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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 6
1989 10
1990 12
1991 25
1992 31
1993 34
1994 53
1995 41
1996 45
1997 37
1998 42
1999 32
2000 33
2001 35
2002 42
2003 23
2004 27
2005 27
2006 40
2007 34
2008 30
2009 26
2010 31
2011 25
2012 17
2013 23
2014 12
2015 14
2016 16
2017 8
2018 8
2019 10
2020 7
2021 10
2022 13
2023 2
2024 1

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824 results

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Page 1
Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis.
Wang J, Liu B, Xu Y, Luan H, Wang C, Yang M, Zhao R, Song M, Liu J, Sun L, You J, Wang W, Sun F, Yan H. Wang J, et al. Exp Neurol. 2022 Jan;347:113870. doi: 10.1016/j.expneurol.2021.113870. Epub 2021 Sep 23. Exp Neurol. 2022. PMID: 34563511
H89, an inhibitor of CREB signaling, abolished these effects of thioperamide to suppress gliosis and proinflammatory cytokine release. ...This study uncovered a novel mechanism involving inflammatory regulating behind the therapeutic effect of thioperamide in AD....
H89, an inhibitor of CREB signaling, abolished these effects of thioperamide to suppress gliosis and proinflammatory cytokine release …
Thioperamide treats neonatal hypoxic-ischemic encephalopathy by postsynaptic H1 receptors.
Jia F, Du L, Hao Y, Liu S, Li N, Jiang H. Jia F, et al. Neural Regen Res. 2013 Jul 5;8(19):1814-22. doi: 10.3969/j.issn.1673-5374.2013.19.009. Neural Regen Res. 2013. PMID: 25206478 Free PMC article.
This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxic-ischemic encephalopathy. ...Experimental findings indicated that pyrilamine reversed the effects of thioperamide; however, cimetidine had no sig …
This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxic-ischemic en …
Activation of CREB-mediated autophagy by thioperamide ameliorates beta-amyloid pathology and cognition in Alzheimer's disease.
Wang J, Liu B, Xu Y, Yang M, Wang C, Song M, Liu J, Wang W, You J, Sun F, Wang D, Liu D, Yan H. Wang J, et al. Aging Cell. 2021 Mar;20(3):e13333. doi: 10.1111/acel.13333. Epub 2021 Mar 8. Aging Cell. 2021. PMID: 33682314 Free PMC article.
However, the effect of thioperamide on autophagic function and Abeta pathology in AD remains unknown. ...This study uncovered a novel mechanism involving autophagic regulating behind the therapeutic effect of thioperamide in AD....
However, the effect of thioperamide on autophagic function and Abeta pathology in AD remains unknown. ...This study uncovered a novel …
Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.
Vohora D, Pal SN, Pillai KK. Vohora D, et al. Life Sci. 2000 Apr 21;66(22):PL297-301. doi: 10.1016/s0024-3205(00)00548-8. Life Sci. 2000. PMID: 10834305
The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely counte …
The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide
[3H]-thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex.
Alves-Rodrigues A, Leurs R, Wu TS, Prell GD, Foged C, Timmerman H. Alves-Rodrigues A, et al. Br J Pharmacol. 1996 Aug;118(8):2045-52. doi: 10.1111/j.1476-5381.1996.tb15642.x. Br J Pharmacol. 1996. PMID: 8864541 Free PMC article.
The purpose of the present study was to characterize the binding of the histamine H3 receptor antagonist, [3H]-thioperamide, to rat cerebral cortical membranes. 2. The binding of [3H]-thioperamide to rat cerebral cortical membranes reached equilibrium after incubati …
The purpose of the present study was to characterize the binding of the histamine H3 receptor antagonist, [3H]-thioperamide, to rat c …
Evaluation of Thioperamide Effects Using Rat's Trachea Model.
Chiu FH, Wang HW. Chiu FH, et al. Clin Exp Otorhinolaryngol. 2013 Mar;6(1):12-7. doi: 10.3342/ceo.2013.6.1.12. Epub 2013 Mar 8. Clin Exp Otorhinolaryngol. 2013. PMID: 23526076 Free PMC article.
This study was to determine the effects of thioperamide on the trachea of rats in vitro. METHODS: We tested the effectiveness of thioperamide on isolated rat trachea submersed in Kreb's solution in a muscle bath. ...RESULTS: Thioperamide induced a significant …
This study was to determine the effects of thioperamide on the trachea of rats in vitro. METHODS: We tested the effectiveness of t
Effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions in mice.
Yokoyama H, Onodera K, Iinuma K, Watanabe T. Yokoyama H, et al. Eur J Pharmacol. 1993 Mar 30;234(1):129-33. doi: 10.1016/0014-2999(93)90717-v. Eur J Pharmacol. 1993. PMID: 8386092
The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. ...Thus, the blockade by mepyramine of the thioperamide-induced decrease in seizure susceptibility indicates that histamine released by thiope
The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. ...Thus, the …
Thioperamide reduces intracellular calcium in mouse brain synaptosomes.
Vohora D, Pal SN, Pillai KK. Vohora D, et al. Eur Neuropsychopharmacol. 2007 Apr;17(5):375-6. doi: 10.1016/j.euroneuro.2006.08.002. Epub 2006 Sep 25. Eur Neuropsychopharmacol. 2007. PMID: 16996723
In this report, we present the first experimental evidence showing a concentration-dependent reduction of free calcium in the mouse brain synaptosomes by thioperamide (THP), an H3 receptor antagonist. This is interesting in view of the recent reports on the anticonvulsant …
In this report, we present the first experimental evidence showing a concentration-dependent reduction of free calcium in the mouse brain sy …
Thioperamide, a histamine H3 receptor antagonist, increases GABA release from the rat hypothalamus.
Yamamoto Y, Mochizuki T, Okakura-Mochizuki K, Uno A, Yamatodani A. Yamamoto Y, et al. Methods Find Exp Clin Pharmacol. 1997 Jun;19(5):289-98. Methods Find Exp Clin Pharmacol. 1997. PMID: 9379777
The addition of thioperamide to the perfusion fluid increased the release of GABA and histamine. ...These results suggest that the effect of thioperamide on GABA release is not mediated by histamine H3 receptors and that thioperamide acts on the transporter t …
The addition of thioperamide to the perfusion fluid increased the release of GABA and histamine. ...These results suggest that the ef …
824 results