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Page 1
The Antibacterial Mechanism of Terpinen-4-ol Against Streptococcus agalactiae.
Zhang Y, Feng R, Li L, Zhou X, Li Z, Jia R, Song X, Zou Y, Yin L, He C, Liang X, Zhou W, Wei Q, Du Y, Yan K, Wu Z, Yin Z. Zhang Y, et al. Curr Microbiol. 2018 Sep;75(9):1214-1220. doi: 10.1007/s00284-018-1512-2. Curr Microbiol. 2018. PMID: 29804206
Therefore, it is in great need to develop ecologically sustainable antimicrobial agents. In the study, the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and action mechanism of terpinen-4-ol against S. …
Therefore, it is in great need to develop ecologically sustainable antimicrobial agents. In the study, the minimal inhibitory …
A comprehensive review on the pharmacological prospects of Terpinen-4-ol: From nature to medicine and beyond.
Prerna, Chadha J, Khullar L, Mudgil U, Harjai K. Prerna, et al. Fitoterapia. 2024 Jul;176:106051. doi: 10.1016/j.fitote.2024.106051. Epub 2024 Jun 3. Fitoterapia. 2024. PMID: 38838826 Review.
Owing to their extensive biological potential, essential oils (EOs) and their bioactive phytochemicals have gained attention from the scientific community. Within this domain, Terpinen-4-ol (T-4-ol), a bioactive monoterpene alcohol and the major constituent o …
Owing to their extensive biological potential, essential oils (EOs) and their bioactive phytochemicals have gained attention from the scient …
Terpinen-4-ol from tea tree oil prevents Aspergillus flavus growth in postharvest wheat grain.
Ren J, Wang YM, Zhang SB, Lv YY, Zhai HC, Wei S, Ma PA, Hu YS. Ren J, et al. Int J Food Microbiol. 2024 Jun 16;418:110741. doi: 10.1016/j.ijfoodmicro.2024.110741. Epub 2024 May 9. Int J Food Microbiol. 2024. PMID: 38733636
Terpinen-4-ol vapor completely inhibited the A. flavus growth on agar plates and 20 % moisture wheat grain at 0.556 and 1.579 muL/mL, respectively, indicating that terpinen-4-ol serves as the main antifungal constituent in TTO volatiles. …
Terpinen-4-ol vapor completely inhibited the A. flavus growth on agar plates and 20 % moisture wheat grain at 0.556 and …
Terpinen-4-ol Targets HIF-1alpha/TGF-beta1/TNF-alpha Axis to Attenuate Ethanol-Induced Hepatotoxicity: Network Pharmacology and In Vitro Validation.
Alsahli TG, Khalid M, Malik MNH, Alshammari SO. Alsahli TG, et al. Medicina (Kaunas). 2025 Jun 6;61(6):1048. doi: 10.3390/medicina61061048. Medicina (Kaunas). 2025. PMID: 40572736 Free PMC article.
Current treatments are limited, highlighting the need for novel therapeutic agents. This study investigated the hepatoprotective effects of 'Terpinen-4-ol (T4OL)', a natural monoterpene from tea tree oil, against ethanol-induced liver injury, focusing …
Current treatments are limited, highlighting the need for novel therapeutic agents. This study investigated the hepatoprotective effe …
Terpinen-4-ol as an Antibacterial and Antibiofilm Agent against Staphylococcus aureus.
Cordeiro L, Figueiredo P, Souza H, Sousa A, Andrade-Júnior F, Medeiros D, Nóbrega J, Silva D, Martins E, Barbosa-Filho J, Lima E. Cordeiro L, et al. Int J Mol Sci. 2020 Jun 25;21(12):4531. doi: 10.3390/ijms21124531. Int J Mol Sci. 2020. PMID: 32630600 Free PMC article.
The essential oil of Melaleuca alternifolia is used as an antibacterial, a property believed to be mainly due to the presence of terpinen-4-ol. Based on this, the objective of this study was to evaluate the antibacterial and antibiofilm potential of terpin …
The essential oil of Melaleuca alternifolia is used as an antibacterial, a property believed to be mainly due to the presence of terpinen …
Antifungal activity and Shore A hardness of a tissue conditioner incorporated with terpinen-4-ol and cinnamaldehyde.
de Fátima Souto Maior L, Maciel PP, Ferreira VYN, de Lima Gouveia Dantas C, de Lima JM, Castellano LRC, Batista AUD, Bonan PRF. de Fátima Souto Maior L, et al. Clin Oral Investig. 2019 Jul;23(7):2837-2848. doi: 10.1007/s00784-019-02925-w. Epub 2019 May 20. Clin Oral Investig. 2019. PMID: 31111285 Review.
PURPOSE: This study investigated the anti-Candida activity and the Shore A hardness of a tissue conditioner (Softone ) modified by incorporation of terpinen-4-ol and cinnamaldehyde. MATERIAL AND METHODS: Agar diffusion, microdilution, and mechanism of …
PURPOSE: This study investigated the anti-Candida activity and the Shore A hardness of a tissue conditioner (Softone ) modified by incorpora …
Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers.
Shapira S, Pleban S, Kazanov D, Tirosh P, Arber N. Shapira S, et al. PLoS One. 2016 Jun 8;11(6):e0156540. doi: 10.1371/journal.pone.0156540. eCollection 2016. PLoS One. 2016. PMID: 27275783 Free PMC article.
AIM: To study the antitumor effects of terpinen-4-ol and its mechanism of action in prostate and GI malignancies, alone and in combination with chemotherapeutic and biological agents. ...CONCLUSION: Terpinen-4-ol significant …
AIM: To study the antitumor effects of terpinen-4-ol and its mechanism of action in prostate and GI malignancies …
Antibacterial mechanisms of terpinen-4-ol against Aeromonas hydrophila.
Lian K, Meng X, Wang Y, Ma S, Li X, Ren R, Liu Y, Zhou L, Peng R. Lian K, et al. Arch Microbiol. 2026 May 11;208(8):383. doi: 10.1007/s00203-026-04944-0. Arch Microbiol. 2026. PMID: 42113198
It is an urgent need to develop new antibacterial agents. Terpinen-4-ol is a natural plant monomer with broad-spectrum antibacterial activity, but its effect and mechanism against A. hydrophila remain unclear. ...This study provides potential st …
It is an urgent need to develop new antibacterial agents. Terpinen-4-ol is a natural plant monomer with broad-sp …
Terpinen-4-ol Enhances Disease Resistance of Postharvest Strawberry Fruit More Effectively than Tea Tree Oil by Activating the Phenylpropanoid Metabolism Pathway.
Li Z, Wang N, Wei Y, Zou X, Jiang S, Xu F, Wang H, Shao X. Li Z, et al. J Agric Food Chem. 2020 Jun 17;68(24):6739-6747. doi: 10.1021/acs.jafc.0c01840. Epub 2020 May 21. J Agric Food Chem. 2020. PMID: 32379969
This study aimed to reveal the effects and possible mechanism of terpinen-4-ol, the main component of tea tree oil (TTO), on the disease resistance of strawberry fruit. ...This indicates that terpinen-4-ol induces the highest disea …
This study aimed to reveal the effects and possible mechanism of terpinen-4-ol, the main component of tea tree o …
Integration of metabolomics and transcriptomics indicates changes in MRSA exposed to terpinen-4-ol.
Cheng F, Mo Y, Chen K, Shang X, Yang Z, Hao B, Shang R, Liang J, Liu Y. Cheng F, et al. BMC Microbiol. 2021 Nov 4;21(1):305. doi: 10.1186/s12866-021-02348-2. BMC Microbiol. 2021. PMID: 34736405 Free PMC article.
BACKGROUND: This study investigated the effects of terpinen-4-ol on methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, and the possible mechanisms governing this effect. ...The MIC and MBC values for terpinen-4-ol …
BACKGROUND: This study investigated the effects of terpinen-4-ol on methicillin-resistant Staphylococcus aureus (MRSA) …
52 results