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Year Number of Results
1995 1
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63 results

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Page 1
Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease.
Mattsson-Carlgren N, Janelidze S, Palmqvist S, Cullen N, Svenningsson AL, Strandberg O, Mengel D, Walsh DM, Stomrud E, Dage JL, Hansson O. Mattsson-Carlgren N, et al. Brain. 2020 Dec 5;143(11):3234-3241. doi: 10.1093/brain/awaa286. Brain. 2020. PMID: 33068398 Free PMC article.
Plasma levels of tau phosphorylated at threonine-217 (p-tau217) is a candidate tool to monitor Alzheimer's disease. We studied 150 cognitively unimpaired participants and 100 patients with mild cognitive impairment in the Swedish BioFINDER study. ...Longitudinal increases …
Plasma levels of tau phosphorylated at threonine-217 (p-tau217) is a candidate tool to monitor Alzheimer's disease. We studied 150 co …
Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2.
Caiola HO, Wu Q, Li J, Wang XF, Soni S, Monahan K, Wagner GC, Pang ZP, Zhang H. Caiola HO, et al. FASEB J. 2024 Oct 31;38(20):e70124. doi: 10.1096/fj.202400454R. FASEB J. 2024. PMID: 39436150 Free PMC article.
Neuronal connectivity is essential for adaptive brain responses and can be modulated by dendritic spine plasticity and the intrinsic excitability of individual neurons. ...However, despite its genetic association with several neurological disorders, the in vivo impa …
Neuronal connectivity is essential for adaptive brain responses and can be modulated by dendritic spine plasticity and the intrinsic …
mTOR in Brain Physiology and Pathologies.
Bockaert J, Marin P. Bockaert J, et al. Physiol Rev. 2015 Oct;95(4):1157-87. doi: 10.1152/physrev.00038.2014. Physiol Rev. 2015. PMID: 26269525 Free article. Review.
In addition, mTOR-controlled signaling pathways regulate many integrated physiological functions of the nervous system including neuronal development, synaptic plasticity, memory storage, and cognition. Thus it is not surprising that deregulation of mTOR signaling is assoc …
In addition, mTOR-controlled signaling pathways regulate many integrated physiological functions of the nervous system including neuronal de …
The role of Cdk5 in cognition and neuropsychiatric and neurological pathology.
Barnett DG, Bibb JA. Barnett DG, et al. Brain Res Bull. 2011 Apr 25;85(1-2):9-13. doi: 10.1016/j.brainresbull.2010.11.016. Epub 2010 Dec 7. Brain Res Bull. 2011. PMID: 21145377 Free PMC article. Review.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts with a myriad of substrates. Its modulation of synaptic plasticity and associated mechanisms of learning and memory as well as neurodegener …
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts …
Repeated Exposure to Lidocaine Induces Alzheimer's‐Like Cognitive Impairment and Neuropathology in Aged Mice Through BDNF‐Regulated Autophagy.
Huang Y, Guo Y, Zhang H, Deng J, Huang Z, Chen A, Wu X, Lin D, Ye P, Chen X, Zheng X. Huang Y, et al. J Cell Mol Med. 2025 Dec;29(23):e70970. doi: 10.1111/jcmm.70970. J Cell Mol Med. 2025. PMID: 41318982 Free PMC article.
Lidocaine is widely used for perioperative pain management, but repeated exposure may cause neurotoxicity, including neurological deficits. This study investigates mechanisms underlying cognitive decline induced by repeated lidocaine exposure. ...The TrkB agonist 7,8-DHF w …
Lidocaine is widely used for perioperative pain management, but repeated exposure may cause neurotoxicity, including neurological def …
Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease.
Jin J, Chen J, Cavaillès C, Yaffe K, Winer J, Stankeviciute L, Lucey BP, Zhou X, Gao S, Peng D, Leng Y. Jin J, et al. Alzheimers Dement. 2025 Feb;21(2):e14495. doi: 10.1002/alz.14495. Epub 2025 Jan 27. Alzheimers Dement. 2025. PMID: 39868572 Free PMC article.
METHODS: We enrolled 128 adults (64 with Alzheimer's disease, 41 with mild cognitive impairment [MCI], and 23 with normal cognition [NC]), mean age 70.8 9.6 years, 56.9% female, from a tertiary hospital in China. Participants underwent overnight polysomnography (PSG), am …
METHODS: We enrolled 128 adults (64 with Alzheimer's disease, 41 with mild cognitive impairment [MCI], and 23 with normal cognition [ …
SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability.
Roychaudhury A, Lee YR, Choi TI, Thomas MG, Khan TN, Yousaf H, Skinner C, Maconachie G, Crosier M, Horak H, Constantinescu CS, Kim TY, Lee KH, Kyung JJ, Wang T, Ku B, Chodirker BN, Hammer MF, Gottlob I, Norton WHJ, Gerlai R, Kim HG, Graziano C, Pippucci T, Iovino E, Montanari F, Severi G, Toro C, Boerkoel CF, Cha HS, Choi CY, Kim S, Yoon JH, Gilmore K, Vora NL, Davis EE, Chudley AE, Schwartz CE, Kim CH. Roychaudhury A, et al. Ann Neurol. 2024 Nov;96(5):914-931. doi: 10.1002/ana.27037. Epub 2024 Jul 29. Ann Neurol. 2024. PMID: 39073169 Free PMC article.
A ninth case, ascertained prenatally, had a complex structural brain phenotype. Together, these data indicate a pathological role of SRPK3 in neurodevelopmental disorders. ...INTERPRETATION: Overall, these results suggest a crucial role of SRPK3 in the pathogenesis of synd …
A ninth case, ascertained prenatally, had a complex structural brain phenotype. Together, these data indicate a pathological role of …
Review of Associations of Diabetes and Insulin Resistance With Brain Health in Three Harmonised Cohort Studies of Ageing and Dementia.
Biswas R, Capuano AW, Mehta RI, Barnes LL, Bennett DA, Arvanitakis Z. Biswas R, et al. Diabetes Metab Res Rev. 2025 Jan;41(1):e70032. doi: 10.1002/dmrr.70032. Diabetes Metab Res Rev. 2025. PMID: 39873127 Free PMC article. Review.
Recent studies have measured additional peripheral and brain IR data, including multi-omics. This review summarises findings from the RADC cohort studies that investigate the relation of diabetes and IR in older adults to cognition, neuropathology, omics in dementia …
Recent studies have measured additional peripheral and brain IR data, including multi-omics. This review summarises findings from the …
Blast exposure predisposes the brain to increased neurological deficits in a model of blast plus blunt traumatic brain injury.
Aravind A, Kosty J, Chandra N, Pfister BJ. Aravind A, et al. Exp Neurol. 2020 Oct;332:113378. doi: 10.1016/j.expneurol.2020.113378. Epub 2020 Jun 15. Exp Neurol. 2020. PMID: 32553593
Soldiers are often exposed to more than one traumatic brain injury (TBI) over the course of their service. In recent years, more attention has been drawn to the increased risk of neurological deficits caused by the 'blast plus' polytrauma, which typically is a blast …
Soldiers are often exposed to more than one traumatic brain injury (TBI) over the course of their service. In recent years, more atte …
Cyclin-dependent kinases in brain development and disease.
Su SC, Tsai LH. Su SC, et al. Annu Rev Cell Dev Biol. 2011;27:465-91. doi: 10.1146/annurev-cellbio-092910-154023. Epub 2011 Jul 5. Annu Rev Cell Dev Biol. 2011. PMID: 21740229 Review.
Over the past decade, Cdk5 activity has been demonstrated to regulate many events during brain development, including neuronal migration as well as axon and dendrite development. Recent evidence also suggests a pivotal role for Cdk5 in synaptic plasticity, behavior, and …
Over the past decade, Cdk5 activity has been demonstrated to regulate many events during brain development, including neuronal migrat …
63 results