Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 2
2006 1
2007 2
2008 1
2009 1
2015 1
2018 1
2019 1
2020 2
2021 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

11 results

Results by year

Filters applied: . Clear all
Page 1
Role of taurine accumulation in keratinocyte hydration.
Janeke G, Siefken W, Carstensen S, Springmann G, Bleck O, Steinhart H, Höger P, Wittern KP, Wenck H, Stäb F, Sauermann G, Schreiner V, Doering T. Janeke G, et al. J Invest Dermatol. 2003 Aug;121(2):354-61. doi: 10.1046/j.1523-1747.2003.12366.x. J Invest Dermatol. 2003. PMID: 12880428 Free article.
Keratinocyte uptake of taurine was inhibited by beta-alanine but not by other osmolytes such as betaine, inositol, or sorbitol. ...Our data indicate that taurine is an important epidermal osmolyte required to maintain keratinocyte hydrati …
Keratinocyte uptake of taurine was inhibited by beta-alanine but not by other osmolytes such as betaine, inositol, or s …
The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression.
Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J. Rockel N, et al. J Immunol. 2007 Sep 15;179(6):3604-12. doi: 10.4049/jimmunol.179.6.3604. J Immunol. 2007. PMID: 17785795
Organic osmolytes, such as taurine, are involved in cell volume homeostasis and cell protection. Epidermal keratinocytes possess an osmolyte strategy, i.e., they take up taurine upon hyperosmotic stress and express the corresponding transporter …
Organic osmolytes, such as taurine, are involved in cell volume homeostasis and cell protection. Epidermal keratinocytes …
Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.
El-Chami C, Foster AR, Johnson C, Clausen RP, Cornwell P, Haslam IS, Steward MC, Watson REB, Young HS, O'Neill CA. El-Chami C, et al. Br J Dermatol. 2021 Mar;184(3):482-494. doi: 10.1111/bjd.19162. Epub 2020 Jul 1. Br J Dermatol. 2021. PMID: 32348549 Free article.
OBJECTIVES: We aimed to characterize osmolyte transporters in skin and keratinocytes, and, using transporter inhibitors, to investigate whether osmolytes can modify TJs. ...Betaine and taurine increased TJ function in primary human keratinocytes …
OBJECTIVES: We aimed to characterize osmolyte transporters in skin and keratinocytes, and, using transporter inhibitors, to in …
Functional characterization of sodium- and chloride-dependent taurine transport in human keratinocytes.
Grafe F, Wohlrab W, Neubert RH, Brandsch M. Grafe F, et al. Eur J Pharm Biopharm. 2004 Mar;57(2):337-41. doi: 10.1016/j.ejpb.2003.10.010. Eur J Pharm Biopharm. 2004. PMID: 15018993
In the skin, taurine acts as an important osmolyte required for keratinocyte hydration. It has antioxidant effects, protects cells from UV-induced stress and has effects on cell proliferation, inflammation and collagenogenesis. This study was performed to fin …
In the skin, taurine acts as an important osmolyte required for keratinocyte hydration. It has antioxidant effects, pro …
Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging.
Foster AR, El Chami C, O'Neill CA, Watson REB. Foster AR, et al. Aging Cell. 2020 Jan;19(1):e13058. doi: 10.1111/acel.13058. Epub 2019 Nov 26. Aging Cell. 2020. PMID: 31769623 Free PMC article.
However, addition of exogenous taurine significantly rescued cell volume; this was corroborated by a reduction in TAUT mRNA and protein in aged, as compared to young, keratinocytes. Collectively, these novel data demonstrate that human epidermal keratinocytes …
However, addition of exogenous taurine significantly rescued cell volume; this was corroborated by a reduction in TAUT mRNA and prote …
The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis.
Warskulat U, Reinen A, Grether-Beck S, Krutmann J, Häussinger D. Warskulat U, et al. J Invest Dermatol. 2004 Sep;123(3):516-21. doi: 10.1111/j.0022-202X.2004.23313.x. J Invest Dermatol. 2004. PMID: 15304091 Free article.
Compatible organic osmolytes, such as betaine, myoinositol, and taurine, are involved in cell volume homeostasis as well as in cell protection, for example, against oxidative stress. This so-called osmolyte strategy requires the expression of specific osmo …
Compatible organic osmolytes, such as betaine, myoinositol, and taurine, are involved in cell volume homeostasis as well as in …
Effect of ultraviolet A exposure on transport of compatible organic osmolytes in human lens epithelial cells.
Wu DY, Zhang JS. Wu DY, et al. Genet Mol Res. 2015 May 18;14(2):5132-40. doi: 10.4238/2015.May.18.3. Genet Mol Res. 2015. PMID: 26125706
This osmolyte strategy requires the expression of specific osmolyte transporters such as betaine (BGT-1), myoinositol (SMIT), and taurine (TAUT). In contrast to the kidney, keratinocytes, and neural cells, few studies have examined osmolytes in …
This osmolyte strategy requires the expression of specific osmolyte transporters such as betaine (BGT-1), myoinositol (SMIT), …
Organic osmolytes preserve the function of the developing tight junction in ultraviolet B-irradiated rat epidermal keratinocytes.
El-Chami C, Haslam IS, Steward MC, O'Neill CA. El-Chami C, et al. Sci Rep. 2018 Mar 26;8(1):5167. doi: 10.1038/s41598-018-22533-0. Sci Rep. 2018. PMID: 29581434 Free PMC article.
The development of the TJ barrier significantly deteriorates in response to ultraviolet B radiation (UVB). Following exposure to UVB, keratinocytes accumulate organic osmolytes, which are known to preserve cell volume during water stress. Since TJs are intimately as …
The development of the TJ barrier significantly deteriorates in response to ultraviolet B radiation (UVB). Following exposure to UVB, ker …
Ultraviolet B radiation induces cell shrinkage and increases osmolyte transporter mRNA expression and osmolyte uptake in HaCaT keratinocytes.
Warskulat U, Brookmann S, Reinen A, Häussinger D. Warskulat U, et al. Biol Chem. 2007 Dec;388(12):1345-52. doi: 10.1515/BC.2007.140. Biol Chem. 2007. PMID: 18020950
We have previously shown that compatible organic osmolytes, such as betaine, myo-inositol and taurine, are part of the stress response of normal human keratinocytes (NHKs) to ultraviolet B (UVB) radiation. ...Exposure to UVB (290-315 nm) radiation induced cel …
We have previously shown that compatible organic osmolytes, such as betaine, myo-inositol and taurine, are part of the stress …
Taurine improves epidermal barrier properties stressed by surfactants-a role for osmolytes in barrier homeostasis.
Anderheggen B, Jassoy C, Waldmann-Laue M, Förster T, Wadle A, Doering T. Anderheggen B, et al. J Cosmet Sci. 2006 Jan-Feb;57(1):1-10. J Cosmet Sci. 2006. PMID: 16676119
Exposure of the epidermis to a dry environment or UV irradiation stimulates barrier lipid synthesis and accumulation of the organic osmolyte taurine in the outermost granular keratinocyte layer. In this work we studied a possible relationship between these tw …
Exposure of the epidermis to a dry environment or UV irradiation stimulates barrier lipid synthesis and accumulation of the organic osmol …
11 results