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Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. te Velthuis AJ, et al. PLoS Pathog. 2010 Nov 4;6(11):e1001176. doi: 10.1371/journal.ppat.1001176. PLoS Pathog. 2010. PMID: 21079686 Free PMC article.

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Zinc-embedded fabrics inactivate SARS-CoV-2 and influenza A virus.

Gopal V, Nilsson-Payant BE, French H, Siegers JY, Yung WS, Hardwick M, Te Velthuis AJW. Gopal V, et al. bioRxiv. 2021 Jan 6:2020.11.02.365833. doi: 10.1101/2020.11.02.365833. Preprint. bioRxiv. 2021. PMID: 33173872 Free PMC article. Updated.

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Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial.

Holubovska O, Bojkova D, Elli S, Bechtel M, Boltz D, Muzzio M, Peng X, Sala F, Cosentino C, Mironenko A, Milde J, Lebed Y, Stammer H, Goy A, Guerrini M, Mueller L, Cinatl J, Margitich V, Te Velthuis AJW. Holubovska O, et al. medRxiv. 2021 Jan 21:2021.01.05.21249237. doi: 10.1101/2021.01.05.21249237. Preprint. medRxiv. 2021. PMID: 33469600 Free PMC article.

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The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent.

te Velthuis AJ, Arnold JJ, Cameron CE, van den Worm SH, Snijder EJ. te Velthuis AJ, et al. Nucleic Acids Res. 2010 Jan;38(1):203-14. doi: 10.1093/nar/gkp904. Epub 2009 Oct 29. Nucleic Acids Res. 2010. PMID: 19875418 Free PMC article.

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Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes.

Knoops K, Swett-Tapia C, van den Worm SH, Te Velthuis AJ, Koster AJ, Mommaas AM, Snijder EJ, Kikkert M. Knoops K, et al. Among authors: te velthuis aj. J Virol. 2010 Jan;84(2):833-46. doi: 10.1128/JVI.01826-09. Epub 2009 Nov 4. J Virol. 2010. PMID: 19889777 Free PMC article.

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The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension.

te Velthuis AJ, van den Worm SH, Snijder EJ. te Velthuis AJ, et al. Nucleic Acids Res. 2012 Feb;40(4):1737-47. doi: 10.1093/nar/gkr893. Epub 2011 Oct 29. Nucleic Acids Res. 2012. PMID: 22039154 Free PMC article.

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Mechanism of nucleic acid unwinding by SARS-CoV helicase.

Adedeji AO, Marchand B, Te Velthuis AJ, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG. Adedeji AO, et al. Among authors: te velthuis aj. PLoS One. 2012;7(5):e36521. doi: 10.1371/journal.pone.0036521. Epub 2012 May 15. PLoS One. 2012. PMID: 22615777 Free PMC article.

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Common and unique features of viral RNA-dependent polymerases.

te Velthuis AJ. te Velthuis AJ. Cell Mol Life Sci. 2014 Nov;71(22):4403-20. doi: 10.1007/s00018-014-1695-z. Epub 2014 Aug 1. Cell Mol Life Sci. 2014. PMID: 25080879 Free PMC article. Review.

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Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA.

Robb NC, Te Velthuis AJ, Wieneke R, Tampé R, Cordes T, Fodor E, Kapanidis AN. Robb NC, et al. Among authors: te velthuis aj. Nucleic Acids Res. 2016 Dec 1;44(21):10304-10315. doi: 10.1093/nar/gkw884. Epub 2016 Sep 30. Nucleic Acids Res. 2016. PMID: 27694620 Free PMC article.

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Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Posthuma CC, Te Velthuis AJW, Snijder EJ. Posthuma CC, et al. Virus Res. 2017 Apr 15;234:58-73. doi: 10.1016/j.virusres.2017.01.023. Epub 2017 Feb 6. Virus Res. 2017. PMID: 28174054 Free PMC article. Review.

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