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Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries.
Thom SR, Yang M, Bhopale VM, Huang S, Milovanova TN. Thom SR, et al. J Appl Physiol (1985). 2011 Feb;110(2):340-51. doi: 10.1152/japplphysiol.00811.2010. Epub 2010 Oct 21. J Appl Physiol (1985). 2011. PMID: 20966192 Free article.
MPs expressing platelet surface markers, in particular, interact with circulating neutrophils, causing them to degranulate and leading to further MP production. ...Both MP abatement strategies reduce decompression-induced intravascular neutrophil activation, neut
MPs expressing platelet surface markers, in particular, interact with circulating neutrophils, causing them to degranulate and leadin …
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil β(2) integrin function.
Thom SR, Bhopale VM, Milovanova TN, Yang M, Bogush M. Thom SR, et al. J Biol Chem. 2012 Aug 31;287(36):30346-57. doi: 10.1074/jbc.M112.355875. Epub 2012 Jul 9. J Biol Chem. 2012. PMID: 22778269 Free PMC article.
The investigation goal was to identify mechanisms for reversal of actin S-nitrosylation in neutrophils after exposure to high oxygen partial pressures. ...S-Nitrosylation accelerates actin filament turnover (by mechanisms described previously (Thom, S. …
The investigation goal was to identify mechanisms for reversal of actin S-nitrosylation in neutrophils after exposure to high …
Neutrophil beta2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with S-nitrosylated actin.
Thom SR, Bhopale VM, Yang M, Bogush M, Huang S, Milovanova TN. Thom SR, et al. J Biol Chem. 2011 Sep 16;286(37):32854-65. doi: 10.1074/jbc.M111.255778. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795685 Free PMC article.
Production of reactive species in neutrophils exposed to hyperoxia causes S-nitrosylation of β-actin, which increases formation of short actin filaments, leading to alterations in the cytoskeletal network that inhibit β(2) integrin-dependent adherence (Thom, S
Production of reactive species in neutrophils exposed to hyperoxia causes S-nitrosylation of β-actin, which increases formatio …
Microparticle enlargement and altered surface proteins after air decompression are associated with inflammatory vascular injuries.
Yang M, Milovanova TN, Bogush M, Uzun G, Bhopale VM, Thom SR. Yang M, et al. Among authors: thom sr. J Appl Physiol (1985). 2012 Jan;112(1):204-11. doi: 10.1152/japplphysiol.00953.2011. Epub 2011 Sep 29. J Appl Physiol (1985). 2012. PMID: 21960660 Free PMC article.
Intravenous injection of naive mice with particles isolated from decompressed mice, but not control mice, caused intravascular neutrophil activation; perivascular neutrophil sequestration and tissue injuries were documented as elevations of vascular permeability and …
Intravenous injection of naive mice with particles isolated from decompressed mice, but not control mice, caused intravascular neutrophil
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