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199 results

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Page 1
Cardiovascular Safety of Testosterone-Replacement Therapy.
Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, Boden WE, Cunningham GR, Granger CB, Khera M, Thompson IM Jr, Wang Q, Wolski K, Davey D, Kalahasti V, Khan N, Miller MG, Snabes MC, Chan A, Dubcenco E, Li X, Yi T, Huang B, Pencina KM, Travison TG, Nissen SE; TRAVERSE Study Investigators. Lincoff AM, et al. N Engl J Med. 2023 Jul 13;389(2):107-117. doi: 10.1056/NEJMoa2215025. Epub 2023 Jun 16. N Engl J Med. 2023. PMID: 37326322 Clinical Trial.
BACKGROUND: The cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypogonadism has not been determined. ...A higher incidence of atrial fibrillation, of acute kidney injury, and of pulmonary embolism was observ …
BACKGROUND: The cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypo …
Testosterone replacement therapy and cardiovascular disease.
Auerbach JM, Khera M. Auerbach JM, et al. Int J Impot Res. 2022 Nov;34(7):685-690. doi: 10.1038/s41443-021-00516-6. Epub 2022 Jan 9. Int J Impot Res. 2022. PMID: 34999717 Review.
Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy. ...The present article synt …
Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular ris …
Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis.
Corona G, Rastrelli G, Sparano C, Carinci V, Casella G, Vignozzi L, Sforza A, Maggi M. Corona G, et al. Expert Opin Drug Saf. 2024 May;23(5):565-579. doi: 10.1080/14740338.2024.2337741. Epub 2024 May 6. Expert Opin Drug Saf. 2024. PMID: 38553429
INTRODUCTION: The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. ...Whereas the incidence of non-fatal arrhythmias and AF was increased in the only trial considering CV safety as the primary endpoi …
INTRODUCTION: The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. …
Male hypogonadism: pathogenesis, diagnosis, and management.
De Silva NL, Papanikolaou N, Grossmann M, Antonio L, Quinton R, Anawalt BD, Jayasena CN. De Silva NL, et al. Lancet Diabetes Endocrinol. 2024 Oct;12(10):761-774. doi: 10.1016/S2213-8587(24)00199-2. Epub 2024 Aug 16. Lancet Diabetes Endocrinol. 2024. PMID: 39159641 Review.
Organic male hypogonadism due to irreversible hypothalamic-pituitary-testicular (HPT) pathology is easily diagnosed and treated with testosterone-replacement therapy. However, controversy surrounds the global practice of prescribing testosterone to symptomati …
Organic male hypogonadism due to irreversible hypothalamic-pituitary-testicular (HPT) pathology is easily diagnosed and treated with test …
Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials.
Braga MAP, Rivera A, Marinheiro G, Felix N, Carvalho PEP, Gewehr DM, Teixeira L, Clemente MRC, Reis PCA, de Amorim LGCR, Marinho AD, Mendes TB, Mesquita FC, Pozzi E, Ramasamy R. Braga MAP, et al. Am J Cardiovasc Drugs. 2025 Nov;25(6):767-777. doi: 10.1007/s40256-025-00737-w. Epub 2025 Jul 22. Am J Cardiovasc Drugs. 2025. PMID: 40694252
INTRODUCTION: The cardiovascular safety of testosterone-replacement therapy (TRT) for middle-aged and older men with low to low-normal levels of testosterone remains unclear. ...CONCLUSION: In men with low to low-normal testosterone, aged …
INTRODUCTION: The cardiovascular safety of testosterone-replacement therapy (TRT) for middle-aged and older men …
Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men.
Blackwell K, Blackwell M, Blackwell T. Blackwell K, et al. Curr Cardiol Rep. 2023 Oct;25(10):1157-1163. doi: 10.1007/s11886-023-01935-1. Epub 2023 Sep 21. Curr Cardiol Rep. 2023. PMID: 37733143 Review.
PURPOSE OF REVIEW: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. RECENT FINDINGS: A few published studies suggest a link between TRT and CV events. ...The use of TRT to …
PURPOSE OF REVIEW: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and advers …
Testosterone replacement and cardiovascular safety: no straight and narrow!
Hans SS, Dhindsa SS, Chemitiganti R. Hans SS, et al. Clin Med Insights Cardiol. 2015 Apr 27;9:33-7. doi: 10.4137/CMC.S23395. eCollection 2015. Clin Med Insights Cardiol. 2015. PMID: 25983562 Free PMC article. Review.
The past decade has seen a tremendous increase in the number of men treated for hypogonadism with the expectation of symptomatic benefit. However, the long-term cardiovascular safety of testosterone replacement remains unknown because retrospective stu …
The past decade has seen a tremendous increase in the number of men treated for hypogonadism with the expectation of symptomatic benefit. Ho …
Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial.
Bhasin S, Travison TG, Pencina KM, O'Leary M, Cunningham GR, Lincoff AM, Nissen SE, Lucia MS, Preston MA, Khera M, Khan N, Snabes MC, Li X, Tangen CM, Buhr KA, Thompson IM Jr. Bhasin S, et al. JAMA Netw Open. 2023 Dec 1;6(12):e2348692. doi: 10.1001/jamanetworkopen.2023.48692. JAMA Netw Open. 2023. PMID: 38150256 Free PMC article. Clinical Trial.
IMPORTANCE: The effect of testosterone replacement therapy (TRT) on the risk of prostate cancer and other adverse prostate events is unknown. ...INTERVENTION: Participants were randomized, with stratification for prior CVD, to topical 1.62% testosterone gel o …
IMPORTANCE: The effect of testosterone replacement therapy (TRT) on the risk of prostate cancer and other adverse prostate eve …
199 results