past 15 years, pioneering works have demonstrated that different types of glial cells regulate the number of synapses by selec …
Synapse diversity and synaptome architecture in human genetic disorders.
Grant SGN. Grant SGN. Hum Mol Genet. 2019 Nov 21;28(R2):R219-R225. doi: 10.1093/hmg/ddz178. Hum Mol Genet. 2019. PMID: 31348488 Free PMC article. Review.
The proteome of synapses is highly complex with over 1000 conserved proteins which are differentially expressed generating a vast, potentially unlimited, number of synapse types. ...The synaptome architecture is built from the hierarchical expression and assembly of …
The proteome of synapses is highly complex with over 1000 conserved proteins which are differentially expressed generating a vast, po …
Developmental synapse remodeling in the cerebellum and visual thalamus.
Kano M, Watanabe T. Kano M, et al. F1000Res. 2019 Jul 25;8:F1000 Faculty Rev-1191. doi: 10.12688/f1000research.18903.1. eCollection 2019. F1000Res. 2019. PMID: 31372212 Free PMC article. Review.
Functional neural circuits of mature animals are shaped during postnatal development by eliminating early-formed redundant synapses and strengthening of necessary connections. In the nervous system of newborn animals, redundant synapses are only transient features o …
Functional neural circuits of mature animals are shaped during postnatal development by eliminating early-formed redundant synapses a …
147,774 results
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