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Page 1
Hypotensive Snake Venom Components-A Mini-Review.
Péterfi O, Boda F, Szabó Z, Ferencz E, Bába L. Péterfi O, et al. Molecules. 2019 Jul 31;24(15):2778. doi: 10.3390/molecules24152778. Molecules. 2019. PMID: 31370142 Free PMC article. Review.
Such snake venom components include bradykinin potentiating peptides (proline-rich oligopeptides), natriuretic peptides, phospholipases A(2), serine-proteases and vascular endothelial growth factors. Some heparin binding hypotensive factors, three-finger …
Such snake venom components include bradykinin potentiating peptides (proline-rich oligopeptides), natriuretic peptides, phosp …
Directed evolution of three-finger toxin to produce serine protease inhibitors.
Cai W, Naimuddin M, Inagaki H, Kameyama K, Ishida N, Kubo T. Cai W, et al. J Recept Signal Transduct Res. 2014 Jun;34(3):154-61. doi: 10.3109/10799893.2013.865747. Epub 2013 Dec 6. J Recept Signal Transduct Res. 2014. PMID: 24308378
Previously, we demonstrated that functional regulatory molecules against interleukin-6 receptor (IL-6R) could be obtained by directed evolution of the three-finger toxin (3F) scaffold. In the present study, trypsin was selected as a target for directed evolut …
Previously, we demonstrated that functional regulatory molecules against interleukin-6 receptor (IL-6R) could be obtained by directed evolut …
Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases.
Kini RM, Koh CY. Kini RM, et al. Biochem Pharmacol. 2020 Nov;181:114105. doi: 10.1016/j.bcp.2020.114105. Epub 2020 Jun 21. Biochem Pharmacol. 2020. PMID: 32579959 Review.
In the recent years, sensitive and high throughput approaches drive discovery and cataloging of new snake venom toxins. As one of the largest class of snake venom toxin, there are now>700 sequences of three-finger toxins (3FTxs) available, ma …
In the recent years, sensitive and high throughput approaches drive discovery and cataloging of new snake venom toxins. As one of the …
Snake Venom Peptides: Tools of Biodiscovery.
Munawar A, Ali SA, Akrem A, Betzel C. Munawar A, et al. Toxins (Basel). 2018 Nov 14;10(11):474. doi: 10.3390/toxins10110474. Toxins (Basel). 2018. PMID: 30441876 Free PMC article. Review.
Venom is known to be a very poisonous mixture, consisting of a variety of molecules, such as carbohydrates, nucleosides, amino acids, lipids, proteins and peptides. Proteins and peptides are the major constituents of the dry weight of snake venoms and are of main in …
Venom is known to be a very poisonous mixture, consisting of a variety of molecules, such as carbohydrates, nucleosides, amino acids, lipids …
Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity.
Pawlak J, Mackessy SP, Sixberry NM, Stura EA, Le Du MH, Ménez R, Foo CS, Ménez A, Nirthanan S, Kini RM. Pawlak J, et al. FASEB J. 2009 Feb;23(2):534-45. doi: 10.1096/fj.08-113555. Epub 2008 Oct 24. FASEB J. 2009. PMID: 18952712
This is the first colubrid three-finger toxin dimer, covalently connected via an interchain disulfide bond. Irditoxin showed taxon-specific lethality toward birds and lizards and was nontoxic toward mice. It produced a potent neuromuscular blockade at the avi …
This is the first colubrid three-finger toxin dimer, covalently connected via an interchain disulfide bond. Irditoxin s …
From Snake Venoms to Therapeutics: A Focus on Natriuretic Peptides.
Ang WF, Koh CY, Kini RM. Ang WF, et al. Pharmaceuticals (Basel). 2022 Sep 16;15(9):1153. doi: 10.3390/ph15091153. Pharmaceuticals (Basel). 2022. PMID: 36145374 Free PMC article. Review.
These biomolecules are classified into different classes based on their functions. They include three-finger toxins, natriuretic peptides, phospholipases and metalloproteinases. The focus for this review is on the natriuretic peptide (NP), which …
These biomolecules are classified into different classes based on their functions. They include three-finger toxins, na …
Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on.
Nirthanan S, Gwee MC. Nirthanan S, et al. J Pharmacol Sci. 2004 Jan;94(1):1-17. doi: 10.1254/jphs.94.1. J Pharmacol Sci. 2004. PMID: 14745112 Free article. Review.
Since then, the sites of interaction between alpha-neurotoxins and nAChRs have largely been delineated, revealing the remarkable plasticity of the three-finger toxin fold that has optimally evolved to utilize different combinations of functional groups to gen …
Since then, the sites of interaction between alpha-neurotoxins and nAChRs have largely been delineated, revealing the remarkable plasticity …
Snake Venom Compounds: A New Frontier in the Battle Against Antibiotic-Resistant Infections.
Muttiah B, Hanafiah A. Muttiah B, et al. Toxins (Basel). 2025 May 1;17(5):221. doi: 10.3390/toxins17050221. Toxins (Basel). 2025. PMID: 40423304 Free PMC article. Review.
Snake venoms are complex combinations of bioactive peptides and proteins, including metalloproteases (MPs), serine proteases (SPs), phospholipase A(2) (PLA(2)) enzymes, three-finger toxins (3FTXs), cysteine-rich secretory proteins (CRISPs), L-amino aci …
Snake venoms are complex combinations of bioactive peptides and proteins, including metalloproteases (MPs), serine proteases (SPs), p …
Identification and characterization of a taxon-specific three-finger toxin from the venom of the Green Vinesnake (Oxybelis fulgidus; family Colubridae).
Heyborne WH, Mackessy SP. Heyborne WH, et al. Biochimie. 2013 Oct;95(10):1923-32. doi: 10.1016/j.biochi.2013.06.025. Epub 2013 Jul 10. Biochimie. 2013. PMID: 23851011
Snake venoms contain a variety of protein and peptide toxins, and the three-finger toxins (3FTxs) are among the best characterized family of venom proteins. ...These findings underscore the importance of rear-fanged snake venoms for understandin …
Snake venoms contain a variety of protein and peptide toxins, and the three-finger toxins (3FTxs) are amo …
Snake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents.
Almeida JR, Resende LM, Watanabe RK, Carregari VC, Huancahuire-Vega S, da S Caldeira CA, Coutinho-Neto A, Soares AM, Vale N, de C Gomes PA, Marangoni S, de A Calderon L, Da Silva SL. Almeida JR, et al. Curr Med Chem. 2017;24(30):3254-3282. doi: 10.2174/0929867323666161028155611. Curr Med Chem. 2017. PMID: 27804880 Review.
Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecular architecture to design and develop tools and agents of scientific and therapeutic interest. ...The present review looks at the mai …
Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecul …
43 results