Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 1
2001 4
2002 2
2003 3
2004 1
2005 3
2006 1
2007 3
2008 4
2009 1
2010 2
2011 3
2012 3
2013 2
2014 4
2015 4
2016 4
2017 5
2018 5
2019 2
2020 4
2021 4
2022 7
2023 8
2024 10
2025 12
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

94 results

Results by year

Filters applied: . Clear all
Page 1
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ. Woolf CJ. Pain. 2011 Mar;152(3 Suppl):S2-S15. doi: 10.1016/j.pain.2010.09.030. Epub 2010 Oct 18. Pain. 2011. PMID: 20961685 Free PMC article. Review.
Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, aftersensations, and enhanced temporal summation. It can be readily and rapidly elicited in human volunteers by diverse exp …
Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesi …
Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms.
Castelo-Branco L, Cardenas-Rojas A, Rebello-Sanchez I, Pacheco-Barrios K, de Melo PS, Gonzalez-Mego P, Marduy A, Vasquez-Avila K, Costa Cortez P, Parente J, Teixeira PEP, Rosa G, McInnis K, Caumo W, Fregni F. Castelo-Branco L, et al. Front Pain Res (Lausanne). 2022 Jun 22;3:881543. doi: 10.3389/fpain.2022.881543. eCollection 2022. Front Pain Res (Lausanne). 2022. PMID: 35812016 Free PMC article.
Experimental pain measurements, such as temporal summation (TS), could serve as markers of central sensitization and have been previously studied in these patients, with conflicting results. ...BPI-pain subscale was associated with more temporal summation …
Experimental pain measurements, such as temporal summation (TS), could serve as markers of central sensitization and have been …
Temporal Summation but Not Expectations of Pain Relief Predict Response to Acupuncture Treatment in Fibromyalgia.
Murphy AE, Buchtel H, Mawla I, Ichesco E, Larkin T, Harte SE, Zhan E, Napadow V, Harris RE. Murphy AE, et al. J Pain. 2024 Oct;25(10):104622. doi: 10.1016/j.jpain.2024.104622. Epub 2024 Jul 8. J Pain. 2024. PMID: 38986891 Free article. Clinical Trial.
Outcome measures included clinical pain severity (Brief Pain Inventory [BPI]), degree of nociplastic pain (Fibromyalgia Survey Questionnaire), and pressure pain tolerance (PPtol). Baseline measures of temporal summation of pain and expectations for treatment …
Outcome measures included clinical pain severity (Brief Pain Inventory [BPI]), degree of nociplastic pain (Fibromyalgia Survey Questi …
Defective Endogenous Pain Modulation in Fibromyalgia: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation Paradigms.
O'Brien AT, Deitos A, Triñanes Pego Y, Fregni F, Carrillo-de-la-Peña MT. O'Brien AT, et al. J Pain. 2018 Aug;19(8):819-836. doi: 10.1016/j.jpain.2018.01.010. Epub 2018 Feb 15. J Pain. 2018. PMID: 29454976 Free article. Review.
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients with healthy controls. ...
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) pati …
Interplay between noxious heat sensitivity and temporal summation magnitude in patients with fibromyalgia and long-term opioid use.
Bao JD, Rosser MA, Park SH, Baker AK, Martucci KT. Bao JD, et al. Front Neurosci. 2023 Oct 12;17:1275921. doi: 10.3389/fnins.2023.1275921. eCollection 2023. Front Neurosci. 2023. PMID: 37901425 Free PMC article.
Using this measurement, we evaluated temporal summation in study participants with fibromyalgia who take opioids long-term (i.e., greater than 90 days duration; n = 24, opioid-FM). ...However, all 3 groups exhibited similar magnitudes of temporal su …
Using this measurement, we evaluated temporal summation in study participants with fibromyalgia who take opioids long-t …
Dynamic Functional Brain Connectivity Underlying Temporal Summation of Pain in Fibromyalgia.
Cheng JC, Anzolin A, Berry M, Honari H, Paschali M, Lazaridou A, Lee J, Ellingsen DM, Loggia ML, Grahl A, Lindquist MA, Edwards RR, Napadow V. Cheng JC, et al. Arthritis Rheumatol. 2022 Apr;74(4):700-710. doi: 10.1002/art.42013. Epub 2022 Mar 10. Arthritis Rheumatol. 2022. PMID: 34725971
OBJECTIVE: Abnormal central pain processing is a leading cause of pain in fibromyalgia (FM) and is perceptually characterized with the psychophysical measure of temporal summation of pain (TSP). ...In 84 FM patients and age- and sex-matched healthy controls, …
OBJECTIVE: Abnormal central pain processing is a leading cause of pain in fibromyalgia (FM) and is perceptually characterized with th …
Central Pain Syndrome.
Dydyk AM, Chiebuka E, Stretanski MF, Givler A. Dydyk AM, et al. 2025 May 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 May 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 31971703 Free Books & Documents.
This state, which includes "wind-up" (temporal summation) as an acute precursor, causes ordinary touch to produce pain (allodynia) or a mild stimulus to feel more painful (hyperalgesia). ...CPS involves pathophysiological mechanisms distinct from those underlying no …
This state, which includes "wind-up" (temporal summation) as an acute precursor, causes ordinary touch to produce pain (allody …
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
Graven-Nielsen T, Kendall SA, Henriksson KG, Bengtsson M, Sörensen J, Johnson A, Gerdle B, Arendt-Nielsen L. Graven-Nielsen T, et al. Pain. 2000 Apr;85(3):483-491. doi: 10.1016/S0304-3959(99)00308-5. Pain. 2000. PMID: 10781923 Clinical Trial.
Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. ...It suggested a link between central hyperexcitability and the mechanisms for facilitated ref …
Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in …
Temporal summation of pain is not amplified in a large proportion of fibromyalgia patients.
Potvin S, Paul-Savoie E, Morin M, Bourgault P, Marchand S. Potvin S, et al. Pain Res Treat. 2012;2012:938595. doi: 10.1155/2012/938595. Epub 2012 Jun 3. Pain Res Treat. 2012. PMID: 22701791 Free PMC article.
Nevertheless, temporal summation was not increased in the other FM subgroup, relative to controls, despite equivalent experimental temperatures. Discussion. Our results suggest that temporal summation of pain is normal, rather than increased, in a larg …
Nevertheless, temporal summation was not increased in the other FM subgroup, relative to controls, despite equivalent experime …
Temporal Summation of the Thermal Grill Illusion is Comparable to That Observed Following Noxious Heat.
Horing B, Kerkemeyer M, Büchel C. Horing B, et al. J Pain. 2024 May;25(5):104432. doi: 10.1016/j.jpain.2023.11.015. Epub 2023 Nov 22. J Pain. 2024. PMID: 37995821 Free article.
It involves the glutamatergic system and is affected in putatively nociplastic syndromes such as fibromyalgia. The glutamatergic system is also involved in wind-up, that is, the increased activation of spinal neurons following repeated noxious stimulation leading to a t …
It involves the glutamatergic system and is affected in putatively nociplastic syndromes such as fibromyalgia. The glutamatergic syst …
94 results