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Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke.
Campbell BCV, Mitchell PJ, Churilov L, Yassi N, Kleinig TJ, Dowling RJ, Yan B, Bush SJ, Dewey HM, Thijs V, Scroop R, Simpson M, Brooks M, Asadi H, Wu TY, Shah DG, Wijeratne T, Ang T, Miteff F, Levi CR, Rodrigues E, Zhao H, Salvaris P, Garcia-Esperon C, Bailey P, Rice H, de Villiers L, Brown H, Redmond K, Leggett D, Fink JN, Collecutt W, Wong AA, Muller C, Coulthard A, Mitchell K, Clouston J, Mahady K, Field D, Ma H, Phan TG, Chong W, Chandra RV, Slater LA, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Bladin CF, Sharma G, Desmond PM, Parsons MW, Donnan GA, Davis SM; EXTEND-IA TNK Investigators. Campbell BCV, et al. N Engl J Med. 2018 Apr 26;378(17):1573-1582. doi: 10.1056/NEJMoa1716405. N Engl J Med. 2018. PMID: 29694815 Free article. Clinical Trial.
BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. ...Symptomatic intracerebral hemorrhage occurred in 1% of the patients in each group. CONCLUSIONS: Tenecteplase before …
BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic …
Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial.
Wang Y, Li S, Pan Y, Li H, Parsons MW, Campbell BCV, Schwamm LH, Fisher M, Che F, Dai H, Li D, Li R, Wang J, Wang Y, Zhao X, Li Z, Zheng H, Xiong Y, Meng X; TRACE-2 Investigators. Wang Y, et al. Lancet. 2023 Feb 25;401(10377):645-654. doi: 10.1016/S0140-6736(22)02600-9. Epub 2023 Feb 9. Lancet. 2023. PMID: 36774935 Clinical Trial.
BACKGROUND: There is increasing interest in replacing alteplase with tenecteplase as the preferred thrombolytic treatment for patients with acute ischaemic stroke. ...INTERPRETATION: Tenecteplase was non-inferior to alteplase in people with isch …
BACKGROUND: There is increasing interest in replacing alteplase with tenecteplase as the preferred thrombolytic treatment for …
Thrombolysis for acute ischaemic stroke: current status and future perspectives.
Tsivgoulis G, Katsanos AH, Sandset EC, Turc G, Nguyen TN, Bivard A, Fischer U, Khatri P. Tsivgoulis G, et al. Lancet Neurol. 2023 May;22(5):418-429. doi: 10.1016/S1474-4422(22)00519-1. Epub 2023 Mar 9. Lancet Neurol. 2023. PMID: 36907201 Review.
Tenecteplase has emerged as a potential alternative thrombolytic agent that might be preferred over alteplase because of its ease of administration and reported efficacy in patients with large vessel occlusion. ...Other research endeavors are looking at the use of i …
Tenecteplase has emerged as a potential alternative thrombolytic agent that might be preferred over alteplase because of its e …
Intravenous Thrombolysis for Acute Ischemic Stroke.
Grotta JC. Grotta JC. Continuum (Minneap Minn). 2023 Apr 1;29(2):425-442. doi: 10.1212/CON.0000000000001207. Continuum (Minneap Minn). 2023. PMID: 37039403 Review.
OBJECTIVE: This article reviews the history of IV thrombolysis, its current indications and implementation, the duality of the "time is brain" versus "tissue clock" approaches, the impact of endovascular thrombectomy on IV thrombolysis, the emergence of te …
OBJECTIVE: This article reviews the history of IV thrombolysis, its current indications and implementation, the duality of the "time is brai …
Femoral Access-Site Complications with Tenecteplase versus Alteplase before Mechanical Thrombectomy for Large-Vessel-Occlusion Stroke.
Hendrix P, Collins MK, Goren O, Weiner GM, Dalal SS, Melamed I, Kole MJ, Griessenauer CJ, Noto A, Schirmer CM. Hendrix P, et al. AJNR Am J Neuroradiol. 2023 Jun;44(6):681-686. doi: 10.3174/ajnr.A7862. Epub 2023 May 11. AJNR Am J Neuroradiol. 2023. PMID: 37169538
However, the incidence of femoral access-site complications with tenecteplase before mechanical thrombectomy requires exploration. Here, femoral access-site complications with tenecteplase versus alteplase before mechanical thrombectomy f …
However, the incidence of femoral access-site complications with tenecteplase before mechanical thrombectomy requires explorat …
Emerging agents for the treatment and prevention of stroke: progress in clinical trials.
Safouris A, Magoufis G, Tsivgoulis G. Safouris A, et al. Expert Opin Investig Drugs. 2021 Oct;30(10):1025-1035. doi: 10.1080/13543784.2021.1985463. Epub 2021 Oct 13. Expert Opin Investig Drugs. 2021. PMID: 34555978 Review.
AREAS COVERED: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and chronic phase post-stroke. We examine the evidence in favor of tenecteplase as an alternative thrombolytic drug to alteplase …
AREAS COVERED: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and c …
Cost-effectiveness of tenecteplase versus alteplase for stroke thrombolysis evaluation trial in the ambulance.
Gao L, Parsons M, Churilov L, Zhao H, Campbell BC, Yan B, Mitchell P, Coote S, Langenberg F, Smith K, Anderson D, Stephenson M, Davis SM, Donnan G, Easton D, Bivard A. Gao L, et al. Eur Stroke J. 2023 Jun;8(2):448-455. doi: 10.1177/23969873231165086. Epub 2023 Mar 26. Eur Stroke J. 2023. PMID: 37231684 Free PMC article.
BACKGROUND: Tenecteplase administered to patients with ischaemic stroke in a mobile stroke unit (MSU) has been shown to reduce the perfusion lesion volumes and result in ultra-early recovery. ...A Markov microsimulation model was developed to simulate the lon …
BACKGROUND: Tenecteplase administered to patients with ischaemic stroke in a mobile stroke unit (MSU) has been shown to …
Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke.
Gao L, Moodie M, Mitchell PJ, Churilov L, Kleinig TJ, Yassi N, Yan B, Parsons MW, Donnan GA, Davis SM, Campbell BCV; EXTEND-IA TNK Investigators. Gao L, et al. Stroke. 2020 Dec;51(12):3681-3689. doi: 10.1161/STROKEAHA.120.029666. Epub 2020 Oct 7. Stroke. 2020. PMID: 33023423 Free article.
BACKGROUND AND PURPOSE: Tenecteplase improved functional outcomes and reduced the requirement for endovascular thrombectomy in ischemic stroke patients with large vessel occlusion in the EXTEND-IA TNK randomized trial. We assessed the cost-effectivenes …
BACKGROUND AND PURPOSE: Tenecteplase improved functional outcomes and reduced the requirement for endovascular thrombectomy in …
Tenecteplase versus alteplase for large vessel occlusion recanalization (T-FLAVOR): Trial protocol.
Kawano H, Hirano T, Inoue M, Fukuda-Doi M, Iwasaki K, Omae K, Tanaka K, Yamamoto H, Koga M, Sakai N, Nagao T, Sasaki M, Hayakawa N, Toyoda K. Kawano H, et al. Eur Stroke J. 2022 Mar;7(1):71-75. doi: 10.1177/23969873211070455. Epub 2022 Jan 7. Eur Stroke J. 2022. PMID: 35300254 Free PMC article.
HYPOTHESIS: Tenecteplase is superior to alteplase in achieving recanalization on the initial angiogram when administered 4.5-hour of stroke onset in patients planned for mechanical thrombectomy (MT) in Japan where alteplase at the unique dose of …
HYPOTHESIS: Tenecteplase is superior to alteplase in achieving recanalization on the initial angiogram when administered 4.5-h …
Major Bleeding Postadministration of Tenecteplase Versus Alteplase in Acute Ischemic Stroke.
Walton MN, Hamilton LA, Salyer S, Wiseman BF, Forster AM, Rowe AS. Walton MN, et al. Ann Pharmacother. 2023 May;57(5):535-543. doi: 10.1177/10600280221120211. Epub 2022 Aug 24. Ann Pharmacother. 2023. PMID: 36004394
Compared to alteplase, tenecteplase is effective for neurologic improvement following ischemic stroke in patients with large vessel occlusions who are eligible for thrombectomy and for mild ischemic strokes with National Institutes of Hea …
Compared to alteplase, tenecteplase is effective for neurologic improvement following ischemic stroke in patient …
27 results