Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1985 1
1986 2
1994 1
1996 1
1997 1
1999 2
2001 2
2004 1
2005 1
2006 1
2007 1
2009 2
2010 1
2011 4
2012 3
2013 2
2014 1
2015 4
2016 2
2017 2
2018 3
2019 2
2020 2
2021 1
2022 2
2023 2
2024 1
2025 4
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

49 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean thobromide chocolate pharmacology (1,568 results)?
Theobromine and the pharmacology of cocoa.
Smit HJ. Smit HJ. Handb Exp Pharmacol. 2011;(200):201-34. doi: 10.1007/978-3-642-13443-2_7. Handb Exp Pharmacol. 2011. PMID: 20859797 Review.
The effects of theobromine in man are underresearched, possibly owing to the assumption that it is behaviourally inert. ...Of all constituents proposed to play a role in our liking for chocolate, caffeine is the most convincing, though a role for theobromine …
The effects of theobromine in man are underresearched, possibly owing to the assumption that it is behaviourally inert. ...Of all con …
Flavan-3-ols, theobromine, and the effects of cocoa and chocolate on cardiometabolic risk factors.
Berends LM, van der Velpen V, Cassidy A. Berends LM, et al. Curr Opin Lipidol. 2015 Feb;26(1):10-9. doi: 10.1097/MOL.0000000000000144. Curr Opin Lipidol. 2015. PMID: 25551798 Review.
This review summarizes the recent research on the cardiometabolic effects of cocoa and chocolate with a focus on two key constituents: flavan-3-ols and theobromine. RECENT FINDINGS: Recent meta-analyses suggest beneficial cardiometabolic effects of chocolate …
This review summarizes the recent research on the cardiometabolic effects of cocoa and chocolate with a focus on two key constituents …
The cardiovascular benefits of dark chocolate.
Kerimi A, Williamson G. Kerimi A, et al. Vascul Pharmacol. 2015 Aug;71:11-5. doi: 10.1016/j.vph.2015.05.011. Epub 2015 May 27. Vascul Pharmacol. 2015. PMID: 26026398 Free article. Review.
Dark chocolate contains many biologically active components, such as catechins, procyanidins and theobromine from cocoa, together with added sucrose and lipids. ...For intervention studies, the situation is complex since suitable placebos are often not available, an …
Dark chocolate contains many biologically active components, such as catechins, procyanidins and theobromine from cocoa, toget …
Reinforcing effects of caffeine and theobromine as found in chocolate.
Smit HJ, Blackburn RJ. Smit HJ, et al. Psychopharmacology (Berl). 2005 Aug;181(1):101-6. doi: 10.1007/s00213-005-2209-3. Epub 2005 Oct 15. Psychopharmacology (Berl). 2005. PMID: 15772863 Clinical Trial.
RATIONALE: Although in a previous study we showed that caffeine and theobromine were the main psychopharmacologically active constituents in a 50-g bar of chocolate, mere activity does not guarantee a role in our liking for the food. ...CONCLUSIONS: Methylxanthines …
RATIONALE: Although in a previous study we showed that caffeine and theobromine were the main psychopharmacologically active constitu …
High levels of methylxanthines in chocolate do not alter theobromine disposition.
Shively CA, Tarka SM Jr, Arnaud MJ, Dvorchik BH, Passananti GT, Vesell ES. Shively CA, et al. Clin Pharmacol Ther. 1985 Apr;37(4):415-24. doi: 10.1038/clpt.1985.65. Clin Pharmacol Ther. 1985. PMID: 3979003
Theobromine disposition was measured twice in 12 normal men, once after 14 days of abstention from all methylxanthines and once after 1 week of theobromine (6 mg/kg/day) in the form of dark chocolate. ...A week of daily theobromine consumption in the f …
Theobromine disposition was measured twice in 12 normal men, once after 14 days of abstention from all methylxanthines and once after …
Chocolate--guilty pleasure or healthy supplement?
Latham LS, Hensen ZK, Minor DS. Latham LS, et al. J Clin Hypertens (Greenwich). 2014 Feb;16(2):101-6. doi: 10.1111/jch.12223. J Clin Hypertens (Greenwich). 2014. PMID: 24734311 Free PMC article. Review.
Dark chocolate and other cocoa products are popular in the population as a whole, but their overall health benefit remains controversial. ...Additionally, several mechanisms have been proposed that might confer cocoa's possible health benefit, but no consensus has been rea …
Dark chocolate and other cocoa products are popular in the population as a whole, but their overall health benefit remains controvers …
To Eat or Not to Eat: A Review of the Relationship between Chocolate and Migraines.
Nowaczewska M, Wiciński M, Kaźmierczak W, Kaźmierczak H. Nowaczewska M, et al. Nutrients. 2020 Feb 26;12(3):608. doi: 10.3390/nu12030608. Nutrients. 2020. PMID: 32110888 Free PMC article. Review.
Here, we identify 25 studies investigating the prevalence of chocolate as a trigger factor in migraineurs. Three provocative studies have also evaluated if chocolate can trigger migraine attacks, comparing it to a placebo. Among them, in 23 studies, chocolate …
Here, we identify 25 studies investigating the prevalence of chocolate as a trigger factor in migraineurs. Three provocative studies …
From Cocoa to Chocolate: Effect of Processing on Flavanols and Methylxanthines and Their Mechanisms of Action.
Goya L, Kongor JE, de Pascual-Teresa S. Goya L, et al. Int J Mol Sci. 2022 Nov 18;23(22):14365. doi: 10.3390/ijms232214365. Int J Mol Sci. 2022. PMID: 36430843 Free PMC article. Review.
More data on the cocoa processing effect on cocoa bioactives are still needed for better understanding the effect of each processing step on the final polyphenolic and methylxanthine composition of chocolate and other cocoa products. Regarding the mechanisms of action, …
More data on the cocoa processing effect on cocoa bioactives are still needed for better understanding the effect of each processing step on …
The Therapeutic Potential of Theobromine in Obesity: A Comprehensive Review.
Tuğal Aslan D, Göktaş Z. Tuğal Aslan D, et al. Nutr Rev. 2025 May 1;83(5):859-868. doi: 10.1093/nutrit/nuae122. Nutr Rev. 2025. PMID: 39271172 Free PMC article. Review.
Phytochemicals found in plants are being explored for therapeutic use, particularly in combating obesity. Among these, theobromine, commonly found in cocoa and chocolate, shows promise. Although not as extensively studied as caffeine, theobromine exhibits pos …
Phytochemicals found in plants are being explored for therapeutic use, particularly in combating obesity. Among these, theobromine, c …
Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.
Monteiro JP, Alves MG, Oliveira PF, Silva BM. Monteiro JP, et al. Molecules. 2016 Jul 27;21(8):974. doi: 10.3390/molecules21080974. Molecules. 2016. PMID: 27472311 Free PMC article. Review.
They are unobtrusively included in daily diet in common products as coffee, tea, energetic drinks, or chocolate. Caffeine is by far the most studied methylxanthine either in animal or epidemiologic studies. Theophylline and theobromine are other relevant methylxanth …
They are unobtrusively included in daily diet in common products as coffee, tea, energetic drinks, or chocolate. Caffeine is by far t …
49 results