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The determinants of food choice.
Leng G, Adan RAH, Belot M, Brunstrom JM, de Graaf K, Dickson SL, Hare T, Maier S, Menzies J, Preissl H, Reisch LA, Rogers PJ, Smeets PAM. Leng G, et al. Proc Nutr Soc. 2017 Aug;76(3):316-327. doi: 10.1017/S002966511600286X. Epub 2016 Dec 1. Proc Nutr Soc. 2017. PMID: 27903310 Review.
However, to produce policy recommendations that are likely to be effective, we need to be able to make valid predictions about the consequences of proposed interventions, and for this, we need a better understanding of the determinants of food choice. These …
However, to produce policy recommendations that are likely to be effective, we need to be able to make valid predictions about the consequen …
Is leptin resistance the cause or the consequence of diet-induced obesity?
de Git KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, Adan RAH. de Git KCG, et al. Int J Obes (Lond). 2018 Aug;42(8):1445-1457. doi: 10.1038/s41366-018-0111-4. Epub 2018 May 22. Int J Obes (Lond). 2018. PMID: 29789721
We here tested whether leptin sensitivity on a chow diet predicts subsequent weight gain and leptin sensitivity on a free choice high-fat high-sucrose (fcHFHS) diet. METHODS: Based upon individual leptin sensitivity on chow diet, rats were grouped in leptin sensitive (LS, …
We here tested whether leptin sensitivity on a chow diet predicts subsequent weight gain and leptin sensitivity on a free choice high …
The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns.
la Fleur SE, Luijendijk MC, van der Zwaal EM, Brans MA, Adan RA. la Fleur SE, et al. Int J Obes (Lond). 2014 May;38(5):643-9. doi: 10.1038/ijo.2013.159. Epub 2013 Aug 27. Int J Obes (Lond). 2014. PMID: 23979221
OBJECTIVES: Rats subjected to a free-choice high-fat high-sugar (fcHFHS) diet persistently overeat, exhibit increased food-motivated behavior and become overtly obese. Conversely, several studies using a non-choice (nc) high-energy diet showed only an …
OBJECTIVES: Rats subjected to a free-choice high-fat high-sugar (fcHFHS) diet persistently overeat, exhibit increased food-mot …
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.
van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RA, la Fleur SE. van den Heuvel JK, et al. Front Behav Neurosci. 2015 Dec 24;9:358. doi: 10.3389/fnbeh.2015.00358. eCollection 2015. Front Behav Neurosci. 2015. PMID: 26733840 Free PMC article.
We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of obesity. The aim of this study was to determine the influence of diet composition on feeding responses to a melanocortin receptor agonist, u …
We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of obesity …
Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats.
Peris-Sampedro F, Mounib M, Schéle E, Edvardsson CE, Stoltenborg I, Adan RAH, Dickson SL. Peris-Sampedro F, et al. Obesity (Silver Spring). 2019 Mar;27(3):409-419. doi: 10.1002/oby.22381. Epub 2019 Jan 30. Obesity (Silver Spring). 2019. PMID: 30699240 Free PMC article.
OBJECTIVE: Rats were exposed to free-choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety-like behavior were explored. ...In a second experiment, after 2 weeks o …
OBJECTIVE: Rats were exposed to free-choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabo …
Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice.
van Meer F, van der Laan LN, Eiben G, Lissner L, Wolters M, Rach S, Herrmann M, Erhard P, Molnar D, Orsi G, Viergever MA, Adan RAH, Smeets PAM; I.Family Consortium. van Meer F, et al. Neuroimage. 2019 Nov 1;201:116016. doi: 10.1016/j.neuroimage.2019.116016. Epub 2019 Jul 13. Neuroimage. 2019. PMID: 31310861 Free article.
Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefr …
Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neur …
The MC4 receptor and control of appetite.
Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M. Adan RA, et al. Br J Pharmacol. 2006 Dec;149(7):815-27. doi: 10.1038/sj.bjp.0706929. Epub 2006 Oct 16. Br J Pharmacol. 2006. PMID: 17043670 Free PMC article. Review.
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by infusion …
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a …
Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance.
de Backer MW, Brans MA, van Rozen AJ, van der Zwaal EM, Luijendijk MC, Garner KG, de Krom M, van Beekum O, la Fleur SE, Adan RA. de Backer MW, et al. J Mol Endocrinol. 2010 Nov;45(5):341-53. doi: 10.1677/JME-10-0057. Epub 2010 Sep 6. J Mol Endocrinol. 2010. PMID: 20819948
Socs3 mRNA was down-regulated by local injection of adeno-associated viral vectors expressing a short hairpin directed against Socs3, after which we determined the response to high-fat high-sucrose choice diet. In contrast to neuronal Socs3 knockout mice, rats with …
Socs3 mRNA was down-regulated by local injection of adeno-associated viral vectors expressing a short hairpin directed against Socs3, after …
Neuropeptide Y and leptin sensitivity is dependent on diet composition.
van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MC, Fliers E, Kalsbeek A, Adan RA, la Fleur SE. van den Heuvel JK, et al. J Neuroendocrinol. 2014 Jun;26(6):377-85. doi: 10.1111/jne.12155. J Neuroendocrinol. 2014. PMID: 24698502
Second, we focused on the role of NPY on feeding behaviour, and measured NPY mRNA levels and sensitivity to NPY after 4 weeks on the different choice diets. To determine leptin sensitivity, we measured food intake after i.p. leptin or vehicle injections in ma …
Second, we focused on the role of NPY on feeding behaviour, and measured NPY mRNA levels and sensitivity to NPY after 4 weeks on the differe …
Association study of POMC variants with body composition measures and nutrient choice.
Ternouth A, Brandys MK, van der Schouw YT, Hendriks J, Jansson JO, Collier D, Adan RA. Ternouth A, et al. Eur J Pharmacol. 2011 Jun 11;660(1):220-5. doi: 10.1016/j.ejphar.2010.10.112. Epub 2011 Jan 3. Eur J Pharmacol. 2011. PMID: 21211529
Genome linkage scans and candidate gene studies have implicated the pro-opiomelanocortin (POMC) locus in traits related to food intake, metabolic function, and body mass index. Here we investigate single nucleotide polymorphisms at the POMC locus in order to evaluate the i …
Genome linkage scans and candidate gene studies have implicated the pro-opiomelanocortin (POMC) locus in traits related to food intak …
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