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131 results

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Page 1
QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations.
Berling I, Yates C, Hoffman RS, Hatten BW, Roberts DM, Wong A, Hoegberg LCG, Lonati D, Ferrer Dufol AMA, Hayes BD, Isbister GK, Paasma R, Heyerdahl F, Mackenzie CA, Othong R, Stanton M, Smith A, Gosselin S. Berling I, et al. Clin Toxicol (Phila). 2025 Nov;63(11):810-837. doi: 10.1080/15563650.2025.2554950. Epub 2025 Nov 19. Clin Toxicol (Phila). 2025. PMID: 41255343 Free article.
INTRODUCTION: Antipsychotic medications are often associated with QT interval prolongation, which can lead to ventricular dysrhythmias, including torsade de pointes. ...Available data suggest that amisulpride, thioridazine and ziprasidone are associated with …
INTRODUCTION: Antipsychotic medications are often associated with QT interval prolongation, which can lead to ventricular dysrhythmia …
Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management.
Tisdale JE. Tisdale JE. Can Pharm J (Ott). 2016 May;149(3):139-52. doi: 10.1177/1715163516641136. Epub 2016 Apr 8. Can Pharm J (Ott). 2016. PMID: 27212965 Free PMC article. Review.
Torsades de pointes (TdP) is a life-threatening arrhythmia associated with prolongation of the corrected QT (QTc) interval on the electrocardiogram. ...Other important pharmacokinetic interactions include antidepressants (bupropion, duloxetine, fluoxetine, paroxetin …
Torsades de pointes (TdP) is a life-threatening arrhythmia associated with prolongation of the corrected QT (QTc) interval on …
Torsade de pointes.
Roden DM. Roden DM. Clin Cardiol. 1993 Sep;16(9):683-6. doi: 10.1002/clc.4960160910. Clin Cardiol. 1993. PMID: 7902224 Free article. Review.
The polymorphic ventricular tachycardia torsade de pointes can occur in the congenital long QT syndromes or as a consequence of therapy with QT-prolonging drugs. The latter can include not only antiarrhythmic drugs such as quinidine, but also a number of drug …
The polymorphic ventricular tachycardia torsade de pointes can occur in the congenital long QT syndromes or as a consequence o …
[Psychopharmaceuticals and arrhythmias].
Binggeli C, Candinas R, Brunckhorst C. Binggeli C, et al. Ther Umsch. 2004 Apr;61(4):279-83. doi: 10.1024/0040-5930.61.4.279. Ther Umsch. 2004. PMID: 15137522 Review. German.
Selective serotonin reuptake inhibitors seem to be safe. Patients with a prolonged QT-interval or patients that experienced Torsade de pointes are at a considerable higher risk upon exposition to a QT-prolonging drug. Drug interactions played a role in many f …
Selective serotonin reuptake inhibitors seem to be safe. Patients with a prolonged QT-interval or patients that experienced Torsad …
Thioridazine for schizophrenia.
Fenton M, Rathbone J, Reilly J, Sultana A. Fenton M, et al. Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD001944. doi: 10.1002/14651858.CD001944.pub2. Cochrane Database Syst Rev. 2007. PMID: 17636691 Free PMC article.
BACKGROUND: Thioridazine is an antipsychotic that can still be used for schizophrenia although it is associated with the cardiac arrhythmia, torsades de pointe. ...Thioridazine is sedating (n=324, 3 RCTs, RR 5.37 CI 3.2 to 9.1, NNH 4 CI 2 to 74). Generally, …
BACKGROUND: Thioridazine is an antipsychotic that can still be used for schizophrenia although it is associated with the cardiac arrh …
Management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval.
Ries R, Sayadipour A. Ries R, et al. J Psychiatr Pract. 2014 Sep;20(5):338-44. doi: 10.1097/01.pra.0000454778.29433.7c. J Psychiatr Pract. 2014. PMID: 25226194 Review.
We review the literature on management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval, a risk factor for torsade de pointes (TdP), and we describe our protocols for treating these patients. ...Prolonged QTc …
We review the literature on management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT …
Antipsychotic drugs and QT prolongation.
Stöllberger C, Huber JO, Finsterer J. Stöllberger C, et al. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51. doi: 10.1097/01.yic.0000166405.49473.70. Int Clin Psychopharmacol. 2005. PMID: 16096514 Review.
AD may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes (TdP) and sudden death. Epidemiologic data and case-control studies indicate an increased rate of sudden death in psychiatric patients taking …
AD may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes ( …
Thioridazine Therapy and CYP2D6 Genotypes.
Dean L, Kane M. Dean L, et al. 2017 Feb 9 [updated 2026 Jan 14]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2017 Feb 9 [updated 2026 Jan 14]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 28520378 Free Books & Documents. Review.
Thioridazine has been shown to prolong the QT interval (the time taken for the heart ventricles to depolarize and repolarize) in a dose related manner. ...The FDA-approved drug label for thioridazine states that thioridazine is contraindicated in indiv …
Thioridazine has been shown to prolong the QT interval (the time taken for the heart ventricles to depolarize and repolarize) …
Antipsychotic drugs and QT interval prolongation.
Zareba W, Lin DA. Zareba W, et al. Psychiatr Q. 2003 Fall;74(3):291-306. doi: 10.1023/a:1024122706337. Psychiatr Q. 2003. PMID: 12918603 Review.
Antipsychotic drugs prolong QT interval usually by blocking the potassium IKr current. Improved understanding of ion channel structure and kinetics and its role in repolarization has tremendous impact on understanding of the mechanisms of drug-induced QT prolongatio …
Antipsychotic drugs prolong QT interval usually by blocking the potassium IKr current. Improved understanding of ion channel structur …
Factors affecting drug concentrations and QT interval during thioridazine therapy.
Thanacoody RH, Daly AK, Reilly JG, Ferrier IN, Thomas SH. Thanacoody RH, et al. Clin Pharmacol Ther. 2007 Nov;82(5):555-65. doi: 10.1038/sj.clpt.6100195. Epub 2007 Apr 25. Clin Pharmacol Ther. 2007. PMID: 17460606
The objective of this study was to investigate factors affecting steady-state plasma concentrations of thioridazine. A cross-sectional study of patients receiving chronic thioridazine was employed. ...Smokers had significantly lower C/D for thioridazine, meso …
The objective of this study was to investigate factors affecting steady-state plasma concentrations of thioridazine. A cross-sectiona …
131 results