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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1904 1
1906 1
1932 1
1942 1
1947 1
1948 3
1962 1
1963 1
1965 2
1968 2
1969 3
1970 9
1971 57
1972 143
1973 232
1974 216
1975 173
1976 199
1977 172
1978 173
1979 139
1980 147
1981 167
1982 109
1983 110
1984 114
1985 107
1986 113
1987 110
1988 102
1989 98
1990 101
1991 140
1992 100
1993 110
1994 93
1995 135
1996 113
1997 125
1998 157
1999 144
2000 167
2001 166
2002 194
2003 193
2004 252
2005 276
2006 295
2007 364
2008 356
2009 296
2010 355
2011 367
2012 444
2013 401
2014 458
2015 473
2016 519
2017 552
2018 655
2019 794
2020 1015
2021 1054
2022 1071
2023 1021
2024 764

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14,750 results

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Page 1
Review of delta-8-tetrahydrocannabinol (delta(8) -THC): Comparative pharmacology with delta(9) -THC.
Tagen M, Klumpers LE. Tagen M, et al. Br J Pharmacol. 2022 Aug;179(15):3915-3933. doi: 10.1111/bph.15865. Epub 2022 Jun 1. Br J Pharmacol. 2022. PMID: 35523678 Free article. Review.
We give special focus to studies that directly compared delta(8) -THC to its more commonly studied isomer, delta(9) -THC. Overall, the pharmacokinetics and pharmacodynamics of delta(8) -THC and delta(9) -THC are very similar. delta(8) -THC is a …
We give special focus to studies that directly compared delta(8) -THC to its more commonly studied isomer, delta(9) -THC. Over …
Oral Administration of Cannabis and delta-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review.
Poyatos L, Pérez-Acevedo AP, Papaseit E, Pérez-Mañá C, Martin S, Hladun O, Siles A, Torrens M, Busardo FP, Farré M. Poyatos L, et al. Medicina (Kaunas). 2020 Jun 23;56(6):309. doi: 10.3390/medicina56060309. Medicina (Kaunas). 2020. PMID: 32585912 Free PMC article.
The purpose of this systematic review is to provide a general overview of the available PK data on cannabis and THC after oral administration. METHODS: A search of the published literature was conducted using the PubMed database to collect available articles describing the …
The purpose of this systematic review is to provide a general overview of the available PK data on cannabis and THC after oral admini …
Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.
Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. Johnson JR, et al. J Pain Symptom Manage. 2010 Feb;39(2):167-79. doi: 10.1016/j.jpainsymman.2009.06.008. Epub 2009 Nov 5. J Pain Symptom Manage. 2010. PMID: 19896326 Free article. Clinical Trial.
This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced cancer. In total, 177 patients with cancer …
This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid syste …
Cannabinoids: Therapeutic Use in Clinical Practice.
Pagano C, Navarra G, Coppola L, Avilia G, Bifulco M, Laezza C. Pagano C, et al. Int J Mol Sci. 2022 Mar 19;23(6):3344. doi: 10.3390/ijms23063344. Int J Mol Sci. 2022. PMID: 35328765 Free PMC article. Review.
Dronabinol and nabilone are used for the treatment of chemotherapy-induced nausea and vomiting in cancer patients. Dronabinol was approved for the treatment of anorexia in patients with AIDS (acquired immune deficiency syndrome). ...
Dronabinol and nabilone are used for the treatment of chemotherapy-induced nausea and vomiting in cancer patients. Dronabinol …
Pharmacokinetics and pharmacodynamics of cannabinoids.
Grotenhermen F. Grotenhermen F. Clin Pharmacokinet. 2003;42(4):327-60. doi: 10.2165/00003088-200342040-00003. Clin Pharmacokinet. 2003. PMID: 12648025 Review.
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidi …
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the …
Recent challenges and trends in forensic analysis: delta9-THC isomers pharmacology, toxicology and analysis.
La Maida N, Di Giorgi A, Pichini S, Busardò FP, Huestis MA. La Maida N, et al. J Pharm Biomed Anal. 2022 Oct 25;220:114987. doi: 10.1016/j.jpba.2022.114987. Epub 2022 Aug 8. J Pharm Biomed Anal. 2022. PMID: 35985136 Review.
Pharmacological activity is qualitatively similar for delta8-THC and delta9-THC, but most preclinical studies in mice, rats, and monkeys documented greater 9-THC potency. ...Current knowledge on the pharmacology of 8-THC and other 9-THC isomers …
Pharmacological activity is qualitatively similar for delta8-THC and delta9-THC, but most preclinical studies in mice, rats, a …
CBD, a precursor of THC in e-cigarettes.
Czégény Z, Nagy G, Babinszki B, Bajtel Á, Sebestyén Z, Kiss T, Csupor-Löffler B, Tóth B, Csupor D. Czégény Z, et al. Sci Rep. 2021 Apr 26;11(1):8951. doi: 10.1038/s41598-021-88389-z. Sci Rep. 2021. PMID: 33903673 Free PMC article.
Depending on the temperature and atmosphere, 25-52% of CBD was transformed into other chemical substances: delta(9)-THC, delta(8)-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC …
Depending on the temperature and atmosphere, 25-52% of CBD was transformed into other chemical substances: delta(9)-THC, delta(8)- …
Toxicogenetic analysis of delta9-THC-metabolizing enzymes.
Gasse A, Vennemann M, Köhler H, Schürenkamp J. Gasse A, et al. Int J Legal Med. 2020 Nov;134(6):2095-2103. doi: 10.1007/s00414-020-02380-3. Epub 2020 Jul 25. Int J Legal Med. 2020. PMID: 32712703 Free PMC article.
Genetic and demographic data as well as plasma concentrations of delta9-THC, 11-hydroxy-delta9-tetrahydrocannabinol (11-OH-delta9-THC), and 11-nor-9-carboxy-delta9-THC (delta9-THC-COOH) were combined and statistically investigated. ...There were also n …
Genetic and demographic data as well as plasma concentrations of delta9-THC, 11-hydroxy-delta9-tetrahydrocannabinol (11-OH-delta9- …
THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid.
Kruger DJ, Bone CC, Meacham MC, Klein C, Kruger JS. Kruger DJ, et al. J Psychoactive Drugs. 2024 Sep-Oct;56(4):563-567. doi: 10.1080/02791072.2023.2230573. Epub 2023 Jun 29. J Psychoactive Drugs. 2024. PMID: 37381980
There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and users have claimed that THC-Oac produces psychedelic effects; the current study is the first to examine this claim. Researchers develope …
There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and use …
Cannabis increases susceptibility to false memory.
Kloft L, Otgaar H, Blokland A, Monds LA, Toennes SW, Loftus EF, Ramaekers JG. Kloft L, et al. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4585-4589. doi: 10.1073/pnas.1920162117. Epub 2020 Feb 10. Proc Natl Acad Sci U S A. 2020. PMID: 32041881 Free PMC article. Clinical Trial.
In a double-blind, randomized, placebo-controlled trial, we examined the acute and delayed effects of delta9-tetrahydrocannabinol (THC) intoxication on susceptibility to false memory in 64 healthy volunteers. Memory was tested immediately (encoding and retrieval under drug …
In a double-blind, randomized, placebo-controlled trial, we examined the acute and delayed effects of delta9-tetrahydrocannabinol (THC …
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