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Page 90
Accurate quantification of 5-Methylcytosine, 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine in genomic DNA from breast cancer by chemical derivatization coupled with ultra performance liquid chromatography- electrospray quadrupole time of flight mass spectrometry analysis.
Guo M, Li X, Zhang L, Liu D, Du W, Yin D, Lyu N, Zhao G, Guo C, Tang D. Guo M, et al. Oncotarget. 2017 Aug 9;8(53):91248-91257. doi: 10.18632/oncotarget.20093. eCollection 2017 Oct 31. Oncotarget. 2017. PMID: 29207640 Free PMC article.
This pathway removes the methyl group from cytosine, which is involved in the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) proteins. Then, 5-hmC can be iteratively oxidized to generate 5-formylcytos …
This pathway removes the methyl group from cytosine, which is involved in the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5-hm …
Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury.
Le Bras A, Yu B, Issa Bhaloo S, Hong X, Zhang Z, Hu Y, Xu Q. Le Bras A, et al. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):232-244. doi: 10.1161/ATVBAHA.117.309853. Epub 2017 Nov 30. Arterioscler Thromb Vasc Biol. 2018. PMID: 29191922 Free PMC article.
After ETV2 transduction, Sca1(+) adventitial cells presented a significant increase in the expression of early endothelial cell genes, including VE-cadherin, Flk-1, and Tie2 at the mRNA and protein levels. ETV2 overexpression also induced the downregulation of a panel of s …
After ETV2 transduction, Sca1(+) adventitial cells presented a significant increase in the expression of early endothelial cell genes, inclu …
Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2'-deoxycytidine level in cultured cancerous cell lines.
Foksinski M, Zarakowska E, Gackowski D, Skonieczna M, Gajda K, Hudy D, Szpila A, Bialkowski K, Starczak M, Labejszo A, Czyz J, Rzeszowska-Wolny J, Olinski R. Foksinski M, et al. PLoS One. 2017 Nov 30;12(11):e0188856. doi: 10.1371/journal.pone.0188856. eCollection 2017. PLoS One. 2017. PMID: 29190698 Free PMC article.
Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed by enzymes of the Ten-Eleven Translocation family proteins (TETs 1, 2 and 3). Here w …
Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5 …
Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells.
Burr S, Caldwell A, Chong M, Beretta M, Metcalf S, Hancock M, Arno M, Balu S, Kropf VL, Mistry RK, Shah AM, Mann GE, Brewer AC. Burr S, et al. Nucleic Acids Res. 2018 Feb 16;46(3):1210-1226. doi: 10.1093/nar/gkx1197. Nucleic Acids Res. 2018. PMID: 29186571 Free PMC article.
The demethylation of 5-methylcytosine (5mC) is achieved via successive oxidation reactions catalysed by the Ten-Eleven-Translocation (Tet) enzymes, yielding the 5-hydroxymethylcytosine (5hmC) intermediate. ...
The demethylation of 5-methylcytosine (5mC) is achieved via successive oxidation reactions catalysed by the Ten-Eleven-Tran …
Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells.
Rea M, Gripshover T, Fondufe-Mittendorf Y. Rea M, et al. Toxicol Appl Pharmacol. 2018 Jan 1;338:124-133. doi: 10.1016/j.taap.2017.11.015. Epub 2017 Nov 22. Toxicol Appl Pharmacol. 2018. PMID: 29175454 Free PMC article.
Furthermore, this increase in hydroxymethylation occurs concurrently with an upregulation of ten-eleven translocation (TET) enzymes that oxidize 5-methylcytosine (5mC) in DNA. To gain an understanding into how iAs might impact TET expression, we found that iA …
Furthermore, this increase in hydroxymethylation occurs concurrently with an upregulation of ten-eleven translocation ( …
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.
Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sürün D, Schnütgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. Spallotta F, et al. Circ Res. 2018 Jan 5;122(1):31-46. doi: 10.1161/CIRCRESAHA.117.311300. Epub 2017 Nov 20. Circ Res. 2018. PMID: 29158345 Free article.
This observation was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-eleven translocation protein 1) association and function with TET1 relocating out of the nucleus. ...
This observation was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-eleven translocation pr …
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation.
Carty SA, Gohil M, Banks LB, Cotton RM, Johnson ME, Stelekati E, Wells AD, Wherry EJ, Koretzky GA, Jordan MS. Carty SA, et al. J Immunol. 2018 Jan 1;200(1):82-91. doi: 10.4049/jimmunol.1700559. Epub 2017 Nov 17. J Immunol. 2018. PMID: 29150566 Free PMC article.
In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD8(+) T cell differentiation. In a murine model of acute viral infection, TET2 loss promotes early acquisition of a memory CD8(+) T cell fate in a c …
In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD8(+) T …
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Raffel S, et al. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. Nature. 2017. PMID: 29144447
Here, by performing high-resolution proteomic analysis of human acute myeloid leukaemia (AML) stem-cell and non-stem-cell populations, we find the BCAA pathway enriched and BCAT1 protein and transcripts overexpressed in leukaemia stem cells. We show that BCAT1, which trans …
Here, by performing high-resolution proteomic analysis of human acute myeloid leukaemia (AML) stem-cell and non-stem-cell populations, we fi …
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.
Jia J, Shi Y, Chen L, Lai W, Yan B, Jiang Y, Xiao D, Xi S, Cao Y, Liu S, Cheng Y, Tao Y. Jia J, et al. Theranostics. 2017 Sep 5;7(16):3920-3932. doi: 10.7150/thno.21389. eCollection 2017. Theranostics. 2017. PMID: 29109788 Free PMC article.
Conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) family enzymes plays an important biological role in embryonic stem cells, development, aging and disease. ...
Conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) family enzym …
Retrieval-Induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation.
Liu C, Sun X, Wang Z, Le Q, Liu P, Jiang C, Wang F, Ma L. Liu C, et al. Int J Neuropsychopharmacol. 2018 Mar 1;21(3):255-266. doi: 10.1093/ijnp/pyx099. Int J Neuropsychopharmacol. 2018. PMID: 29106571 Free PMC article.
RESULTS: Chemogenetically silencing the activity of the pyramidal neurons in the dorsal hippocampus immediately after memory retrieval markedly impaired memory reconsolidation, and the ribosome-associated mRNA level of the ten-eleven translocation (Tet) famil …
RESULTS: Chemogenetically silencing the activity of the pyramidal neurons in the dorsal hippocampus immediately after memory retrieval marke …
1,399 results