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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1975 2
1976 2
1978 1
1979 1
1980 1
1983 1
1986 1
1988 5
1989 1
1990 3
1991 3
1992 4
1993 7
1994 9
1995 7
1996 4
1997 9
1998 3
1999 4
2000 5
2001 4
2002 4
2003 5
2004 3
2005 10
2006 8
2007 5
2008 10
2009 11
2010 6
2011 6
2012 8
2013 10
2014 9
2015 11
2016 15
2017 11
2018 8
2019 16
2020 25
2021 27
2022 27
2023 20
2024 24
2025 10
2026 5

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337 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
What is the optimum thiamine dose to treat or prevent Wernicke's encephalopathy or Wernicke-Korsakoff syndrome? Results of a randomized controlled trial.
Dingwall KM, Delima JF, Binks P, Batey R, Bowden SC. Dingwall KM, et al. Alcohol Clin Exp Res. 2022 Jun;46(6):1133-1147. doi: 10.1111/acer.14843. Epub 2022 May 10. Alcohol Clin Exp Res. 2022. PMID: 35428992 Free PMC article. Clinical Trial.
While observational studies show parenteral thiamine administration drastically reduced WKS-related mortality, relevant treatment trials have never been conducted to determine the optimum thiamine dose. ...CONCLUSIONS: The results of this study showed no clear benef …
While observational studies show parenteral thiamine administration drastically reduced WKS-related mortality, relevant treatment tri …
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW; VICTAS Investigators. Sevransky JE, et al. JAMA. 2021 Feb 23;325(8):742-750. doi: 10.1001/jama.2020.24505. JAMA. 2021. PMID: 33620405 Free PMC article. Clinical Trial.
IMPORTANCE: Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis. OBJECTIVE: To determine whether a combination of vitamin C, t …
IMPORTANCE: Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticost …
Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.
Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R; VITAMINS Trial Investigators. Fujii T, et al. JAMA. 2020 Feb 4;323(5):423-431. doi: 10.1001/jama.2019.22176. JAMA. 2020. PMID: 31950979 Free PMC article. Clinical Trial.
IMPORTANCE: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. ...The finding suggests that treatment with intravenous vitamin C, hydrocortisone, and thiamine does not …
IMPORTANCE: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting …
Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
Nakanishi N, Abe Y, Matsuo M, Tampo A, Yamada K, Hatakeyama J, Yoshida M, Yamamoto R, Higashibeppu N, Nakamura K, Kotani J. Nakanishi N, et al. Clin Nutr. 2024 Nov;43(11):1-9. doi: 10.1016/j.clnu.2024.09.002. Epub 2024 Sep 16. Clin Nutr. 2024. PMID: 39307094
BACKGROUND &AIMS: Thiamine is an essential micronutrient for energy metabolism. Thiamine deficiency is frequently observed in critically ill patients. However, the effect of thiamine administration is unclear in critically ill patients. METHODS: We conduc …
BACKGROUND &AIMS: Thiamine is an essential micronutrient for energy metabolism. Thiamine deficiency is frequently observed …
Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials.
Qian X, Zhang Z, Li F, Wu L. Qian X, et al. Am J Emerg Med. 2020 Dec;38(12):2718-2722. doi: 10.1016/j.ajem.2020.08.050. Epub 2020 Aug 21. Am J Emerg Med. 2020. PMID: 33036854
INTRODUCTION: The efficacy of intravenous thiamine to treat septic shock remains controversial. We conduct a systematic review and meta-analysis to explore the impact of intravenous thiamine on treatment efficacy of septic shock. ...CONCLUSIONS: Intravenous thiam …
INTRODUCTION: The efficacy of intravenous thiamine to treat septic shock remains controversial. We conduct a systematic review and me …
Association between diabetes and thiamine status - A systematic review and meta-analysis.
Ziegler D, Reiners K, Strom A, Obeid R. Ziegler D, et al. Metabolism. 2023 Jul;144:155565. doi: 10.1016/j.metabol.2023.155565. Epub 2023 Apr 23. Metabolism. 2023. PMID: 37094704 Free article.
BACKGROUND: Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism. ...Compared to controls, individuals with d …
BACKGROUND: Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine stat …
ESPEN micronutrient guideline.
Berger MM, Shenkin A, Schweinlin A, Amrein K, Augsburger M, Biesalski HK, Bischoff SC, Casaer MP, Gundogan K, Lepp HL, de Man AME, Muscogiuri G, Pietka M, Pironi L, Rezzi S, Cuerda C. Berger MM, et al. Clin Nutr. 2022 Jun;41(6):1357-1424. doi: 10.1016/j.clnu.2022.02.015. Epub 2022 Feb 26. Clin Nutr. 2022. PMID: 35365361 Free article.
Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials.
Syed ARS, Syed AA, Akram A, Azam MS, Muzammil MA, Deepak, Ansari AI, Eqbal F, Farooq MH, Khatri M, Kumar S, Kumar N. Syed ARS, et al. Heart Lung. 2023 Sep-Oct;61:37-45. doi: 10.1016/j.hrtlng.2023.04.011. Epub 2023 Apr 30. Heart Lung. 2023. PMID: 37126872
BACKGROUND: Heart failure is a pathophysiological condition where decreased cardiac output is observed subsequent to any structural deformity or cessation of normal function. Thiamine deficiency is one of the risk factors responsible for causing HF; other risk factors incl …
BACKGROUND: Heart failure is a pathophysiological condition where decreased cardiac output is observed subsequent to any structural deformit …
Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis.
Ge Z, Huang J, Liu Y, Xiang J, Gao Y, Walline JH, Lu X, Yu S, Zhao L, Li Y. Ge Z, et al. Eur J Emerg Med. 2021 Jun 1;28(3):189-195. doi: 10.1097/MEJ.0000000000000812. Eur J Emerg Med. 2021. PMID: 33709993
BACKGROUND: Thiamine and vitamin C have been increasingly used in patients with sepsis or septic shock because of their potential for improving metabolism and reducing mortality. OBJECTIVE: We aim to determine if thiamine combined vitamin C can reduce mortality in p …
BACKGROUND: Thiamine and vitamin C have been increasingly used in patients with sepsis or septic shock because of their potential for …
Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta-Analysis of Randomized Controlled Trials.
He S, Wang S, Xu T, Wang S, Qi M, Chen Q, Lin L, Wu H, Gan P. He S, et al. Clin Cardiol. 2024 Jul;47(7):e24309. doi: 10.1002/clc.24309. Clin Cardiol. 2024. PMID: 38940395 Free PMC article.
BACKGROUND: Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine supplementation in CHF patients remains uncertain. HYPOTHESIS: Receiving supplementary thiamine may not confer benefits to patients w …
BACKGROUND: Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine …
337 results