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Advances in Evaluation of Chronic Diarrhea in Infants.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG; PediCODE Consortium. Thiagarajah JR, et al. Gastroenterology. 2018 Jun;154(8):2045-2059.e6. doi: 10.1053/j.gastro.2018.03.067. Epub 2018 Apr 12. Gastroenterology. 2018. PMID: 29654747 Free PMC article. Review.

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Secretory diarrhoea: mechanisms and emerging therapies.

Thiagarajah JR, Donowitz M, Verkman AS. Thiagarajah JR, et al. Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):446-57. doi: 10.1038/nrgastro.2015.111. Epub 2015 Jun 30. Nat Rev Gastroenterol Hepatol. 2015. PMID: 26122478 Free PMC article. Review.

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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.

Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. Grey MJ, et al. Among authors: thiagarajah jr. J Cell Biol. 2020 Feb 3;219(2):e201904048. doi: 10.1083/jcb.201904048. J Cell Biol. 2020. PMID: 31985747 Free PMC article.

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Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.

Jardine S, Anderson S, Babcock S, Leung G, Pan J, Dhingani N, Warner N, Guo C, Siddiqui I, Kotlarz D, Dowling JJ, Melnyk RA, Snapper SB, Klein C, Thiagarajah JR, Muise AM. Jardine S, et al. Among authors: thiagarajah jr. Gastroenterology. 2020 Mar;158(4):1000-1015. doi: 10.1053/j.gastro.2019.11.019. Epub 2019 Nov 16. Gastroenterology. 2020. PMID: 31743734 Free PMC article.

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CFTR inhibitors.

Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. Verkman AS, et al. Among authors: thiagarajah jr. Curr Pharm Des. 2013;19(19):3529-41. doi: 10.2174/13816128113199990321. Curr Pharm Des. 2013. PMID: 23331030 Free PMC article. Review.

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Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling.

Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Chang D, et al. Among authors: thiagarajah jr. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117. Epub 2020 Oct 21. Proc Natl Acad Sci U S A. 2020. PMID: 33087577 Free article.

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CFTR inhibitors for treating diarrheal disease.

Thiagarajah JR, Verkman AS. Thiagarajah JR, et al. Clin Pharmacol Ther. 2012 Sep;92(3):287-90. doi: 10.1038/clpt.2012.114. Epub 2012 Aug 1. Clin Pharmacol Ther. 2012. PMID: 22850599 Free PMC article. Review.

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A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.

Luong P, Li Q, Chen PF, Wrighton PJ, Chang D, Dwyer S, Bayer MT, Snapper SB, Hansen SH, Thiagarajah JR, Goessling W, Lencer WI. Luong P, et al. Among authors: thiagarajah jr. Mol Biol Cell. 2020 Mar 19;31(7):511-519. doi: 10.1091/mbc.E19-07-0375. Epub 2019 Nov 27. Mol Biol Cell. 2020. PMID: 31774722 Free PMC article.

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Chloride channel-targeted therapy for secretory diarrheas.

Thiagarajah JR, Verkman AS. Thiagarajah JR, et al. Curr Opin Pharmacol. 2013 Dec;13(6):888-94. doi: 10.1016/j.coph.2013.08.005. Epub 2013 Aug 27. Curr Opin Pharmacol. 2013. PMID: 23992767 Free PMC article. Review.

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Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.

Duan T, Cil O, Thiagarajah JR, Verkman AS. Duan T, et al. Among authors: thiagarajah jr. JCI Insight. 2019 Feb 21;4(4):e126444. doi: 10.1172/jci.insight.126444. eCollection 2019 Feb 21. JCI Insight. 2019. PMID: 30668547 Free PMC article.

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