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268,544 results

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Targeting cancer metabolism in the era of precision oncology.
Stine ZE, Schug ZT, Salvino JM, Dang CV. Stine ZE, et al. Nat Rev Drug Discov. 2022 Feb;21(2):141-162. doi: 10.1038/s41573-021-00339-6. Epub 2021 Dec 3. Nat Rev Drug Discov. 2022. PMID: 34862480 Free PMC article. Review.
However, progress in targeting cancer metabolism therapeutically in the past decade has been limited. Only a few metabolism-based drugs for cancer have been successfully developed, some of which are in - or en route to - clinical trials. Strateg …
However, progress in targeting cancer metabolism therapeutically in the past decade has been limited. Only a few met …
Targeting Metabolism for Cancer Therapy.
Luengo A, Gui DY, Vander Heiden MG. Luengo A, et al. Cell Chem Biol. 2017 Sep 21;24(9):1161-1180. doi: 10.1016/j.chembiol.2017.08.028. Cell Chem Biol. 2017. PMID: 28938091 Free PMC article. Review.
Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have been effective cancer treatments for decades, and the success of these therapi …
Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. …
Targeting mitochondrial metabolism for precision medicine in cancer.
Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M. Sainero-Alcolado L, et al. Cell Death Differ. 2022 Jul;29(7):1304-1317. doi: 10.1038/s41418-022-01022-y. Epub 2022 Jul 13. Cell Death Differ. 2022. PMID: 35831624 Free PMC article. Review.
During decades, the research field of cancer metabolism was based on the Warburg effect, described almost one century ago. Lately, the key role of mitochondria in cancer development has been demonstrated. ...The role of mitochondria in cancer is indisp …
During decades, the research field of cancer metabolism was based on the Warburg effect, described almost one century ago. Lat …
Targeting allosteric regulation of cancer metabolism.
Kremer DM, Lyssiotis CA. Kremer DM, et al. Nat Chem Biol. 2022 May;18(5):441-450. doi: 10.1038/s41589-022-00997-6. Epub 2022 Apr 28. Nat Chem Biol. 2022. PMID: 35484254 Review.
Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. ...We then discuss the mechanistic insights garnered from their application in cancer …
Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their t …
Emerging therapies in cancer metabolism.
Xiao Y, Yu TJ, Xu Y, Ding R, Wang YP, Jiang YZ, Shao ZM. Xiao Y, et al. Cell Metab. 2023 Aug 8;35(8):1283-1303. doi: 10.1016/j.cmet.2023.07.006. Cell Metab. 2023. PMID: 37557070 Free article. Review.
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment targets to impede tumor progression in preclinical studies, with some advancing to clinical t …
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals treatment vulnerabilities. Numerous metabolic mo …
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets.
Park JH, Pyun WY, Park HW. Park JH, et al. Cells. 2020 Oct 16;9(10):2308. doi: 10.3390/cells9102308. Cells. 2020. PMID: 33081387 Free PMC article. Review.
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. ...We also provi …
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and in …
Targeting amino acid metabolism in cancer.
Safrhansova L, Hlozkova K, Starkova J. Safrhansova L, et al. Int Rev Cell Mol Biol. 2022;373:37-79. doi: 10.1016/bs.ircmb.2022.08.001. Epub 2022 Sep 15. Int Rev Cell Mol Biol. 2022. PMID: 36283767 Review.
Nevertheless, we propose that targeting the phenotype of cancer cells could be another way of treatment aiming to avoid drug resistance and non-responsiveness of cancer patients. ...Higher requirement for essential amino acids such as methionine and cysteine …
Nevertheless, we propose that targeting the phenotype of cancer cells could be another way of treatment aiming to avoid drug r …
Targeting Cancer Metabolism and Current Anti-Cancer Drugs.
Sukjoi W, Ngamkham J, Attwood PV, Jitrapakdee S. Sukjoi W, et al. Adv Exp Med Biol. 2021;1286:15-48. doi: 10.1007/978-3-030-55035-6_2. Adv Exp Med Biol. 2021. PMID: 33725343 Review.
Several studies have exploited the metabolic hallmarks that distinguish between normal and cancer cells, aiming at identifying specific targets of anti-cancer drugs. It has become apparent that metabolic flexibility allows cancer cells to survive durin …
Several studies have exploited the metabolic hallmarks that distinguish between normal and cancer cells, aiming at identifying specif …
Targeting mTOR and Metabolism in Cancer: Lessons and Innovations.
Magaway C, Kim E, Jacinto E. Magaway C, et al. Cells. 2019 Dec 6;8(12):1584. doi: 10.3390/cells8121584. Cells. 2019. PMID: 31817676 Free PMC article. Review.
Cancer cells support their growth and proliferation by reprogramming their metabolism in order to gain access to nutrients. ...In this review, we discuss the functions of mTOR in cancer metabolism that have been illuminated from pre-clinical studies. W …
Cancer cells support their growth and proliferation by reprogramming their metabolism in order to gain access to nutrients. .. …
Targeting the dynamics of cancer metabolism in the era of precision oncology.
Zheng P, Lin Z, Ding Y, Duan S. Zheng P, et al. Metabolism. 2023 Aug;145:155615. doi: 10.1016/j.metabol.2023.155615. Epub 2023 Jun 5. Metabolism. 2023. PMID: 37286129 Review.
Cancer metabolic reprogramming is a promising target for cancer therapy. The progression of tumors, including their growth, development, metastasis, and spread, is a dynamic process that varies over time and location. ...A recent study found that energy produ …
Cancer metabolic reprogramming is a promising target for cancer therapy. The progression of tumors, including their gro …
268,544 results
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