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Therapeutic drug monitoring to individualize the dosing of pazopanib: a pharmacokinetic feasibility study.
de Wit D, van Erp NP, den Hartigh J, Wolterbeek R, den Hollander-van Deursen M, Labots M, Guchelaar HJ, Verheul HM, Gelderblom H. de Wit D, et al. Ther Drug Monit. 2015 Jun;37(3):331-8. doi: 10.1097/FTD.0000000000000141. Ther Drug Monit. 2015. PMID: 25271729 Clinical Trial.
The primary objective of this study was to evaluate the feasibility of pharmacokinetics (PK)-guided individualized dosing to reduce the interpatient variability in pazopanib exposure. ...During the second period, the patients either recei …
The primary objective of this study was to evaluate the feasibility of pharmacokinetics (PK)-guided individualized
Optimizing the dose in cancer patients treated with imatinib, sunitinib and pazopanib.
Lankheet NAG, Desar IME, Mulder SF, Burger DM, Kweekel DM, van Herpen CML, van der Graaf WTA, van Erp NP. Lankheet NAG, et al. Br J Clin Pharmacol. 2017 Oct;83(10):2195-2204. doi: 10.1111/bcp.13327. Epub 2017 Jul 4. Br J Clin Pharmacol. 2017. PMID: 28500677 Free PMC article.
A relationship between plasma exposure and treatment outcome has been established, which supports the rationale for dose optimization of these drugs. The aim of this study was to monitor how many patients reached adequate trough levels after therapeutic drug
A relationship between plasma exposure and treatment outcome has been established, which supports the rationale for dose optimization of the …