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The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. Heikamp EB, et al. Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806. Blood. 2022. PMID: 34582559 Free PMC article.
Integrative Proteogenomics Using ProteomeGenerator2.
Kwok N, Aretz Z, Takao S, Ser Z, Cifani P, Kentsis A. Kwok N, et al. J Proteome Res. 2023 Aug 4;22(8):2750-2764. doi: 10.1021/acs.jproteome.3c00005. Epub 2023 Jul 7. J Proteome Res. 2023. PMID: 37418425 Free PMC article.
Integrative proteogenomics using ProteomeGenerator2.
Kwok N, Aretz Z, Takao S, Ser Z, Cifani P, Kentsis A. Kwok N, et al. bioRxiv [Preprint]. 2023 Jan 4:2023.01.04.522774. doi: 10.1101/2023.01.04.522774. bioRxiv. 2023. PMID: 36711693 Free PMC article. Updated. Preprint.
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia.
Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O'Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivtsov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis A. Brown FC, et al. Cancer Discov. 2018 Apr;8(4):478-497. doi: 10.1158/2159-8290.CD-17-1271. Epub 2018 Feb 5. Cancer Discov. 2018. PMID: 29431698 Free PMC article.