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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1957 1
1959 1
1960 1
1962 2
1963 2
1964 4
1965 10
1966 7
1967 14
1968 18
1969 31
1970 37
1971 44
1972 72
1973 85
1974 86
1975 377
1976 417
1977 402
1978 393
1979 504
1980 609
1981 755
1982 819
1983 1165
1984 1328
1985 1530
1986 1791
1987 2024
1988 2316
1989 2929
1990 3289
1991 3803
1992 4378
1993 5043
1994 5878
1995 6862
1996 7847
1997 8747
1998 9832
1999 11506
2000 13034
2001 14529
2002 16444
2003 18791
2004 21721
2005 24101
2006 27255
2007 29916
2008 32469
2009 34751
2010 39407
2011 44181
2012 48696
2013 52561
2014 55970
2015 59442
2016 61236
2017 63751
2018 66624
2019 71085
2020 78919
2021 83249
2022 80736
2023 77838
2024 88241
2025 108910
2026 42842

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1,293,785 results

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Page 1
PROTAC targeted protein degraders: the past is prologue.
Békés M, Langley DR, Crews CM. Békés M, et al. Nat Rev Drug Discov. 2022 Mar;21(3):181-200. doi: 10.1038/s41573-021-00371-6. Epub 2022 Jan 18. Nat Rev Drug Discov. 2022. PMID: 35042991 Free PMC article. Review.
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept o …
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing protein …
Control of protein stability by post-translational modifications.
Lee JM, Hammarén HM, Savitski MM, Baek SH. Lee JM, et al. Nat Commun. 2023 Jan 13;14(1):201. doi: 10.1038/s41467-023-35795-8. Nat Commun. 2023. PMID: 36639369 Free PMC article. Review.
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein's stability. These regions, called degrons, are often controlled by PTMs, which act as signals to …
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins …
Protein palmitoylation and cancer.
Ko PJ, Dixon SJ. Ko PJ, et al. EMBO Rep. 2018 Oct;19(10):e46666. doi: 10.15252/embr.201846666. Epub 2018 Sep 19. EMBO Rep. 2018. PMID: 30232163 Free PMC article. Review.
Protein S-palmitoylation is a reversible post-translational modification that alters the localization, stability, and function of hundreds of proteins in the cell. ...Targeting S-palmitoylation or the enzymes responsible for palmitoylation dynamics may …
Protein S-palmitoylation is a reversible post-translational modification that alters the localization, stability, and function …
Protein S as a therapeutic target.
Prince Eladnani R, Diab R, Angelillo-Scherrer A. Prince Eladnani R, et al. J Thromb Haemost. 2026 Feb;24(2):354-367. doi: 10.1016/j.jtha.2025.10.024. Epub 2025 Nov 4. J Thromb Haemost. 2026. PMID: 41197807 Free article. Review.
Protein S (PS) is a key anticoagulant with additional roles in cell signaling through its interaction with Tyro3-Axl-MerTK family receptor tyrosine kinases Tyro3 and MerTK. Therapeutic targeting of PS-either enhancing or inhibiting its activity-has emerged as …
Protein S (PS) is a key anticoagulant with additional roles in cell signaling through its interaction with Tyro3-Axl-MerTK fam …
TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away.
Mevissen TET, Prasad AV, Walter JC. Mevissen TET, et al. Cell Rep. 2023 Feb 28;42(2):112125. doi: 10.1016/j.celrep.2023.112125. Epub 2023 Feb 18. Cell Rep. 2023. PMID: 36807144 Free PMC article.
TRIM21 also underlies the antibody-dependent protein targeting method Trim-Away. Current evidence suggests that TRIM21 binding to antibodies leads to formation of a self-anchored K63 ubiquitin chain on the N terminus of TRIM21 that triggers the destruction of TRIM21 …
TRIM21 also underlies the antibody-dependent protein targeting method Trim-Away. Current evidence suggests that TRIM21 binding …
Targeting the undruggables-the power of protein degraders.
Zhang C, Liu Y, Li G, Yang Z, Han C, Sun X, Sheng C, Ding K, Rao Y. Zhang C, et al. Sci Bull (Beijing). 2024 Jun 15;69(11):1776-1797. doi: 10.1016/j.scib.2024.03.056. Epub 2024 Mar 29. Sci Bull (Beijing). 2024. PMID: 38614856 Free article. Review.
Among them, targeted protein degradation technology is a breakthrough drug development strategy for challenging drug targets. This technology can specifically identify target proteins and directly degrade pathogenic target proteins …
Among them, targeted protein degradation technology is a breakthrough drug development strategy for challenging drug target …
Chasing molecular glue degraders: screening approaches.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C. Domostegui A, et al. Chem Soc Rev. 2022 Jul 4;51(13):5498-5517. doi: 10.1039/d2cs00197g. Chem Soc Rev. 2022. PMID: 35723413 Review.
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate PPIs through induced protein proximity. ...This and other pharmacological strategies of targeted protein degradation (e.g. proteolysis-targetin …
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate PPIs through induced pro …
RIPTACs: A groundbreaking approach to drug discovery.
Ma Z, Bolinger AA, Zhou J. Ma Z, et al. Drug Discov Today. 2023 Nov;28(11):103774. doi: 10.1016/j.drudis.2023.103774. Epub 2023 Sep 19. Drug Discov Today. 2023. PMID: 37734702 Free PMC article. Review.
Regulated induced proximity targeting chimeras (RIPTACs), a new class of heterobifunctional molecules, show promise in specifically targeting and eliminating cancer cells while leaving healthy cells unharmed. As a groundbreaking drug discovery approach, RIPTACs work …
Regulated induced proximity targeting chimeras (RIPTACs), a new class of heterobifunctional molecules, show promise in specifically …
Targeted protein degradation via cellular trafficking of nanoparticles.
Liu Y, Liu R, Dong J, Xia X, Yang H, Wei S, Fan L, Fang M, Zou Y, Zheng M, Leong KW, Shi B. Liu Y, et al. Nat Nanotechnol. 2025 Feb;20(2):296-302. doi: 10.1038/s41565-024-01801-3. Epub 2024 Oct 28. Nat Nanotechnol. 2025. PMID: 39468359
Strategies that selectively bind proteins of interest and target them to the intracellular protein recycling machinery for targeted protein degradation have recently emerged as powerful tools for undruggable targets in biomedical research …
Strategies that selectively bind proteins of interest and target them to the intracellular protein recycling machinery …
Selective protein covalent binding and target organ toxicity.
Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA. Cohen SD, et al. Toxicol Appl Pharmacol. 1997 Mar;143(1):1-12. doi: 10.1006/taap.1996.8074. Toxicol Appl Pharmacol. 1997. PMID: 9073586 Review.
Modern biochemical, molecular, and immunochemical approaches have facilitated identification of specific protein targets of xenobiotic covalent binding. Such studies have revealed that protein covalent binding is not random, but rather selective with respect …
Modern biochemical, molecular, and immunochemical approaches have facilitated identification of specific protein targets of xe …
1,293,785 results
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