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Year Number of Results
1964 1
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1974 7
1975 7
1976 3
1977 2
1978 5
1979 2
1980 4
1981 9
1983 6
1984 11
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1986 11
1987 4
1988 12
1989 14
1990 20
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1992 28
1993 40
1994 50
1995 79
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1998 86
1999 93
2000 121
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2002 148
2003 135
2004 152
2005 147
2006 130
2007 140
2008 144
2009 163
2010 164
2011 214
2012 250
2013 263
2014 284
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6,806 results

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Page 1
mTOR inhibition improves immune function in the elderly.
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB. Mannick JB, et al. Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892. Sci Transl Med. 2014. PMID: 25540326 Clinical Trial.
To begin to assess the effects of mTOR inhibition on human aging-related conditions, we evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence (the decline in immune function during aging) in elderly volunteers, as assessed by their response to inf …
To begin to assess the effects of mTOR inhibition on human aging-related conditions, we evaluated whether the mTOR inhibitor RAD001 ameliora …
l-Threonine improves intestinal mucin synthesis and immune function of intrauterine growth-retarded weanling piglets.
Zhang H, Chen Y, Li Y, Zhang T, Ying Z, Su W, Zhang L, Wang T. Zhang H, et al. Nutrition. 2019 Mar;59:182-187. doi: 10.1016/j.nut.2018.07.114. Epub 2018 Aug 22. Nutrition. 2019. PMID: 30504005
OBJECTIVES: The aim of this study was to investigate the effects of dietary l-threonine supplementation on the growth performance, intestinal immune function, mucin synthesis, and goblet cell differentiation in weanling piglets with intrauterine growth retard …
OBJECTIVES: The aim of this study was to investigate the effects of dietary l-threonine supplementation on the growth performance, in …
O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.
Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. Li X, et al. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770249 Free PMC article.
However, the role of individual glucose metabolic pathways during immune cell activation and inflammation remains incompletely understood. Here, we demonstrate a previously unrecognized anti-inflammatory function of the O-linked beta-N-acetylglucosamine (O-GlcNAc) s …
However, the role of individual glucose metabolic pathways during immune cell activation and inflammation remains incompletely unders …
More TOR: The expanding role of mTOR in regulating immune responses.
Patel CH, Powell JD. Patel CH, et al. Immunity. 2025 Jul 8;58(7):1629-1645. doi: 10.1016/j.immuni.2025.06.010. Epub 2025 Jun 30. Immunity. 2025. PMID: 40592340 Review.
Decades worth of studies have intricately dissected the mTOR pathway to identify regulatory signals that are essential for regulating immune cell activation, differentiation, and function. As the mTOR field continues to evolve, so too does our understanding of these …
Decades worth of studies have intricately dissected the mTOR pathway to identify regulatory signals that are essential for regulating imm …
Innate immune function of serine/threonine-protein kinase from Macrobrachium rosenbergii in response to host-pathogen interactions.
Ravichandran G, Pasupuleti M, Arasu MV, Al-Dhabi NA, Arshad A, Arockiaraj J. Ravichandran G, et al. Fish Shellfish Immunol. 2020 Nov;106:332-340. doi: 10.1016/j.fsi.2020.07.068. Epub 2020 Aug 3. Fish Shellfish Immunol. 2020. PMID: 32758637
Triggering the natural defense mechanism would provide an effective and safest way of protecting the host system. Hence, we have investigated the innate immune function of serine/threonine-protein kinase (STPK) in Macrobrachium rosenbergii (Mr). ...Thi …
Triggering the natural defense mechanism would provide an effective and safest way of protecting the host system. Hence, we have inve …
The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling.
Stegmann M, Monaghan J, Smakowska-Luzan E, Rovenich H, Lehner A, Holton N, Belkhadir Y, Zipfel C. Stegmann M, et al. Science. 2017 Jan 20;355(6322):287-289. doi: 10.1126/science.aal2541. Science. 2017. PMID: 28104890 Free article.
This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENS …
This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex forma …
Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.
Zhang Z, Geng C, Song M, Liang H, Zhou K, Liu Y, Wu J, Huang X, Zhou J, Fan J, Peng DH, Zhang L, Cang Y, Sun Y. Zhang Z, et al. J Hepatol. 2025 Aug;83(2):397-410. doi: 10.1016/j.jhep.2025.01.027. Epub 2025 Jan 30. J Hepatol. 2025. PMID: 39892819
BACKGROUND & AIMS: Immune evasion by tumor cells is a principal obstacle to effectively targeting metastasis in hepatocellular carcinoma (HCC). ...SGK1 expression in metastatic lesions may serve as a predictive biomarker for response to immune checkpoint inhibit …
BACKGROUND & AIMS: Immune evasion by tumor cells is a principal obstacle to effectively targeting metastasis in hepatocellular ca …
Immune function of a C-type lectin with long tandem repeats and abundant threonine in the ridgetail white prawn Exopalaemon carinicauda.
Cui X, Jiang Z, Xu J, Yu Y, Liu Q, Ren Q, Wang L, Wan X, Huang X. Cui X, et al. Fish Shellfish Immunol. 2024 Aug;151:109721. doi: 10.1016/j.fsi.2024.109721. Epub 2024 Jun 23. Fish Shellfish Immunol. 2024. PMID: 38917950
Our study revealed a new CTL that is composed of two long tandem repeats, abundant threonine, and one carbohydrate recognition domain (CRD) in Exopalaemon carinicauda and has been designated EcTR-CTL. ...These findings indicate that 1) CTLs with tandem repeats may be ubiqu …
Our study revealed a new CTL that is composed of two long tandem repeats, abundant threonine, and one carbohydrate recognition domain …
Necroptosis in anti-viral inflammation.
Nailwal H, Chan FK. Nailwal H, et al. Cell Death Differ. 2019 Jan;26(1):4-13. doi: 10.1038/s41418-018-0172-x. Epub 2018 Jul 26. Cell Death Differ. 2019. PMID: 30050058 Free PMC article. Review.
The primary function of the immune system is to protect the host from invading pathogens. In response, microbial pathogens have developed various strategies to evade detection and destruction by the immune system. ...Since pathogen-specific T ce …
The primary function of the immune system is to protect the host from invading pathogens. In response, microbial pathog …
6,806 results