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4,626 results

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Page 1
Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities.
Tabrizi SJ, Estevez-Fraga C, van Roon-Mom WMC, Flower MD, Scahill RI, Wild EJ, Muñoz-Sanjuan I, Sampaio C, Rosser AE, Leavitt BR. Tabrizi SJ, et al. Lancet Neurol. 2022 Jul;21(7):645-658. doi: 10.1016/S1474-4422(22)00121-1. Lancet Neurol. 2022. PMID: 35716694 Free PMC article. Review.
Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder; however, no disease-modifying interventions are available for patients with this disease. ...Potential interventions for Huntington's disea …
Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder; however, no disease-mod …
New Avenues for the Treatment of Huntington's Disease.
Kim A, Lalonde K, Truesdell A, Gomes Welter P, Brocardo PS, Rosenstock TR, Gil-Mohapel J. Kim A, et al. Int J Mol Sci. 2021 Aug 4;22(16):8363. doi: 10.3390/ijms22168363. Int J Mol Sci. 2021. PMID: 34445070 Free PMC article. Review.
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum and cortex. ...
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HD gene. The disease …
Huntington's disease: a clinical review.
McColgan P, Tabrizi SJ. McColgan P, et al. Eur J Neurol. 2018 Jan;25(1):24-34. doi: 10.1111/ene.13413. Epub 2017 Sep 22. Eur J Neurol. 2018. PMID: 28817209 Review.
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. ...In recent years there have been significant advances in understandin …
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG tr …
Gene targeting techniques for Huntington's disease.
Fields E, Vaughan E, Tripu D, Lim I, Shrout K, Conway J, Salib N, Lee Y, Dhamsania A, Jacobsen M, Woo A, Xue H, Cao K. Fields E, et al. Ageing Res Rev. 2021 Sep;70:101385. doi: 10.1016/j.arr.2021.101385. Epub 2021 Jun 5. Ageing Res Rev. 2021. PMID: 34098113 Free PMC article. Review.
Huntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. ...Additionally, this review discusses a potential application of recent CRISPR prime editing technology in targeting …
Huntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in …
Huntington's disease.
Ha AD, Fung VS. Ha AD, et al. Curr Opin Neurol. 2012 Aug;25(4):491-8. doi: 10.1097/WCO.0b013e3283550c97. Curr Opin Neurol. 2012. PMID: 22772878 Review.
PURPOSE OF REVIEW: This review highlights the recent advances in Huntington's disease, with particular focus on clinical characterization of prodromal Huntington's disease, as well as the growing literature regarding pathophysiological me …
PURPOSE OF REVIEW: This review highlights the recent advances in Huntington's disease, with particular focus on clinica …
Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.
Tabrizi SJ, Ghosh R, Leavitt BR. Tabrizi SJ, et al. Neuron. 2019 Mar 6;101(5):801-819. doi: 10.1016/j.neuron.2019.01.039. Neuron. 2019. PMID: 30844400 Free article. Review.
Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. ...Improvements in the delivery and distribution of such agents as well …
Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predomin …
Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies.
Tong H, Yang T, Xu S, Li X, Liu L, Zhou G, Yang S, Yin S, Li XJ, Li S. Tong H, et al. Int J Mol Sci. 2024 Mar 29;25(7):3845. doi: 10.3390/ijms25073845. Int J Mol Sci. 2024. PMID: 38612657 Free PMC article. Review.
Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) with a polyglutamine stretch in its N-terminus. ...Although there is currently no eff …
Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the huntingtin gene (HTT), resulting in …
Huntington's disease: from molecular pathogenesis to clinical treatment.
Ross CA, Tabrizi SJ. Ross CA, et al. Lancet Neurol. 2011 Jan;10(1):83-98. doi: 10.1016/S1474-4422(10)70245-3. Lancet Neurol. 2011. PMID: 21163446 Review.
Huntington's disease has served as a model for the study of other more common neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. ...Pathogenic pathways of Huntington's disease are beginning to …
Huntington's disease has served as a model for the study of other more common neurodegenerative disorders, such as Alzh …
Clinical Features of Huntington's Disease.
Ghosh R, Tabrizi SJ. Ghosh R, et al. Adv Exp Med Biol. 2018;1049:1-28. doi: 10.1007/978-3-319-71779-1_1. Adv Exp Med Biol. 2018. PMID: 29427096 Review.
Huntington's disease (HD) is the most common monogenic neurodegenerative disease and the commonest genetic dementia in the developed world. ...Recent developments in therapeutics research, including gene silencing and targeted small molecule app …
Huntington's disease (HD) is the most common monogenic neurodegenerative disease and the commonest genetic demen …
A biological classification of Huntington's disease: the Integrated Staging System.
Tabrizi SJ, Schobel S, Gantman EC, Mansbach A, Borowsky B, Konstantinova P, Mestre TA, Panagoulias J, Ross CA, Zauderer M, Mullin AP, Romero K, Sivakumaran S, Turner EC, Long JD, Sampaio C; Huntington's Disease Regulatory Science Consortium (HD-RSC). Tabrizi SJ, et al. Lancet Neurol. 2022 Jul;21(7):632-644. doi: 10.1016/S1474-4422(22)00120-X. Lancet Neurol. 2022. PMID: 35716693 Review.
The HD-ISS characterises individuals for research purposes from birth, starting at Stage 0 (ie, individuals with the Huntington's disease genetic mutation without any detectable pathological change) by using a genetic definition of Huntington's …
The HD-ISS characterises individuals for research purposes from birth, starting at Stage 0 (ie, individuals with the Huntington's …
4,626 results